thioctic acid has been researched along with Kidney Diseases in 30 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Adriamycin-induced nephrotoxicity was characterized by hyperlipidemia, proteinuria, and hypoproteinemia, by decreased activities of the enzymes N-acetyl-beta-D-glucosaminidase and cathepsin D, by increased lipid peroxidation and decreases in serum catalase and glutathione activities, and by increased urinary and serum urea, creatinine and urinary glycosaminoglycans." | 3.72 | The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats. ( Balachandar, AV; Malarkodi, KP; Varlakshmi, P, 2003) |
| "Vascular calcification is prevalent in patients with chronic kidney disease and leads to increased cardiovascular morbidity and mortality." | 1.38 | α-Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway. ( Choi, YK; Ha, CM; Harris, RA; Jeong, D; Kim, H; Kim, HJ; Kim, HS; Kim, JM; Kim, JR; Kim, JY; Lee, IK; Lee, K; Lee, SJ, 2012) |
| "Cyclosporine A (CsA)-induced dyslipidemia is one of the most important risk factors for morbidity and mortality after solid organ transplantation." | 1.34 | Beneficial effect of DL-alpha-lipoic acid on cyclosporine A induced hyperlipidemic nephropathy in rats. ( Amudha, G; Josephine, A; Varalakshmi, P, 2007) |
| "Amrinone was the most effective drug as judged on the basis of the pathological findings." | 1.33 | Protective effects of different antioxidants and amrinone on vancomycin-induced nephrotoxicity. ( Akbulut, HH; Akpolat, N; Celik, I; Cihangiroglu, M; Ilhan, N, 2005) |
| "Adriamycin, which is widely used in the treatment of various neoplastic conditions, exerts toxic effects in several organs." | 1.32 | The influence of lipoic acid on adriamycin induced nephrotoxicity in rats. ( Balachandar, AV; Malarkodi, KP; Varalakshmi, P, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.33) | 18.7374 |
| 1990's | 1 (3.33) | 18.2507 |
| 2000's | 14 (46.67) | 29.6817 |
| 2010's | 12 (40.00) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, J | 1 |
| Wang, Y | 1 |
| Yi, S | 1 |
| Zhao, T | 1 |
| Xu, Y | 1 |
| El-Sayed, EM | 1 |
| Mansour, AM | 1 |
| El-Sawy, WS | 1 |
| Abuyassin, B | 1 |
| Badran, M | 1 |
| Ayas, NT | 1 |
| Laher, I | 1 |
| Cavdar, Z | 1 |
| Oktan, MA | 1 |
| Ural, C | 1 |
| Calisir, M | 1 |
| Kocak, A | 1 |
| Heybeli, C | 1 |
| Yildiz, S | 1 |
| Arici, A | 1 |
| Ellidokuz, H | 1 |
| Celik, A | 1 |
| Yilmaz, O | 1 |
| Sarioglu, S | 1 |
| Cavdar, C | 1 |
| Cicek, M | 1 |
| Yıldırır, A | 1 |
| Okyay, K | 1 |
| Yazici, AC | 1 |
| Aydinalp, A | 1 |
| Kanyilmaz, S | 1 |
| Muderrisoglu, H | 1 |
| Jo, SH | 1 |
| Kim, SA | 1 |
| Kim, HS | 2 |
| Han, SJ | 1 |
| Park, WJ | 1 |
| Choi, YJ | 1 |
| Wongmekiat, O | 1 |
| Leelarungrayub, D | 1 |
| Thamprasert, K | 1 |
| Armagan, I | 1 |
| Bayram, D | 1 |
| Candan, IA | 1 |
| Yigit, A | 1 |
| Celik, E | 1 |
| Armagan, HH | 1 |
| Uğuz, AC | 1 |
| Çakır, T | 1 |
| Polat, C | 1 |
| Baştürk, A | 1 |
| Gül, M | 1 |
| Aslaner, A | 1 |
| Durgut, H | 1 |
| Şehirli, AÖ | 1 |
| Aykaç, A | 1 |
| Bahar, L | 1 |
| Sabuncuoglu, MZ | 1 |
| Ambrosi, N | 1 |
| Arrosagaray, V | 1 |
| Guerrieri, D | 1 |
| Uva, PD | 1 |
| Petroni, J | 1 |
| Herrera, MB | 1 |
| Iovanna, JL | 1 |
| León, L | 1 |
| Incardona, C | 1 |
| Chuluyan, HE | 1 |
| Casadei, DH | 1 |
| Cho, SH | 1 |
| Noh, JR | 1 |
| Cho, MY | 1 |
| Go, MJ | 1 |
| Kim, YH | 2 |
| Kang, ES | 1 |
| Lee, CH | 1 |
| Lim, YT | 1 |
| Kim, H | 1 |
| Kim, HJ | 1 |
| Lee, K | 1 |
| Kim, JM | 1 |
| Kim, JR | 1 |
| Ha, CM | 1 |
| Choi, YK | 1 |
| Lee, SJ | 1 |
| Kim, JY | 1 |
| Harris, RA | 1 |
| Jeong, D | 1 |
| Lee, IK | 1 |
| Tahira, A | 1 |
| Saleem, U | 1 |
| Mahmood, S | 1 |
| Hashmi, FK | 1 |
| Hussain, K | 1 |
| Bukhari, NI | 1 |
| Ahmad, B | 1 |
| Arambašić, J | 1 |
| Mihailović, M | 1 |
| Uskoković, A | 1 |
| Dinić, S | 1 |
| Grdović, N | 1 |
| Marković, J | 1 |
| Poznanović, G | 1 |
| Bajec, D | 1 |
| Vidaković, M | 1 |
| Malarkodi, KP | 2 |
| Balachandar, AV | 2 |
| Varalakshmi, P | 6 |
| Varlakshmi, P | 1 |
| MORGANO, G | 1 |
| ABBONA, C | 1 |
| Sivaprasad, TR | 1 |
| Malarkodi, SP | 1 |
| Murugavel, P | 1 |
| Pari, L | 1 |
| Celik, I | 1 |
| Cihangiroglu, M | 1 |
| Ilhan, N | 1 |
| Akpolat, N | 1 |
| Akbulut, HH | 1 |
| Lexis, LA | 1 |
| Fassett, RG | 1 |
| Coombes, JS | 1 |
| Louhelainen, M | 1 |
| Merasto, S | 1 |
| Finckenberg, P | 1 |
| Lapatto, R | 1 |
| Cheng, ZJ | 1 |
| Mervaala, EM | 1 |
| Kumar, SA | 1 |
| Sudhahar, V | 2 |
| Amudha, G | 3 |
| Josephine, A | 3 |
| Mythili, Y | 1 |
| Sundarapandiyan, R | 1 |
| Abdel-Zaher, AO | 1 |
| Abdel-Hady, RH | 1 |
| Mahmoud, MM | 1 |
| Farrag, MM | 1 |
| Baker, H | 1 |
| Deangelis, B | 1 |
| Baker, ER | 1 |
| Hutner, SH | 1 |
| Somani, SM | 1 |
| Husain, K | 1 |
| Whitworth, C | 1 |
| Trammell, GL | 1 |
| Malafa, M | 1 |
| Rybak, LP | 1 |
| Takaoka, M | 1 |
| Kobayashi, Y | 1 |
| Yuba, M | 1 |
| Ohkita, M | 1 |
| Matsumura, Y | 1 |
3 trials available for thioctic acid and Kidney Diseases
| Article | Year |
|---|---|
Use of alpha-lipoic acid in prevention of contrast-induced nephropathy in diabetic patients.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Contrast Media; Coronary Angiography; Diabetes Complic | 2013 |
Alpha-lipoic acid for the prevention of contrast-induced nephropathy in patients undergoing coronary angiography: the ALIVE study - a prospective randomized trial.
Topics: Administration, Oral; Aged; Angina, Stable; Antioxidants; Contrast Media; Coronary Angiography; Crea | 2013 |
α-Lipoic Acid Protects Against Ischemia-Reperfusion Injury in Simultaneous Kidney-Pancreas Transplantation.
Topics: Adult; Anti-Inflammatory Agents; Antioxidants; Argentina; Biomarkers; Female; Humans; Inflammation M | 2016 |
27 other studies available for thioctic acid and Kidney Diseases
| Article | Year |
|---|---|
α-Lipoic acid ameliorates renal fibrosis in diabetic rats through TGF-β1/Smads signaling pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Fibrosis; Humans; Kidney Diseases; Rats; Signal Transducti | 2022 |
Alpha lipoic acid prevents doxorubicin-induced nephrotoxicity by mitigation of oxidative stress, inflammation, and apoptosis in rats.
Topics: Animals; Apoptosis; Doxorubicin; Inflammation; Kidney; Kidney Diseases; Male; Oxidative Stress; Rats | 2017 |
The antioxidant α-lipoic acid attenuates intermittent hypoxia-related renal injury in a mouse model of sleep apnea.
Topics: Animals; Antioxidants; Disease Models, Animal; Hypoxia; Inflammation; Kidney; Kidney Diseases; Male; | 2019 |
Renoprotective Effects of Alpha Lipoic Acid on Iron Overload-Induced Kidney Injury in Rats by Suppressing NADPH Oxidase 4 and p38 MAPK Signaling.
Topics: Animals; Cell Adhesion Molecules; Gene Expression; Iron Overload; Kidney; Kidney Diseases; Male; MAP | 2020 |
Alpha-lipoic acid attenuates renal injury in rats with obstructive nephropathy.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Body Weight; Creatinine; Glutathione; Kidney; Kidney Dis | 2013 |
Effects of pentoxifylline and alpha lipoic acid on methotrexate-induced damage in liver and kidney of rats.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; G | 2015 |
The effect of alpha lipoic acid on rat kidneys in methotrexate induced oxidative injury.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Female; Glutathione; Interleukin-1beta; Kidney; Kid | 2015 |
An injectable collagen/poly(γ-glutamic acid) hydrogel as a scaffold of stem cells and α-lipoic acid for enhanced protection against renal dysfunction.
Topics: Animals; Cell Survival; Cisplatin; Collagen; Disease Models, Animal; Hydrogels; Kidney Diseases; Mes | 2017 |
α-Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway.
Topics: Animals; Apoptosis; Axl Receptor Tyrosine Kinase; Calcium; Caspase 3; Caspase 9; Cells, Cultured; Ch | 2012 |
Evaluation of protective and curative role of α-lipoic acid and selenium in gentamicin-induced nephrotoxicity in rabbits.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Drug Evaluation, Preclinical; Drug Therapy, | 2012 |
Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism.
Topics: Acetylglucosamine; Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; | 2013 |
The influence of lipoic acid on adriamycin induced nephrotoxicity in rats.
Topics: Acetylglucosaminidase; Adenosine Triphosphatases; Animals; Citric Acid Cycle; Doxorubicin; Enzymes; | 2003 |
The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats.
Topics: Acetylglucosaminidase; Animals; Antioxidants; Catalase; Cathepsin D; Cholesterol; Creatinine; Doxoru | 2003 |
[Relations between thioctic acid and renal function; effects of thioctic acid on diuresis and renal clearances in normal & nephropathic subjects].
Topics: Diuresis; Diuretics; Humans; Kidney Diseases; Kidney Function Tests; Thioctic Acid; Urinary Tract Ph | 1957 |
Therapeutic efficacy of lipoic acid in combination with dimercaptosuccinic acid against lead-induced renal tubular defects and on isolated brush-border enzyme activities.
Topics: 5-Aminolevulinate Synthetase; Animals; Antioxidants; Biomarkers; Body Weight; Chelating Agents; Dise | 2004 |
Attenuation of chloroquine-induced renal damage by alpha-lipoic acid: possible antioxidant mechanism.
Topics: Animals; Antimalarials; Antioxidants; Chloroquine; Female; Kidney Diseases; Lipid Peroxidation; Mode | 2004 |
Protective effects of different antioxidants and amrinone on vancomycin-induced nephrotoxicity.
Topics: Amrinone; Animals; Anti-Bacterial Agents; Antioxidants; Female; Free Radicals; Ginkgo biloba; Glutat | 2005 |
Alpha-tocopherol and alpha-lipoic acid enhance the erythrocyte antioxidant defence in cyclosporine A-treated rats.
Topics: alpha-Tocopherol; Animals; Antioxidants; Catalase; Creatinine; Cyclosporine; Dietary Supplements; Er | 2006 |
Lipoic acid supplementation prevents cyclosporine-induced hypertension and nephrotoxicity in spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Blood Pressure; Cyclosporine; Hypertension; Kidney Diseases; Male; Rats; Rats | 2006 |
Oxidative renal injury and lipoprotein oxidation in hypercholesterolemic atherogenesis: Role of eicosapentaenoate-lipoate (EPA-LA) derivative.
Topics: Animals; Atherosclerosis; Diet, Atherogenic; Dietary Supplements; Eicosapentaenoic Acid; Hypercholes | 2006 |
Beneficial effect of DL-alpha-lipoic acid on cyclosporine A induced hyperlipidemic nephropathy in rats.
Topics: Animals; Antioxidants; Cyclosporine; Humans; Hyperlipidemias; Immunosuppressive Agents; Kidney Disea | 2007 |
Therapeutic efficacy of DL-alpha-lipoic acid on cyclosporine A induced renal alterations.
Topics: Animals; Biomarkers; Cyclosporine; Disease Models, Animal; Enzymes; Kidney; Kidney Diseases; Male; P | 2007 |
Protective effect of lipoic acid on oxidative and peroxidative damage in cyclosporine A-induced renal toxicity.
Topics: Albinism; Animals; Antioxidants; Cyclosporine; Gene Expression Regulation, Enzymologic; Kidney Disea | 2007 |
The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidan | 2008 |
A practical assay of lipoate in biologic fluids and liver in health and disease.
Topics: Absorption; Adult; Animals; Biological Assay; Body Fluids; Humans; Kidney Diseases; Kinetics; Liver; | 1998 |
Dose-dependent protection by lipoic acid against cisplatin-induced nephrotoxicity in rats: antioxidant defense system.
Topics: Animals; Antineoplastic Agents; Antioxidants; Catalase; Cisplatin; Creatinine; Dose-Response Relatio | 2000 |
Effects of alpha-lipoic acid on deoxycorticosterone acetate-salt-induced hypertension in rats.
Topics: Animals; Aorta; Blood Pressure; Body Weight; Desoxycorticosterone; Dose-Response Relationship, Drug; | 2001 |