thioctic acid has been researched along with Obesity in 73 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eicosapentaenoic acid (EPA) and α-lipoic acid (α-LA) have been investigated for their beneficial effects on obesity and cardiovascular risk factors." | 9.27 | Untargeted metabolomic on urine samples after α-lipoic acid and/or eicosapentaenoic acid supplementation in healthy overweight/obese women. ( González-Navarro, CJ; Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Ramos-López, O; Romo-Hualde, A, 2018) |
| "This study investigated possible mechanisms for cardioprotective effects of lipoic acid (LA), quercetin (Q) and resveratrol (R) on oxidative stress related to thyroid hormone alterations in long-term obesity." | 7.83 | Cardioprotective effects of lipoic acid, quercetin and resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity. ( Cheserek, MJ; Karangwa, E; Le, G; Li, L; Shi, Y; Wu, G, 2016) |
| "We compared body weight and food intake among vehicle-, olanzapine-, and olanzapine plus ALA-treated mice, and measured hypothalamic AMP-activated protein kinase (AMPK) activity by detecting levels of Thr(172) and Ser(485/491) phosphorylation, which indicate activation and inhibition of AMPK, respectively." | 7.80 | Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine. ( Cho, HS; Jeong, J; Kim, E; Kim, H; Lee, BI; Lee, SK; Namkoong, K; Park, JY; Park, M, 2014) |
| "We evaluate the effect of supplementation, at 300 mg kg(-1) body weight (BW), with the antioxidants α-lipoic acid (AL), betaine (BT), l-carnitine (LC), and the combination of these and exercise on obesity induced by a 9 week high-fat diet (HFD) in mice." | 7.80 | The effect of dietary α-lipoic acid, betaine, l-carnitine, and swimming on the obesity of mice induced by a high-fat diet. ( Jang, A; Jo, C; Jung, S; Kim, D; Kim, HJ; Sung, KS, 2014) |
| "Body weight loss was significantly higher (P<0." | 6.80 | Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. ( Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Navas-Carretero, S; Prieto-Hontoria, PL, 2015) |
| "Polycystic ovary syndrome is characterized by several endocrine impairments, insulin resistance and hyperinsulinemia." | 5.51 | Differential insulin response to oral glucose tolerance test (OGTT) in overweight/obese polycystic ovary syndrome patients undergoing to myo-inositol (MYO), alpha lipoic acid (ALA), or combination of both. ( Genazzani, AD; Marchini, F; Napolitano, A; Petrillo, T; Prati, A; Simoncini, T, 2019) |
| "Eicosapentaenoic acid (EPA) and α-lipoic acid (α-LA) have been investigated for their beneficial effects on obesity and cardiovascular risk factors." | 5.27 | Untargeted metabolomic on urine samples after α-lipoic acid and/or eicosapentaenoic acid supplementation in healthy overweight/obese women. ( González-Navarro, CJ; Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Ramos-López, O; Romo-Hualde, A, 2018) |
| " The objectives of the present study were to analyse the relationship between irisin and glucose metabolism at baseline and during an oral glucose tolerance test (OGTT) and to determine the effects of eicosapentaenoic acid (EPA) and/or α-lipoic acid treatment on irisin production in cultured human adipocytes and in vivo in healthy overweight/obese women following a weight loss program." | 5.20 | Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid. ( Cuervo, M; Fernández-Galilea, M; Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Prieto-Hontoria, PL; Sáinz, N, 2015) |
| "Lipid mediators derived from arachidonic acid (AA) are implicated with the occurrence of inflammation and oxidative stress." | 4.12 | α-lipoic acid ameliorates inflammation state and oxidative stress by reducing the content of bioactive lipid derivatives in the left ventricle of rats fed a high-fat diet. ( Chabowski, A; Hodun, K; Sztolsztener, K, 2022) |
| "This study investigated possible mechanisms for cardioprotective effects of lipoic acid (LA), quercetin (Q) and resveratrol (R) on oxidative stress related to thyroid hormone alterations in long-term obesity." | 3.83 | Cardioprotective effects of lipoic acid, quercetin and resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity. ( Cheserek, MJ; Karangwa, E; Le, G; Li, L; Shi, Y; Wu, G, 2016) |
| "We compared body weight and food intake among vehicle-, olanzapine-, and olanzapine plus ALA-treated mice, and measured hypothalamic AMP-activated protein kinase (AMPK) activity by detecting levels of Thr(172) and Ser(485/491) phosphorylation, which indicate activation and inhibition of AMPK, respectively." | 3.80 | Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine. ( Cho, HS; Jeong, J; Kim, E; Kim, H; Lee, BI; Lee, SK; Namkoong, K; Park, JY; Park, M, 2014) |
| "We evaluate the effect of supplementation, at 300 mg kg(-1) body weight (BW), with the antioxidants α-lipoic acid (AL), betaine (BT), l-carnitine (LC), and the combination of these and exercise on obesity induced by a 9 week high-fat diet (HFD) in mice." | 3.80 | The effect of dietary α-lipoic acid, betaine, l-carnitine, and swimming on the obesity of mice induced by a high-fat diet. ( Jang, A; Jo, C; Jung, S; Kim, D; Kim, HJ; Sung, KS, 2014) |
| " Body weight, food intake, fat mass, phosphorylated AMPKα (pAMPKα), and phosphorylated acetyl-CoA carboxylase (ACC) protein expression in both the hypothalamus and white adipose tissue (WAT) as well as plasma leptin and adiponectin levels were measured in rats after either Ovx or sham operations." | 3.77 | Reciprocal effects of α-lipoic acid on adenosine monophosphate-activated protein kinase activity in obesity induced by ovariectomy in rats. ( Cheng, PY; Lam, KK; Lee, YM; Peng, JC; Yen, MH, 2011) |
| "The advanced glycation end product inhibitor pyridoxamine (PYR) and the antioxidant alpha-lipoic acid (LA) interact to ameliorate insulin resistance in obese Zucker rats following short-term (6-week) treatment." | 3.75 | Metabolic interactions of AGE inhibitor pyridoxamine and antioxidant alpha-lipoic acid following 22 weeks of treatment in obese Zucker rats. ( Diehl, CJ; Hasselwander, O; Henriksen, EJ; Lindborg, KA; Matuschek, M; Muellenbach, EM; Teachey, MK, 2009) |
| "Obesity is defined as a chronic disease, and is known as a public health problem in developed and developing countries." | 3.01 | The effect of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric parameters, body composition and angiogenesis factor, sirtunin-1 and peroxisome proliferator-activated receptor-γ coactivator-1α in obese people under a ( Ahmadi-Angali, K; Helli, B; Mohammadshahi, M; Ravanbakhsh, M; Zakizadeh, E, 2021) |
| "Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury." | 2.90 | The effect of alpha-lipoic acid on inflammatory markers and body composition in obese patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial. ( Amirkhizi, F; Ebrahimi-Mameghani, M; Hosseinpour-Arjmand, S, 2019) |
| "On the other hand, α-LA treats central obesity by increasing adiponectin levels and mitochondrial biogenesis and can reduce food intake mainly by SIRT1 stimulation." | 2.82 | Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review. ( Ghasemzadeh Rahbardar, M; Hosseinzadeh, H; Mehri, S; Najafi, N, 2022) |
| "Body weight loss was significantly higher (P<0." | 2.80 | Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. ( Huerta, AE; Martínez, JA; Moreno-Aliaga, MJ; Navas-Carretero, S; Prieto-Hontoria, PL, 2015) |
| "There are numerous trials reported the effect of alpha-lipoic acid (ALA) on obesity measurements; while no summarised dose-response meta-analysis is available to address the effects of dose and duration of ALA supplementation on obesity measurements." | 2.66 | Alpha-lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta-analysis of randomised placebo-controlled clinical trials. ( Abbasalizad Farhangi, M; Vajdi, M, 2020) |
| " Data suggests that ALA has a short half-life and bioavailability (about 30%) triggered by its hepatic degradation, reduced solubility as well as instability in the stomach." | 2.61 | Insights on the Use of α-Lipoic Acid for Therapeutic Purposes. ( Akram, M; Antika, G; Berkay Yılmaz, Y; Boyunegmez Tumer, T; Capanoglu, E; Cho, WC; Fawzi Mahomoodally, M; Lobine, D; Martins, N; Riaz, M; Salehi, B; Sharifi-Rad, J; Sharopov, F, 2019) |
| "The incidence of NIDDM is highest in economically developed nations, particularly the U." | 2.41 | Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes. ( McDonald, RB; Ruhe, RC, 2001) |
| "Correlation between type 2 diabetes and other abnormalities such as obesity with redox balance disturbance was analyzed in many reports." | 1.72 | The Effect of α-Lipoic Acid on Oxidative Stress in Adipose Tissue of Rats with Obesity-Induced Insulin Resistance. ( Chabowski, A; Dajnowicz-Brzezik, P; Maciejczyk, M; Zalewska, A; Żebrowska, E, 2022) |
| "Obesity is becoming pandemic and is associated with impaired reproductive potential." | 1.56 | Effects of α-lipoic acid and myo-inositol supplementation on the oocyte environment of infertile obese women: A preliminary study. ( Anelli, GM; Cetin, I; Lisso, F; Mandò, C; Marzorati, A; Novielli, C; Oneta, M; Parrilla, B; Savasi, VM, 2020) |
| "Obesity is already responsible for 300,000 deaths per year." | 1.51 | The influence of apocynin, lipoic acid and probiotics on antioxidant enzyme levels in the pulmonary tissues of obese asthmatic mice. ( Kleniewska, P; Pawliczak, R, 2019) |
| "Polycystic ovary syndrome is characterized by several endocrine impairments, insulin resistance and hyperinsulinemia." | 1.51 | Differential insulin response to oral glucose tolerance test (OGTT) in overweight/obese polycystic ovary syndrome patients undergoing to myo-inositol (MYO), alpha lipoic acid (ALA), or combination of both. ( Genazzani, AD; Marchini, F; Napolitano, A; Petrillo, T; Prati, A; Simoncini, T, 2019) |
| "ALA integrative administration at a low dosage as 400 mg daily improved the metabolic impairment of all PCOS patients especially in those PCOS with familiar diabetes who have a higher grade of risk of NAFLD and predisposition to diabetes." | 1.48 | Modulatory effects of alpha-lipoic acid (ALA) administration on insulin sensitivity in obese PCOS patients. ( Della Casa, D; Despini, G; Genazzani, AD; Manzo, A; Napolitano, A; Prati, A; Shefer, K; Simoncini, T, 2018) |
| "Alpha-lipoic acid at a dosage of 50 mg/kg b." | 1.43 | Hypotensive effect of alpha-lipoic acid after a single administration in rats. ( Bilska-Wilkosz, A; Dudek, M; Filipek, B; Iciek, M; Razny, K; Sapa, J; Wlodek, L, 2016) |
| "Fatty liver is common in obese subjects with insulin resistance." | 1.35 | Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. ( Choi, HS; Hwang, JS; Jang, BK; Kim, HS; Kim, JB; Kim, MO; Kim, YD; Koh, EH; Lee, IK; Lee, KU; Min, AK; Park, HS; Park, JY; Park, KG; Yoon, TS, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (4.11) | 18.2507 |
| 2000's | 15 (20.55) | 29.6817 |
| 2010's | 43 (58.90) | 24.3611 |
| 2020's | 12 (16.44) | 2.80 |
| Authors | Studies |
|---|---|
| Abdul Sater, Z | 1 |
| Cero, C | 1 |
| Pierce, AE | 1 |
| Lea, HJ | 1 |
| Abdul Sater, H | 1 |
| Zhu, KY | 1 |
| Liu, N | 1 |
| Ma, Y | 1 |
| Gavrilova, O | 1 |
| Cypess, AM | 1 |
| Najafi, N | 1 |
| Mehri, S | 1 |
| Ghasemzadeh Rahbardar, M | 1 |
| Hosseinzadeh, H | 1 |
| Wołosowicz, M | 1 |
| Łukaszuk, B | 1 |
| Kasacka, I | 1 |
| Chabowski, A | 3 |
| Dajnowicz-Brzezik, P | 1 |
| Żebrowska, E | 1 |
| Maciejczyk, M | 1 |
| Zalewska, A | 1 |
| Sztolsztener, K | 1 |
| Hodun, K | 1 |
| Kleniewska, P | 2 |
| Pawliczak, R | 2 |
| Tutunchi, H | 1 |
| Arefhosseini, S | 1 |
| Ebrahimi-Mameghani, M | 2 |
| Salehi, B | 1 |
| Berkay Yılmaz, Y | 1 |
| Antika, G | 1 |
| Boyunegmez Tumer, T | 1 |
| Fawzi Mahomoodally, M | 1 |
| Lobine, D | 1 |
| Akram, M | 1 |
| Riaz, M | 1 |
| Capanoglu, E | 1 |
| Sharopov, F | 1 |
| Martins, N | 1 |
| Cho, WC | 1 |
| Sharifi-Rad, J | 1 |
| Takenouchi, Y | 1 |
| Tsuboi, K | 1 |
| Ohsuka, K | 1 |
| Nobe, K | 1 |
| Ohtake, K | 1 |
| Okamoto, Y | 1 |
| Kasono, K | 1 |
| Vajdi, M | 1 |
| Abbasalizad Farhangi, M | 1 |
| Artini, PG | 1 |
| Obino, MER | 1 |
| Micelli, E | 1 |
| Malacarne, E | 1 |
| Vacca, C | 1 |
| Papini, F | 1 |
| Cela, V | 1 |
| Mohammadshahi, M | 1 |
| Zakizadeh, E | 1 |
| Ahmadi-Angali, K | 1 |
| Ravanbakhsh, M | 1 |
| Helli, B | 1 |
| Novielli, C | 1 |
| Anelli, GM | 1 |
| Lisso, F | 1 |
| Marzorati, A | 1 |
| Parrilla, B | 1 |
| Oneta, M | 1 |
| Savasi, VM | 1 |
| Cetin, I | 1 |
| Mandò, C | 1 |
| Nasiri, G | 1 |
| Bastani, A | 1 |
| Haji-Aghamohammadi, AA | 1 |
| Nooshabadi, MR | 1 |
| Shahmirzalou, P | 1 |
| Haghighian, HK | 1 |
| Al-Ghamdi, MA | 1 |
| Choudhry, H | 1 |
| Al-Doghather, HA | 1 |
| Huwait, EH | 1 |
| Kumosani, TA | 1 |
| Moselhy, SS | 1 |
| Liu, Z | 1 |
| Patil, I | 1 |
| Sancheti, H | 1 |
| Yin, F | 1 |
| Cadenas, E | 1 |
| Genazzani, AD | 2 |
| Shefer, K | 1 |
| Della Casa, D | 1 |
| Prati, A | 2 |
| Napolitano, A | 2 |
| Manzo, A | 1 |
| Despini, G | 1 |
| Simoncini, T | 2 |
| Romo-Hualde, A | 1 |
| Huerta, AE | 4 |
| González-Navarro, CJ | 1 |
| Ramos-López, O | 1 |
| Moreno-Aliaga, MJ | 8 |
| Martínez, JA | 7 |
| Castro, MC | 2 |
| Villagarcía, HG | 1 |
| Massa, ML | 2 |
| Francini, F | 2 |
| Hosseinpour-Arjmand, S | 1 |
| Amirkhizi, F | 1 |
| Marchini, F | 1 |
| Petrillo, T | 1 |
| Ratliff, JC | 1 |
| Palmese, LB | 1 |
| Reutenauer, EL | 1 |
| Tek, C | 1 |
| Yi, X | 1 |
| Pashaj, A | 2 |
| Xia, M | 2 |
| Moreau, R | 2 |
| Miao, Y | 1 |
| Ren, J | 1 |
| Jiang, L | 1 |
| Liu, J | 1 |
| Jiang, B | 1 |
| Zhang, X | 1 |
| Cappelli, V | 1 |
| Di Sabatino, A | 1 |
| Musacchio, MC | 1 |
| De Leo, V | 1 |
| Carrier, B | 3 |
| Wen, S | 2 |
| Zigouras, S | 1 |
| Browne, RW | 2 |
| Li, Z | 2 |
| Patel, MS | 1 |
| Williamson, DL | 2 |
| Rideout, TC | 3 |
| Kim, H | 1 |
| Park, M | 1 |
| Lee, SK | 1 |
| Jeong, J | 1 |
| Namkoong, K | 1 |
| Cho, HS | 2 |
| Park, JY | 5 |
| Lee, BI | 1 |
| Kim, E | 2 |
| Jang, A | 1 |
| Kim, D | 1 |
| Sung, KS | 1 |
| Jung, S | 1 |
| Kim, HJ | 1 |
| Jo, C | 1 |
| Fernández-Galilea, M | 6 |
| Pérez-Matute, P | 4 |
| Prieto-Hontoria, PL | 6 |
| Sáinz, N | 2 |
| López-Yoldi, M | 1 |
| Houssier, M | 2 |
| Langin, D | 2 |
| Dungan, CM | 1 |
| Burrell, MA | 1 |
| Navas-Carretero, S | 1 |
| Raslawsky, A | 1 |
| Harding, SV | 1 |
| Cuervo, M | 1 |
| Okanović, A | 1 |
| Prnjavorac, B | 1 |
| Jusufović, E | 1 |
| Sejdinović, R | 1 |
| Dudek, M | 1 |
| Razny, K | 1 |
| Bilska-Wilkosz, A | 1 |
| Iciek, M | 1 |
| Sapa, J | 1 |
| Wlodek, L | 1 |
| Filipek, B | 1 |
| Moon, HS | 1 |
| Cheserek, MJ | 1 |
| Wu, G | 1 |
| Li, L | 2 |
| Karangwa, E | 1 |
| Shi, Y | 1 |
| Le, G | 1 |
| Cui, J | 1 |
| Huang, D | 1 |
| Zheng, Y | 1 |
| Escoté, X | 1 |
| Li, N | 2 |
| Yan, W | 1 |
| Hu, X | 1 |
| Huang, Y | 1 |
| Wang, F | 1 |
| Zhang, W | 1 |
| Wang, Q | 2 |
| Wang, X | 1 |
| Sun, K | 1 |
| Park, KG | 2 |
| Min, AK | 1 |
| Koh, EH | 4 |
| Kim, HS | 3 |
| Kim, MO | 1 |
| Park, HS | 2 |
| Kim, YD | 1 |
| Yoon, TS | 1 |
| Jang, BK | 1 |
| Hwang, JS | 1 |
| Kim, JB | 1 |
| Choi, HS | 1 |
| Lee, IK | 3 |
| Lee, KU | 4 |
| Muellenbach, EM | 1 |
| Diehl, CJ | 1 |
| Teachey, MK | 2 |
| Lindborg, KA | 1 |
| Hasselwander, O | 2 |
| Matuschek, M | 1 |
| Henriksen, EJ | 8 |
| Timmers, S | 1 |
| de Vogel-van den Bosch, J | 1 |
| Towler, MC | 1 |
| Schaart, G | 1 |
| Moonen-Kornips, E | 1 |
| Mensink, RP | 1 |
| Hesselink, MK | 1 |
| Hardie, DG | 1 |
| Schrauwen, P | 1 |
| Carbonelli, MG | 1 |
| Di Renzo, L | 1 |
| Bigioni, M | 1 |
| Di Daniele, N | 1 |
| De Lorenzo, A | 1 |
| Fusco, MA | 1 |
| Lee, WJ | 3 |
| Lee, SA | 1 |
| Kim, EH | 1 |
| Cho, EH | 1 |
| Jeong, E | 1 |
| Kim, DW | 1 |
| Kim, MS | 3 |
| Lee, HJ | 1 |
| Lim, S | 1 |
| Jang, HC | 1 |
| Lee, KH | 1 |
| Huang, YD | 1 |
| Zhang, WG | 1 |
| Hu, XJ | 1 |
| Wang, CC | 1 |
| Xu, RW | 1 |
| Yan, K | 1 |
| Hou, XY | 1 |
| Wang, XL | 1 |
| Yan, WL | 1 |
| Prieto-Hontoria, P | 1 |
| Cheng, PY | 1 |
| Lee, YM | 1 |
| Yen, MH | 1 |
| Peng, JC | 1 |
| Lam, KK | 1 |
| Zhang, Y | 1 |
| Han, P | 1 |
| Wu, N | 1 |
| He, B | 1 |
| Lu, Y | 1 |
| Li, S | 1 |
| Liu, Y | 1 |
| Zhao, S | 1 |
| Liu, L | 1 |
| Li, Y | 1 |
| Xiao, C | 1 |
| Giacca, A | 1 |
| Lewis, GF | 1 |
| Deiuliis, JA | 1 |
| Kampfrath, T | 1 |
| Ying, Z | 1 |
| Maiseyeu, A | 1 |
| Rajagopalan, S | 1 |
| McNeilly, AM | 1 |
| Davison, GW | 1 |
| Murphy, MH | 1 |
| Nadeem, N | 1 |
| Trinick, T | 1 |
| Duly, E | 1 |
| Novials, A | 1 |
| McEneny, J | 1 |
| Alfredo Martínez, J | 1 |
| Schinella, G | 1 |
| Gagliardino, JJ | 1 |
| Taylor, ZC | 1 |
| Maier, T | 2 |
| Saengsirisuwan, V | 3 |
| Sloniger, JA | 2 |
| Jacob, S | 3 |
| Klatt, MJ | 1 |
| Ptock, A | 1 |
| Kraemer, K | 1 |
| Perez, FR | 1 |
| Doggrell, SA | 1 |
| Song, KH | 1 |
| Koh, JM | 1 |
| Youn, JY | 1 |
| Youn, JH | 2 |
| Kim, YM | 1 |
| Won, JC | 1 |
| Han, SM | 1 |
| Jo, I | 1 |
| Oh, GT | 1 |
| Park, IS | 1 |
| Park, SW | 1 |
| Banday, AA | 2 |
| Fazili, FR | 1 |
| Marwaha, A | 1 |
| Lokhandwala, MF | 2 |
| Park, DW | 1 |
| Choi, SH | 1 |
| Kim, JJ | 1 |
| Streeper, RS | 2 |
| Hokama, JY | 2 |
| Fogt, DL | 2 |
| Tritschler, HJ | 5 |
| Konrad, T | 1 |
| Vicini, P | 1 |
| Kusterer, K | 1 |
| Höflich, A | 1 |
| Assadkhani, A | 1 |
| Böhles, HJ | 1 |
| Sewell, A | 1 |
| Cobelli, C | 1 |
| Usadel, KH | 1 |
| Peth, JA | 1 |
| Kinnick, TR | 2 |
| Youngblood, EB | 1 |
| Weinstein, RB | 1 |
| Schmit, MB | 1 |
| Ruhe, RC | 1 |
| McDonald, RB | 1 |
| Eason, RC | 1 |
| Archer, HE | 1 |
| Akhtar, S | 1 |
| Bailey, CJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| A Randomized, Double-blind, Controlled Trial to Evaluate the Efficacy on Overweight With Oral Supplemenation of Probiotics and Prebiotics[NCT05710055] | 200 participants (Actual) | Interventional | 2023-02-06 | Completed | |||
| Cellular and Molecular Effects of Lipoic Acid and Eicosapentaenoic Acid (EPA) on Adipose Tissue: Potential Application in Human Obesity[NCT01138774] | 103 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| An Open-Label Pilot Trial of Alpha Lipoic Acid (ALA) for Weight Loss in Schizophrenia[NCT01355952] | 17 participants (Actual) | Interventional | 2011-05-31 | Completed | |||
| Dysfunction of Adipose Tissue in Obesity, Inflammation and Aging: Mechanisms and Effects of Physical Exercise and Omega-3 Fatty Acids.[NCT03300388] | 85 participants (Actual) | Interventional | 2017-08-21 | Completed | |||
| Immunometabolic Effects of Non-drug Strategies in the Clinical Management of Obesity: Translational Study[NCT04436419] | 40 participants (Actual) | Interventional | 2018-07-02 | Completed | |||
| Alpha-lipoic Acid Adjunctive Therapy in Schizophrenia: A Randomized, Double-blind, Placebo-controlled Trial[NCT03788759] | Phase 2/Phase 3 | 48 participants (Actual) | Interventional | 2019-09-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for thioctic acid and Obesity
| Article | Year |
|---|---|
Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review.
Topics: AMP-Activated Protein Kinases; Cholesterol; Humans; Insulin Resistance; Lipoproteins, LDL; Metabolic | 2022 |
Insights on the Use of α-Lipoic Acid for Therapeutic Purposes.
Topics: Animals; Antioxidants; Biological Availability; Central Nervous System Diseases; Diabetic Neuropathi | 2019 |
Alpha-lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta-analysis of randomised placebo-controlled clinical trials.
Topics: Antioxidants; Body Mass Index; Body Weight; Dietary Supplements; Female; Humans; Male; Obesity; Thio | 2020 |
Alpha-lipoic acid and its protective role in fructose induced endocrine-metabolic disturbances.
Topics: Animals; Diabetes Mellitus, Type 2; Endocrine System; Fructose; Humans; Obesity; Oxidative Stress; T | 2019 |
α-Lipoic acid as a triglyceride-lowering nutraceutical.
Topics: Animals; Dietary Supplements; Humans; Obesity; Thioctic Acid; Triglycerides | 2015 |
Chemopreventive Effects of Alpha Lipoic Acid on Obesity-Related Cancers.
Topics: Animals; Antioxidants; Humans; Neoplasms; Obesity; Thioctic Acid | 2016 |
Alpha-lipoic acid, an anti-obesity agent?
Topics: AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Disease Models, Animal; Humans; Lipid M | 2004 |
Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes.
Topics: Antioxidants; Blood Glucose; Cardiovascular Diseases; Developed Countries; Diabetes Complications; D | 2001 |
15 trials available for thioctic acid and Obesity
| Article | Year |
|---|---|
Clinical effectiveness of α-lipoic acid, myo-inositol and propolis supplementation on metabolic profiles and liver function in obese patients with NAFLD: A randomized controlled clinical trial.
Topics: Cholesterol; Dietary Supplements; Humans; Metabolome; Non-alcoholic Fatty Liver Disease; Obesity; Pr | 2023 |
The effect of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric parameters, body composition and angiogenesis factor, sirtunin-1 and peroxisome proliferator-activated receptor-γ coactivator-1α in obese people under a
Topics: Adolescent; Adult; Angiogenesis Inducing Agents; Body Composition; Dietary Supplements; Female; Huma | 2021 |
Effects of probiotic and alpha-lipoic acid supplements, separately or in combination on the anthropometric indicators and maintenance of weight in overweight individuals.
Topics: Diet, Reducing; Dietary Supplements; Humans; Obesity; Overweight; Probiotics; Thioctic Acid | 2021 |
Untargeted metabolomic on urine samples after α-lipoic acid and/or eicosapentaenoic acid supplementation in healthy overweight/obese women.
Topics: Adipose Tissue; Adult; Antioxidants; Cardiovascular Diseases; Dietary Supplements; Eicosapentaenoic | 2018 |
The effect of alpha-lipoic acid on inflammatory markers and body composition in obese patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial.
Topics: Adiponectin; Adult; Biomarkers; Body Composition; Double-Blind Method; Female; Humans; Inflammation; | 2019 |
[Evaluation of a new association between insulin-sensitizers and α-lipoic acid in obese women affected by PCOS].
Topics: Adult; Antioxidants; Blood Glucose; Body Mass Index; Drug Therapy, Combination; Electron Transport; | 2013 |
Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss.
Topics: Administration, Oral; Adult; Antioxidants; Body Composition; Cholesterol; Dietary Supplements; Doubl | 2015 |
Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid.
Topics: Adipocytes, White; Adult; Blood Glucose; Caloric Restriction; Cells, Cultured; Double-Blind Method; | 2015 |
Effects of oral α-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antioxidants; Body Weight; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Mid | 2017 |
Effects of alpha-lipoic Acid on body weight in obese subjects.
Topics: Adult; Body Weight; Double-Blind Method; Female; Humans; Male; Obesity; Thioctic Acid | 2011 |
[The effect of oral alpha-lipoic acid in overweight/obese individuals on brachial-ankle pulse wave velocity and supine blood pressure: a randomized, crossover, double-blind, placebo-controlled trial].
Topics: Adult; Blood Pressure; Blood Pressure Determination; Cross-Over Studies; Double-Blind Method; Female | 2011 |
Amelioration of lipid abnormalities by α-lipoic acid through antioxidative and anti-inflammatory effects.
Topics: Adiponectin; Adult; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Glucose Intolerance; Humans; | 2011 |
Short-term oral α-lipoic acid does not prevent lipid-induced dysregulation of glucose homeostasis in obese and overweight nondiabetic men.
Topics: Administration, Oral; Adult; Fatty Acids, Nonesterified; Glucose; Homeostasis; Humans; Insulin Resis | 2011 |
Effect of α-lipoic acid and exercise training on cardiovascular disease risk in obesity with impaired glucose tolerance.
Topics: Antioxidants; Blood Glucose; Body Composition; Cardiovascular Diseases; Energy Intake; Exercise Ther | 2011 |
A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia.
Topics: Adult; Antioxidants; Antipsychotic Agents; Appetite; Blood Glucose; Body Mass Index; Brief Psychiatr | 2008 |
50 other studies available for thioctic acid and Obesity
| Article | Year |
|---|---|
Combining a β3 adrenergic receptor agonist with alpha-lipoic acid reduces inflammation in male mice with diet-induced obesity.
Topics: Adipose Tissue, Brown; Adrenergic Agonists; Animals; Diet, High-Fat; Humans; Inflammation; Male; Mic | 2022 |
Diverse Impact of N-Acetylcysteine or Alpha-Lipoic Acid Supplementation during High-Fat Diet Regime on Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Visceral and Subcutaneous Adipose Tissue.
Topics: Acetylcysteine; Animals; Antioxidants; Diet, High-Fat; Dietary Supplements; Male; Matrix Metalloprot | 2022 |
The Effect of α-Lipoic Acid on Oxidative Stress in Adipose Tissue of Rats with Obesity-Induced Insulin Resistance.
Topics: Adipose Tissue; Animals; Antioxidants; Body Weight; Diabetes Mellitus, Type 2; Diet, High-Fat; Insul | 2022 |
α-lipoic acid ameliorates inflammation state and oxidative stress by reducing the content of bioactive lipid derivatives in the left ventricle of rats fed a high-fat diet.
Topics: Animals; Arachidonic Acid; Diet, High-Fat; Heart Ventricles; Inflammation; Inflammation Mediators; M | 2022 |
Does Oxidative Stress Along with Dysbiosis Participate in the Pathogenesis of Asthma in the Obese?
Topics: Animals; Asthma; Diet, High-Fat; Dysbiosis; Hydrogen Peroxide; Mice; Mice, Inbred C57BL; Obesity; Ox | 2023 |
The influence of apocynin, lipoic acid and probiotics on antioxidant enzyme levels in the pulmonary tissues of obese asthmatic mice.
Topics: Acetophenones; Animals; Antioxidants; Asthma; Catalase; Glutathione Peroxidase; Lung; Male; Mice, In | 2019 |
Chronic Treatment with α-Lipoic Acid Improves Endothelium-Dependent Vasorelaxation of Aortas in High-Fat Diet-Fed Mice.
Topics: Animals; Antioxidants; Aorta; Blood Glucose; Body Weight; Diet, High-Fat; Dietary Supplements; Dose- | 2019 |
Effect of d-chiro-inositol and alpha-lipoic acid combination on COH outcomes in overweight/obese PCOS women.
Topics: Adult; Drug Therapy, Combination; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotr | 2020 |
Effects of α-lipoic acid and myo-inositol supplementation on the oocyte environment of infertile obese women: A preliminary study.
Topics: Adult; Anti-Inflammatory Agents; Antioxidants; Dietary Supplements; DNA, Mitochondrial; Female; Fert | 2020 |
POTENTIAL ADMINISTRATION OF LIPOIC ACID AND COENZYME Q AGAINST ADIPOGENSIS: TARGET FOR WEIGHT REDUCTION.
Topics: Adipogenesis; Animals; Anti-Obesity Agents; Humans; Lipoprotein Lipase; Male; Obesity; Rats; Thiocti | 2017 |
Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and
Topics: Animals; Anti-Obesity Agents; Antioxidants; Astrocytes; Biological Transport; Brain; Brain Chemistry | 2017 |
Modulatory effects of alpha-lipoic acid (ALA) administration on insulin sensitivity in obese PCOS patients.
Topics: Adult; Antioxidants; Body Mass Index; Diabetes Mellitus; Female; Follow-Up Studies; Humans; Insulin | 2018 |
Differential insulin response to oral glucose tolerance test (OGTT) in overweight/obese polycystic ovary syndrome patients undergoing to myo-inositol (MYO), alpha lipoic acid (ALA), or combination of both.
Topics: Adult; Androstenedione; Drug Therapy, Combination; Estradiol; Female; Follicle Stimulating Hormone; | 2019 |
An open-label pilot trial of alpha-lipoic acid for weight loss in patients with schizophrenia without diabetes.
Topics: Adolescent; Adult; Aged; Antioxidants; Antipsychotic Agents; Female; Humans; Male; Middle Aged; Obes | 2015 |
Reversal of obesity-induced hypertriglyceridemia by (R)-α-lipoic acid in ZDF (fa/fa) rats.
Topics: Animals; Body Weight; Fatty Acids; Gene Expression Regulation; Hypertriglyceridemia; Insulin; Ketone | 2013 |
α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat diet.
Topics: Animals; Brain-Derived Neurotrophic Factor; Diet, High-Fat; Female; Hippocampus; Obesity; Ovariectom | 2013 |
Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese Zucker rats.
Topics: Animals; Antioxidants; Diet, High-Fat; Energy Intake; Lipoproteins, LDL; Liver; Male; Obesity; Propr | 2014 |
Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Antipsychotic Agents; Benzodiazepines; | 2014 |
The effect of dietary α-lipoic acid, betaine, l-carnitine, and swimming on the obesity of mice induced by a high-fat diet.
Topics: Adipocytes; Animals; Antioxidants; Betaine; Blood Glucose; Body Weight; Carnitine; Cholesterol; Diet | 2014 |
α-lipoic acid reduces fatty acid esterification and lipogenesis in adipocytes from overweight/obese subjects.
Topics: Adipocytes; Cells, Cultured; Down-Regulation; Esterification; Fatty Acids; Female; Humans; Lipid Met | 2014 |
Alpha-lipoic acid supplementation reduces mTORC1 signaling in skeletal muscle from high fat fed, obese Zucker rats.
Topics: AMP-Activated Protein Kinases; Animals; Carnitine O-Palmitoyltransferase; Carrier Proteins; Diet, Hi | 2014 |
α-Lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects.
Topics: Acetylation; Adipocytes, Brown; Antioxidants; Apoptosis Regulatory Proteins; Carnitine O-Palmitoyltr | 2015 |
Complementary Cholesterol-Lowering Response of a Phytosterol/α-Lipoic Acid Combination in Obese Zucker Rats.
Topics: Acyl Coenzyme A; Animals; Anticholesteremic Agents; Antioxidants; Bile Acids and Salts; Cholesterol; | 2016 |
Alpha-lipoic acid reduces body weight and regulates triglycerides in obese patients with diabetes mellitus.
Topics: Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Female; Humans; Male; Metformin; Middle Aged; O | 2015 |
Hypotensive effect of alpha-lipoic acid after a single administration in rats.
Topics: Animals; Antioxidants; Blood Pressure; Hypertension; Male; Obesity; Rats; Rats, Wistar; Thioctic Aci | 2016 |
Cardioprotective effects of lipoic acid, quercetin and resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity.
Topics: Animals; Anti-Obesity Agents; Antihypertensive Agents; Antioxidants; Biomarkers; Cardiotonic Agents; | 2016 |
Ameliorative effects of α-lipoic acid on high-fat diet-induced oxidative stress and glucose uptake impairment of T cells.
Topics: Animals; Diet, High-Fat; Glucose; Humans; Male; Mice; Mice, Inbred C57BL; Obesity; Oxidative Stress; | 2016 |
Effects of dietary supplementation with EPA and/or α-lipoic acid on adipose tissue transcriptomic profile of healthy overweight/obese women following a hypocaloric diet.
Topics: Abdominal Fat; Administration, Oral; Adult; Anti-Inflammatory Agents; Caloric Restriction; Dietary S | 2017 |
Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways.
Topics: AMP-Activated Protein Kinases; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Activation; Fatty | 2008 |
Metabolic interactions of AGE inhibitor pyridoxamine and antioxidant alpha-lipoic acid following 22 weeks of treatment in obese Zucker rats.
Topics: Animals; Antioxidants; Blood Glucose; Drug Synergism; Female; Glucose Tolerance Test; Glycation End | 2009 |
Prevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activation.
Topics: Absorption; Adult; AMP-Activated Protein Kinases; Animals; Body Composition; Body Weight; Dietary Fa | 2010 |
Alpha-lipoic acid supplementation: a tool for obesity therapy?
Topics: Adolescent; Adult; Antioxidants; Blood Pressure; Body Mass Index; Body Weight; Dietary Supplements; | 2010 |
Effects of lipoic acid on apelin in 3T3-L1 adipocytes and in high-fat fed rats.
Topics: 3T3-L1 Cells; Adipocytes, White; Animals; Apelin; Blood Glucose; Body Weight; Chromones; Diet, High- | 2011 |
Reciprocal effects of α-lipoic acid on adenosine monophosphate-activated protein kinase activity in obesity induced by ovariectomy in rats.
Topics: Acetyl-CoA Carboxylase; Adiponectin; Adipose Tissue; Animals; Body Weight; Cyclic AMP-Dependent Prot | 2011 |
Lipoic acid attenuates innate immune infiltration and activation in the visceral adipose tissue of obese insulin resistant mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Blood Glucose; Blood Vessels; Body Weight; | 2011 |
Effects of lipoic acid on AMPK and adiponectin in adipose tissue of low- and high-fat-fed rats.
Topics: Adiponectin; Adipose Tissue, Brown; Adipose Tissue, White; Adiposity; AMP-Activated Protein Kinases; | 2013 |
Lipoic acid prevents liver metabolic changes induced by administration of a fructose-rich diet.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Diet; Fructose; Gene Expression Regulation; Insuli | 2013 |
Interactions of conjugated linoleic acid and lipoic acid on insulin action in the obese Zucker rat.
Topics: Animals; Antioxidants; Biological Transport; Blood Glucose; Deoxyglucose; Drug Interactions; Fatty A | 2003 |
Interactions of exercise training and alpha-lipoic acid on insulin signaling in skeletal muscle of obese Zucker rats.
Topics: Animals; Antioxidants; Biological Transport; Body Weight; Female; Glucose; Glucose Transporter Type | 2004 |
alpha-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats.
Topics: Animals; Antioxidants; Body Weight; Diabetes Mellitus, Type 1; Disease Susceptibility; Male; Obesity | 2005 |
Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase.
Topics: Adenoviridae; AMP-Activated Protein Kinase Kinases; Animals; Aorta; Apoptosis; Atherosclerosis; Cell | 2005 |
Mitogen-activated protein kinase upregulation reduces renal D1 receptor affinity and G-protein coupling in obese rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antioxidants; Blood Glucose; Cy | 2007 |
Oxidative stress reduces renal dopamine D1 receptor-Gq/11alpha G protein-phospholipase C signaling involving G protein-coupled receptor kinase 2.
Topics: Alkaline Phosphatase; Animals; Antioxidants; beta-Adrenergic Receptor Kinases; Blotting, Western; Di | 2007 |
Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle.
Topics: Animals; Antioxidants; Biological Transport; Blood Glucose; Deoxyglucose; Fatty Acids, Nonesterified | 1997 |
Stimulation by alpha-lipoic acid of glucose transport activity in skeletal muscle of lean and obese Zucker rats.
Topics: Animals; Biological Transport; Dose-Response Relationship, Drug; Female; Glucose; Muscle Contraction | 1997 |
alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes.
Topics: Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fasting; Glucose Tolerance Test; Glycat | 1999 |
Effects of a unique conjugate of alpha-lipoic acid and gamma-linolenic acid on insulin action in obese Zucker rats.
Topics: Animals; Biological Transport; Blood Glucose; Drug Combinations; Fatty Acids, Nonesterified; Female; | 2000 |
Antioxidant alpha-lipoic acid and protein turnover in insulin-resistant rat muscle.
Topics: Animals; Biological Transport; Female; Free Radicals; Glucose; In Vitro Techniques; Insulin; Insulin | 2001 |
Interactions of exercise training and lipoic acid on skeletal muscle glucose transport in obese Zucker rats.
Topics: Animals; Antioxidants; Body Weight; Enzymes; Female; Glucose Tolerance Test; Glucose Transporter Typ | 2001 |
Lipoic acid increases glucose uptake by skeletal muscles of obese-diabetic ob/ob mice.
Topics: Animals; Biological Transport; Cell Line; Cell Survival; Deoxyglucose; Glucose; Kinetics; Mice; Mice | 2002 |