Page last updated: 2024-10-19

thioctic acid and Hypoxia

thioctic acid has been researched along with Hypoxia in 15 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
" During the period of hypoxia, the volunteers received as a short-term treatment either 1200 mg thioctic acid, or N-acetylcysteine 600 mg or placebo (0."9.10Influence of controlled hypoxia and radical scavenging agents on erythropoietin and malondialdehyde concentrations in humans. ( Freudenthaler, SM; Gleiter, CH; Pilz, J; Schreeb, KH; Wiese, A, 2002)
" During the period of hypoxia, the volunteers received as a short-term treatment either 1200 mg thioctic acid, or N-acetylcysteine 600 mg or placebo (0."5.10Influence of controlled hypoxia and radical scavenging agents on erythropoietin and malondialdehyde concentrations in humans. ( Freudenthaler, SM; Gleiter, CH; Pilz, J; Schreeb, KH; Wiese, A, 2002)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.67)18.7374
1990's4 (26.67)18.2507
2000's1 (6.67)29.6817
2010's8 (53.33)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Wang, Y1
Zheng, Y1
Qi, B1
Liu, Y1
Cheng, X1
Feng, J1
Gao, W1
Li, T1
Paredes, F1
Sheldon, K1
Lassègue, B1
Williams, HC1
Faidley, EA1
Benavides, GA1
Torres, G1
Sanhueza-Olivares, F1
Yeligar, SM1
Griendling, KK1
Darley-Usmar, V1
San Martin, A1
Casciato, P1
Ambrosi, N1
Caro, F1
Vazquez, M1
Müllen, E1
Gadano, A1
de Santibañes, E1
de Santibañes, M1
Zandomeni, M1
Chahdi, M1
Lazarte, JC1
Biagiola, DA1
Iaquinandi, JC1
Santofimia-Castaño, P1
Iovanna, J1
Incardona, C1
Chuluyan, E1
Pérez-López, A1
Martin-Rincon, M1
Santana, A1
Perez-Suarez, I1
Dorado, C1
Calbet, JAL1
Morales-Alamo, D1
Abuyassin, B1
Badran, M1
Ayas, NT1
Laher, I1
Yoo, TH1
Lee, JH1
Chun, HS1
Chi, SG1
Röhnert, P1
Schröder, UH1
Ziabreva, I1
Täger, M1
Reymann, KG1
Striggow, F1
Volchegorskiĭ, IA1
Rassokhina, LM1
Miroshnichenko, IIu1
Xie, R1
Li, X1
Ling, Y1
Shen, C1
Wu, X1
Xu, W1
Gao, X1
Haramaki, N2
Packer, L2
Assadnazari, H3
Zimmer, G3
Freisleben, HJ1
Werk, W1
Leibfritz, D1
Schepkin, V1
Wood, JG1
Johnson, JS1
Mattioli, LF1
Gonzalez, NC1
Freudenthaler, SM1
Schreeb, KH1
Wiese, A1
Pilz, J1
Gleiter, CH1
Wideman, J1

Trials

3 trials available for thioctic acid and Hypoxia

ArticleYear
α-lipoic acid reduces postreperfusion syndrome in human liver transplantation - a pilot study.
    Transplant international : official journal of the European Society for Organ Transplantation, 2018, Volume: 31, Issue:12

    Topics: Aged; Alarmins; Apoptosis; Biopsy; Cold Ischemia; Cytokines; Double-Blind Method; Female; Follow-Up

2018
Antioxidants Facilitate High-intensity Exercise IL-15 Expression in Skeletal Muscle.
    International journal of sports medicine, 2019, Volume: 40, Issue:1

    Topics: Adult; Antioxidants; Ascorbic Acid; Double-Blind Method; Exercise; Exercise Test; Humans; Hypoxia; I

2019
Influence of controlled hypoxia and radical scavenging agents on erythropoietin and malondialdehyde concentrations in humans.
    Acta physiologica Scandinavica, 2002, Volume: 174, Issue:3

    Topics: Acetylcysteine; Adult; Antioxidants; Area Under Curve; Erythropoietin; Free Radical Scavengers; Huma

2002

Other Studies

12 other studies available for thioctic acid and Hypoxia

ArticleYear
α-Lipoic acid alleviates myocardial injury and induces M2b macrophage polarization after myocardial infarction via HMGB1/NF-kB signaling pathway.
    International immunopharmacology, 2023, Volume: 121

    Topics: Animals; Cytokines; Heart Injuries; HMGB1 Protein; Hypoxia; Macrophages; Mice; Myocardial Infarction

2023
Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer.
    Proceedings of the National Academy of Sciences of the United States of America, 2018, 02-20, Volume: 115, Issue:8

    Topics: Animals; Coenzyme A Ligases; Humans; Hypoxia; Ketoglutarate Dehydrogenase Complex; Lipoylation; Mice

2018
The antioxidant α-lipoic acid attenuates intermittent hypoxia-related renal injury in a mouse model of sleep apnea.
    Sleep, 2019, 06-11, Volume: 42, Issue:6

    Topics: Animals; Antioxidants; Disease Models, Animal; Hypoxia; Inflammation; Kidney; Kidney Diseases; Male;

2019
α-Lipoic acid prevents p53 degradation in colon cancer cells by blocking NF-κB induction of RPS6KA4.
    Anti-cancer drugs, 2013, Volume: 24, Issue:6

    Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Dose-Response Relationship, Drug; G1 Phase Cell Cycl

2013
Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion.
    Journal of neuroscience research, 2012, Volume: 90, Issue:1

    Topics: Animals; Brain Ischemia; Cell Death; Disease Models, Animal; Ethidium; Fluoresceins; Gerbillinae; Gl

2012
[Antihypoxic effect of 3-hydroxypyridine and succinic acid derivatives and their nootropic action in alloxan diabetes].
    Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:12

    Topics: Alloxan; Animals; Conditioning, Classical; Diabetes Mellitus, Experimental; Diabetic Neuropathies; D

2011
Alpha-lipoic acid pre- and post-treatments provide protection against in vitro ischemia-reperfusion injury in cerebral endothelial cells via Akt/mTOR signaling.
    Brain research, 2012, Oct-30, Volume: 1482

    Topics: Analysis of Variance; Animals; Antioxidants; Cell Survival; Cells, Cultured; Cerebral Cortex; Drug A

2012
Cardiac recovery during post-ischemic reperfusion is improved by combination of vitamin E with dihydrolipoic acid.
    Biochemical and biophysical research communications, 1993, Nov-15, Volume: 196, Issue:3

    Topics: Analysis of Variance; Animals; Biomarkers; Coronary Circulation; Food, Fortified; Hypoxia; In Vitro

1993
Cardioprotective efficiency of dihydrolipoic acid in working rat hearts during hypoxia and reoxygenation. 31P nuclear magnetic resonance investigations.
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:4

    Topics: Adenosine Triphosphate; Animals; Creatine Kinase; Heart; Heart Diseases; Hypoxia; In Vitro Technique

1993
The influence of vitamin E and dihydrolipoic acid on cardiac energy and glutathione status under hypoxia-reoxygenation.
    Biochemistry and molecular biology international, 1995, Volume: 37, Issue:3

    Topics: Animals; Antioxidants; Energy Metabolism; Glutathione; Glutathione Disulfide; Heart; Hypoxia; Male;

1995
Systemic hypoxia promotes leukocyte-endothelial adherence via reactive oxidant generation.
    Journal of applied physiology (Bethesda, Md. : 1985), 1999, Volume: 87, Issue:5

    Topics: Animals; Antioxidants; Catalase; Cell Adhesion; Endothelium, Vascular; Hypoxia; Leukocytes; Male; Mi

1999
Regulation of thiols in the brain. 4. Glutathione--cystine transhydrogenase activity during hypoxia and its substrate specificity in different parts of the rat brain.
    Resuscitation, 1974, Volume: 3, Issue:1

    Topics: Animals; Brain; Brain Stem; Cattle; Cerebellum; Cystine; Cytoplasm; Disulfides; Glutathione Reductas

1974