thioctic acid has been researched along with Innate Inflammatory Response in 117 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aims to evaluate the effects of dietary α-lipoic acid (α-LA) on bioaccumulation, oxidative stress, apoptosis, and inflammation in Channa argus after 28 d of lead (Pb) exposure." | 8.02 | Dietary α-lipoic acid can alleviate the bioaccumulation, oxidative stress, cell apoptosis, and inflammation induced by lead (Pb) in Channa argus. ( Kong, Y; Li, M; Niu, X; Wang, G; Wu, X; Yin, Z, 2021) |
| "Objective To observe the expression of Notch2, NLR family pyrin domain containing 3 (NLRP3) in the renal tissue of rats with diabetes mellitus (DM), and the effects of alpha-lipoamide (ALM) on the expression of Notch2, Toll-like receptor 4 (TLR4), NLRP3 and collagen, to explore the possible protective mechanism of ALM against diabetic renal inflammation and renal fibrosis." | 7.88 | [Alpha-lipoamide inhibits renal inflammation and collagen 4 production in diabetic rats and its mechanism]. ( Guo, B; Jiang, X; Mao, Y; Peng, C; Tang, L; Wang Wang, Y; Xiao, Y; Yuan, Z; Zhang, F; Zhang, Y, 2018) |
| " The antitumor effect of Poly-MVA was evaluated against 7,12-dimethylbenz[a] anthracene-initiated croton oil-promoted papilloma formation on mice skin." | 7.85 | Poly-MVA attenuates 7,12- dimethylbenz[a]anthracene initiated and croton oil promoted skin papilloma formation on mice skin. ( Ajith, TA; Antonawich, F; Janardhanan, KK; Veena, RK, 2017) |
| " After 15 days, rats were investigated for the presence of mechanical and cold allodynia, and those with allodynia received intraperitoneal injection with normal saline or 1, 5, or 10 mg/kg thioctic acid." | 7.81 | The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model. ( Chung, EY; Kahng, J; Kim, TK; Kim, YS; Moon, JY, 2015) |
| " This study was planned to determine whether ALA might protect Nile tilapia's kidneys from the toxic effects of GA and the probable underlying mechanisms." | 5.91 | Alpha-lipoic acid suppresses gibberellic acid nephrotoxicity in Nile tilapia (Oreochromis niloticus) via modulating oxidative stress, inflammation, cytokine production, and apoptosis. ( Abd-Elhakim, YM; Abdel-Warith, AA; Arisha, AH; Davies, SJ; El-Houseiny, W; Hassan, BA; Metwally, MMM; Younis, EM, 2023) |
| "Dihydrolipoic acid (DHLA) has been reported as a strong antioxidant and exhibits anti-inflammatory properties in various diseases, albeit the direct relevance between DHLA and depression is yet unknown." | 5.56 | Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat. ( Bian, H; Huang, J; Liang, L; Wang, G; Wang, H; Wei, Y; Xiao, L; Zheng, Y, 2020) |
| "Inflammation was induced by injection of 0." | 5.36 | Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA. ( El-Desoky, K; El-Ghareib, MA; El-Masry, SA; El-Shitany, NA, 2010) |
| "In a randomized placebo-controlled trial, we examined the effects of 2-month supplementation by vitamin E and ALA (alone or combined) on biomarkers of lipid peroxidation (malondialdehyde), inflammation (high-sensitivity C-Reactive protein and interleukin-6), and malnutrition (Subjective Global Assessment and body mass index) in 85 hemodialysis patients receiving ALA (600 mg), vitamin E (400 IU), ALA and vitamin E, and placebo." | 5.17 | Effect of alpha-lipoic acid and vitamin E supplementation on oxidative stress, inflammation, and malnutrition in hemodialysis patients. ( Ahmadi, A; Hasanzade, J; Mazloom, Z; Mazooji, N; Roozbeh, J, 2013) |
| "Combination of oral mixed tocopherols and ALA treatment for 2 months does not influence biomarkers of oxidative stress and inflammation in patients with stage 3 to 4 CKD." | 5.15 | Effects of combination tocopherols and alpha lipoic acid therapy on oxidative stress and inflammatory biomarkers in chronic kidney disease. ( Himmelfarb, J; Ikizler, TA; Kane, J; Le, P; McMonagle, E; Ramos, LF; Shintani, A; Wu, P, 2011) |
| "Lipid mediators derived from arachidonic acid (AA) are implicated with the occurrence of inflammation and oxidative stress." | 4.12 | α-lipoic acid ameliorates inflammation state and oxidative stress by reducing the content of bioactive lipid derivatives in the left ventricle of rats fed a high-fat diet. ( Chabowski, A; Hodun, K; Sztolsztener, K, 2022) |
| " In this study, a novel NIR photothermal injectable hydrogel with anti-oxidation and anti-inflammation by incorporating α-lipoic acid modified palladium nanoparticles into calcium ions crosslinked sodium alginate hydrogel was developed." | 4.12 | Scavenging ROS and inflammation produced during treatment to enhance the wound repair efficacy of photothermal injectable hydrogel. ( Jia, M; Li, P; Liu, C; Lu, R; Luo, Y; Zhang, S; Zhou, X, 2022) |
| "This study aims to evaluate the effects of dietary α-lipoic acid (α-LA) on bioaccumulation, oxidative stress, apoptosis, and inflammation in Channa argus after 28 d of lead (Pb) exposure." | 4.02 | Dietary α-lipoic acid can alleviate the bioaccumulation, oxidative stress, cell apoptosis, and inflammation induced by lead (Pb) in Channa argus. ( Kong, Y; Li, M; Niu, X; Wang, G; Wu, X; Yin, Z, 2021) |
| " In correlation with the cisplatin group, Rutin and alpha-lipoic acid ameliorated cisplatin-induction increase in serum urea, creatinine, albumin, oxidative stress and inflammation were observed." | 3.91 | Potential Protective Role of Rutin and Alpha-lipoic Acid Against Cisplatin-induced Nephrotoxicity in Rats. ( Aniss, NN; Motelp, BAAE; Zaazaa, AM, 2019) |
| "Objective To observe the expression of Notch2, NLR family pyrin domain containing 3 (NLRP3) in the renal tissue of rats with diabetes mellitus (DM), and the effects of alpha-lipoamide (ALM) on the expression of Notch2, Toll-like receptor 4 (TLR4), NLRP3 and collagen, to explore the possible protective mechanism of ALM against diabetic renal inflammation and renal fibrosis." | 3.88 | [Alpha-lipoamide inhibits renal inflammation and collagen 4 production in diabetic rats and its mechanism]. ( Guo, B; Jiang, X; Mao, Y; Peng, C; Tang, L; Wang Wang, Y; Xiao, Y; Yuan, Z; Zhang, F; Zhang, Y, 2018) |
| " The antitumor effect of Poly-MVA was evaluated against 7,12-dimethylbenz[a] anthracene-initiated croton oil-promoted papilloma formation on mice skin." | 3.85 | Poly-MVA attenuates 7,12- dimethylbenz[a]anthracene initiated and croton oil promoted skin papilloma formation on mice skin. ( Ajith, TA; Antonawich, F; Janardhanan, KK; Veena, RK, 2017) |
| "To assess inflammation, cellular uptake and endocytic mechanisms of gold nanoparticles (AuNP) in human epidermal keratinocytes with and without a protein corona." | 3.83 | Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticles. ( Li, Y; Monteiro-Riviere, NA, 2016) |
| " After 15 days, rats were investigated for the presence of mechanical and cold allodynia, and those with allodynia received intraperitoneal injection with normal saline or 1, 5, or 10 mg/kg thioctic acid." | 3.81 | The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model. ( Chung, EY; Kahng, J; Kim, TK; Kim, YS; Moon, JY, 2015) |
| "This study was designed to evaluate the effect of low level of Aflatoxin B1 (AFB1) on oxidative stress, immune reaction and inflammation response and the possible ameliorating effects of dietary alpha-lipoic acid (α-LA) in broilers." | 3.80 | Effects of lipoic acid on immune function, the antioxidant defense system, and inflammation-related genes expression of broiler chickens fed aflatoxin contaminated diets. ( Duan, GX; Ji, C; Li, Y; Ma, QG; Wei, H; Zhang, JY; Zhao, LH, 2014) |
| " There were significant differences in the lumen area, neointima area, percent area stenosis, fibrin score, and inflammation score among the four groups [2." | 3.80 | Effect of polymer-free TiO2 stent coated with abciximab or alpha lipoic acid in porcine coronary restenosis model. ( Ahn, Y; Bae, IH; Cho, DL; Hong, YJ; Jeong, HY; Jeong, MH; Kim, HS; Kim, JH; Kim, JM; Kim, YS; Lim, KS; Park, DS; Park, JK; Park, KH; Sim, DS; Song, SJ; Yang, EJ, 2014) |
| "Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury." | 2.90 | The effect of alpha-lipoic acid on inflammatory markers and body composition in obese patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial. ( Amirkhizi, F; Ebrahimi-Mameghani, M; Hosseinpour-Arjmand, S, 2019) |
| "The metabolic syndrome is associated with increased angiotensin II activity, induction of a proinflammatory and oxidative state, and endothelial dysfunction." | 2.71 | Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. ( Cheema, FA; Khan, BV; Khan-Merchant, N; Menon, RG; Mir, MQ; Parthasarathy, S; Sola, S, 2005) |
| "The aging risk factor for Parkinson's disease is described in terms of specific disease markers including mitochondrial and gene dysfunctions relevant to energy metabolism." | 2.50 | Management of the aging risk factor for Parkinson's disease. ( Phillipson, OT, 2014) |
| "Primary biliary cirrhosis is an enigmatic autoimmune disease of women characterized by antimitochondrial antibodies and destruction of intrahepatic bile ducts." | 2.41 | Antimitochondrial antibodies in primary biliary cirrhosis: the role of xenobiotics. ( Gershwin, ME; Long, SA; Van de Water, J, 2002) |
| "Inflammation was found to be less in both the ALA and DXP groups." | 1.91 | Comparison of the effects of alpha lipoic acid and dexpanthenol in an experimental tracheal reconstruction animal model. ( Altınok, T; Esen, HH; Kuru, M; Metin, B, 2023) |
| "This study investigated the effects of trelagliptin and remogliflozin, alone and in combination with alpha lipoic acid (ALA), on cardiac biomarkers in diabetic cardiomyopathy (DCM)." | 1.91 | Impacts of trelagliptin and remogliflozin alone and in combination with Alpha Lipoic Acid on cardiac function in streptozotocin-induced diabetes mellitus in rats. ( Abdullah Ali, M; Kareem Hamad, B; Naji Alhassani, A, 2023) |
| " This study was planned to determine whether ALA might protect Nile tilapia's kidneys from the toxic effects of GA and the probable underlying mechanisms." | 1.91 | Alpha-lipoic acid suppresses gibberellic acid nephrotoxicity in Nile tilapia (Oreochromis niloticus) via modulating oxidative stress, inflammation, cytokine production, and apoptosis. ( Abd-Elhakim, YM; Abdel-Warith, AA; Arisha, AH; Davies, SJ; El-Houseiny, W; Hassan, BA; Metwally, MMM; Younis, EM, 2023) |
| "Twenty-four male Wistar-Kyoto rats (220-240 g, 12 weeks old) were dosed with 50 μL of 10 nm GNPs administered intraperitoneally with or without 200 mg/kg/day Vit E or 200 mg/kg/day α-Lip." | 1.56 | The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles. ( Abdelhalim, MAK; Al-Mohy, YH; Ghannam, MM; Qaid, HA, 2020) |
| "Dihydrolipoic acid (DHLA) has been reported as a strong antioxidant and exhibits anti-inflammatory properties in various diseases, albeit the direct relevance between DHLA and depression is yet unknown." | 1.56 | Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat. ( Bian, H; Huang, J; Liang, L; Wang, G; Wang, H; Wei, Y; Xiao, L; Zheng, Y, 2020) |
| " Results showed that vaginal ALA was well absorbed and distributed." | 1.51 | α-Lipoic Acid Vaginal Administration Contrasts Inflammation and Preterm Delivery in Rats. ( Ergur, BU; Fuso, A; Goker, A; Kuscu, K; Micili, SC, 2019) |
| "Sepsis is a complication of an infection which imbalance the normal regulation of several organ systems, including the central nervous system (CNS)." | 1.46 | Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis. ( Barichello, T; Bellettini-Santos, T; Budni, J; da Rosa, N; Dal-Pizzol, F; Danielski, LG; Della Giustina, A; Fileti, ME; Florentino, D; Fortunato, JJ; Garbossa, L; Goldim, MP; Martins Laurentino, AO; Mathias, K; Mina, F; Oliveira Junior, AN; Petronilho, F; Zarbato, GF, 2017) |
| "A choice of the optimal treatment for Graves ophthalmopathy (GO) is a challenge due to the complexity of the pathogenesis." | 1.43 | Inhibitory Effects of α-Lipoic Acid on Oxidative Stress-Induced Adipogenesis in Orbital Fibroblasts From Patients With Graves Ophthalmopathy. ( Byun, JW; Hwang, S; Lee, EJ; Yoon, JS, 2016) |
| "Inflammation was decreased and recovery time was shortened in the ALA + RT group compared with the RT group." | 1.43 | Effect of alpha-lipoic acid on radiation-induced small intestine injury in mice. ( Choi, BH; Choi, HS; Hahm, JR; Jeong, BK; Jeong, H; Jung, JH; Jung, MH; Kang, KM; Kim, JH; Song, JH; Woo, SH, 2016) |
| "Sepsis is often initiated by invasive infection, characterized by overwhelming induction of pro-inflammatory cytokines." | 1.42 | Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. ( Fu, J; Ji, K; Li, G; Luan, T; Zang, B; Zhao, Y, 2015) |
| "A total of 36 cases with type 2 diabetes with microalbuminuria and fasting plasma glucose (FPG) levels less than 9 mmol/L and glycated hemoglobin A1c (HbA1c) ≤9." | 1.40 | Alleviation of podocyte injury: the possible pathway implicated in anti-inflammation of alpha-lipoic acid in type 2 diabetics. ( Bao, XH; Chen, Y; Xu, J; Yang, CL; Ye, SD, 2014) |
| "Then, inflammation was induced in inflammation groups by subcutaneous talc injection." | 1.39 | The effect of alpha-lipoic acid in ovariectomy and inflammation-mediated osteoporosis on the skeletal status of rat bone. ( Albayrak, A; Bayir, Y; Bilen, H; Cadirci, E; Halici, Z; Karakus, E; Polat, B; Sahin, A; Yuksel, TN, 2013) |
| "Non-alcoholic steatohepatitis (NASH) is a liver disease that causes fat accumulation, inflammation and fibrosis." | 1.38 | Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice. ( Kim, HS; Kim, JG; Kim, MK; Lee, IK; Lee, KU; Min, AK; Park, KG; Seo, HY, 2012) |
| " In conclusion, mGST in combination with GSH has a synergistic effect in reducing airway inflammation compared to the individual antioxidants and has potential for the treatment of asthma." | 1.36 | Mutated glutathione S-transferase in combination with reduced glutathione shows a synergistic effect in ameliorating oxidative stress and airway inflammation. ( Arora, N; Nair, S; Singh, BP; Tripathi, P, 2010) |
| "Inflammation was induced by injection of 0." | 1.36 | Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA. ( El-Desoky, K; El-Ghareib, MA; El-Masry, SA; El-Shitany, NA, 2010) |
| "Inflammation is the major complication associated with Abeta peptide vaccination." | 1.33 | The protective role of DL-alpha-lipoic acid in biogenic amines catabolism triggered by Abeta amyloid vaccination in mice. ( Davis, GD; Jayakumar, R; Jesudason, EP; Kirubagaran, R; Masilamoni, JG, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.85) | 18.2507 |
| 2000's | 16 (13.68) | 29.6817 |
| 2010's | 74 (63.25) | 24.3611 |
| 2020's | 26 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Li, M | 1 |
| Kong, Y | 1 |
| Wu, X | 1 |
| Yin, Z | 1 |
| Niu, X | 1 |
| Wang, G | 2 |
| Abdul Sater, Z | 1 |
| Cero, C | 1 |
| Pierce, AE | 1 |
| Lea, HJ | 1 |
| Abdul Sater, H | 1 |
| Zhu, KY | 1 |
| Liu, N | 1 |
| Ma, Y | 1 |
| Gavrilova, O | 1 |
| Cypess, AM | 1 |
| Mao, J | 1 |
| Gao, H | 1 |
| Bai, W | 1 |
| Zeng, H | 1 |
| Ren, Y | 1 |
| Liu, Y | 2 |
| Yang, X | 2 |
| Sztolsztener, K | 2 |
| Hodun, K | 1 |
| Chabowski, A | 2 |
| Lekhanya, PK | 1 |
| Mokgalaboni, K | 1 |
| Li, Z | 1 |
| Han, Y | 1 |
| Ji, Y | 1 |
| Sun, K | 1 |
| Chen, Y | 2 |
| Hu, K | 1 |
| Luo, Y | 1 |
| Zhou, X | 2 |
| Liu, C | 2 |
| Lu, R | 2 |
| Jia, M | 2 |
| Li, P | 2 |
| Zhang, S | 3 |
| Qi, B | 1 |
| Zheng, Y | 2 |
| Gao, W | 1 |
| Qi, Z | 1 |
| Gong, Y | 1 |
| Wang, Y | 2 |
| Cheng, X | 1 |
| Ning, M | 1 |
| Lang, Y | 1 |
| Feng, J | 1 |
| Li, T | 1 |
| Fasipe, B | 1 |
| Faria, A | 1 |
| Laher, I | 2 |
| Reis, R | 1 |
| Kolci, K | 1 |
| Bahcivan, İ | 1 |
| Coskun, GP | 1 |
| Sipahi, H | 1 |
| Alshammari, GM | 1 |
| Al-Ayed, MS | 1 |
| Abdelhalim, MA | 1 |
| Al-Harbi, LN | 1 |
| Yahya, MA | 1 |
| Schwartz, L | 1 |
| Aparicio-Alonso, M | 1 |
| Henry, M | 1 |
| Radman, M | 1 |
| Attal, R | 1 |
| Bakkar, A | 1 |
| Kuru, M | 1 |
| Altınok, T | 1 |
| Metin, B | 1 |
| Esen, HH | 1 |
| Yan, Z | 1 |
| Wan, J | 1 |
| Liu, J | 1 |
| Yao, B | 1 |
| Lu, Y | 1 |
| Guo, Z | 1 |
| Li, Y | 5 |
| Abdullah Ali, M | 1 |
| Naji Alhassani, A | 1 |
| Kareem Hamad, B | 1 |
| Zwierz, M | 1 |
| El-Houseiny, W | 1 |
| Arisha, AH | 1 |
| Metwally, MMM | 1 |
| Abdel-Warith, AA | 1 |
| Younis, EM | 1 |
| Davies, SJ | 1 |
| Hassan, BA | 1 |
| Abd-Elhakim, YM | 1 |
| Theodosis-Nobelos, P | 1 |
| Papagiouvannis, G | 1 |
| Kourounakis, PN | 1 |
| Rekka, EA | 1 |
| Zaazaa, AM | 1 |
| Motelp, BAAE | 1 |
| Aniss, NN | 1 |
| Abdelhalim, MAK | 1 |
| Qaid, HA | 1 |
| Al-Mohy, YH | 1 |
| Ghannam, MM | 1 |
| Bian, H | 1 |
| Huang, J | 1 |
| Liang, L | 1 |
| Wei, Y | 1 |
| Wang, H | 2 |
| Xiao, L | 1 |
| Van Nguyen, T | 1 |
| Piao, CH | 1 |
| Fan, YJ | 1 |
| Shin, DU | 1 |
| Kim, SY | 1 |
| Song, HJ | 1 |
| Song, CH | 1 |
| Shin, HS | 1 |
| Chai, OH | 1 |
| Giustina, AD | 1 |
| de Souza Goldim, MP | 1 |
| Danielski, LG | 3 |
| Garbossa, L | 2 |
| Junior, ANO | 1 |
| Cidreira, T | 1 |
| Denicol, T | 1 |
| Bonfante, S | 2 |
| da Rosa, N | 2 |
| Fortunato, JJ | 2 |
| Palandi, J | 1 |
| de Oliveira, BH | 1 |
| Martins, DF | 1 |
| Bobinski, F | 1 |
| Garcez, M | 1 |
| Bellettini-Santos, T | 2 |
| Budni, J | 2 |
| Colpo, G | 1 |
| Scaini, G | 1 |
| Giridharan, VV | 1 |
| Barichello, T | 2 |
| Petronilho, F | 3 |
| Isenmann, E | 1 |
| Trittel, L | 1 |
| Diel, P | 1 |
| Vajdi, M | 1 |
| Mahmoudi-Nezhad, M | 1 |
| Farhangi, MA | 1 |
| Wang, HH | 1 |
| Lin, CJ | 1 |
| Tseng, YM | 1 |
| Lee, HI | 1 |
| Lee, YN | 1 |
| Yeh, HI | 1 |
| Yang, PS | 1 |
| Peng, HY | 1 |
| Wu, YJ | 1 |
| Sencar, L | 1 |
| Coşkun, G | 1 |
| Şaker, D | 1 |
| Sapmaz, T | 1 |
| Kara, S | 1 |
| Çelenk, A | 1 |
| Polat, S | 2 |
| Yılmaz, DM | 1 |
| Dağlıoğlu, YK | 1 |
| Cho, HS | 1 |
| Kim, JH | 3 |
| Jang, HN | 1 |
| Lee, TW | 1 |
| Jung, MH | 2 |
| Kim, TH | 1 |
| Chang, SH | 1 |
| Park, DJ | 1 |
| El-Sayed, EM | 1 |
| Mansour, AM | 1 |
| El-Sawy, WS | 1 |
| Della Giustina, A | 1 |
| Goldim, MP | 2 |
| Florentino, D | 2 |
| Mathias, K | 1 |
| Oliveira Junior, AN | 1 |
| Fileti, ME | 1 |
| Zarbato, GF | 1 |
| Martins Laurentino, AO | 1 |
| Mina, F | 1 |
| Dal-Pizzol, F | 1 |
| Szulc-Kielbik, I | 1 |
| Kielbik, M | 1 |
| Klink, M | 1 |
| Veena, RK | 1 |
| Ajith, TA | 1 |
| Janardhanan, KK | 1 |
| Antonawich, F | 1 |
| Zhang, YH | 1 |
| Wang, DW | 1 |
| Xu, SF | 1 |
| Fan, YG | 1 |
| Yang, YY | 1 |
| Guo, SQ | 1 |
| Wang, S | 1 |
| Guo, T | 1 |
| Wang, ZY | 1 |
| Guo, C | 1 |
| Micili, SC | 1 |
| Goker, A | 1 |
| Kuscu, K | 1 |
| Ergur, BU | 1 |
| Fuso, A | 1 |
| Saboori, S | 1 |
| Falahi, E | 1 |
| Eslampour, E | 1 |
| Zeinali Khosroshahi, M | 1 |
| Yousefi Rad, E | 1 |
| Fayez, AM | 1 |
| Zakaria, S | 1 |
| Moustafa, D | 1 |
| Kohlová, M | 1 |
| Amorim, CG | 1 |
| Araújo, A | 1 |
| Santos-Silva, A | 1 |
| Solich, P | 1 |
| Montenegro, MCBSM | 1 |
| Kumar, D | 1 |
| Moore, RM | 1 |
| Sharma, A | 1 |
| Mercer, BM | 1 |
| Mansour, JM | 1 |
| Moore, JJ | 1 |
| Ozturk, O | 1 |
| Saygin, M | 2 |
| Ozmen, O | 1 |
| Ilhan, I | 1 |
| Peng, C | 1 |
| Jiang, X | 1 |
| Xiao, Y | 1 |
| Yuan, Z | 1 |
| Mao, Y | 1 |
| Wang Wang, Y | 1 |
| Zhang, Y | 1 |
| Zhang, F | 1 |
| Tang, L | 1 |
| Guo, B | 1 |
| Hosseinpour-Arjmand, S | 1 |
| Amirkhizi, F | 1 |
| Ebrahimi-Mameghani, M | 1 |
| Deveci, HA | 1 |
| Akyuva, Y | 1 |
| Nur, G | 1 |
| Nazıroğlu, M | 1 |
| Zheng, GH | 1 |
| Shan, Q | 1 |
| Mu, JJ | 1 |
| Wang, YJ | 2 |
| Zhang, ZF | 1 |
| Fan, SH | 1 |
| Hu, B | 1 |
| Li, MQ | 1 |
| Xie, J | 1 |
| Chen, P | 1 |
| Wu, DM | 1 |
| Lu, J | 1 |
| Zheng, YL | 1 |
| Abuyassin, B | 1 |
| Badran, M | 1 |
| Ayas, NT | 1 |
| Kim, SM | 2 |
| Ha, JS | 1 |
| Han, AR | 1 |
| Cho, SW | 1 |
| Yang, SJ | 1 |
| Delgobo, M | 1 |
| Agnes, JP | 1 |
| Gonçalves, RM | 1 |
| Dos Santos, VW | 1 |
| Parisotto, EB | 1 |
| Zamoner, A | 1 |
| Zanotto-Filho, A | 1 |
| Jia, J | 1 |
| Gong, X | 1 |
| Zhao, Y | 2 |
| Yang, Z | 1 |
| Ji, K | 2 |
| Luan, T | 2 |
| Zang, B | 2 |
| Li, G | 2 |
| Kwon, MY | 1 |
| Park, J | 1 |
| Lee, J | 2 |
| Cho, H | 2 |
| Park, JH | 2 |
| Han, IO | 2 |
| Baky, NA | 1 |
| Faddah, LM | 1 |
| Al-Rasheed, NM | 2 |
| Fatani, AJ | 1 |
| Mérida, S | 1 |
| Sancho-Tello, M | 1 |
| Muriach, M | 1 |
| Miranda, M | 1 |
| Navea, A | 1 |
| Bosch-Morell, F | 1 |
| Spreafico, A | 1 |
| Millucci, L | 1 |
| Ghezzi, L | 1 |
| Geminiani, M | 1 |
| Braconi, D | 1 |
| Amato, L | 1 |
| Chellini, F | 1 |
| Frediani, B | 1 |
| Moretti, E | 1 |
| Collodel, G | 1 |
| Bernardini, G | 1 |
| Santucci, A | 1 |
| Polat, B | 1 |
| Halici, Z | 2 |
| Cadirci, E | 2 |
| Albayrak, A | 1 |
| Karakus, E | 1 |
| Bayir, Y | 2 |
| Bilen, H | 1 |
| Sahin, A | 1 |
| Yuksel, TN | 1 |
| Ahmadi, A | 1 |
| Mazooji, N | 1 |
| Roozbeh, J | 1 |
| Mazloom, Z | 1 |
| Hasanzade, J | 1 |
| Phillipson, OT | 1 |
| Scumpia, PO | 1 |
| Kelly-Scumpia, K | 1 |
| Stevens, BR | 1 |
| Rocamonde, B | 1 |
| Paradells, S | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| Effect of Alpha Lipoic Acid on Non-alcoholic Fatty Liver Diseases: A Randomized Placebo-controlled Clinical Trial[NCT04475276] | Phase 4 | 120 participants (Anticipated) | Interventional | 2021-02-23 | Recruiting | ||
| Impact of Lipoic Acid Use on Stroke Outcome After Reperfusion Therapy in Patients With Diabetes[NCT04041167] | Phase 3 | 120 participants (Anticipated) | Interventional | 2018-08-01 | Recruiting | ||
| Effects of the Supplementation of α-lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D to Women Presenting Risk Factor for Pre-term Birth[NCT03952533] | 122 participants (Actual) | Interventional | 2019-05-05 | Completed | |||
| Exploratory Study of Lipoic Acid Supplementation on Oxidative Stress, Inflammatory and Functional Markers in Asthmatic Patients: Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial.[NCT01221350] | 55 participants (Actual) | Interventional | 2010-11-30 | Completed | |||
| Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment[NCT04881851] | 90 participants (Anticipated) | Interventional | 2015-05-07 | Recruiting | |||
| Alpha-lipoic Acid Adjunctive Therapy in Schizophrenia: A Randomized, Double-blind, Placebo-controlled Trial[NCT03788759] | Phase 2/Phase 3 | 48 participants (Actual) | Interventional | 2019-09-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Proteins can become modified by a large number of reactions involving reactive oxygen species. Among these, carbonylation is an irreversible and unrepairable oxidative reaction. The main protein modifications originated from oxidative stress comprise direct oxidation of aminoacids with a thiol group, such as cysteine, oxidative glycation, and carbonylation. Oxidative protein carbonylation induce protein degradation in a nonspecific manner. Chemically, oxidative carbonylation preferentially occurs at proline, threonine, lysine, and arginine, presumably through a metal-catalyzed activation of hydrogen peroxide to a reactive intermediate. Carbonylation usually refers to a process that forms reactive ketones or aldehydes that can be reacted by 2,4-dinitrophenylhydrazine (DNPH) to form hydrazones. Direct oxidation of side chains of lysine, arginine, proline, and threonine residues, among other aminoacids, produces DNPH detectable protein products (NCT01221350)
Timeframe: Baseline
| Intervention | nmol/mg (Mean) |
|---|---|
| Lipoic Acid | 7.5 |
| Placebo | 10.12 |
Proteins can become modified by a large number of reactions involving reactive oxygen species. Among these, carbonylation is an irreversible and unrepairable oxidative reaction. The main protein modifications originated from oxidative stress comprise direct oxidation of aminoacids with a thiol group, such as cysteine, oxidative glycation, and carbonylation. Oxidative protein carbonylation induce protein degradation in a nonspecific manner. Chemically, oxidative carbonylation preferentially occurs at proline, threonine, lysine, and arginine, presumably through a metal-catalyzed activation of hydrogen peroxide to a reactive intermediate. Carbonylation usually refers to a process that forms reactive ketones or aldehydes that can be reacted by 2,4-dinitrophenylhydrazine (DNPH) to form hydrazones. Direct oxidation of side chains of lysine, arginine, proline, and threonine residues, among other aminoacids, produces DNPH detectable protein products. (NCT01221350)
Timeframe: 60 days
| Intervention | nmol/mg (Mean) |
|---|---|
| Lipoic Acid | 3.24 |
| Placebo | 4.21 |
Eosinophils, a prominent feature of asthma, are found in increased numbers in the circulation and sputum, usually in relation to the severity of asthma. (NCT01221350)
Timeframe: Baseline
| Intervention | Eosinophil percentage in sputum cells (Mean) |
|---|---|
| Lipoic Acid | 12.88 |
| Placebo | 6.10 |
Eosinophils, a prominent feature of asthma, are found in increased numbers in the circulation and sputum, usually in relation to the severity of asthma. (NCT01221350)
Timeframe: 60 days
| Intervention | Eosinophil percentage in sputum cells (Mean) |
|---|---|
| Lipoic Acid | 6.39 |
| Placebo | 5.68 |
Induced sputum of GSH and GSSG levels at baseline. The ratio GSH/GSSG is considered an index of antioxidant status and reductive -SH groups. GSH and GSSG were measured by a microplate fluorescent assay. (NCT01221350)
Timeframe: Baseline
| Intervention | ratio (Mean) |
|---|---|
| Lipoic Acid | 81.42 |
| Placebo | 35.77 |
Change in the induced sputum of antioxidant parameters GSH and GSSG levels after 60 days of treatment. The ratio GSH/GSSG is considered an index of antioxidant status and reductive -SH groups. GSH and GSSG were measured by a microplate fluorescent assay. (NCT01221350)
Timeframe: 60 days
| Intervention | ratio (Mean) |
|---|---|
| Lipoic Acid | 58.6 |
| Placebo | 37.5 |
Inflammatory IL-4 sputum levels after 60 days of treatment. Sputum induction is a semi-invasive technique used to detect and monitor airway inflammation. IL-4 is a Th2 cytokine that promote airway inflammation in asthma. IL-4 drives the production of IgE in B cells. IL-4 was measured by ELISA. (NCT01221350)
Timeframe: 60 days
| Intervention | pg/mL (Mean) |
|---|---|
| Lipoic Acid | 14.53 |
| Placebo | 23.19 |
Inflammatory IL-4 sputum levels after 60 days of treatment. Sputum induction is a semi-invasive technique used to detect and monitor airway inflammation. IL-4 is a Th2 cytokine that promote airway inflammation in asthma. IL-4 drives the production of immunoglobulin E (IgE) in B cells. IL-4 was measured by ELISA. (NCT01221350)
Timeframe: Baseline
| Intervention | pg/mL (Mean) |
|---|---|
| Lipoic Acid | 37.77 |
| Placebo | 39.90 |
Assessment of Quality of life scores with the ACT (Asthma Control Test). The ACT is a way to determine if the asthma symptoms are well controlled. The Asthma Control Test™ (ACT™) is a five question health survey used to measure asthma control in individuals 12 years of age and older. The survey measures the elements of asthma control as defined by the National Heart, Lung, and Blood Institute (NHLBI). ACT is an efficient, reliable, and valid method of measuring asthma control, with or without, lung functioning measures such as spirometry. Each item includes 5 response options corresponding to a 5-point Likert-type rating scale. In scoring the ACT survey, responses for each of the 5 items are summed to yield a score ranging from 5 (poor control of asthma) to 25 (complete control of asthma). (NCT01221350)
Timeframe: Baseline
| Intervention | units on a scale (Mean) |
|---|---|
| Lipoic Acid | 13.65 |
| Placebo | 14.46 |
Assessment of Quality of life scores with the ACT (Asthma Control Test). The ACT is a way to determine if the asthma symptoms are well controlled. The Asthma Control Test™ (ACT™) is a five question health survey used to measure asthma control in individuals 12 years of age and older. The survey measures the elements of asthma control as defined by the National Heart, Lung, and Blood Institute (NHLBI). ACT is an efficient, reliable, and valid method of measuring asthma control, with or without, lung functioning measures such as spirometry. Each item includes 5 response options corresponding to a 5-point Likert-type rating scale. In scoring the ACT survey, responses for each of the 5 items are summed to yield a score ranging from 5 (poor control of asthma) to 25 (complete control of asthma). (NCT01221350)
Timeframe: 60 days
| Intervention | units on a scale (Mean) |
|---|---|
| Lipoic Acid | 19.13 |
| Placebo | 17.71 |
"The Asthma Quality of Life Questionnaire (AQLQ) was developed to measure the functional problems (physical, emotional, social and occupational) that are most troublesome to adults (17-70 years) with asthma.~There are 32 questions in the AQLQ and they are in 4 domains (symptoms, activity limitation, emotional function and environmental stimuli). The activity domain contains 5 'patient-specific' questions. This allows patients to select 5 activities in which they are most limited and these activities will be assessed at each follow-up. Patients are asked to think about how they have been during the previous two weeks and to respond to each of the 32 questions on a 7-point scale (7 = not impaired at all - 1 = severely impaired). The overall AQLQ score is the mean of all 32 responses and the individual domain scores are the means of the items in those domains (http://www.qoltech.co.uk/aqlq.html)." (NCT01221350)
Timeframe: Baseline
| Intervention | units on a scale (Mean) |
|---|---|
| Lipoic Acid | 3.86 |
| Placebo | 3.72 |
"The Asthma Quality of Life Questionnaire (AQLQ) was developed to measure the functional problems (physical, emotional, social and occupational) that are most troublesome to adults (17-70 years) with asthma.~There are 32 questions in the AQLQ and they are in 4 domains (symptoms, activity limitation, emotional function and environmental stimuli). The activity domain contains 5 'patient-specific' questions. This allows patients to select 5 activities in which they are most limited and these activities will be assessed at each follow-up. Patients are asked to think about how they have been during the previous two weeks and to respond to each of the 32 questions on a 7-point scale (7 = not impaired at all - 1 = severely impaired). The overall AQLQ score is the mean of all 32 responses and the individual domain scores are the means of the items in those domains (http://www.qoltech.co.uk/aqlq.html)." (NCT01221350)
Timeframe: 60 days
| Intervention | units on a scale (Mean) |
|---|---|
| Lipoic Acid | 5.57 |
| Placebo | 5.10 |
Measurement of spirometric parameters at baseline: Forced expiratory flow (FEF) is the flow (or speed) of air coming out of the lung during the middle portion of a forced expiration. (NCT01221350)
Timeframe: Baseline
| Intervention | Liters/sec (Mean) |
|---|---|
| Lipoic Acid | 4.89 |
| Placebo | 6.09 |
Measurement of spirometric FEF after 60 days of treatment: Forced expiratory flow (FEF) is the flow (or speed) of air coming out of the lung during the middle portion of a forced expiration. (NCT01221350)
Timeframe: 60 days
| Intervention | Liters/sec (Mean) |
|---|---|
| Lipoic Acid | 5.47 |
| Placebo | 6.10 |
Measurement of spirometric predicted parameters at baseline: Forced expiratory volume in 1 second (FEV1), volume that has been exhaled at the end of the first second of forced expiration. (NCT01221350)
Timeframe: Baseline
| Intervention | Liters (Mean) |
|---|---|
| Lipoic Acid | 2.01 |
| Placebo | 2.37 |
Measurement of spirometric predicted parameters after 60 days of treatment. Forced expiratory volume in 1 second (FEV1), volume that has been exhaled at the end of the first second of forced expiration. (NCT01221350)
Timeframe: 60 days
| Intervention | Liters (Mean) |
|---|---|
| Lipoic Acid | 2.26 |
| Placebo | 2.35 |
Measurement of spirometric predicted parameters at baseline. Forced vital capacity (FVC) is the volume of air that can forcibly be blown out after full inspiration, measured in liters. (NCT01221350)
Timeframe: Baseline
| Intervention | Liters (Mean) |
|---|---|
| Lipoic Acid | 2.74 |
| Placebo | 3.07 |
Measurement of spirometric predicted parameters at the baseline and after 60 days of treatment: Forced vital capacity (FVC) is the volume of air that can forcibly be blown out after full inspiration, measured in liters. (NCT01221350)
Timeframe: 60 days
| Intervention | Liters (Mean) |
|---|---|
| Lipoic Acid | 2.82 |
| Placebo | 3.06 |
12 reviews available for thioctic acid and Innate Inflammatory Response
| Article | Year |
|---|---|
Potential for Novel Therapeutic Uses of Alpha Lipoic Acid.
Topics: Antioxidants; Diabetic Neuropathies; Humans; Inflammation; Oxidative Stress; Thioctic Acid | 2023 |
An updated systematic review and dose-response meta-analysis of the randomized controlled trials on the effects of alpha-lipoic acid supplementation on inflammatory biomarkers.
Topics: Adult; Biomarkers; C-Reactive Protein; Dietary Supplements; Humans; Inflammation; Interleukin-6; Ran | 2023 |
Effects of alpha-lipoic acid supplementation on C-reactive protein level: A systematic review and meta-analysis of randomized controlled clinical trials.
Topics: Adult; Aged; Anti-Inflammatory Agents; Biomarkers; C-Reactive Protein; Dietary Supplements; Down-Reg | 2018 |
The biocompatibility and bioactivity of hemodialysis membranes: their impact in end-stage renal disease.
Topics: Antioxidants; Biocompatible Materials; Cellulose; Humans; Inflammation; Kidney Failure, Chronic; Mem | 2019 |
Management of the aging risk factor for Parkinson's disease.
Topics: Acetylcarnitine; Adenosine Triphosphate; Aging; alpha-Synuclein; Antioxidant Response Elements; Carb | 2014 |
Lipoic Acid: its antioxidant and anti-inflammatory role and clinical applications.
Topics: Aging; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Clinical Trials as Topic; Dis | 2015 |
Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS.
Topics: Alzheimer Disease; Animals; Antioxidants; Central Nervous System Diseases; Diabetic Neuropathies; Hu | 2008 |
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Topics: Animals; Diabetic Neuropathies; Dietary Supplements; Humans; Hypertension; Inflammation; Models, Bio | 2009 |
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Topics: Animals; Diabetic Neuropathies; Dietary Supplements; Humans; Hypertension; Inflammation; Models, Bio | 2009 |
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Topics: Animals; Diabetic Neuropathies; Dietary Supplements; Humans; Hypertension; Inflammation; Models, Bio | 2009 |
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Topics: Animals; Diabetic Neuropathies; Dietary Supplements; Humans; Hypertension; Inflammation; Models, Bio | 2009 |
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Topics: Animals; Diabetic Neuropathies; Dietary Supplements; Humans; Hypertension; Inflammation; Models, Bio | 2009 |
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Topics: Animals; Diabetic Neuropathies; Dietary Supplements; Humans; Hypertension; Inflammation; Models, Bio | 2009 |
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Topics: Animals; Diabetic Neuropathies; Dietary Supplements; Humans; Hypertension; Inflammation; Models, Bio | 2009 |
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Topics: Animals; Diabetic Neuropathies; Dietary Supplements; Humans; Hypertension; Inflammation; Models, Bio | 2009 |
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Topics: Animals; Diabetic Neuropathies; Dietary Supplements; Humans; Hypertension; Inflammation; Models, Bio | 2009 |
Evidence for using alpha-lipoic acid in reducing lipoprotein and inflammatory related atherosclerotic risk.
Topics: Antioxidants; Atherosclerosis; Cholesterol, HDL; Cholesterol, LDL; Dietary Supplements; Inflammation | 2012 |
Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential.
Topics: Animals; Antioxidants; Cardiovascular Diseases; Chelating Agents; Diabetes Mellitus; Dietary Supplem | 2013 |
Antimitochondrial antibodies in primary biliary cirrhosis: the role of xenobiotics.
Topics: Animals; Autoantibodies; Autoimmune Diseases; Bile Ducts, Intrahepatic; Female; Humans; Inflammation | 2002 |
Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity.
Topics: Animals; Antioxidants; Free Radical Scavengers; Glutathione; Humans; Inflammation; Models, Chemical; | 2008 |
9 trials available for thioctic acid and Innate Inflammatory Response
| Article | Year |
|---|---|
The effects of alpha lipoic acid on muscle strength recovery after a single and a short-term chronic supplementation - a study in healthy well-trained individuals after intensive resistance and endurance training.
Topics: Antioxidants; Athletes; Athletic Performance; Cross-Over Studies; Dietary Supplements; Double-Blind | 2020 |
The effect of alpha-lipoic acid on inflammatory markers and body composition in obese patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial.
Topics: Adiponectin; Adult; Biomarkers; Body Composition; Double-Blind Method; Female; Humans; Inflammation; | 2019 |
Effect of alpha-lipoic acid and vitamin E supplementation on oxidative stress, inflammation, and malnutrition in hemodialysis patients.
Topics: Adult; Antioxidants; C-Reactive Protein; Dietary Supplements; Female; Humans; Inflammation; Interleu | 2013 |
Effects of Alpha-Lipoic Acid Supplementation on Inflammatory Biomarkers and Matrix Metalloproteinase-3 in Rheumatoid Arthritis Patients.
Topics: Adult; Antioxidants; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Dietary Supplements; Dou | 2015 |
A Clinical Trial about a Food Supplement Containing α-Lipoic Acid on Oxidative Stress Markers in Type 2 Diabetic Patients.
Topics: Adult; Biomarkers; Blood Glucose; Body Mass Index; Body Weight; C-Reactive Protein; Carnosine; Diabe | 2016 |
Effects of combination tocopherols and alpha lipoic acid therapy on oxidative stress and inflammatory biomarkers in chronic kidney disease.
Topics: Administration, Oral; Aged; Antioxidants; Biomarkers; C-Reactive Protein; Double-Blind Method; Drug | 2011 |
Effects of alpha-lipoic acid supplementation on inflammation, oxidative stress, and serum lipid profile levels in patients with end-stage renal disease on hemodialysis.
Topics: Adult; Aged; Antioxidants; C-Reactive Protein; Cholesterol; Dietary Supplements; Double-Blind Method | 2012 |
Physical activity and alpha-lipoic acid modulate inflammatory response through changes in thiol redox status.
Topics: Creatine Kinase; Cross-Over Studies; Exercise; Glutathione; Humans; Hydrogen Peroxide; Inflammation; | 2013 |
Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Antioxidants; Biomarkers; Biphenyl Compounds; Brachi | 2005 |
96 other studies available for thioctic acid and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Dietary α-lipoic acid can alleviate the bioaccumulation, oxidative stress, cell apoptosis, and inflammation induced by lead (Pb) in Channa argus.
Topics: Animal Feed; Animals; Antioxidants; Apoptosis; Bioaccumulation; Diet; Fish Proteins; Inflammation; K | 2021 |
Combining a β3 adrenergic receptor agonist with alpha-lipoic acid reduces inflammation in male mice with diet-induced obesity.
Topics: Adipose Tissue, Brown; Adrenergic Agonists; Animals; Diet, High-Fat; Humans; Inflammation; Male; Mic | 2022 |
Lipoic acid alleviates LPS‑evoked PC12 cell damage by targeting p53 and inactivating the NF‑κB pathway.
Topics: Animals; Apoptosis; Inflammation; Lipopolysaccharides; NF-kappa B; PC12 Cells; Rats; Thioctic Acid; | 2021 |
α-lipoic acid ameliorates inflammation state and oxidative stress by reducing the content of bioactive lipid derivatives in the left ventricle of rats fed a high-fat diet.
Topics: Animals; Arachidonic Acid; Diet, High-Fat; Heart Ventricles; Inflammation; Inflammation Mediators; M | 2022 |
Exploring the effectiveness of vitamin B
Topics: Diabetes Mellitus; Diabetic Neuropathies; Humans; Inflammation; Meta-Analysis as Topic; Randomized C | 2022 |
The effect of a-Lipoic acid (ALA) on oxidative stress, inflammation, and apoptosis in high glucose-induced human corneal epithelial cells.
Topics: Apoptosis; Epithelial Cells; Glucose; Glycation End Products, Advanced; Humans; Inflammation; Interl | 2023 |
Scavenging ROS and inflammation produced during treatment to enhance the wound repair efficacy of photothermal injectable hydrogel.
Topics: Alginates; Antioxidants; Calcium; Escherichia coli; Humans; Hydrogels; Inflammation; Interleukin-1be | 2022 |
Alpha-lipoic acid impedes myocardial ischemia-reperfusion injury, myocardial apoptosis, and oxidative stress by regulating HMGB1 expression.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Cytokines; HMGB1 Prot | 2022 |
Alpha-Lipoic Acid Modulates the Oxidative and Inflammatory Responses Induced by Traditional and Novel Tobacco Products in Human Liver Epithelial Cells.
Topics: Epithelial Cells; Humans; Inflammation; Interleukin-6; Liver; Nicotiana; Oxidative Stress; Superoxid | 2023 |
Effects of Antioxidant Combinations on the Renal Toxicity Induced Rats by Gold Nanoparticles.
Topics: Animals; Antioxidants; Glutathione; Gold; Inflammation; Kidney; Melanins; Metal Nanoparticles; NF-ka | 2023 |
Topics: Animals; Chitosan; Hydrogels; Inflammation; Mice; Neoplasm, Residual; Oligosaccharides; Skin Neoplas | 2023 |
Toxicity of the spike protein of COVID-19 is a redox shift phenomenon: A novel therapeutic approach.
Topics: COVID-19; Humans; Inflammation; Methylene Blue; Oxidation-Reduction; Spike Glycoprotein, Coronavirus | 2023 |
Comparison of the effects of alpha lipoic acid and dexpanthenol in an experimental tracheal reconstruction animal model.
Topics: Animals; Female; Inflammation; Models, Animal; Rats; Rats, Sprague-Dawley; Thioctic Acid; Trachea | 2023 |
α-lipoic acid ameliorates hepatotoxicity induced by chronic ammonia toxicity in crucian carp (Carassius auratus gibelio) by alleviating oxidative stress, inflammation and inhibiting ERS pathway.
Topics: Ammonia; Animals; Antioxidants; Carps; Chemical and Drug Induced Liver Injury; Goldfish; Humans; Inf | 2023 |
Impacts of trelagliptin and remogliflozin alone and in combination with Alpha Lipoic Acid on cardiac function in streptozotocin-induced diabetes mellitus in rats.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Inflammation; Male; | 2023 |
α-Lipoic acid - a promising agent for attenuating inflammation and preventing steatohepatitis in rats fed a high-fat diet.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Diet, High-Fat; Fatty Liver; Inflammation; Liver; Male | 2023 |
Alpha-lipoic acid suppresses gibberellic acid nephrotoxicity in Nile tilapia (Oreochromis niloticus) via modulating oxidative stress, inflammation, cytokine production, and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Cichlids; Gene Expression; Inflammation; Oxidative Stress; Thiocti | 2023 |
Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam.
Topics: Acrylates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carrageenan; Chromans; Hu | 2019 |
Potential Protective Role of Rutin and Alpha-lipoic Acid Against Cisplatin-induced Nephrotoxicity in Rats.
Topics: Albumins; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cisplatin; Creatinine; Erythr | 2019 |
The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles.
Topics: Animals; Biomarkers; Creatinine; Glutathione; Gold; Inflammation; Kidney; Lipid Peroxidation; Male; | 2020 |
Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Heme Oxygenase (Decyclizing); Illness Behavior; Infl | 2020 |
Anti-allergic rhinitis activity of α-lipoic acid via balancing Th17/Treg expression and enhancing Nrf2/HO-1 pathway signaling.
Topics: Animals; Cytokines; Down-Regulation; Eosinophils; Epitopes; Goblet Cells; Heme Oxygenase-1; Histamin | 2020 |
Lipoic Acid and Fish Oil Combination Potentiates Neuroinflammation and Oxidative Stress Regulation and Prevents Cognitive Decline of Rats After Sepsis.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Catalase; Cells, Cultured; Cognitive Dysfunction; | 2020 |
Dihydrolipoic acid-coated gold nanocluster bioactivity against senescence and inflammation through the mitochondria-mediated JNK/AP-1 pathway.
Topics: Anti-Inflammatory Agents; Cells, Cultured; Cellular Senescence; Coated Materials, Biocompatible; Gol | 2021 |
Effects of Theranekron and alpha-lipoic acid combined treatment on GAP-43 and Krox-20 gene expressions and inflammation markers in peripheral nerve injury.
Topics: Animals; GAP-43 Protein; Gene Expression; Inflammation; Peripheral Nerve Injuries; Rats; Rats, Wista | 2021 |
Alpha-lipoic acid ameliorates the epithelial mesenchymal transition induced by unilateral ureteral obstruction in mice.
Topics: Animals; Epithelial-Mesenchymal Transition; Fibrosis; Inflammation; Intercellular Adhesion Molecule- | 2017 |
Alpha lipoic acid prevents doxorubicin-induced nephrotoxicity by mitigation of oxidative stress, inflammation, and apoptosis in rats.
Topics: Animals; Apoptosis; Doxorubicin; Inflammation; Kidney; Kidney Diseases; Male; Oxidative Stress; Rats | 2017 |
Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis.
Topics: Acute Disease; Animals; Antioxidants; Brain; Cognitive Dysfunction; Coinfection; Inflammation; Infla | 2017 |
Ferulic acid but not alpha-lipoic acid effectively protects THP-1-derived macrophages from oxidant and pro-inflammatory response to LPS.
Topics: Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Cell Line; Coumaric Acids; Free Radical | 2017 |
Poly-MVA attenuates 7,12- dimethylbenz[a]anthracene initiated and croton oil promoted skin papilloma formation on mice skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetylcysteine; Animals; Carcinogens; Croton Oil; Dietary Suppleme | 2017 |
α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice.
Topics: Alzheimer Disease; Animals; Cell Death; Disease Models, Animal; Female; Inflammation; Lipid Peroxida | 2018 |
α-Lipoic Acid Vaginal Administration Contrasts Inflammation and Preterm Delivery in Rats.
Topics: Administration, Intravaginal; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cervix Uteri; Embryo | 2019 |
Alpha lipoic acid exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Heme Oxygenase-1; Hepatic Stellate Cells; Inflammation | 2018 |
In an in-vitro model using human fetal membranes, α-lipoic acid inhibits inflammation induced fetal membrane weakening.
Topics: Extraembryonic Membranes; Fetal Membranes, Premature Rupture; Granulocyte-Macrophage Colony-Stimulat | 2018 |
The effects of chronic smoking on lung tissue and the role of alpha lipoic acid.
Topics: Animals; Comet Assay; DNA Damage; Female; Immunohistochemistry; Inflammation; Lung; Lung Injury; Oxi | 2018 |
[Alpha-lipoamide inhibits renal inflammation and collagen 4 production in diabetic rats and its mechanism].
Topics: Animals; Collagen Type IV; Diabetes Mellitus, Experimental; Inflammation; Interleukin-6; Kidney; NLR | 2018 |
Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line.
Topics: Antioxidants; Apoptosis; Cell Line, Tumor; Cell Survival; Glioblastoma; Humans; Inflammation; Inflam | 2019 |
Purple Sweet Potato Color Attenuates Kidney Damage by Blocking VEGFR2/ROS/NLRP3 Signaling in High-Fat Diet-Treated Mice.
Topics: Animals; Diet, High-Fat; Gene Knockdown Techniques; Inflammation; Ipomoea batatas; Kidney; Male; Mic | 2019 |
The antioxidant α-lipoic acid attenuates intermittent hypoxia-related renal injury in a mouse model of sleep apnea.
Topics: Animals; Antioxidants; Disease Models, Animal; Hypoxia; Inflammation; Kidney; Kidney Diseases; Male; | 2019 |
Effects of α-lipoic acid on LPS-induced neuroinflammation and NLRP3 inflammasome activation through the regulation of BV-2 microglial cells activation.
Topics: Animals; Anti-Inflammatory Agents; Caspase 1; Cell Line; Cytokines; Extracellular Signal-Regulated M | 2019 |
N-acetylcysteine and alpha-lipoic acid improve antioxidant defenses and decrease oxidative stress, inflammation and serum lipid levels in ovariectomized rats via estrogen-independent mechanisms.
Topics: Acetylcysteine; Animals; Antioxidants; Cytokines; Dietary Supplements; Estrogens; Female; Glutathion | 2019 |
Autophagy Enhancing Contributes to the Organ Protective Effect of Alpha-Lipoic Acid in Septic Rats.
Topics: Animals; Apoptosis; Autophagy; Cytokines; Disease Models, Animal; Inflammation; Male; NF-kappa B; Pr | 2019 |
An alpha-lipoic acid-decursinol hybrid compound attenuates lipopolysaccharide-mediated inflammation in BV2 and RAW264.7 cells.
Topics: Animals; Benzopyrans; Butyrates; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; I | 2019 |
Induction of inflammation, DNA damage and apoptosis in rat heart after oral exposure to zinc oxide nanoparticles and the cardioprotective role of α-lipoic acid and vitamin E.
Topics: Animals; Apoptosis; Body Weight; Calcium; Caspase 3; Comet Assay; DNA Damage; Heart; Inflammation; N | 2013 |
Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines release.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cytokines; Disease Models, Animal; I | 2013 |
Antioxidants inhibit SAA formation and pro-inflammatory cytokine release in a human cell model of alkaptonuria.
Topics: Acetylcysteine; Alkaptonuria; Antioxidants; Ascorbic Acid; Cell Line; Chondrocytes; Cytokines; Human | 2013 |
The effect of alpha-lipoic acid in ovariectomy and inflammation-mediated osteoporosis on the skeletal status of rat bone.
Topics: Animals; Biomarkers; Bone Density; Cytokines; Female; Femur; Inflammation; Osteoporosis; Ovariectomy | 2013 |
Alpha-lipoic acid effects on brain glial functions accompanying double-stranded RNA antiviral and inflammatory signaling.
Topics: Animals; eIF-2 Kinase; Humans; Inflammation; Neuroglia; Rats; Rats, Sprague-Dawley; RNA, Double-Stra | 2014 |
Lipoic acid treatment after brain injury: study of the glial reaction.
Topics: Animals; Antioxidants; Astrocytes; Blood-Brain Barrier; Brain; Brain Injuries; Disease Models, Anima | 2013 |
Inhibitory effect of natural anti-inflammatory compounds on cytokines released by chronic venous disease patient-derived endothelial cells.
Topics: Adult; Aged; Anti-Inflammatory Agents; Cell Membrane; Cell Survival; Chemokines; Cytokines; Endothel | 2013 |
Alleviation of podocyte injury: the possible pathway implicated in anti-inflammation of alpha-lipoic acid in type 2 diabetics.
Topics: Adult; Albumins; Anti-Inflammatory Agents; Blood Glucose; Blood Pressure; Case-Control Studies; Chem | 2014 |
Effects of lipoic acid on immune function, the antioxidant defense system, and inflammation-related genes expression of broiler chickens fed aflatoxin contaminated diets.
Topics: Aflatoxin B1; Animal Feed; Animals; Antioxidants; Chickens; Diet; Dietary Supplements; Glutathione P | 2014 |
Effect of polymer-free TiO2 stent coated with abciximab or alpha lipoic acid in porcine coronary restenosis model.
Topics: Abciximab; Animals; Antibodies, Monoclonal; Coronary Restenosis; Disease Models, Animal; Drug-Elutin | 2014 |
Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Cel | 2015 |
Combination therapies prevent the neuropathic, proinflammatory characteristics of bone marrow in streptozotocin-induced diabetic rats.
Topics: Adipose Tissue; Animals; Bone Marrow; Cytokines; Diabetes Mellitus, Experimental; Diabetic Neuropath | 2015 |
α-Lipoic acid protects kidney from oxidative stress and mitochondrial dysfunction associated to inflammatory conditions.
Topics: Animals; Female; Inflammation; Kidney; Mitochondria; Oxidative Stress; Protective Agents; Rats; Rats | 2014 |
A dopamine-alpha-lipoic acid hybridization compound and its acetylated form inhibit LPS-mediated inflammation.
Topics: Acetylation; Animals; Cell Line; Cell Proliferation; Cell Survival; Dopamine; Inflammation; Lipopoly | 2015 |
Alpha-lipoic acid prevents endotoxic shock and multiple organ dysfunction syndrome induced by endotoxemia in rats.
Topics: Animals; Antioxidants; Antithrombins; Aorta; Caspase 3; Disulfides; Endotoxemia; Enzyme Activation; | 2015 |
Multiple protective mechanisms of alpha-lipoic acid in oxidation, apoptosis and inflammation against hydrogen peroxide induced toxicity in human lymphocytes.
Topics: Apoptosis; Caspase 3; Caspase 9; Cell Survival; Flow Cytometry; Fluorescence; Humans; Hydrogen Perox | 2015 |
Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signalling pathway.
Topics: Andrographis; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diterpenes; Dose- | 2015 |
The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, | 2015 |
Anti-oxidative and anti-inflammatory effects of lipoic acid in rat liver.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Glutathione; Hydrogen Peroxide; Inflammation; Lipop | 2015 |
Alpha-lipoic acid treatment is neurorestorative and promotes functional recovery after stroke in rats.
Topics: Animals; Biomarkers; Brain; Brain Infarction; Bromodeoxyuridine; Cell Proliferation; Doublecortin Pr | 2015 |
The impact of high fructose on cardiovascular system: Role of α-lipoic acid.
Topics: Animals; Antioxidants; Aorta, Thoracic; Cardiovascular System; Endothelium, Vascular; Female; High F | 2016 |
Effect of alpha lipoic acid co-administration on structural and immunohistochemical changes in subcutaneous tissue of anterior abdominal wall of adult male albino rat in response to polypropylene mesh implantation.
Topics: Abdominal Wall; Animals; Antigens, CD34; Collagen; Elastic Tissue; Equipment Design; Foreign-Body Re | 2015 |
The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Apoptosis; Bromelains; Cells, Cultured; Disease M | 2015 |
Fructose-induced inflammation, insulin resistance and oxidative stress: A liver pathological triad effectively disrupted by lipoic acid.
Topics: Animals; Antioxidants; Blood Glucose; Cyclooxygenase 2; Dietary Supplements; Fructose; Gene Expressi | 2015 |
Antioxidative effects of α-lipoic acid in the brain, liver and kidneys in selected mouse organs exposed to zymosan.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Brain; Inflammation; Kidney; Liver; Male; Mice; Oxi | 2015 |
Alpha-Lipoic Acid Attenuates Oxidative Damage in Organs After Sepsis.
Topics: Animals; Antioxidants; Catalase; Cecum; Inflammation; Kidney; Lipid Peroxidation; Liver; Lung; Male; | 2016 |
The Influence of α-Lipoic Acid and Garlic Administration on Biomarkers of Oxidative Stress and Inflammation in Rabbits Exposed to Oxidized Nutrition Oils.
Topics: Administration, Oral; Animals; Antioxidants; Biomarkers; Cytokines; Dietary Supplements; Garlic; Inf | 2015 |
Molecular Mechanisms of Lipoic Acid Protection against Aflatoxin B₁-Induced Liver Oxidative Damage and Inflammatory Responses in Broilers.
Topics: Aflatoxin B1; Animals; Chickens; Glutathione Peroxidase; Glutathione Transferase; Heme Oxygenase (De | 2015 |
Inhibitory Effects of α-Lipoic Acid on Oxidative Stress-Induced Adipogenesis in Orbital Fibroblasts From Patients With Graves Ophthalmopathy.
Topics: Adipogenesis; Adult; Antioxidants; Cells, Cultured; Chemokines; Drug Evaluation, Preclinical; Female | 2016 |
Effect of alpha-lipoic acid on radiation-induced small intestine injury in mice.
Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Gamma | 2016 |
Alpha-Lipoic Acid Alleviates Acute Inflammation and Promotes Lipid Mobilization During the Inflammatory Response in White Adipose Tissue of Mice.
Topics: Adipose Tissue, White; Animals; Disease Models, Animal; Energy Metabolism; Fatty Acids, Nonesterifie | 2016 |
Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticles.
Topics: Blood Proteins; Cells, Cultured; Endocytosis; Gold; Humans; Inflammation; Keratinocytes; Metal Nanop | 2016 |
Mutated glutathione-S-transferase reduced airway inflammation by limiting oxidative stress and Th2 response.
Topics: Animals; Binding Sites; Bronchoalveolar Lavage Fluid; Circular Dichroism; Disease Models, Animal; En | 2008 |
Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Cyclooxygenase Inhi | 2010 |
Mutated glutathione S-transferase in combination with reduced glutathione shows a synergistic effect in ameliorating oxidative stress and airway inflammation.
Topics: Animals; Antioxidants; Asthma; Disease Models, Animal; Drug Synergism; Glutathione; Glutathione Tran | 2010 |
Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism.
Topics: Acetophenones; Aging; Androstadienes; Animals; Antioxidants; Aorta; Apoptosis; Diabetes Mellitus, Ty | 2010 |
Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.
Topics: Aging; Animals; Aorta; Dietary Supplements; Inflammation; Male; Oxidative Stress; Rats; Rats, Inbred | 2010 |
α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Cotton Fiber; Disease Models, Animal; | 2011 |
Effects of intragastric fructose and dextrose on mesenteric microvascular inflammation and postprandial hyperemia in the rat.
Topics: Animals; Antioxidants; Arterioles; Cell Adhesion; Fructose; Glucose; Hyperemia; Inflammation; Leukoc | 2011 |
Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline; Choline Deficiency; Cyto | 2012 |
Dietary supplementation with N-acetyl cysteine, α-tocopherol and α-lipoic acid reduces the extent of oxidative stress and proinflammatory state in aged rat brain.
Topics: Acetylcysteine; alpha-Tocopherol; Animals; Brain; Cell Nucleus; Cytokines; Dietary Supplements; Enzy | 2012 |
alpha-Lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; DNA; Immunoglobulin E; Inflammation; Lung; Male; Methach | 2004 |
The protective role of DL-alpha-lipoic acid in the oxidative vulnerability triggered by Abeta-amyloid vaccination in mice.
Topics: Adenosine Triphosphatases; Amyloid beta-Peptides; Animals; Antioxidants; Astrocytes; Body Weight; Br | 2005 |
The protective role of DL-alpha-lipoic acid in biogenic amines catabolism triggered by Abeta amyloid vaccination in mice.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Antioxidants; Biogenic Amines; Brain; Chromato | 2005 |
alpha-Lipoic acid inhibits inflammatory bone resorption by suppressing prostaglandin E2 synthesis.
Topics: Animals; Antioxidants; Blotting, Western; Bone and Bones; Bone Marrow Cells; Bone Resorption; Carrie | 2006 |
Modulation of p38 mitogen-activated protein kinase cascade and metalloproteinase activity in diaphragm muscle in response to free radical scavenger administration in dystrophin-deficient Mdx mice.
Topics: Animals; Apoptosis; Calcium; Carnitine; Creatine Kinase; Diaphragm; Dystroglycans; Dystrophin; Free | 2007 |
Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line, Tumor; Humans; Inflammation; Lipopolysac | 2007 |
Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase 2; Dinoprostone; Disease Models, Ani | 2007 |
Alpha-lipoic acid may be a clinically useful therapy in interstitial cystitis.
Topics: Animals; Antioxidants; Cystitis, Interstitial; Disease Models, Animal; Humans; Inflammation; Mice; R | 2007 |
Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Body Weight; Cholesterol; Dietary Supplements; Disease | 2008 |
Efficacy of DL-alpha lipoic acid against systemic inflammation-induced mice: antioxidant defense system.
Topics: Adenosine Triphosphatases; Animals; Antioxidants; Astrocytes; Cell Membrane; Glial Fibrillary Acidic | 2008 |
Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice.
Topics: Animals; Antioxidants; Cyclophosphamide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; | 1994 |