thioctic acid has been researched along with Non-alcoholic Fatty Liver Disease in 15 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Non-alcoholic Fatty Liver Disease: Fatty liver finding without excessive ALCOHOL CONSUMPTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury." | 2.90 | The effect of alpha-lipoic acid on inflammatory markers and body composition in obese patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial. ( Amirkhizi, F; Ebrahimi-Mameghani, M; Hosseinpour-Arjmand, S, 2019) |
| "Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of lipids within hepatocytes, which compromises liver functionality following mitochondrial dysfunction and increased production of reactive oxygen species (ROS)." | 1.91 | (+)-Lipoic Acid Reduces Lipotoxicity and Regulates Mitochondrial Homeostasis and Energy Balance in an In Vitro Model of Liver Steatosis. ( Aguennouz, M; Alanazi, AM; Amorini, AM; Barbagallo, IA; Distefano, A; Giallongo, S; Lazzarino, G; Longhitano, L; Macaione, V; Nicolosi, A; Orlando, L; Salomone, F; Saoca, C; Tibullo, D; Tropea, E; Volti, GL, 2023) |
| "Development of nonalcoholic fatty liver disease (NAFLD) occurs through initial steatosis and subsequent oxidative stress." | 1.40 | The effects of α-lipoic acid on liver oxidative stress and free fatty acid composition in methionine-choline deficient diet-induced NAFLD. ( de Luka, S; Ethuričić, I; Jorgačević, B; Mladenović, D; Ninković, M; Radosavljević, TS; Sobajić, S; Stanković, MN; Vukicevic, RJ, 2014) |
| "Similarly, treatment of the fatty liver cell model with alpha-lipoic acid reduced intracellular lipid accumulation in HepG2 cells, increased AMPK phosphorylation, and induced ATGL expression." | 1.38 | Alpha-lipoic acid induces adipose triglyceride lipase expression and decreases intracellular lipid accumulation in HepG2 cells. ( Chen, WL; Kuo, YT; Lee, HM; Lin, TH, 2012) |
| "Chronic ALA supplementation prevents NAFLD through multiple mechanisms by reducing steatosis, oxidative stress, immune activation and inflammation in the liver." | 1.38 | α-lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats. ( Hahm, JR; Jeon, BT; Jung, TS; Kim, SK; Roh, GS; Shin, HJ, 2012) |
| "Carnitine treatment increased the mRNA expression of carnitine palmitoyltransferase 1A and peroxisome proliferator-activated receptor-γ, and carnitine-lipoic acid further augmented the mRNA expression." | 1.37 | Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction. ( Cho, WK; Choi, HS; Hahm, JS; Jang, KS; Jeon, HJ; Jun, DW; Jun, JH; Kim, HJ; Kwon, HJ; Lee, HL; Lee, KN; Lee, MH; Lee, OY; Yoon, BC, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (73.33) | 24.3611 |
| 2020's | 4 (26.67) | 2.80 |
| Authors | Studies |
|---|---|
| Sasunova, AN | 1 |
| Goncharov, AA | 1 |
| Morozov, SV | 1 |
| Isakov, VA | 1 |
| Tutunchi, H | 1 |
| Arefhosseini, S | 1 |
| Ebrahimi-Mameghani, M | 3 |
| Longhitano, L | 1 |
| Distefano, A | 1 |
| Amorini, AM | 1 |
| Orlando, L | 1 |
| Giallongo, S | 1 |
| Tibullo, D | 1 |
| Lazzarino, G | 2 |
| Nicolosi, A | 1 |
| Alanazi, AM | 1 |
| Saoca, C | 1 |
| Macaione, V | 1 |
| Aguennouz, M | 1 |
| Salomone, F | 1 |
| Tropea, E | 1 |
| Barbagallo, IA | 1 |
| Volti, GL | 1 |
| Frank, J | 1 |
| Kisters, K | 1 |
| Stirban, OA | 1 |
| Obeid, R | 1 |
| Lorkowski, S | 1 |
| Wallert, M | 1 |
| Egert, S | 1 |
| Podszun, MC | 1 |
| Eckert, GP | 1 |
| Pettersen, JA | 1 |
| Venturelli, S | 1 |
| Classen, HG | 1 |
| Golombek, J | 1 |
| Hosseinpour-Arjmand, S | 2 |
| Amirkhizi, F | 2 |
| Rahmanabadi, A | 1 |
| Mahboob, S | 1 |
| Xu, J | 1 |
| Gao, H | 1 |
| Song, L | 1 |
| Yang, W | 1 |
| Chen, C | 1 |
| Deng, Q | 1 |
| Huang, Q | 1 |
| Yang, J | 1 |
| Huang, F | 1 |
| Kathirvel, E | 1 |
| Morgan, K | 1 |
| French, SW | 1 |
| Morgan, TR | 1 |
| Stanković, MN | 1 |
| Mladenović, D | 1 |
| Ninković, M | 1 |
| Ethuričić, I | 1 |
| Sobajić, S | 1 |
| Jorgačević, B | 1 |
| de Luka, S | 1 |
| Vukicevic, RJ | 1 |
| Radosavljević, TS | 1 |
| Yang, Y | 1 |
| Li, W | 1 |
| Liu, Y | 1 |
| Li, Y | 1 |
| Gao, L | 1 |
| Zhao, JJ | 1 |
| Pilar Valdecantos, M | 1 |
| Prieto-Hontoria, PL | 2 |
| Pardo, V | 1 |
| Módol, T | 1 |
| Santamaría, B | 1 |
| Weber, M | 1 |
| Herrero, L | 1 |
| Serra, D | 1 |
| Muntané, J | 1 |
| Cuadrado, A | 1 |
| Moreno-Aliaga, MJ | 2 |
| Alfredo Martínez, J | 1 |
| Valverde, ÁM | 1 |
| Jun, DW | 1 |
| Cho, WK | 1 |
| Jun, JH | 1 |
| Kwon, HJ | 1 |
| Jang, KS | 1 |
| Kim, HJ | 1 |
| Jeon, HJ | 1 |
| Lee, KN | 1 |
| Lee, HL | 1 |
| Lee, OY | 1 |
| Yoon, BC | 1 |
| Choi, HS | 1 |
| Hahm, JS | 1 |
| Lee, MH | 1 |
| Valdecantos, MP | 1 |
| Pérez-Matute, P | 1 |
| González-Muniesa, P | 1 |
| Martínez, JA | 1 |
| Kuo, YT | 1 |
| Lin, TH | 1 |
| Chen, WL | 1 |
| Lee, HM | 1 |
| Jung, TS | 1 |
| Kim, SK | 1 |
| Shin, HJ | 1 |
| Jeon, BT | 1 |
| Hahm, JR | 1 |
| Roh, GS | 1 |
1 review available for thioctic acid and Non-alcoholic Fatty Liver Disease
| Article | Year |
|---|---|
The role of biofactors in the prevention and treatment of age-related diseases.
Topics: Aged; Cardiovascular Diseases; Dementia; Diabetes Mellitus; Dietary Fiber; Dietary Supplements; Epig | 2021 |
4 trials available for thioctic acid and Non-alcoholic Fatty Liver Disease
| Article | Year |
|---|---|
[Modification of dietary patterns in patients with non-alcoholic steatohepatitis].
Topics: Alkaline Phosphatase; Carnitine; Cholesterol; Dietary Fiber; Female; Humans; Non-alcoholic Fatty Liv | 2022 |
Clinical effectiveness of α-lipoic acid, myo-inositol and propolis supplementation on metabolic profiles and liver function in obese patients with NAFLD: A randomized controlled clinical trial.
Topics: Cholesterol; Dietary Supplements; Humans; Metabolome; Non-alcoholic Fatty Liver Disease; Obesity; Pr | 2023 |
The effect of alpha-lipoic acid on inflammatory markers and body composition in obese patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial.
Topics: Adiponectin; Adult; Biomarkers; Body Composition; Double-Blind Method; Female; Humans; Inflammation; | 2019 |
Oral α-lipoic acid supplementation in patients with non-alcoholic fatty liver disease: effects on adipokines and liver histology features.
Topics: Adipokines; Administration, Oral; Adult; Double-Blind Method; Female; Humans; Insulin; Leptin; Liver | 2019 |
10 other studies available for thioctic acid and Non-alcoholic Fatty Liver Disease
| Article | Year |
|---|---|
(+)-Lipoic Acid Reduces Lipotoxicity and Regulates Mitochondrial Homeostasis and Energy Balance in an In Vitro Model of Liver Steatosis.
Topics: Energy Metabolism; Hepatocytes; Humans; Liver; Mitochondria; Non-alcoholic Fatty Liver Disease; Olei | 2023 |
Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard.
Topics: Animals; Diet, High-Fat; Dietary Fats; Fatty Liver; Humans; Linseed Oil; Lipid Accumulation Product; | 2013 |
Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease.
Topics: Acetylcarnitine; Adipose Tissue; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransfe | 2013 |
The effects of α-lipoic acid on liver oxidative stress and free fatty acid composition in methionine-choline deficient diet-induced NAFLD.
Topics: Animals; Choline; Diet; Fatty Acids, Nonesterified; Fatty Liver; Humans; Lipid Peroxidation; Liver; | 2014 |
Alpha-lipoic acid attenuates insulin resistance and improves glucose metabolism in high fat diet-fed mice.
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Diet, High-Fat; Down-Regulatio | 2014 |
Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes.
Topics: Active Transport, Cell Nucleus; Animals; Antioxidant Response Elements; Antioxidants; Apoptosis; Cel | 2015 |
Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Carnitine; Carnitine O-Palmitoyltransferase; Choline Def | 2011 |
Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3.
Topics: Animals; Antioxidants; Blotting, Western; Body Weight; Diet, High-Fat; Disease Models, Animal; Fatty | 2012 |
Alpha-lipoic acid induces adipose triglyceride lipase expression and decreases intracellular lipid accumulation in HepG2 cells.
Topics: Active Transport, Cell Nucleus; AMP-Activated Protein Kinases; Cell Nucleus; Enzyme Activation; Fatt | 2012 |
α-lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats.
Topics: Acetyl-CoA Carboxylase; Adiponectin; Aldehydes; Animals; Azo Compounds; Blood Glucose; Blotting, Wes | 2012 |