thioctic acid has been researched along with Ochronosis in 1 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Ochronosis: The yellowish discoloration of connective tissue due to deposition of HOMOGENTISIC ACID (a brown-black pigment). This is due to defects in the metabolism of PHENYLALANINE and TYROSINE. Ochronosis occurs in ALKAPTONURIA, but has also been associated with exposure to certain chemicals (e.g., PHENOL, trinitrophenol, BENZENE DERIVATIVES).
| Excerpt | Relevance | Reference |
|---|---|---|
| " This leads to the accumulation of homogentisic acid (HGA) and its oxidized/polymerized products in connective tissues, which in turn become characterized by the presence of melanin-like pigments (ochronosis)." | 3.76 | Evaluation of anti-oxidant treatments in an in vitro model of alkaptonuric ochronosis. ( Amato, L; Bernardini, G; Braconi, D; Cavallo, G; Laschi, M; Marcolongo, R; Millucci, L; Santucci, A; Spreafico, A, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Braconi, D | 1 |
| Laschi, M | 1 |
| Amato, L | 1 |
| Bernardini, G | 1 |
| Millucci, L | 1 |
| Marcolongo, R | 1 |
| Cavallo, G | 1 |
| Spreafico, A | 1 |
| Santucci, A | 1 |
1 other study available for thioctic acid and Ochronosis
| Article | Year |
|---|---|
Evaluation of anti-oxidant treatments in an in vitro model of alkaptonuric ochronosis.
Topics: Acetylcysteine; Alkaptonuria; Antioxidants; Ascorbic Acid; Cells, Cultured; Coumaric Acids; Homogent | 2010 |