thioctic acid has been researched along with Leukemia in 5 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Etoposide (VP-16) is an antitumor drug currently in use for the treatment of a number of human cancers." | 1.29 | Tyrosinase-induced phenoxyl radicals of etoposide (VP-16): interaction with reductants in model systems, K562 leukemic cell and nuclear homogenates. ( Gantchev, T; Kagan, V; Stoyanovsky, D; Yalowich, J, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Richter, F | 1 |
| Mapfumo, P | 1 |
| Martin, L | 1 |
| Solomun, JI | 1 |
| Hausig, F | 1 |
| Frietsch, JJ | 1 |
| Ernst, T | 1 |
| Hoeppener, S | 1 |
| Brendel, JC | 1 |
| Traeger, A | 1 |
| Selvakumar, E | 1 |
| Hsieh, TC | 1 |
| Zhu, YY | 1 |
| Yu, G | 1 |
| Zhang, Y | 1 |
| Xu, Z | 1 |
| Wang, YQ | 1 |
| Yan, GR | 1 |
| He, QY | 1 |
| Ogborne, RM | 1 |
| Rushworth, SA | 1 |
| O'Connell, MA | 1 |
| Stoyanovsky, D | 1 |
| Yalowich, J | 1 |
| Gantchev, T | 1 |
| Kagan, V | 1 |
5 other studies available for thioctic acid and Leukemia
| Article | Year |
|---|---|
Improved gene delivery to K-562 leukemia cells by lipoic acid modified block copolymer micelles.
Topics: Animals; Antioxidants; Cations; Cell Line, Tumor; DNA; Gene Transfer Techniques; HEK293 Cells; Human | 2021 |
Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy.
Topics: Anticarcinogenic Agents; Apoptosis; Apoptosis Inducing Factor; bcl-2-Associated X Protein; Cell Cycl | 2008 |
A novel andrographolide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism.
Topics: Apoptosis; Cell Survival; Diterpenes; DNA Damage; G2 Phase Cell Cycle Checkpoints; Gene Expression R | 2013 |
Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells.
Topics: Active Transport, Cell Nucleus; Cell Line, Tumor; Gene Expression; Genes, Dominant; Heme Oxygenase-1 | 2005 |
Tyrosinase-induced phenoxyl radicals of etoposide (VP-16): interaction with reductants in model systems, K562 leukemic cell and nuclear homogenates.
Topics: Ascorbic Acid; Cell Nucleus; Chromatography, High Pressure Liquid; Deferoxamine; Electron Spin Reson | 1993 |