thioctic acid has been researched along with Nerve Degeneration in 16 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic systemic exposure of mice, rats, and Drosophila to D-galactose causes the acceleration of senescence and has been used as an aging model." | 3.73 | Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. ( Cui, X; Hu, Y; Li, X; Liu, J; Long, J; Packer, L; Zhang, Q; Zuo, P, 2006) |
| " GSH plays a key role in antioxidant defense, and HNE exposure causes an initial depletion of GSH that leads to gradual toxic accumulation of reactive oxygen species." | 1.34 | Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. ( Abdul, HM; Butterfield, DA, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dietrich, M | 1 |
| Helling, N | 1 |
| Hilla, A | 1 |
| Heskamp, A | 1 |
| Issberner, A | 1 |
| Hildebrandt, T | 1 |
| Kohne, Z | 1 |
| Küry, P | 1 |
| Berndt, C | 1 |
| Aktas, O | 1 |
| Fischer, D | 1 |
| Hartung, HP | 1 |
| Albrecht, P | 1 |
| Inman, DM | 1 |
| Lambert, WS | 1 |
| Calkins, DJ | 1 |
| Horner, PJ | 1 |
| Kuhla, A | 1 |
| Ludwig, SC | 1 |
| Kuhla, B | 1 |
| Münch, G | 1 |
| Vollmar, B | 1 |
| D'Mello, F | 1 |
| Braidy, N | 1 |
| Marçal, H | 1 |
| Guillemin, G | 1 |
| Rossi, F | 1 |
| Chinian, M | 1 |
| Laurent, D | 1 |
| Teo, C | 1 |
| Neilan, BA | 1 |
| Militão, GC | 1 |
| Ferreira, PM | 1 |
| de Freitas, RM | 1 |
| Emmez, H | 1 |
| Yildirim, Z | 1 |
| Kale, A | 1 |
| Tönge, M | 1 |
| Durdağ, E | 1 |
| Börcek, AO | 1 |
| Uçankuş, LN | 1 |
| Doğulu, F | 1 |
| Kiliç, N | 1 |
| Baykaner, MK | 1 |
| De Araújo, DP | 1 |
| Lobato, Rde F | 1 |
| Cavalcanti, JR | 1 |
| Sampaio, LR | 1 |
| Araújo, PV | 1 |
| Silva, MC | 1 |
| Neves, KR | 1 |
| Fonteles, MM | 1 |
| Sousa, FC | 1 |
| Vasconcelos, SM | 1 |
| Pirlich, M | 1 |
| Kiok, K | 1 |
| Sandig, G | 1 |
| Lochs, H | 1 |
| Grune, T | 1 |
| Cui, X | 1 |
| Zuo, P | 1 |
| Zhang, Q | 1 |
| Li, X | 1 |
| Hu, Y | 1 |
| Long, J | 1 |
| Packer, L | 2 |
| Liu, J | 1 |
| Bolognesi, ML | 1 |
| Minarini, A | 1 |
| Tumiatti, V | 1 |
| Melchiorre, C | 1 |
| Abdul, HM | 1 |
| Butterfield, DA | 1 |
| Ronowska, A | 1 |
| Gul-Hinc, S | 1 |
| Bielarczyk, H | 1 |
| Pawełczyk, T | 1 |
| Szutowicz, A | 1 |
| Barbeau, A | 1 |
| Angel, R | 1 |
| Greenamyre, JT | 1 |
| Tritschler, HJ | 1 |
| Wessel, K | 1 |
| Gonzalez-Perez, O | 1 |
| Gonzalez-Castañeda, RE | 1 |
| Huerta, M | 1 |
| Luquin, S | 1 |
| Gomez-Pinedo, U | 1 |
| Sanchez-Almaraz, E | 1 |
| Navarro-Ruiz, A | 1 |
| Garcia-Estrada, J | 1 |
4 reviews available for thioctic acid and Nerve Degeneration
| Article | Year |
|---|---|
The contributions of antioxidant activity of lipoic acid in reducing neurogenerative progression of Parkinson's disease: a review.
Topics: Animals; Antioxidants; Apoptosis; Disease Progression; Humans; Nerve Degeneration; Oxidative Stress; | 2011 |
Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration.
Topics: Animals; Drug Design; Humans; Nerve Degeneration; Oxidative Stress; Thioctic Acid | 2006 |
Friedreich's ataxia 1980. An overview of the physiopathology.
Topics: Cardiomyopathy, Hypertrophic; Cell Membrane; Chemical Phenomena; Chemistry; Diabetes Complications; | 1980 |
Neuroprotection by the metabolic antioxidant alpha-lipoic acid.
Topics: Animals; Antioxidants; Brain; Humans; Nerve Degeneration; Nervous System; Neuroprotective Agents; Ox | 1997 |
12 other studies available for thioctic acid and Nerve Degeneration
| Article | Year |
|---|---|
Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model.
Topics: Animals; CD3 Complex; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; G | 2018 |
α-Lipoic acid antioxidant treatment limits glaucoma-related retinal ganglion cell death and dysfunction.
Topics: Administration, Oral; Animals; Antioxidants; Axons; Cell Death; Dietary Supplements; DNA Damage; Dru | 2013 |
Advanced glycation end products are mitogenic signals and trigger cell cycle reentry of neurons in Alzheimer's disease brain.
Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Cell Cycle; Cells, Cultured; Cyclin D1; Disease Model | 2015 |
Cytotoxic Effects of Environmental Toxins on Human Glial Cells.
Topics: Amino Acids, Diamino; Astrocytes; Calcium; Cell Proliferation; Ciguatoxins; Cyanobacteria Toxins; Ge | 2017 |
Effects of lipoic acid on oxidative stress in rat striatum after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Catalase; Convulsants; Corpus Striatum; Disease Models, Animal; Drug Interact | 2010 |
Anti-apoptotic and neuroprotective effects of α-lipoic acid on spinal cord ischemia-reperfusion injury in rabbits.
Topics: Animals; Apoptosis; Disease Models, Animal; Male; Nerve Degeneration; Neuroprotective Agents; Rabbit | 2010 |
Alpha-lipoic acid prevents ethanol-induced protein oxidation in mouse hippocampal HT22 cells.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Antioxidants; Cell Death; Cell Survival; Cells, | 2002 |
Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Cell Differentiatio | 2006 |
Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.
Topics: Acetylcarnitine; Aldehydes; Alzheimer Disease; Animals; Apoptosis; Cell Survival; Cerebral Cortex; C | 2007 |
Effects of zinc on SN56 cholinergic neuroblastoma cells.
Topics: Acetyl Coenzyme A; Acetylcholine; Aconitate Hydratase; Adenosine Triphosphate; Animals; Cell Line, T | 2007 |
Chronic treatment with thioctic acid does not protect against malonate toxicity in vivo.
Topics: Animals; Corpus Striatum; Male; Malonates; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Thioctic | 1995 |
Beneficial effects of alpha-lipoic acid plus vitamin E on neurological deficit, reactive gliosis and neuronal remodeling in the penumbra of the ischemic rat brain.
Topics: Animals; Astrocytes; Brain; Disease Models, Animal; Free Radical Scavengers; GAP-43 Protein; Glial F | 2002 |