thioctic acid has been researched along with Myocardial Ischemia in 10 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To reduce reperfusion injury, conditions were ameliorated including the treatment with antioxidants, lipoate or dihydrolipoate." | 1.31 | Lipoate ameliorates ischemia-reperfusion in animal models. ( Freisleben, HJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dudek, M | 1 |
| Knutelska, J | 1 |
| Bednarski, M | 1 |
| Nowiński, L | 1 |
| Zygmunt, M | 1 |
| Bilska-Wilkosz, A | 1 |
| Iciek, M | 1 |
| Otto, M | 1 |
| Żytka, I | 1 |
| Sapa, J | 1 |
| Włodek, L | 1 |
| Filipek, B | 1 |
| Hagiwara, S | 1 |
| Teshima, Y | 1 |
| Takahashi, N | 1 |
| Koga, H | 1 |
| Saikawa, T | 1 |
| Noguchi, T | 1 |
| Wang, X | 1 |
| Yu, Y | 1 |
| Ji, L | 1 |
| Liang, X | 1 |
| Zhang, T | 1 |
| Hai, CX | 1 |
| Makeeva, AV | 1 |
| Popova, TN | 1 |
| Matasova, LV | 1 |
| Yama, IN | 1 |
| Schönheit, K | 1 |
| Gille, L | 1 |
| Nohl, H | 1 |
| Sumegi, B | 1 |
| Butwell, NB | 1 |
| Malloy, CR | 1 |
| Sherry, AD | 1 |
| Haramaki, N | 1 |
| Packer, L | 2 |
| Assadnazari, H | 1 |
| Zimmer, G | 1 |
| Freisleben, HJ | 2 |
| Coombes, JS | 1 |
| Powers, SK | 1 |
| Hamilton, KL | 1 |
| Demirel, HA | 1 |
| Shanely, RA | 1 |
| Zergeroglu, MA | 1 |
| Sen, CK | 1 |
| Ji, LL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of The Effect of Alpha Lipoic Acid Administration on Oxidative Stress Markers and Occurrence of No-Reflow Phenomenon in Post Myocardial Infarction Patients[NCT05360602] | 60 participants (Anticipated) | Interventional | 2022-07-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 other studies available for thioctic acid and Myocardial Ischemia
| Article | Year |
|---|---|
Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Antioxidants; Arrhythmias, C | 2014 |
New lipoic acid derivative drug sodium zinc dihydrolipoylhistidinate prevents cardiac dysfunction in an isolated perfused rat heart model.
Topics: Animals; Cardiotonic Agents; Cells, Cultured; Disease Models, Animal; Heart; Histidine; Male; Membra | 2011 |
Alpha-lipoic acid protects against myocardial ischemia/reperfusion injury via multiple target effects.
Topics: Animals; Antioxidants; Apoptosis; Blotting, Western; Catalase; Creatine Kinase; Glutathione; Male; M | 2011 |
Effects of lipoic acid on citrate content, aconitate hydratase activity, and oxidative status during myocardial ischemia in rats.
Topics: Aconitate Hydratase; Animals; Antioxidants; Citric Acid; Male; Myocardial Ischemia; Myocardium; Oxid | 2008 |
Effect of alpha-lipoic acid and dihydrolipoic acid on ischemia/reperfusion injury of the heart and heart mitochondria.
Topics: Animals; Hemodynamics; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardial Reperfusion Injury | 1995 |
Lipoamide influences substrate selection in post-ischaemic perfused rat hearts.
Topics: Acetates; Acetylation; Animals; Aspartic Acid; Binding, Competitive; Carbon Isotopes; Glutamates; Gl | 1994 |
Cardiac recovery during post-ischemic reperfusion is improved by combination of vitamin E with dihydrolipoic acid.
Topics: Analysis of Variance; Animals; Biomarkers; Coronary Circulation; Food, Fortified; Hypoxia; In Vitro | 1993 |
Lipoic acid reduces ischemia-reperfusion injury in animal models.
Topics: Adenosine Triphosphatases; Animals; Creatine Kinase; Disease Models, Animal; Heart; Hindlimb; In Vit | 2000 |
Improved cardiac performance after ischemia in aged rats supplemented with vitamin E and alpha-lipoic acid.
Topics: Animals; Antioxidants; Blood Pressure; Dietary Supplements; Heart; Lipid Peroxidation; Male; Myocard | 2000 |
Lipoate ameliorates ischemia-reperfusion in animal models.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Aorta, Thoracic; Cell Hypoxia; Constriction; Creatine | 2000 |