thioctic acid has been researched along with Mitochondrial Diseases in 17 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitochondrial diseases are a group of rare multisystem disorders characterized by genetic heterogeneity and pleomorphic clinical manifestations." | 1.48 | Nutritional support in mitochondrial diseases: the state of the art. ( Cintoni, M; Mele, MC; Pizzoferrato, M; Rinninella, E; Servidei, S, 2018) |
| "Acrolein is a highly reactive unsaturated hazardous air pollutant of human health concern, particularly as a component of cigarette smoke." | 1.35 | Protective effect of lipoic acid against acrolein-induced cytotoxicity in IMR-90 human fibroblasts. ( Bai, Y; Jia, L; Zhai, L; Zhang, Z, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 10 (58.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rinninella, E | 1 |
| Pizzoferrato, M | 1 |
| Cintoni, M | 1 |
| Servidei, S | 1 |
| Mele, MC | 1 |
| Nicolson, GL | 1 |
| Lacasa Maseri, A | 1 |
| Yun Castilla, C | 1 |
| Mota Ybancos, JL | 1 |
| Rodríguez-Pombo, P | 1 |
| Mehrotra, A | 1 |
| Kanwal, A | 1 |
| Banerjee, SK | 1 |
| Sandhir, R | 1 |
| Kishita, Y | 1 |
| Pajak, A | 1 |
| Bolar, NA | 1 |
| Marobbio, CM | 1 |
| Maffezzini, C | 1 |
| Miniero, DV | 1 |
| Monné, M | 1 |
| Kohda, M | 1 |
| Stranneheim, H | 1 |
| Murayama, K | 1 |
| Naess, K | 1 |
| Lesko, N | 1 |
| Bruhn, H | 1 |
| Mourier, A | 1 |
| Wibom, R | 1 |
| Nennesmo, I | 1 |
| Jespers, A | 1 |
| Govaert, P | 1 |
| Ohtake, A | 1 |
| Van Laer, L | 1 |
| Loeys, BL | 1 |
| Freyer, C | 1 |
| Palmieri, F | 1 |
| Wredenberg, A | 1 |
| Okazaki, Y | 1 |
| Wedell, A | 1 |
| Jia, L | 2 |
| Zhang, Z | 1 |
| Zhai, L | 1 |
| Bai, Y | 1 |
| Orsucci, D | 1 |
| Filosto, M | 1 |
| Siciliano, G | 1 |
| Mancuso, M | 1 |
| Brenner, SR | 1 |
| Navarro-Sastre, A | 2 |
| Tort, F | 2 |
| Stehling, O | 1 |
| Uzarska, MA | 1 |
| Arranz, JA | 2 |
| Del Toro, M | 2 |
| Labayru, MT | 1 |
| Landa, J | 1 |
| Font, A | 2 |
| Garcia-Villoria, J | 1 |
| Merinero, B | 1 |
| Ugarte, M | 1 |
| Gutierrez-Solana, LG | 1 |
| Campistol, J | 2 |
| Garcia-Cazorla, A | 2 |
| Vaquerizo, J | 1 |
| Riudor, E | 2 |
| Briones, P | 2 |
| Elpeleg, O | 1 |
| Ribes, A | 2 |
| Lill, R | 1 |
| Pfeffer, G | 1 |
| Majamaa, K | 1 |
| Turnbull, DM | 1 |
| Thorburn, D | 1 |
| Chinnery, PF | 1 |
| Haack, TB | 1 |
| Rolinski, B | 1 |
| Haberberger, B | 1 |
| Zimmermann, F | 1 |
| Schum, J | 1 |
| Strecker, V | 1 |
| Graf, E | 1 |
| Athing, U | 1 |
| Hoppen, T | 1 |
| Wittig, I | 1 |
| Sperl, W | 1 |
| Freisinger, P | 1 |
| Mayr, JA | 1 |
| Strom, TM | 1 |
| Meitinger, T | 1 |
| Prokisch, H | 1 |
| Ferrer-Cortès, X | 1 |
| Bujan, N | 1 |
| Matalonga, L | 1 |
| Mythili, Y | 1 |
| Sudharsan, PT | 1 |
| Varalakshmi, P | 1 |
| Rodriguez, MC | 1 |
| MacDonald, JR | 1 |
| Mahoney, DJ | 1 |
| Parise, G | 1 |
| Beal, MF | 1 |
| Tarnopolsky, MA | 1 |
| Liu, Z | 1 |
| Sun, L | 1 |
| Miller, SS | 1 |
| Ames, BN | 1 |
| Cotman, CW | 1 |
| Liu, J | 2 |
| Ambrose, M | 1 |
| Goldstine, JV | 1 |
| Gatti, RA | 1 |
| Shen, W | 1 |
| Liu, K | 1 |
| Tian, C | 1 |
| Yang, L | 1 |
| Li, X | 1 |
| Ren, J | 1 |
| Packer, L | 1 |
| Head, E | 1 |
| Sharman, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blinded, Placebo-controlled Trial of Idebenone in the Prevention of Episodic Migraine[NCT04151472] | Phase 3 | 180 participants (Anticipated) | Interventional | 2021-12-08 | Recruiting | ||
| A Phase II, Monocenter, Single Arm Study To Assess The Safety and Efficacy Of Combination Deoxycytidine and Deoxythymidine For Mitochondrial Depletion Disorders[NCT04802707] | Phase 2 | 50 participants (Anticipated) | Interventional | 2021-10-18 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thioctic acid and Mitochondrial Diseases
| Article | Year |
|---|---|
Electron transfer mediators and other metabolites and cofactors in the treatment of mitochondrial dysfunction.
Topics: Acidosis, Lactic; Animals; Antioxidants; Carnitine; Creatine; Dietary Supplements; Electron Transpor | 2009 |
Treatment for mitochondrial disorders.
Topics: Creatine; Dichloroacetic Acid; Humans; Mitochondrial Diseases; Randomized Controlled Trials as Topic | 2012 |
1 trial available for thioctic acid and Mitochondrial Diseases
| Article | Year |
|---|---|
Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adolescent; Adult; Analysis of Variance; Antioxidants; Body Composition | 2007 |
14 other studies available for thioctic acid and Mitochondrial Diseases
| Article | Year |
|---|---|
Nutritional support in mitochondrial diseases: the state of the art.
Topics: Arginine; Deglutition Disorders; Diet, High-Fat; Energy Metabolism; Humans; Mitochondria; Mitochondr | 2018 |
Mitochondrial dysfunction and chronic disease: treatment with natural supplements.
Topics: Carnitine; Dietary Supplements; Fatigue Syndrome, Chronic; Humans; Mitochondrial Diseases; NAD; Thio | 2014 |
[Severe pulmonary hypertension: initial manifestation of a new deficiency of the lipoic acid metabolism].
Topics: Biomarkers; Carrier Proteins; Fatal Outcome; Genetic Markers; Humans; Hypertension, Pulmonary; Infan | 2014 |
Mitochondrial modulators in experimental Huntington's disease: reversal of mitochondrial dysfunctions and cognitive deficits.
Topics: Acetylcarnitine; Animals; Cognition Disorders; Drug Therapy, Combination; Female; Huntington Disease | 2015 |
Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Calcium-Binding Proteins; Child, Preschool; DNA M | 2015 |
Protective effect of lipoic acid against acrolein-induced cytotoxicity in IMR-90 human fibroblasts.
Topics: Acrolein; Adenosine Triphosphate; Air Pollutants; Antioxidants; Cell Line; Cell Survival; Cytotoxins | 2009 |
Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs.
Topics: Brain Diseases, Metabolic; Chronic Disease; Disease Progression; DNA, Mitochondrial; Genetic Predisp | 2010 |
A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins.
Topics: Amino Acid Oxidoreductases; Carrier Proteins; Chromosomes, Human, Pair 2; Female; HeLa Cells; Homozy | 2011 |
Homozygous missense mutation in BOLA3 causes multiple mitochondrial dysfunctions syndrome in two siblings.
Topics: Amino Acid Sequence; Electron Transport; Female; Fibroblasts; Homozygote; Humans; Infant, Newborn; M | 2013 |
Protein expression profiles in patients carrying NFU1 mutations. Contribution to the pathophysiology of the disease.
Topics: Carrier Proteins; Electron Transport; Fibroblasts; Genotype; Homozygote; Humans; Infant; Mitochondri | 2013 |
dl-alpha-lipoic acid ameliorates cyclophosphamide induced cardiac mitochondrial injury.
Topics: Animals; Antineoplastic Agents, Alkylating; Cyclophosphamide; Electron Transport Chain Complex Prote | 2005 |
Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid.
Topics: Acrolein; Antioxidants; Cell Line; Cell Survival; Cytoprotection; Electron Transport Chain Complex P | 2007 |
Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells.
Topics: Antioxidants; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Ce | 2007 |
Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid.
Topics: Acetylcarnitine; Animals; Cell Line, Tumor; Insulinoma; Islets of Langerhans; Mitochondrial Diseases | 2008 |