thioctic acid has been researched along with Neoplasms in 43 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " High attrition rates due to poor patient compliance and manner of dosage administration in this trial demonstrated a lack of feasibility for this intervention." | 2.79 | Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial. ( Dakhil, SR; Eng, C; Fisch, MJ; Forman, A; Gilman, P; Guo, Y; Jones, D; Mills, GM; Noga, SJ; Overman, MJ; Palmer, JL; Velasco, MR; Weiss, M, 2014) |
| "Radiation therapy is one of the main cancer treatment modalities applied in 50-70% of cancer patients." | 2.72 | The radioprotective effects of alpha-lipoic acid on radiotherapy-induced toxicities: A systematic review. ( Abedi-Firouzjah, R; Dastranj, L; Dorri-Giv, M; Farhood, B; Khodaverdian, S; Mohammad Hosseini, S; Sheikholeslami, S; Souri, S; Zamani, H, 2021) |
| "Accumulation of formaldehyde in cancer cells is combined with activation of the processes of cellular formaldehyde clearance." | 2.58 | Human Endogenous Formaldehyde as an Anticancer Metabolite: Its Oxidation Downregulation May Be a Means of Improving Therapy. ( Bialik, TE; Dorokhov, YL; Komarova, TV; Sheshukova, EV, 2018) |
| "It is a longstanding debate whether cancer is one disease or a set of very diverse diseases." | 2.55 | The Warburg Effect and the Hallmarks of Cancer. ( Alfarouk, KO; Schwartz, L; Supuran, CT, 2017) |
| "We then focus on its mode of action in cancer cells, in which it triggers primarily the mitochondrial pathway of apoptosis, whereas non-transformed primary cells are hardly affected." | 2.53 | The disulfide compound α-lipoic acid and its derivatives: A novel class of anticancer agents targeting mitochondria. ( Dörsam, B; Fahrer, J, 2016) |
| "Finally, the results of LA use in human cancer chemotherapy and as chemopreventive agent are discussed in the light of LA future inclusion into chemotherapeutic protocols." | 2.44 | alpha-Lipoic acid: the potential for use in cancer therapy. ( Cojocel, C; Novotny, L; Rauko, P, 2008) |
| " As the radiolabeling strategy can significantly impact pharmacokinetics and biodistribution, we explored in this work a site-specific radiofluorination strategy on an anti-PD-L1 fragment antigen-binding (Fab) and compared the pharmacokinetic and biodistribution properties with the same Fab labeled using stochastic radiolabeling chemistry." | 1.72 | Impact of Radiolabeling Strategies on the Pharmacokinetics and Distribution of an Anti-PD-L1 PET Ligand. ( Bouleau, A; Chevaleyre, C; Dubois, S; Evans, MJ; Kereselidze, D; Kuhnast, B; Nozach, H; Richard, M; Specklin, S; Tran, VL; Truillet, C, 2022) |
| "One hallmark of solid tumors, regardless of its type or stage, is the existence of an unsual acidic microenvironment, which has been considered a specific and ideal target for cancer imaging." | 1.51 | pH-Activatable tumor-targeting gold nanoprobe for near-infrared fluorescence/CT dual-modal imaging in vivo. ( Cheng, D; Lin, Y; Qian, X; Shi, H; Tang, Y; Xu, Y; Zhang, J; Zhu, W, 2019) |
| "The gold nanoclusters were coated with dihydrolipoic acid incorporated γ-cyclodextrins." | 1.43 | NIR-emitting chiral gold nanoclusters coated with γ-cyclodextrin are pH sensitive: Application as biomarker. ( Das, T; Poria, DK; Purkayastha, P, 2016) |
| "Gold nanorods were functionalized chemically to generate active groups for the attachment of drug molecules and subsequently attached to folic acid." | 1.42 | A novel drug delivery system of gold nanorods with doxorubicin and study of drug release by single molecule spectroscopy. ( Mirza, AZ, 2015) |
| " We have developed a screening method to assess the best drug combination for cancer treatment based on targeting several factors implicated in tumor specific metabolism." | 1.38 | Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice. ( Abolhassani, M; Baronzio, G; Bonte, J; Campion, F; Fichtner, I; Fiorentini, G; Guais, A; Israël, M; Sanders, E; Schwartz, L, 2012) |
| "Injury caused by cancer in the organism may affect other organs, as well as the tumors organs and tissues." | 1.35 | The effect of lipoic acid on macro and trace metal levels in living tissues exposed to oxidative stress. ( Bakal, U; Ciftci, H, 2009) |
| "Potassium dichromate was administered to Swiss albino mice orally ad libitum at the doses of 5, 10 or 25 mg/kg body weight in drinking water to set DNA damage in cells, which was characterized in mouse peripheral blood mononuclear cells and bone marrow cells using single-cell gel electrophoresis and analyses of generated comets for Tail moment, Tail DNA and Tail length." | 1.35 | Cytoprotection against Cr(6+)-induced DNA damage by alpha-lipoic acid: implications in reducing occupational cancer risk. ( Budhwar, R; Kumar, S; Nigam, A; Priya, S, 2009) |
| "Similar effects were observed in PC3 prostate cancer and Ramos B-cell lymphoma cell lines." | 1.33 | Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines. ( Biaglow, JE; Chawannakul, D; Hacia, JG; Ho, VV; Karaman, MW; Lecane, P; Lepp, C; Magda, D; Mesfin, M; Miles, D; Miller, RA; Nagpal, S, 2005) |
| "The response of PBMC isolated from cancer patients to anti-CD3 MAb was significantly lower than that of controls." | 1.31 | Restoration of functional defects in peripheral blood mononuclear cells isolated from cancer patients by thiol antioxidants alpha-lipoic acid and N-acetyl cysteine. ( Macciò, A; Mantovani, G; Massa, E; Melis, G; Mudu, MC; Mura, L, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.98) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (18.60) | 29.6817 |
| 2010's | 22 (51.16) | 24.3611 |
| 2020's | 10 (23.26) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 2 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 2 |
| Mao, H | 2 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Chakravarti, B | 1 |
| Rajput, S | 1 |
| Raza, S | 1 |
| Rajak, S | 1 |
| Tewari, A | 1 |
| Gupta, P | 1 |
| Upadhyay, A | 1 |
| Chattopadhyay, N | 1 |
| Sinha, RA | 1 |
| Tran, VL | 1 |
| Bouleau, A | 1 |
| Nozach, H | 1 |
| Richard, M | 1 |
| Chevaleyre, C | 1 |
| Dubois, S | 1 |
| Kereselidze, D | 1 |
| Kuhnast, B | 1 |
| Evans, MJ | 1 |
| Specklin, S | 1 |
| Truillet, C | 1 |
| Lv, SY | 1 |
| He, S | 1 |
| Ling, XL | 1 |
| Wang, YQ | 1 |
| Huang, C | 1 |
| Long, JR | 1 |
| Wang, JQ | 1 |
| Qin, Y | 1 |
| Wei, H | 1 |
| Yu, CY | 1 |
| Mondal, A | 1 |
| Das, S | 1 |
| Ali, SM | 1 |
| Kolay, S | 1 |
| Sengupta, A | 1 |
| Molla, MR | 1 |
| Namoju, R | 1 |
| Chilaka, NK | 1 |
| Frank, J | 1 |
| Kisters, K | 1 |
| Stirban, OA | 1 |
| Obeid, R | 1 |
| Lorkowski, S | 1 |
| Wallert, M | 1 |
| Egert, S | 1 |
| Podszun, MC | 1 |
| Eckert, GP | 1 |
| Pettersen, JA | 1 |
| Venturelli, S | 1 |
| Classen, HG | 1 |
| Golombek, J | 1 |
| Hou, X | 1 |
| Zhong, D | 1 |
| Yang, J | 1 |
| Zhang, H | 1 |
| Luo, K | 1 |
| Gong, Q | 1 |
| Gu, Z | 1 |
| Wang, L | 1 |
| Jing, P | 1 |
| Tan, J | 1 |
| Liao, C | 1 |
| Chen, Y | 1 |
| Yu, Y | 1 |
| Sheikholeslami, S | 1 |
| Khodaverdian, S | 1 |
| Dorri-Giv, M | 1 |
| Mohammad Hosseini, S | 1 |
| Souri, S | 1 |
| Abedi-Firouzjah, R | 1 |
| Zamani, H | 1 |
| Dastranj, L | 1 |
| Farhood, B | 1 |
| Fleminger, G | 1 |
| Dayan, A | 1 |
| Yang, S | 1 |
| Wang, Y | 1 |
| Ren, Z | 1 |
| Chen, M | 1 |
| Chen, W | 1 |
| Zhang, X | 1 |
| Maiti, B | 1 |
| Kumar, K | 1 |
| Moitra, P | 1 |
| Kondaiah, P | 1 |
| Bhattacharya, S | 1 |
| Paredes, F | 1 |
| Sheldon, K | 1 |
| Lassègue, B | 1 |
| Williams, HC | 1 |
| Faidley, EA | 1 |
| Benavides, GA | 1 |
| Torres, G | 1 |
| Sanhueza-Olivares, F | 1 |
| Yeligar, SM | 1 |
| Griendling, KK | 1 |
| Darley-Usmar, V | 1 |
| San Martin, A | 1 |
| Wang, X | 2 |
| Cheng, R | 1 |
| Cheng, L | 1 |
| Zhong, Z | 1 |
| Dolinar, K | 1 |
| Jan, V | 1 |
| Pavlin, M | 1 |
| Chibalin, AV | 1 |
| Pirkmajer, S | 1 |
| Dorokhov, YL | 1 |
| Sheshukova, EV | 1 |
| Bialik, TE | 1 |
| Komarova, TV | 1 |
| Ling, L | 1 |
| Ismail, M | 1 |
| Du, Y | 1 |
| Xia, Q | 1 |
| He, W | 1 |
| Yao, C | 1 |
| Li, X | 1 |
| Tang, Y | 1 |
| Shi, H | 1 |
| Cheng, D | 1 |
| Zhang, J | 1 |
| Lin, Y | 1 |
| Xu, Y | 1 |
| Qian, X | 1 |
| Zhu, W | 1 |
| Guo, Y | 1 |
| Jones, D | 1 |
| Palmer, JL | 1 |
| Forman, A | 1 |
| Dakhil, SR | 1 |
| Velasco, MR | 1 |
| Weiss, M | 1 |
| Gilman, P | 1 |
| Mills, GM | 1 |
| Noga, SJ | 1 |
| Eng, C | 1 |
| Overman, MJ | 1 |
| Fisch, MJ | 1 |
| Schwartz, L | 4 |
| Buhler, L | 1 |
| Icard, P | 1 |
| Lincet, H | 1 |
| Steyaert, JM | 1 |
| Mirza, AZ | 1 |
| Tian, Z | 1 |
| Yang, C | 1 |
| Wang, W | 1 |
| Yuan, Z | 1 |
| Bingham, PM | 2 |
| Stuart, SD | 2 |
| Zachar, Z | 2 |
| Dörsam, B | 1 |
| Fahrer, J | 1 |
| Das, T | 1 |
| Poria, DK | 1 |
| Purkayastha, P | 1 |
| Moon, HS | 1 |
| Supuran, CT | 1 |
| Alfarouk, KO | 2 |
| Seyfried, T | 1 |
| Da Veiga Moreira, J | 1 |
| Fais, S | 1 |
| Desideri, I | 1 |
| Francolini, G | 1 |
| Becherini, C | 1 |
| Terziani, F | 1 |
| Delli Paoli, C | 1 |
| Olmetto, E | 1 |
| Loi, M | 1 |
| Perna, M | 1 |
| Meattini, I | 1 |
| Scotti, V | 1 |
| Greto, D | 1 |
| Bonomo, P | 1 |
| Sulprizio, S | 1 |
| Livi, L | 1 |
| Magda, D | 2 |
| Lecane, P | 2 |
| Wang, Z | 1 |
| Hu, W | 1 |
| Thiemann, P | 1 |
| Ma, X | 1 |
| Dranchak, PK | 1 |
| Lynch, V | 1 |
| Wei, W | 1 |
| Csokai, V | 1 |
| Hacia, JG | 2 |
| Sessler, JL | 1 |
| Ciftci, H | 1 |
| Bakal, U | 1 |
| Kumar, S | 1 |
| Budhwar, R | 1 |
| Nigam, A | 1 |
| Priya, S | 1 |
| Abolhassani, M | 1 |
| Guais, A | 1 |
| Sanders, E | 1 |
| Campion, F | 1 |
| Fichtner, I | 1 |
| Bonte, J | 1 |
| Baronzio, G | 1 |
| Fiorentini, G | 1 |
| Israël, M | 1 |
| Marecek, J | 1 |
| Maturo, C | 1 |
| Gupta, S | 1 |
| Howell, K | 1 |
| Schauble, A | 1 |
| Lem, J | 1 |
| Piramzadian, A | 1 |
| Karnik, S | 1 |
| Lee, K | 1 |
| Rodriguez, R | 1 |
| Shorr, R | 1 |
| LIMBOSCH-ROLIN, S | 1 |
| HUBER, R | 2 |
| ALTENBRUNN, HJ | 1 |
| Jakupec, MA | 1 |
| Galanski, M | 1 |
| Keppler, BK | 1 |
| Miller, RA | 1 |
| Lepp, C | 1 |
| Miles, D | 1 |
| Mesfin, M | 1 |
| Biaglow, JE | 1 |
| Ho, VV | 1 |
| Chawannakul, D | 1 |
| Nagpal, S | 1 |
| Karaman, MW | 1 |
| Mantovani, G | 2 |
| Macciò, A | 2 |
| Madeddu, C | 1 |
| Gramignano, G | 1 |
| Lusso, MR | 1 |
| Serpe, R | 1 |
| Massa, E | 2 |
| Astara, G | 1 |
| Deiana, L | 1 |
| Novotny, L | 1 |
| Rauko, P | 1 |
| Cojocel, C | 1 |
| Melis, G | 1 |
| Mura, L | 1 |
| Mudu, MC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for thioctic acid and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Review of lipoic acid: From a clinical therapeutic agent to various emerging biomaterials.
Topics: Alzheimer Disease; Antioxidants; Biocompatible Materials; Humans; Neoplasms; Polyesters; Thioctic Ac | 2022 |
The role of biofactors in the prevention and treatment of age-related diseases.
Topics: Aged; Cardiovascular Diseases; Dementia; Diabetes Mellitus; Dietary Fiber; Dietary Supplements; Epig | 2021 |
The radioprotective effects of alpha-lipoic acid on radiotherapy-induced toxicities: A systematic review.
Topics: Animals; Antioxidants; Humans; Neoplasms; Radiation Injuries; Radiation-Protective Agents; Radiother | 2021 |
The moonlighting activities of dihydrolipoamide dehydrogenase: Biotechnological and biomedical applications.
Topics: Animals; Dihydrolipoamide Dehydrogenase; Humans; Mitochondria; Neoplasms; Oxidation-Reduction; Photo | 2021 |
Human Endogenous Formaldehyde as an Anticancer Metabolite: Its Oxidation Downregulation May Be a Means of Improving Therapy.
Topics: Acetaldehyde Dehydrogenase Inhibitors; Aldehyde Dehydrogenase; Antineoplastic Agents; Biomarkers, Tu | 2018 |
Lipoic acid and lipoic acid analogs in cancer metabolism and chemotherapy.
Topics: Animals; Antineoplastic Agents; Citric Acid Cycle; Humans; Mitochondria; Neoplasms; Thioctic Acid | 2014 |
The disulfide compound α-lipoic acid and its derivatives: A novel class of anticancer agents targeting mitochondria.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caprylates; Drug Discovery; Energy Metabolism; Humans; Mi | 2016 |
Chemopreventive Effects of Alpha Lipoic Acid on Obesity-Related Cancers.
Topics: Animals; Antioxidants; Humans; Neoplasms; Obesity; Thioctic Acid | 2016 |
The Warburg Effect and the Hallmarks of Cancer.
Topics: Acidosis; Adenosine Triphosphate; Alkalosis; Animals; Carbon Dioxide; Cell Proliferation; Citrates; | 2017 |
Out of Warburg effect: An effective cancer treatment targeting the tumor specific metabolism and dysregulated pH.
Topics: Animals; Citrates; Humans; Hydrogen-Ion Concentration; Neoplasms; Oxidative Phosphorylation; Oxygen; | 2017 |
The effect of cytoprotective agents in platinum anticancer therapy.
Topics: Amifostine; Antineoplastic Agents; Cell Survival; Glutathione; Humans; Mesna; Neoplasms; Platinum Co | 2004 |
alpha-Lipoic acid: the potential for use in cancer therapy.
Topics: Animals; Free Radical Scavengers; Humans; Neoplasms; Thioctic Acid | 2008 |
3 trials available for thioctic acid and Neoplasms
| Article | Year |
|---|---|
Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cispl | 2014 |
Use of an alpha lipoic, methylsulfonylmethane and bromelain dietary supplement (Opera
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bromelains; Diet | 2017 |
A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress.
Topics: Adult; Aged; Anorexia; Ascorbic Acid; Cachexia; Carbocysteine; Celecoxib; Dietary Supplements; Docos | 2006 |
27 other studies available for thioctic acid and Neoplasms
| Article | Year |
|---|---|
Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness.
Topics: Autophagosomes; Autophagy; Energy Metabolism; Neoplasms; Reactive Oxygen Species; Thioctic Acid | 2022 |
Impact of Radiolabeling Strategies on the Pharmacokinetics and Distribution of an Anti-PD-L1 PET Ligand.
Topics: Amides; Animals; B7-H1 Antigen; Cell Line, Tumor; Fluorine Radioisotopes; Immunoglobulin Fragments; | 2022 |
Bioderived Lipoic Acid-Based Dynamic Covalent Nanonetworks of Poly(disulfide)s: Enhanced Encapsulation Stability and Cancer Cell-Selective Delivery of Drugs.
Topics: Antibiotics, Antineoplastic; Disulfides; Doxorubicin; Drug Carriers; Drug Delivery Systems; Hydrogen | 2023 |
Alpha-lipoic acid ameliorates cytarabine-induced developmental anomalies in rat fetus.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Cytarabine; Female; Fetal Development; | 2021 |
Facile fabrication of multi-pocket nanoparticles with stepwise size transition for promoting deep penetration and tumor targeting.
Topics: Animals; Antineoplastic Agents; Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Liberation; | 2021 |
"One-stitch" bioorthogonal prodrug activation based on cross-linked lipoic acid nanocapsules.
Topics: Humans; Nanocapsules; Neoplasms; Prodrugs; Thioctic Acid; Tissue Distribution | 2021 |
Stepwise pH/reduction-responsive polymeric conjugates for enhanced drug delivery to tumor.
Topics: A549 Cells; Animals; Antibiotics, Antineoplastic; Cell Survival; Doxorubicin; Drug Carriers; Drug Li | 2018 |
Reduction Responsive Nanovesicles Derived from Novel α-Tocopheryl-Lipoic Acid Conjugates for Efficacious Drug Delivery to Sensitive and Drug Resistant Cancer Cells.
Topics: alpha-Tocopherol; Antineoplastic Agents; Cell Survival; Delayed-Action Preparations; Doxorubicin; He | 2018 |
Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer.
Topics: Animals; Coenzyme A Ligases; Humans; Hypoxia; Ketoglutarate Dehydrogenase Complex; Lipoylation; Mice | 2018 |
Lipoyl Ester Terminated Star PLGA as a Simple and Smart Material for Controlled Drug Delivery Application.
Topics: Antioxidants; Biodegradable Plastics; Dioxanes; Doxorubicin; Drug Delivery Systems; Drug Liberation; | 2018 |
Nucleosides block AICAR-stimulated activation of AMPK in skeletal muscle and cancer cells.
Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Ascorbic Acid; Cell Lin | 2018 |
High Drug Loading, Reversible Disulfide Core-Cross-Linked Multifunctional Micelles for Triggered Release of Camptothecin.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cross-Linking Reagents; Drug Carriers; Drug Compoun | 2018 |
pH-Activatable tumor-targeting gold nanoprobe for near-infrared fluorescence/CT dual-modal imaging in vivo.
Topics: A549 Cells; Animals; Carbocyanines; Cell Death; Folic Acid; Gold; HeLa Cells; Humans; Hydrogen-Ion C | 2019 |
Metabolic treatment of cancer: intermediate results of a prospective case series.
Topics: Adult; Aged; Citrates; Compassionate Use Trials; Female; Humans; Male; Middle Aged; Naltrexone; Neop | 2014 |
A novel drug delivery system of gold nanorods with doxorubicin and study of drug release by single molecule spectroscopy.
Topics: Antineoplastic Agents; Doxorubicin; Drug Delivery Systems; Drug Liberation; Folic Acid; Folic Acid T | 2015 |
Shieldable tumor targeting based on pH responsive self-assembly/disassembly of gold nanoparticles.
Topics: Drug Delivery Systems; Endocytosis; Fluorescence; Glycyrrhetinic Acid; Gold; Hep G2 Cells; Humans; H | 2014 |
NIR-emitting chiral gold nanoclusters coated with γ-cyclodextrin are pH sensitive: Application as biomarker.
Topics: Biomarkers, Tumor; Cell Tracking; Cellular Microenvironment; Early Detection of Cancer; gamma-Cyclod | 2016 |
Synthesis and anticancer properties of water-soluble zinc ionophores.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Gene Expression Profiling; Gene E | 2008 |
The effect of lipoic acid on macro and trace metal levels in living tissues exposed to oxidative stress.
Topics: Animals; Antioxidants; Free Radicals; Humans; Neoplasms; Oxidative Stress; Thioctic Acid; Trace Elem | 2009 |
Cytoprotection against Cr(6+)-induced DNA damage by alpha-lipoic acid: implications in reducing occupational cancer risk.
Topics: Animals; Antioxidants; Bone Marrow Cells; Chromium; Comet Assay; DNA Damage; Dose-Response Relations | 2009 |
Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Citrates; Disease Mo | 2012 |
Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo.
Topics: Animals; Antineoplastic Agents; Antioxidants; Caprylates; Cell Line, Tumor; Drug Screening Assays, A | 2011 |
[Comparative study of the effects of various agents on the division of cancer and normal cells].
Topics: Adenosine Triphosphate; Cell Division; Humans; Neoplasms; Research Design; Sulfhydryl Compounds; Thi | 1963 |
[THE EFFECT OF S-BETA-AMINOETHYLISOTHIURONIUM BR HBR (AET), CYSTEAMINE (MEA) AND THIOCTIC ACID ON WALKER CARCINOMA WITH FRACTIONATED LOCAL IRRADIATION].
Topics: Animals; beta-Aminoethyl Isothiourea; Carcinoma; Carcinoma 256, Walker; Cysteamine; Neoplasms; Pharm | 1963 |
EXPERIMENTS ON INFLUENCEING THE RADIO-SENSITIVITY OF ANIMAL TUMOURS BY SH-COMPOUNDS.
Topics: beta-Aminoethyl Isothiourea; Carcinoma; Carcinoma 256, Walker; Cytochromes; Lymphoma; Lymphoma, Non- | 1964 |
Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines.
Topics: Acetates; Antineoplastic Agents; Cadmium; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Gene | 2005 |
Restoration of functional defects in peripheral blood mononuclear cells isolated from cancer patients by thiol antioxidants alpha-lipoic acid and N-acetyl cysteine.
Topics: Acetylcysteine; Adult; Aged; Antioxidants; Cell Cycle; Cytokines; fas Receptor; Flow Cytometry; Huma | 2000 |