thioctic acid has been researched along with Liver Cirrhosis in 28 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of the present study was to investigate the mechanisms by which ALA protects the liver from carbon tetrachloride (CCl4)‑induced liver cirrhosis." | 7.91 | α‑lipoic acid protects against carbon tetrachloride‑induced liver cirrhosis through the suppression of the TGF‑β/Smad3 pathway and autophagy. ( Gui, S; Liu, G; Liu, J; Lu, B; Pian, L, 2019) |
| "Liver cirrhosis is the final consequence of a progressive fibrotic process characterized by excessive collagen deposition and destruction of the normal liver architecture." | 5.40 | Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats. ( Ali, SO; Darwish, HA; Ismail, NA, 2014) |
| " The aim of the present study was to investigate the mechanisms by which ALA protects the liver from carbon tetrachloride (CCl4)‑induced liver cirrhosis." | 3.91 | α‑lipoic acid protects against carbon tetrachloride‑induced liver cirrhosis through the suppression of the TGF‑β/Smad3 pathway and autophagy. ( Gui, S; Liu, G; Liu, J; Lu, B; Pian, L, 2019) |
| "Liver fibrosis was induced via thioacetamide (TAA) intoxication in rats; TAA-intoxicated rats were treated with either silymarin or ALA." | 1.56 | α-Lipoic acid modulates liver fibrosis: A cross talk between TGF-β1, autophagy, and apoptosis. ( El-Lakkany, NM; El-Maadawy, WH; Hammam, OA; Seif El-Din, SH, 2020) |
| "In the livers of mice with liver fibrosis, the mRNA levels of LA synthetic pathway enzymes, including MCAT, OXSM, MECR, and LIAS, were significantly reduced." | 1.56 | Lipoic acid alleviates schistosomiasis-induced liver fibrosis by upregulating Drp1 phosphorylation. ( Luo, J; Shen, S, 2020) |
| "A histological assessment of the liver fibrosis was performed using stained liver samples." | 1.40 | Effects of the dihydrolipoyl histidinate zinc complex against carbon tetrachloride-induced hepatic fibrosis in rats. ( Inomata, M; Iwashita, Y; Kawano, Y; Kitano, S; Komori, Y; Ohta, M, 2014) |
| "Liver cirrhosis is the final consequence of a progressive fibrotic process characterized by excessive collagen deposition and destruction of the normal liver architecture." | 1.40 | Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats. ( Ali, SO; Darwish, HA; Ismail, NA, 2014) |
| "Liver fibrosis is a major health problem that can lead to the development of liver cirrhosis and hepatocellular carcinoma." | 1.38 | Protective effects of curcumin, α-lipoic acid, and N-acetylcysteine against carbon tetrachloride-induced liver fibrosis in rats. ( Abdalla, AM; Abdelwahab, SA; Mahmoud, AM; Mahmoud, ME; Morsy, MA, 2012) |
| "However, PZQ does not improve liver fibrosis." | 1.38 | Therapeutic effect of alpha lipoic acid combined with praziquantel on liver fibrosis induced by Schistosoma mansoni challenged mice. ( Aabdel-Wahab, S; Abdel-Hafeez, EH; Abdulla, AM; Ahmad, AK; Mosalem, FA, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (67.86) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (25.00) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| El-Maadawy, WH | 1 |
| Hammam, OA | 1 |
| Seif El-Din, SH | 1 |
| El-Lakkany, NM | 1 |
| Luo, J | 1 |
| Shen, S | 1 |
| Liu, G | 1 |
| Liu, J | 1 |
| Pian, L | 1 |
| Gui, S | 1 |
| Lu, B | 1 |
| Kawano, Y | 1 |
| Ohta, M | 1 |
| Iwashita, Y | 1 |
| Komori, Y | 1 |
| Inomata, M | 1 |
| Kitano, S | 1 |
| Ali, SO | 1 |
| Darwish, HA | 1 |
| Ismail, NA | 1 |
| Min, AK | 1 |
| Kim, MK | 1 |
| Seo, HY | 1 |
| Kim, HS | 1 |
| Jang, BK | 1 |
| Hwang, JS | 1 |
| Choi, HS | 1 |
| Lee, KU | 1 |
| Park, KG | 1 |
| Lee, IK | 1 |
| Foo, NP | 1 |
| Lin, SH | 1 |
| Lee, YH | 1 |
| Wu, MJ | 1 |
| Wang, YJ | 1 |
| Morsy, MA | 1 |
| Abdalla, AM | 1 |
| Mahmoud, AM | 1 |
| Abdelwahab, SA | 1 |
| Mahmoud, ME | 1 |
| Abdel-Hafeez, EH | 1 |
| Ahmad, AK | 1 |
| Abdulla, AM | 1 |
| Aabdel-Wahab, S | 1 |
| Mosalem, FA | 1 |
| PURPURA, F | 1 |
| SCHREIBER, HW | 1 |
| SCHOENFELDER, M | 1 |
| SCHRIEFERS, KH | 1 |
| BREUER, H | 1 |
| DE PASQUALE, C | 1 |
| NARDI, E | 1 |
| RONCHI, F | 1 |
| da COSTA, S | 1 |
| de SOUSA, R | 1 |
| da SILVA, I | 1 |
| LEE, SJ | 1 |
| KAO, MS | 1 |
| HUANG, PC | 1 |
| SUNG, JL | 1 |
| PRIMAVESI, L | 1 |
| FERRITO, A | 1 |
| GOLDNER, R | 1 |
| SEMENDIAEVA, ME | 1 |
| ALEKBEROVA, ZS | 1 |
| PONOMAREVA, OA | 1 |
| KONO, H | 1 |
| ORREGO, H | 1 |
| WALSHE, JM | 1 |
| BRAVO, M | 1 |
| PAGLIARO, L | 1 |
| Möller, E | 2 |
| Schmitt, R | 1 |
| Khvorostinka, VN | 1 |
| Teslenko, VG | 1 |
| Khvisiuk, SS | 1 |
| Kosenko, NP | 1 |
| Borisenko, GV | 1 |
| Esser, G | 1 |
| Brinkmann, W | 1 |
| Weber, O | 1 |
| Wildhirt, E | 2 |
| Moser, K | 1 |
| Lujf, A | 1 |
| Gómez Ponsa, JM | 1 |
| Loginow, AS | 1 |
| Romanov, VS | 1 |
1 trial available for thioctic acid and Liver Cirrhosis
| Article | Year |
|---|---|
[A contribution to the treatment of chronic liver diseases (author's transl)].
Topics: Administration, Oral; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Chronic Disease; Cl | 1976 |
27 other studies available for thioctic acid and Liver Cirrhosis
| Article | Year |
|---|---|
α-Lipoic acid modulates liver fibrosis: A cross talk between TGF-β1, autophagy, and apoptosis.
Topics: Animals; Apoptosis; Autophagy; Biomarkers; Disease Models, Animal; Liver Cirrhosis; Male; Oxidative | 2020 |
Lipoic acid alleviates schistosomiasis-induced liver fibrosis by upregulating Drp1 phosphorylation.
Topics: Animals; Cell Line, Tumor; Dynamins; Female; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Mitochondria | 2020 |
α‑lipoic acid protects against carbon tetrachloride‑induced liver cirrhosis through the suppression of the TGF‑β/Smad3 pathway and autophagy.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Autophagy; Carbon Tetrachloride; Down-Re | 2019 |
Effects of the dihydrolipoyl histidinate zinc complex against carbon tetrachloride-induced hepatic fibrosis in rats.
Topics: Animals; Antimycin A; Antioxidants; Carbon Tetrachloride; Cells, Cultured; Glutathione; Hepatic Stel | 2014 |
Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Curcumin; Gene Expression | 2014 |
Alpha-lipoic acid inhibits hepatic PAI-1 expression and fibrosis by inhibiting the TGF-beta signaling pathway.
Topics: Animals; Antioxidants; Extracellular Signal-Regulated MAP Kinases; Liver Cirrhosis; MAP Kinase Kinas | 2010 |
α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β.
Topics: Animals; Antioxidants; Becaplermin; Biomarkers; Cell Line; Cell Proliferation; Cytokines; Gene Expre | 2011 |
Protective effects of curcumin, α-lipoic acid, and N-acetylcysteine against carbon tetrachloride-induced liver fibrosis in rats.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; | 2012 |
Therapeutic effect of alpha lipoic acid combined with praziquantel on liver fibrosis induced by Schistosoma mansoni challenged mice.
Topics: Animals; Anthelmintics; Antioxidants; Drug Therapy, Combination; Liver Cirrhosis; Male; Mice; Mice, | 2012 |
[Effects of thioctic acid and partial hepatectomy in experimental hepatic fibrosis induced by carbon tetrachloride].
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hepatectomy; Liver; Liver Cirrhosis; Thioctic | 1957 |
[Effect of thioctic acid on the ammonia content of blood in liver cirrhoses].
Topics: Ammonia; Humans; Liver Cirrhosis; Thioctic Acid | 1961 |
[Considerations on the use of thioctic acid in the treatment of hepatic cirrhosis].
Topics: Liver Cirrhosis; Thioctic Acid | 1959 |
[The effect of various drugs used in liver cirrhosis on the proteinograms of ascites fluid and serum. Preliminary report].
Topics: Ascites; Blood Protein Electrophoresis; Cortisone; Folic Acid; Glutamates; Hematinics; Humans; Immun | 1963 |
THE EFFECT OF THIOCTIC ACID ON BLOOD ALPHA-KETO ACID LEVELS IN LIVER DISEASES.
Topics: Blood Chemical Analysis; Carcinoma, Hepatocellular; Chromatography; Hepatic Encephalopathy; Hepatiti | 1963 |
[A NEW TREATMENT OF ASCITOGENIC CIRRHOSIS. (PRELIMINARY REPORT)].
Topics: Ascites; Humans; Liver Cirrhosis; Thiamine Pyrophosphate; Thioctic Acid | 1963 |
[SIGNIFICANCE OF LIPOIC (THIOCTIC) ACID IN COMBINED TREATMENT OF BOTKIN'S DISEASE].
Topics: Drug Therapy; Fructose-Bisphosphate Aldolase; Hepatitis; Hepatitis A; Humans; Hyperbilirubinemia; Li | 1964 |
[CLINICAL RESEARCH ON PYRUVIC ACID METABOLISM IN LIVER DISEASES. II. EFFECTS OF DIFFERENT DRUGS ON THE PYRUVIC ACID BLOOD LEVEL IN LIVER DISEASES].
Topics: Adrenal Cortex Hormones; Asparagine; Blood Chemical Analysis; Glucose; Hepatitis; Hepatitis A; Liver | 1964 |
[Lactic and pyruvic acids in liver cirrhosis before and after the oral administration of glucose. Influence of thioctic acid on such acids].
Topics: Administration, Oral; Glucose; Lactates; Liver Cirrhosis; Pyruvates; Pyruvic Acid; Thioctic Acid | 1959 |
[On a case of siderosis with liver cirrhosis treated with thioctic acid].
Topics: Liver Cirrhosis; Organic Chemicals; Siderosis; Thioctic Acid | 1959 |
[Use of repeat courses of unithiol in the complex treatment of liver cirrhosis].
Topics: Adult; Dimercaprol; Drug Administration Schedule; Drug Therapy, Combination; Female; Furosemide; Hum | 1986 |
[Peculiarities of the surgical technic in the performance of portocaval anastomoses].
Topics: Ascorbic Acid; Female; Fructose; Humans; Liver Cirrhosis; Male; Pancreatic Extracts; Portacaval Shun | 1967 |
[Treatment of chronic liver diseases with thioctic acid].
Topics: Adult; Alcoholism; Chronic Disease; Female; Hepatitis; Humans; Injections, Intravenous; Liver Cirrho | 1967 |
[Therapeutic progress in chronic liver diseases].
Topics: Choline; Chronic Disease; Folic Acid; Hepatitis; Humans; Liver Cirrhosis; Orotic Acid; Thioctic Acid | 1968 |
[Metabolic changes in liver diseases and experimental liver damage caused by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride Poisoning; Carboxy-Lyases; Chemical and Drug Induced Liver Injury; Cit | 1967 |
[1st experiences with the use of a new liver protector in liver diseases].
Topics: Adult; Aged; Female; Hepatitis; Humans; Liver Cirrhosis; Male; Middle Aged; Thioctic Acid; Trometham | 1970 |
[Therapy of chronic liver diseases with prednisolone and alpha-lipoic acid].
Topics: Amides; Bilirubin; Blood Proteins; Cholesterol; Chronic Disease; Depression, Chemical; Esophageal Di | 1970 |
[Use of lipoic acid and its amide in chronic liver diseases].
Topics: Amides; Chronic Disease; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Thioctic Acid | 1971 |