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thioctic acid and Parkinsonian Disorders

thioctic acid has been researched along with Parkinsonian Disorders in 4 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.

Research Excerpts

ExcerptRelevanceReference
"In a model of early-stage Parkinson's disease induced by a single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to Wistar rats, a neuroprotective effect of a new derivative of carnosine and α-lipoic acid (C/LA nanomicellar complex) was demonstrated."1.48Neuroprotective effect of the carnosine - α-lipoic acid nanomicellar complex in a model of early-stage Parkinson's disease. ( Berezhnoy, DS; Fedorova, TN; Kulikova, OI; Lopachev, AV; Orlova, VS; Stvolinsky, SL, 2018)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kulikova, OI1
Berezhnoy, DS1
Stvolinsky, SL1
Lopachev, AV1
Orlova, VS1
Fedorova, TN1
Jalali-Nadoushan, M1
Roghani, M1
Li, YH1
He, Q1
Yu, JZ1
Liu, CY1
Feng, L1
Chai, Z1
Wang, Q1
Zhang, HZ1
Zhang, GX1
Xiao, BG1
Ma, CG1
Karunakaran, S1
Diwakar, L1
Saeed, U1
Agarwal, V1
Ramakrishnan, S1
Iyengar, S1
Ravindranath, V1

Other Studies

4 other studies available for thioctic acid and Parkinsonian Disorders

ArticleYear
Neuroprotective effect of the carnosine - α-lipoic acid nanomicellar complex in a model of early-stage Parkinson's disease.
    Regulatory toxicology and pharmacology : RTP, 2018, Volume: 95

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antioxidants; Brain; Carnosine; Dopamine; Homovanillic Acid

2018
Alpha-lipoic acid protects against 6-hydroxydopamine-induced neurotoxicity in a rat model of hemi-parkinsonism.
    Brain research, 2013, Apr-10, Volume: 1505

    Topics: Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Dose-Response Relationship, Drug; F

2013
Lipoic acid protects dopaminergic neurons in LPS-induced Parkinson's disease model.
    Metabolic brain disease, 2015, Volume: 30, Issue:5

    Topics: Animals; Antioxidants; Dopaminergic Neurons; Female; Lipopolysaccharides; Mice; Mice, Inbred C57BL;

2015
Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by alpha-lipoic acid.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2007, Volume: 21, Issue:9

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylcysteine; Alkynes; Animals; Antioxidants; Antipa

2007