thioctic acid has been researched along with Injuries, Radiation in 12 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Radiation therapy is one of the main cancer treatment modalities applied in 50-70% of cancer patients." | 2.72 | The radioprotective effects of alpha-lipoic acid on radiotherapy-induced toxicities: A systematic review. ( Abedi-Firouzjah, R; Dastranj, L; Dorri-Giv, M; Farhood, B; Khodaverdian, S; Mohammad Hosseini, S; Sheikholeslami, S; Souri, S; Zamani, H, 2021) |
| "Premature ovarian failure is a well-known side effect of conventional, low linear energy transfer (LET) cancer radiotherapy, but little is known about the effects of high LET charged particles on the ovary." | 1.46 | Very low doses of heavy oxygen ion radiation induce premature ovarian failure. ( Luderer, U; Mishra, B; Ortiz, L; Ripperdan, R, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 9 (75.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, H | 1 |
| Yoo, WS | 1 |
| Jung, JH | 2 |
| Jeong, BK | 2 |
| Woo, SH | 2 |
| Kim, JH | 2 |
| Kim, SJ | 1 |
| Yahyapour, R | 1 |
| Amini, P | 1 |
| Saffar, H | 1 |
| Motevaseli, E | 1 |
| Farhood, B | 2 |
| Pooladvand, V | 1 |
| Shabeeb, D | 1 |
| Musa, AE | 1 |
| Najafi, M | 1 |
| Sheikholeslami, S | 1 |
| Khodaverdian, S | 1 |
| Dorri-Giv, M | 1 |
| Mohammad Hosseini, S | 1 |
| Souri, S | 1 |
| Abedi-Firouzjah, R | 1 |
| Zamani, H | 1 |
| Dastranj, L | 1 |
| Mishra, B | 1 |
| Ripperdan, R | 1 |
| Ortiz, L | 1 |
| Luderer, U | 1 |
| Jung, J | 1 |
| Kim, SK | 1 |
| Kang, KM | 1 |
| Jung, MH | 1 |
| Hahm, JR | 1 |
| Steliou, K | 1 |
| Faller, DV | 1 |
| Pinkert, CA | 1 |
| Irwin, MH | 1 |
| Moos, WH | 1 |
| Ryu, SH | 1 |
| Park, EY | 1 |
| Kwak, S | 1 |
| Heo, SH | 1 |
| Ryu, JW | 1 |
| Park, JH | 1 |
| Choi, KC | 1 |
| Lee, SW | 1 |
| Velauthapillai, N | 1 |
| Barfett, J | 1 |
| Jaffer, H | 1 |
| Mikulis, D | 1 |
| Murphy, K | 1 |
| Sridharan, V | 1 |
| Seawright, JW | 1 |
| Antonawich, FJ | 1 |
| Garnett, M | 1 |
| Cao, M | 1 |
| Singh, P | 1 |
| Boerma, M | 1 |
| Ramachandran, L | 1 |
| Krishnan, CV | 1 |
| Nair, CK | 1 |
| Beitner, H | 1 |
| Ilinich, VK | 1 |
| Plastun, FF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Alpha Lipoic Acid on the Incidence and Severity of Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients[NCT05023863] | Phase 2/Phase 3 | 70 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thioctic acid and Injuries, Radiation
| Article | Year |
|---|---|
The radioprotective effects of alpha-lipoic acid on radiotherapy-induced toxicities: A systematic review.
Topics: Animals; Antioxidants; Humans; Neoplasms; Radiation Injuries; Radiation-Protective Agents; Radiother | 2021 |
[Treatment of acute hepatic insufficiency (a survey of the literature)].
Topics: Acute Disease; Adenosine Triphosphate; Arginine; Chemical and Drug Induced Liver Injury; Exchange Tr | 1972 |
2 trials available for thioctic acid and Injuries, Radiation
| Article | Year |
|---|---|
Antioxidants Taken Orally prior to Diagnostic Radiation Exposure Can Prevent DNA Injury.
Topics: Acetylcysteine; Administration, Oral; Adult; Aged; Aged, 80 and over; Antioxidants; Ascorbic Acid; b | 2017 |
Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin.
Topics: Administration, Cutaneous; Adult; Aged; Antioxidants; Dermatologic Agents; Double-Blind Method; Faci | 2003 |
8 other studies available for thioctic acid and Injuries, Radiation
| Article | Year |
|---|---|
Alpha-Lipoic Acid Ameliorates Radiation-Induced Lacrimal Gland Injury through NFAT5-Dependent Signaling.
Topics: Animals; Lacrimal Apparatus; Male; Radiation Injuries; Radiation-Protective Agents; Rats; Rats, Spra | 2019 |
Protective Effect of Metformin, Resveratrol and Alpha-lipoic Acid on Radiation- Induced Pneumonitis and Fibrosis: A Histopathological Study.
Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Hypoglycemic Agents; Lung; Male; Metformin; | 2019 |
Very low doses of heavy oxygen ion radiation induce premature ovarian failure.
Topics: Animals; Antioxidants; Apoptosis; Astronauts; DNA Damage; Dose-Response Relationship, Radiation; Est | 2017 |
Alpha lipoic acid attenuates radiation-induced thyroid injury in rats.
Topics: Animals; Antioxidants; Cytokines; Disease Models, Animal; Fibrosis; Male; Oxidative Stress; Radiatio | 2014 |
Bioprotective carnitinoids: lipoic acid, butyrate, and mitochondria-targeting to treat radiation injury: mitochondrial drugs come of age.
Topics: Animals; Antioxidants; Butyric Acid; Carnitine; Histone Deacetylase Inhibitors; Humans; Mitochondria | 2015 |
Protective effect of α-lipoic acid against radiation-induced fibrosis in mice.
Topics: Animals; Antioxidants; Fibrosis; Mice; Mice, Inbred BALB C; Radiation Injuries; Radiation-Protective | 2016 |
Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; CD2 Antigens; Disease Models, Anim | 2017 |
Radioprotection by alpha-lipoic acid palladium complex formulation (POLY-MVA) in mice.
Topics: Animals; Comet Assay; DNA Damage; Drug Combinations; Gamma Rays; Male; Mice; Mice, Inbred BALB C; Pa | 2010 |