thioctic acid has been researched along with Liver Cirrhosis, Biliary in 28 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Liver Cirrhosis, Biliary: FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cholangitis involves the destruction of small intra-hepatic bile ducts and decreased bile secretion. Secondary biliary cholangitis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The serologic hallmark of primary biliary cirrhosis (PBC) is the presence of antimitochondrial autoantibodies (AMAs) directed against the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2)." | 5.38 | Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis? ( Coppel, RL; Gershwin, ME; Kurth, MJ; Lam, K; Leung, PS, 2012) |
| " Importantly, we have demonstrated that murine immunization with one such mimic, 2-octynoic acid coupled to bovine serum albumin (BSA), induces anti-mitochondrial antibodies (AMAs) and cholangitis." | 3.77 | Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity. ( Ansari, AA; Butler, JD; Coppel, RL; Gershwin, ME; Guggenheim, KG; Kenny, TP; Kurth, MJ; Lam, K; Leung, PS; López-Hoyos, M; Meng, L; Naiyanetr, P; Pfeiff, J; Reiger, R, 2011) |
| "Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease in which an immune-mediated injury targets the small intrahepatic bile ducts." | 2.47 | The autoimmunity of primary biliary cirrhosis and the clonal selection theory. ( Gershwin, ME; Mackay, IR; Selmi, C, 2011) |
| "Primary biliary cirrhosis is an enigmatic autoimmune disease of women characterized by antimitochondrial antibodies and destruction of intrahepatic bile ducts." | 2.41 | Antimitochondrial antibodies in primary biliary cirrhosis: the role of xenobiotics. ( Gershwin, ME; Long, SA; Van de Water, J, 2002) |
| "Primary biliary cirrhosis (PBC) is associated with a high incidence of autoantibodies directed at mitochondrial autoantigens (the antimito-chondrial antibodies), identified as the E2 components of PDC, OGDC, and BCOADC, together with protein X and the E1 alpha and E1 beta subunits of PDC." | 2.40 | Biochemistry and autoimmune response to the 2-oxoacid dehydrogenase complexes in primary biliary cirrhosis. ( Bassendine, MF; Jones, DE; Yeaman, SJ, 1997) |
| "The serologic hallmark of primary biliary cirrhosis (PBC) is the presence of antimitochondrial autoantibodies (AMAs) directed against the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2)." | 1.38 | Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis? ( Coppel, RL; Gershwin, ME; Kurth, MJ; Lam, K; Leung, PS, 2012) |
| "Primary biliary cirrhosis (PBC) is characterized by loss of tolerance against ubiquitously expressed mitochondrial autoantigens followed by biliary and salivary gland epithelial cell (BEC and SGEC) destruction by autoreactive T cells." | 1.33 | T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis. ( Allina, J; Bronk, SF; Fiel, MI; Gershwin, ME; Gores, GJ; Hu, B; Huebert, RC; LaRusso, NF; Odin, JA; Sullivan, DM; Thung, SN; van de Water, J, 2006) |
| "The immunodominant autoantigen in primary biliary cirrhosis (PBC), E2 components of pyruvate dehydrogenase complexes (PDC-E2), has a lipoate molecule bonded to the domain to which autoantibodies are directed." | 1.32 | Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis. ( Amano, K; Ansari, AA; Benson, GD; Bruggraber, SF; Coppel, RL; Gershwin, ME; Kurth, MJ; Leung, PS; Luketic, V; Nantz, MH; Quan, C; Roche, TE; Van de Water, J, 2003) |
| "In primary biliary cirrhosis (PBC), the major autoepitope recognized by both T and B cells is the inner lipoyl domain of the E2 component of pyruvate dehydrogenase." | 1.31 | Immunoreactivity of organic mimeotopes of the E2 component of pyruvate dehydrogenase: connecting xenobiotics with primary biliary cirrhosis. ( Ansari, A; Barsky, D; Colvin, ME; Coppel, RL; Gershwin, ME; Kurth, MJ; Lam, KS; Long, SA; Nantz, MH; Quan, C; Van de Water, J, 2001) |
| "Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the presence of antimitochondrial antibodies (AMA) directed primarily against the E2 subunits of the pyruvate dehydrogenase complex, the branched chain 2-oxo-acid dehydrogenase complex, the 2-oxoglutarate dehydrogenase complex, as well as the dihydrolipoamide dehydrogenase-binding protein (E3BP) of pyruvate dehydrogenase complex." | 1.30 | Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase-binding protein (E3BP) and the glycine cleavage proteins in primary biliary cirrhosis. ( Ansari, A; Coppel, R; Dubel, L; Gershwin, ME; Johanet, C; Leung, PS; Motokawa, Y; Roche, T; Tanaka, A; Van de Water, J, 1999) |
| "Primary biliary cirrhosis (PBC) is an autoimmune disease of liver associated with a unique serologic response to mitochondrial autoantigens." | 1.29 | Autoantibodies to BCOADC-E2 in patients with primary biliary cirrhosis recognize a conformational epitope. ( Ansari, A; Cha, S; Chuang, DT; Coppel, RL; Danner, DJ; Gershwin, ME; Leung, PS; Wynn, RM, 1995) |
| "Approximately 95% of patients with primary biliary cirrhosis have antimitochondrial antibodies against the E2 component of the pyruvate dehydrogenase complex (E2p)." | 1.29 | Lipoylated and unlipoylated domains of human PDC-E2 as autoantigens in primary biliary cirrhosis: significance of lipoate attachment. ( Bassendine, MF; Diamond, AG; James, OF; Palmer, JM; Quinn, J; Yeaman, SJ, 1993) |
| "Sera from patients with primary biliary cirrhosis exhibit variable autoantibody reactivity against mitochondria, the commonest antigen (designated M2) including three structures of approximate M." | 1.28 | Antimitochondrial antibodies in primary biliary cirrhosis recognize both specific peptides and shared epitopes of the M2 family of antigens. ( Baum, H; Brumfitt, W; Burroughs, AK; Butler, P; Chelliah, J; Flannery, GR; Hamilton-Miller, J, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.71) | 18.7374 |
| 1990's | 11 (39.29) | 18.2507 |
| 2000's | 8 (28.57) | 29.6817 |
| 2010's | 5 (17.86) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, Y | 1 |
| Choi, J | 1 |
| Chen, Y | 1 |
| Invernizzi, P | 1 |
| Yang, G | 1 |
| Zhang, W | 1 |
| Shao, TH | 1 |
| Jordan, F | 1 |
| Nemeria, NS | 1 |
| Coppel, RL | 12 |
| Ridgway, WM | 1 |
| Kurth, M | 1 |
| Ansari, AA | 6 |
| Leung, PSC | 1 |
| Gershwin, ME | 19 |
| Walden, HR | 1 |
| Kirby, JA | 1 |
| Yeaman, SJ | 5 |
| Gray, J | 1 |
| Jones, DE | 3 |
| Palmer, JM | 3 |
| Selmi, C | 2 |
| Mackay, IR | 1 |
| Naiyanetr, P | 2 |
| Butler, JD | 1 |
| Meng, L | 1 |
| Pfeiff, J | 1 |
| Kenny, TP | 3 |
| Guggenheim, KG | 1 |
| Reiger, R | 1 |
| Lam, K | 2 |
| Kurth, MJ | 6 |
| López-Hoyos, M | 1 |
| Leung, PS | 13 |
| Shimoda, S | 1 |
| Tsuneyama, K | 1 |
| Kikuchi, K | 1 |
| Harada, K | 1 |
| Nakanuma, Y | 2 |
| Nakamura, M | 1 |
| Ishibashi, H | 1 |
| Hisamoto, S | 1 |
| Niiro, H | 1 |
| Akashi, K | 1 |
| Wang, J | 1 |
| Lam, KS | 3 |
| Long, SA | 2 |
| Van de Water, J | 6 |
| Bruggraber, SF | 1 |
| Amano, K | 2 |
| Quan, C | 3 |
| Nantz, MH | 3 |
| Benson, GD | 1 |
| Luketic, V | 1 |
| Roche, TE | 3 |
| Xu, Q | 1 |
| Marik, J | 1 |
| Zeniya, M | 1 |
| Padgett, KA | 1 |
| Balkwill, DL | 1 |
| Allina, J | 1 |
| Hu, B | 1 |
| Sullivan, DM | 1 |
| Fiel, MI | 1 |
| Thung, SN | 1 |
| Bronk, SF | 1 |
| Huebert, RC | 1 |
| LaRusso, NF | 1 |
| Gores, GJ | 1 |
| Odin, JA | 1 |
| Chuang, DT | 1 |
| Wynn, RM | 1 |
| Cha, S | 1 |
| Danner, DJ | 1 |
| Ansari, A | 5 |
| Quinn, J | 1 |
| Diamond, AG | 2 |
| Bassendine, MF | 4 |
| James, OF | 2 |
| Gut, J | 1 |
| Christen, U | 1 |
| Frey, N | 1 |
| Koch, V | 1 |
| Stoffler, D | 1 |
| Moteki, S | 1 |
| Dickson, ER | 1 |
| Kaplan, MM | 1 |
| Munoz, S | 2 |
| Dubel, L | 1 |
| Tanaka, A | 1 |
| Coppel, R | 2 |
| Roche, T | 1 |
| Johanet, C | 1 |
| Motokawa, Y | 1 |
| Marley, R | 1 |
| Holt, S | 1 |
| Fernando, B | 1 |
| Harry, D | 1 |
| Anand, R | 1 |
| Goodier, D | 1 |
| Davies, S | 1 |
| Moore, K | 1 |
| Sasaki, M | 1 |
| Pumford, N | 1 |
| Humphries, KM | 1 |
| Szweda, LI | 1 |
| Bach, JF | 1 |
| Barsky, D | 1 |
| Colvin, ME | 1 |
| Iwayama, T | 1 |
| Fregeau, DR | 1 |
| Davis, PA | 1 |
| Fussey, SP | 1 |
| Flannery, GR | 1 |
| Burroughs, AK | 1 |
| Butler, P | 1 |
| Chelliah, J | 1 |
| Hamilton-Miller, J | 1 |
| Brumfitt, W | 1 |
| Baum, H | 1 |
| Loginow, AS | 1 |
5 reviews available for thioctic acid and Liver Cirrhosis, Biliary
| Article | Year |
|---|---|
The autoimmunity of primary biliary cirrhosis and the clonal selection theory.
Topics: Animals; Autoantibodies; Autoantigens; Autoimmunity; Clonal Deletion; Dihydrolipoyllysine-Residue Ac | 2011 |
Antimitochondrial antibodies in primary biliary cirrhosis: the role of xenobiotics.
Topics: Animals; Autoantibodies; Autoimmune Diseases; Bile Ducts, Intrahepatic; Female; Humans; Inflammation | 2002 |
Molecular mimicry in halothane hepatitis: biochemical and structural characterization of lipoylated autoantigens.
Topics: Autoantigens; Chemical and Drug Induced Liver Injury; Cross Reactions; Halothane; Humans; Liver Cirr | 1995 |
Biochemistry and autoimmune response to the 2-oxoacid dehydrogenase complexes in primary biliary cirrhosis.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Antigen-Antibody Reactions; Autoantibodies; Autoa | 1997 |
Antimitochondrial antibodies in primary biliary cirrhosis.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Autoantibodies; Autoantigens; Autoimmune Diseases | 1997 |
23 other studies available for thioctic acid and Liver Cirrhosis, Biliary
| Article | Year |
|---|---|
E. coli and the etiology of human PBC: Antimitochondrial antibodies and spreading determinants.
Topics: Autoantibodies; Autoantigens; Case-Control Studies; Cross Reactions; Dihydrolipoyllysine-Residue Ace | 2022 |
Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway.
Topics: Adenosine Triphosphate; Animals; Autoimmunity; Caproates; Carcinoma, Hepatocellular; Cell Line; Cell | 2008 |
Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoantibodies; Autoantigens; Autoi | 2011 |
The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis.
Topics: Animals; Autoantibodies; Autoantigens; Biomimetic Materials; Cattle; Cells, Cultured; Cytokines; Dih | 2012 |
Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis?
Topics: Acetaminophen; Animals; Autoantibodies; Autoimmunity; Humans; Liver Cirrhosis, Biliary; Mice; Mitoch | 2012 |
Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Autoantibodies; Binding Sites; Epitopes; Humans; Liver Cirr | 2013 |
Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis.
Topics: Animals; Antibodies; Autoimmunity; Epitopes; Hemocyanins; Humans; Immunoglobulin Isotypes; Liver Cir | 2003 |
Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible.
Topics: Animals; Autoantibodies; Autoantigens; Binding Sites, Antibody; Binding, Competitive; Dihydrolipoyll | 2004 |
Phylogenetic and immunological definition of four lipoylated proteins from Novosphingobium aromaticivorans, implications for primary biliary cirrhosis.
Topics: Acyltransferases; Amino Acid Sequence; Animals; Antigens, Bacterial; Autoantigens; Autoimmune Diseas | 2005 |
T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis.
Topics: Animals; Apoptosis; Autoantigens; Cathepsin B; Dihydrolipoyllysine-Residue Acetyltransferase; Epithe | 2006 |
Autoantibodies to BCOADC-E2 in patients with primary biliary cirrhosis recognize a conformational epitope.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Amino Acid Sequence; Antibody Specificity; Autoan | 1995 |
Lipoylated and unlipoylated domains of human PDC-E2 as autoantigens in primary biliary cirrhosis: significance of lipoate attachment.
Topics: Acetyltransferases; Antigen-Antibody Reactions; Autoantibodies; Autoantigens; Dihydrolipoyllysine-Re | 1993 |
Use of a designer triple expression hybrid clone for three different lipoyl domain for the detection of antimitochondrial autoantibodies.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Animals; Autoantibodies; Autoantigens; Base Seque | 1996 |
Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase-binding protein (E3BP) and the glycine cleavage proteins in primary biliary cirrhosis.
Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Animals; Antibody Specificity; Autoantibodies; Carr | 1999 |
T cell responses to the putative dominant autoepitope in primary biliary cirrhosis (PBC).
Topics: Autoantigens; Autoimmunity; Dihydrolipoyllysine-Residue Acetyltransferase; Epitopes; Humans; Immunod | 1999 |
Lipoic acid prevents development of the hyperdynamic circulation in anesthetized rats with biliary cirrhosis.
Topics: Animals; Blood Circulation; Cardiovascular Diseases; Glutathione; Hemodynamics; Lipid Peroxides; Liv | 1999 |
Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic.
Topics: Animals; Antigen-Antibody Reactions; Autoantibodies; Cattle; Cytosol; Dihydrolipoyllysine-Residue Ac | 2000 |
Immunoreactivity of organic mimeotopes of the E2 component of pyruvate dehydrogenase: connecting xenobiotics with primary biliary cirrhosis.
Topics: Amino Acid Sequence; Autoantibodies; Autoantigens; Epitopes; Humans; Liver Cirrhosis, Biliary; Molec | 2001 |
Site-directed mutagenesis of lysine within the immunodominant autoepitope of PDC-E2.
Topics: Autoantigens; Base Sequence; Binding Sites; DNA; Electrophoresis, Agar Gel; Electrophoresis, Polyacr | 1990 |
Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme.
Topics: Antigen-Antibody Reactions; Autoantibodies; Autoantigens; Blotting, Western; Humans; Kidney; Liver C | 1990 |
Characterisation of the reactivity of autoantibodies in primary biliary cirrhosis.
Topics: Acetylation; Antigens; Autoantibodies; Blotting, Western; Epitopes; Escherichia coli; Ethylmaleimide | 1989 |
Antimitochondrial antibodies in primary biliary cirrhosis recognize both specific peptides and shared epitopes of the M2 family of antigens.
Topics: Autoantibodies; Autoantigens; Cross Reactions; Dihydrolipoyllysine-Residue Acetyltransferase; Electr | 1989 |
[Therapy of chronic liver diseases with prednisolone and alpha-lipoic acid].
Topics: Amides; Bilirubin; Blood Proteins; Cholesterol; Chronic Disease; Depression, Chemical; Esophageal Di | 1970 |