thioctic acid has been researched along with Multiple Sclerosis in 16 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multiple sclerosis is a neurodegenerative and demyelinating disease of central nervous system." | 2.79 | Effect of lipoic acid consumption on oxidative stress among multiple sclerosis patients: a randomized controlled clinical trial. ( Azimi, A; Eghtesadi, S; Eskandari, G; Khalili, M; Mirshafiey, A; Moftakhar, S; Motevalian, A; Norouzi, A; Sahraian, MA; Sanoobar, M, 2014) |
| " We performed serum pharmacokinetic studies in patients with multiple sclerosis after a single oral dose of 1200 mg lipoic acid." | 2.75 | Pharmacokinetic study of lipoic acid in multiple sclerosis: comparing mice and human pharmacokinetic parameters. ( Alvarez, L; Bourdette, DN; Cherala, G; Koop, DR; Marracci, GH; Munar, MY; Shinto, L; Stuber, LE; Yadav, V, 2010) |
| "Multiple sclerosis is an immune-mediated disease that produces chronic inflammation and neural degeneration." | 2.52 | [Antioxidant use as dietary therapy in patients with multiple sclerosis]. ( Flores-Aldana, M; González-González, L; Hernández-Girón, C; Macías-Morales, N; Pérez-Cortéz, JG, 2015) |
| "Carvedilol is an adrenergic receptor antagonist." | 1.91 | Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination. ( Ahmed, KA; Ibrahim Fouad, G, 2023) |
| " Although (R)-alpha lipoic acid (ALA) evoked significant pain relief efficacy in a mouse model of multiple sclerosis-associated central neuropathic pain (MS-CNP), this dietary supplement has poor oral bioavailability due to low gastric stability." | 1.72 | Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. ( Blanchfield, JT; Carpinelli de Jesus, M; Jones, A; Khan, N; Kong, D; Saqer, AA; Smith, MT; Williams, CM, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 5 (31.25) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, H | 1 |
| Yang, X | 1 |
| Cao, Y | 1 |
| Long, X | 1 |
| Shang, H | 1 |
| Jia, Z | 1 |
| Mishra, MK | 1 |
| Wang, J | 1 |
| Mirzaei, R | 1 |
| Chan, R | 1 |
| Melo, H | 1 |
| Zhang, P | 1 |
| Ling, CC | 1 |
| Bruccoleri, A | 1 |
| Tang, L | 1 |
| Yong, VW | 1 |
| Kong, D | 1 |
| Saqer, AA | 1 |
| Carpinelli de Jesus, M | 1 |
| Khan, N | 1 |
| Jones, A | 1 |
| Blanchfield, JT | 1 |
| Smith, MT | 1 |
| Williams, CM | 1 |
| Ibrahim Fouad, G | 1 |
| Ahmed, KA | 1 |
| Fiedler, SE | 1 |
| Spain, RI | 1 |
| Kim, E | 1 |
| Salinthone, S | 3 |
| Behzadi, AH | 1 |
| Gupta, A | 1 |
| Prince, MR | 1 |
| Evans, E | 1 |
| Piccio, L | 1 |
| Cross, AH | 1 |
| Khalili, M | 2 |
| Eghtesadi, S | 2 |
| Mirshafiey, A | 2 |
| Eskandari, G | 2 |
| Sanoobar, M | 2 |
| Sahraian, MA | 2 |
| Motevalian, A | 2 |
| Norouzi, A | 2 |
| Moftakhar, S | 1 |
| Azimi, A | 2 |
| Izadi, V | 1 |
| Farhoudi, M | 1 |
| Amani, F | 1 |
| González-González, L | 1 |
| Pérez-Cortéz, JG | 1 |
| Flores-Aldana, M | 1 |
| Macías-Morales, N | 1 |
| Hernández-Girón, C | 1 |
| Plemel, JR | 1 |
| Juzwik, CA | 1 |
| Benson, CA | 1 |
| Monks, M | 1 |
| Harris, C | 1 |
| Ploughman, M | 1 |
| Yadav, V | 4 |
| Bourdette, DN | 3 |
| Carr, DW | 2 |
| Marracci, GH | 1 |
| Munar, MY | 1 |
| Cherala, G | 1 |
| Stuber, LE | 1 |
| Alvarez, L | 1 |
| Shinto, L | 2 |
| Koop, DR | 1 |
| Schillace, RV | 1 |
| MATTMANN, E | 1 |
| Marracci, G | 1 |
| Lovera, J | 1 |
| Woodward, W | 1 |
| Bogardus, K | 1 |
| Marquardt, W | 1 |
| Morris, C | 1 |
| Bourdette, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD:A Randomized, Double Blind, Placebo-controlled, Multicentric Trial.[NCT04284059] | Phase 4 | 504 participants (Anticipated) | Interventional | 2021-02-25 | Recruiting | ||
| Assessment of the Clinical Importance of Insulin Resistance & Steroid-Associated Hyperglycemia in Relapsing Multiple Sclerosis[NCT03004079] | 160 participants (Anticipated) | Observational | 2016-10-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for thioctic acid and Multiple Sclerosis
| Article | Year |
|---|---|
Role of lipoic acid in multiple sclerosis.
Topics: Animals; Antioxidants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; | 2022 |
Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis: A Review.
Topics: Acetylcarnitine; Animals; Ascorbic Acid; Biotin; Caffeine; Creatine; Curcumin; Dietary Supplements; | 2018 |
[Antioxidant use as dietary therapy in patients with multiple sclerosis].
Topics: Animals; Antioxidants; Disease Progression; Humans; Multiple Sclerosis; Myelin Sheath; Oxidative Str | 2015 |
Over-the-counter anti-oxidant therapies for use in multiple sclerosis: A systematic review.
Topics: Animals; Antioxidants; Catechin; Ginkgo biloba; Humans; Multiple Sclerosis; Nonprescription Drugs; Q | 2015 |
Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS.
Topics: Alzheimer Disease; Animals; Antioxidants; Central Nervous System Diseases; Diabetic Neuropathies; Hu | 2008 |
5 trials available for thioctic acid and Multiple Sclerosis
| Article | Year |
|---|---|
Effect of lipoic acid consumption on oxidative stress among multiple sclerosis patients: a randomized controlled clinical trial.
Topics: Adolescent; Adult; Antioxidants; Biomarkers; Double-Blind Method; Female; Glutathione Peroxidase; Hu | 2014 |
Does lipoic acid consumption affect the cytokine profile in multiple sclerosis patients: a double-blind, placebo-controlled, randomized clinical trial.
Topics: Administration, Oral; Adolescent; Adult; Antioxidants; Cytokines; Disability Evaluation; Double-Blin | 2014 |
Pharmacokinetic study of lipoic acid in multiple sclerosis: comparing mice and human pharmacokinetic parameters.
Topics: Administration, Oral; Adult; Aged; Animals; Antioxidants; Area Under Curve; Biological Availability; | 2010 |
Lipoic acid attenuates inflammation via cAMP and protein kinase A signaling.
Topics: Adolescent; Adult; Aged; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; Interleukin-17; I | 2010 |
Lipoic acid in multiple sclerosis: a pilot study.
Topics: Adult; Aged; Antioxidants; Female; Humans; Intercellular Adhesion Molecule-1; Male; Matrix Metallopr | 2005 |
6 other studies available for thioctic acid and Multiple Sclerosis
| Article | Year |
|---|---|
A Distinct
Topics: Animals; Antioxidants; Hibiscus; Iron; Mice; Multiple Sclerosis; Neurotoxicity Syndromes; Plant Extr | 2022 |
Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain.
Topics: Animals; Biological Availability; Caco-2 Cells; Humans; Mice; Multiple Sclerosis; Neuralgia; Prodrug | 2022 |
Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination.
Topics: Animals; Carvedilol; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C | 2023 |
Lipoic acid modulates inflammatory responses of monocytes and monocyte-derived macrophages from healthy and relapsing-remitting multiple sclerosis patients.
Topics: Cells, Cultured; Cytokines; Humans; Macrophages; Monocytes; Multiple Sclerosis; Multiple Sclerosis, | 2021 |
Potential role of lipoic acid as a chelator in prevention and treatment of gadolinium brain retention.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain; Chelating Agents; Gadolinium; Humans; Magnetic Re | 2018 |
[TREATMENT OF MULTIPLE SCLEROSIS WITH THIOCTIC ACID].
Topics: Humans; Multiple Sclerosis; Thioctic Acid | 1963 |