thioctic acid has been researched along with Neural Tube Defects in 2 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Neural Tube Defects: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In rats treated only during pregnancy days 1 to 5 (before diabetes induction), lipoic acid failed to exert its protective effects against neural tube defects, which emphasizes the importance of the presence of lipoic acid during the organogenesis period." | 1.30 | Lipoic acid prevention of neural tube defects in offspring of rats with streptozocin-induced diabetes. ( Ayalon, N; Bashan, N; Hershkovitz, R; Khamaisi, M; Reece, EA; Trischler, H; Wiznitzer, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sugimura, Y | 1 |
| Murase, T | 1 |
| Kobayashi, K | 1 |
| Oyama, K | 1 |
| Hayasaka, S | 1 |
| Kanou, Y | 1 |
| Oiso, Y | 1 |
| Murata, Y | 1 |
| Wiznitzer, A | 1 |
| Ayalon, N | 1 |
| Hershkovitz, R | 1 |
| Khamaisi, M | 1 |
| Reece, EA | 1 |
| Trischler, H | 1 |
| Bashan, N | 1 |
2 other studies available for thioctic acid and Neural Tube Defects
| Article | Year |
|---|---|
Alpha-lipoic acid reduces congenital malformations in the offspring of diabetic mice.
Topics: Animals; Blood Glucose; Cardiovascular Abnormalities; Congenital Abnormalities; Diabetes Mellitus, E | 2009 |
Lipoic acid prevention of neural tube defects in offspring of rats with streptozocin-induced diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Neural Tube Defects; Placenta; Pregnancy; Pregnanc | 1999 |