thioctic acid has been researched along with MS (Multiple Sclerosis) in 16 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multiple sclerosis is a neurodegenerative and demyelinating disease of central nervous system." | 2.79 | Effect of lipoic acid consumption on oxidative stress among multiple sclerosis patients: a randomized controlled clinical trial. ( Azimi, A; Eghtesadi, S; Eskandari, G; Khalili, M; Mirshafiey, A; Moftakhar, S; Motevalian, A; Norouzi, A; Sahraian, MA; Sanoobar, M, 2014) |
| " We performed serum pharmacokinetic studies in patients with multiple sclerosis after a single oral dose of 1200 mg lipoic acid." | 2.75 | Pharmacokinetic study of lipoic acid in multiple sclerosis: comparing mice and human pharmacokinetic parameters. ( Alvarez, L; Bourdette, DN; Cherala, G; Koop, DR; Marracci, GH; Munar, MY; Shinto, L; Stuber, LE; Yadav, V, 2010) |
| "Multiple sclerosis is an immune-mediated disease that produces chronic inflammation and neural degeneration." | 2.52 | [Antioxidant use as dietary therapy in patients with multiple sclerosis]. ( Flores-Aldana, M; González-González, L; Hernández-Girón, C; Macías-Morales, N; Pérez-Cortéz, JG, 2015) |
| "Carvedilol is an adrenergic receptor antagonist." | 1.91 | Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination. ( Ahmed, KA; Ibrahim Fouad, G, 2023) |
| " Although (R)-alpha lipoic acid (ALA) evoked significant pain relief efficacy in a mouse model of multiple sclerosis-associated central neuropathic pain (MS-CNP), this dietary supplement has poor oral bioavailability due to low gastric stability." | 1.72 | Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. ( Blanchfield, JT; Carpinelli de Jesus, M; Jones, A; Khan, N; Kong, D; Saqer, AA; Smith, MT; Williams, CM, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 5 (31.25) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, H | 1 |
| Yang, X | 1 |
| Cao, Y | 1 |
| Long, X | 1 |
| Shang, H | 1 |
| Jia, Z | 1 |
| Mishra, MK | 1 |
| Wang, J | 1 |
| Mirzaei, R | 1 |
| Chan, R | 1 |
| Melo, H | 1 |
| Zhang, P | 1 |
| Ling, CC | 1 |
| Bruccoleri, A | 1 |
| Tang, L | 1 |
| Yong, VW | 1 |
| Kong, D | 1 |
| Saqer, AA | 1 |
| Carpinelli de Jesus, M | 1 |
| Khan, N | 1 |
| Jones, A | 1 |
| Blanchfield, JT | 1 |
| Smith, MT | 1 |
| Williams, CM | 1 |
| Ibrahim Fouad, G | 1 |
| Ahmed, KA | 1 |
| Fiedler, SE | 1 |
| Spain, RI | 1 |
| Kim, E | 1 |
| Salinthone, S | 3 |
| Behzadi, AH | 1 |
| Gupta, A | 1 |
| Prince, MR | 1 |
| Evans, E | 1 |
| Piccio, L | 1 |
| Cross, AH | 1 |
| Khalili, M | 2 |
| Eghtesadi, S | 2 |
| Mirshafiey, A | 2 |
| Eskandari, G | 2 |
| Sanoobar, M | 2 |
| Sahraian, MA | 2 |
| Motevalian, A | 2 |
| Norouzi, A | 2 |
| Moftakhar, S | 1 |
| Azimi, A | 2 |
| Izadi, V | 1 |
| Farhoudi, M | 1 |
| Amani, F | 1 |
| González-González, L | 1 |
| Pérez-Cortéz, JG | 1 |
| Flores-Aldana, M | 1 |
| Macías-Morales, N | 1 |
| Hernández-Girón, C | 1 |
| Plemel, JR | 1 |
| Juzwik, CA | 1 |
| Benson, CA | 1 |
| Monks, M | 1 |
| Harris, C | 1 |
| Ploughman, M | 1 |
| Yadav, V | 4 |
| Bourdette, DN | 3 |
| Carr, DW | 2 |
| Marracci, GH | 1 |
| Munar, MY | 1 |
| Cherala, G | 1 |
| Stuber, LE | 1 |
| Alvarez, L | 1 |
| Shinto, L | 2 |
| Koop, DR | 1 |
| Schillace, RV | 1 |
| MATTMANN, E | 1 |
| Marracci, G | 1 |
| Lovera, J | 1 |
| Woodward, W | 1 |
| Bogardus, K | 1 |
| Marquardt, W | 1 |
| Morris, C | 1 |
| Bourdette, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD:A Randomized, Double Blind, Placebo-controlled, Multicentric Trial.[NCT04284059] | Phase 4 | 504 participants (Anticipated) | Interventional | 2021-02-25 | Recruiting | ||
| Assessment of the Clinical Importance of Insulin Resistance & Steroid-Associated Hyperglycemia in Relapsing Multiple Sclerosis[NCT03004079] | 160 participants (Anticipated) | Observational | 2016-10-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for thioctic acid and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Role of lipoic acid in multiple sclerosis.
Topics: Animals; Antioxidants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; | 2022 |
Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis: A Review.
Topics: Acetylcarnitine; Animals; Ascorbic Acid; Biotin; Caffeine; Creatine; Curcumin; Dietary Supplements; | 2018 |
[Antioxidant use as dietary therapy in patients with multiple sclerosis].
Topics: Animals; Antioxidants; Disease Progression; Humans; Multiple Sclerosis; Myelin Sheath; Oxidative Str | 2015 |
Over-the-counter anti-oxidant therapies for use in multiple sclerosis: A systematic review.
Topics: Animals; Antioxidants; Catechin; Ginkgo biloba; Humans; Multiple Sclerosis; Nonprescription Drugs; Q | 2015 |
Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS.
Topics: Alzheimer Disease; Animals; Antioxidants; Central Nervous System Diseases; Diabetic Neuropathies; Hu | 2008 |
5 trials available for thioctic acid and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Effect of lipoic acid consumption on oxidative stress among multiple sclerosis patients: a randomized controlled clinical trial.
Topics: Adolescent; Adult; Antioxidants; Biomarkers; Double-Blind Method; Female; Glutathione Peroxidase; Hu | 2014 |
Does lipoic acid consumption affect the cytokine profile in multiple sclerosis patients: a double-blind, placebo-controlled, randomized clinical trial.
Topics: Administration, Oral; Adolescent; Adult; Antioxidants; Cytokines; Disability Evaluation; Double-Blin | 2014 |
Pharmacokinetic study of lipoic acid in multiple sclerosis: comparing mice and human pharmacokinetic parameters.
Topics: Administration, Oral; Adult; Aged; Animals; Antioxidants; Area Under Curve; Biological Availability; | 2010 |
Lipoic acid attenuates inflammation via cAMP and protein kinase A signaling.
Topics: Adolescent; Adult; Aged; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; Interleukin-17; I | 2010 |
Lipoic acid in multiple sclerosis: a pilot study.
Topics: Adult; Aged; Antioxidants; Female; Humans; Intercellular Adhesion Molecule-1; Male; Matrix Metallopr | 2005 |
6 other studies available for thioctic acid and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
A Distinct
Topics: Animals; Antioxidants; Hibiscus; Iron; Mice; Multiple Sclerosis; Neurotoxicity Syndromes; Plant Extr | 2022 |
Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain.
Topics: Animals; Biological Availability; Caco-2 Cells; Humans; Mice; Multiple Sclerosis; Neuralgia; Prodrug | 2022 |
Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination.
Topics: Animals; Carvedilol; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C | 2023 |
Lipoic acid modulates inflammatory responses of monocytes and monocyte-derived macrophages from healthy and relapsing-remitting multiple sclerosis patients.
Topics: Cells, Cultured; Cytokines; Humans; Macrophages; Monocytes; Multiple Sclerosis; Multiple Sclerosis, | 2021 |
Potential role of lipoic acid as a chelator in prevention and treatment of gadolinium brain retention.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain; Chelating Agents; Gadolinium; Humans; Magnetic Re | 2018 |
[TREATMENT OF MULTIPLE SCLEROSIS WITH THIOCTIC ACID].
Topics: Humans; Multiple Sclerosis; Thioctic Acid | 1963 |