thioctic acid has been researched along with Intellectual Disability in 4 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
| Excerpt | Relevance | Reference |
|---|---|---|
| " This infant was found to have lactic acidosis, low cerebrospinal fluid glucose, hyperalaninemia, and increased levels of urine lactate, pyruvate and alanine." | 7.65 | Hyperalaninemia hyperpyruvicemia and lactic acidosis due to pyruvate carboxylase deficiency of the liver; treatment with thiamine and lipoic acid. ( Komiya, K; Maesaka, H; Misugi, K; Tada, K, 1976) |
| " This infant was found to have lactic acidosis, low cerebrospinal fluid glucose, hyperalaninemia, and increased levels of urine lactate, pyruvate and alanine." | 3.65 | Hyperalaninemia hyperpyruvicemia and lactic acidosis due to pyruvate carboxylase deficiency of the liver; treatment with thiamine and lipoic acid. ( Komiya, K; Maesaka, H; Misugi, K; Tada, K, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maesaka, H | 1 |
| Komiya, K | 1 |
| Misugi, K | 1 |
| Tada, K | 1 |
| Pincus, JH | 1 |
| Grover, WD | 1 |
| Auerbach, VH | 1 |
| Patel, MS | 1 |
| Dayan, AD | 1 |
| Ockenden, BG | 1 |
| Crome, L | 1 |
4 other studies available for thioctic acid and Intellectual Disability
| Article | Year |
|---|---|
Hyperalaninemia hyperpyruvicemia and lactic acidosis due to pyruvate carboxylase deficiency of the liver; treatment with thiamine and lipoic acid.
Topics: Acidosis; Alanine; Female; Glucose; Humans; Infant; Intellectual Disability; Lactates; Liver; Metabo | 1976 |
Subacute necrotizing encephalomyelopathy (Leigh's disease): a consideration of clinical features and etiology.
Topics: Age Factors; Brain Stem; Carbon Dioxide; Chronic Disease; Encephalomalacia; Humans; Infant; Infant, | 1972 |
Biochemical studies and therapy in subacute necrotizing encephalomyelopathy (Leigh's syndrome).
Topics: Biotin; Brain; Brain Stem; Carboxy-Lyases; Encephalomalacia; Humans; Infant; Intellectual Disability | 1972 |
Necrotizing encephalomyelopathy of Leigh. Neuropathological findings in 8 cases.
Topics: Adolescent; Basal Ganglia; Brain Stem; Caudate Nucleus; Cerebral Ventricles; Child; Child, Preschool | 1970 |