thioctic acid has been researched along with Hyperglycemia, Postprandial in 27 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Hyperglycemia, Postprandial: Abnormally high BLOOD GLUCOSE level after a meal.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of 3-oxypyridine and succinic acid derivatives (emoxipine, reamberin and mexidol) on affective disorders in rats with alloxan diabetes were studied." | 7.81 | [Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes]. ( Faizullin, RM; Kalugina, AV; Miroshnichenko, IY; Pryakhina, KE; Rassokhina, LM; Volchegorskii, LA, 2015) |
| "The effects of original Russian preparations, derivatives of 3-hydroxypyridine and succinic acid (emoxipin, reamberin, mexidol), on the cellular composition of the cerebrocortical and diencephalic structures were studied and correlations of shifts in the cellular composition with changes in the severity of hyperglycemia in rats with alloxan diabetes were analyzed." | 7.79 | Cerebroprotective effects of emoxipin, reamberin, and mexidol in alloxan diabetes. ( Miroshnichenko, IY; Rassokhina, LM; Volchegorskii, IA, 2013) |
| "The effects of 3-oxypyridine and succinic acid derivatives (emoxipine, reamberin and mexidol) on affective disorders in rats with alloxan diabetes were studied." | 3.81 | [Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes]. ( Faizullin, RM; Kalugina, AV; Miroshnichenko, IY; Pryakhina, KE; Rassokhina, LM; Volchegorskii, LA, 2015) |
| "The effects of original Russian preparations, derivatives of 3-hydroxypyridine and succinic acid (emoxipin, reamberin, mexidol), on the cellular composition of the cerebrocortical and diencephalic structures were studied and correlations of shifts in the cellular composition with changes in the severity of hyperglycemia in rats with alloxan diabetes were analyzed." | 3.79 | Cerebroprotective effects of emoxipin, reamberin, and mexidol in alloxan diabetes. ( Miroshnichenko, IY; Rassokhina, LM; Volchegorskii, IA, 2013) |
| " In other rats, glucose, insulin, uric acid, and insulin sensitivity index, were determined before and after fructose or lipoic acid plus fructose." | 3.79 | A single oral dose of fructose induces some features of metabolic syndrome in rats: role of oxidative stress. ( Hong, E; Moreno, JA, 2013) |
| " Compared with control rats, D developed increased urinary excretion of albumin and transforming growth factor beta, renal insufficiency, glomerular mesangial matrix expansion, and glomerulosclerosis in association with depletion of glutathione and accumulation of malondialdehyde in renal cortex." | 3.71 | Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. ( Craven, PA; DeRubertis, FR; Liachenko, J; Melhem, MF, 2002) |
| "Male participants with and without type 1 diabetes were studied in the General Clinical Research Centre of the Albert Einstein College of Medicine." | 2.73 | Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes. ( Brownlee, M; Du, X; Edelstein, D, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 4 (14.81) | 18.2507 |
| 2000's | 9 (33.33) | 29.6817 |
| 2010's | 12 (44.44) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Zalewska, A | 1 |
| Zięba, S | 1 |
| Kostecka-Sochoń, P | 1 |
| Matczuk, J | 1 |
| Żendzian-Piotrowska, M | 1 |
| Maciejczyk, M | 1 |
| Gao, T | 1 |
| Qian, S | 1 |
| Shen, S | 1 |
| Zhang, X | 1 |
| Liu, J | 1 |
| Jia, W | 1 |
| Chen, Z | 1 |
| Ye, J | 1 |
| Volchegorskii, IA | 3 |
| Rassokhina, LM | 4 |
| Miroshnichenko, IY | 2 |
| Yang, Y | 1 |
| Li, W | 1 |
| Liu, Y | 1 |
| Li, Y | 1 |
| Gao, L | 1 |
| Zhao, JJ | 1 |
| Coletta, C | 1 |
| Módis, K | 1 |
| Szczesny, B | 1 |
| Brunyánszki, A | 1 |
| Oláh, G | 1 |
| Rios, EC | 1 |
| Yanagi, K | 1 |
| Ahmad, A | 1 |
| Papapetropoulos, A | 1 |
| Szabo, C | 1 |
| Volchegorskii, LA | 1 |
| Faizullin, RM | 1 |
| Pryakhina, KE | 1 |
| Kalugina, AV | 1 |
| Du, X | 1 |
| Edelstein, D | 1 |
| Brownlee, M | 1 |
| Poh, ZX | 1 |
| Goh, KP | 1 |
| Santos, JM | 1 |
| Kowluru, RA | 1 |
| Koliadich, MI | 1 |
| Alekseev, MI | 1 |
| Miroshnichenko, IIu | 1 |
| Moreno, JA | 1 |
| Hong, E | 1 |
| Vorob'eva, OV | 1 |
| Arambašić, J | 1 |
| Mihailović, M | 1 |
| Uskoković, A | 1 |
| Dinić, S | 1 |
| Grdović, N | 1 |
| Marković, J | 1 |
| Poznanović, G | 1 |
| Bajec, D | 1 |
| Vidaković, M | 1 |
| Rochette, L | 1 |
| Ghibu, S | 1 |
| Richard, C | 1 |
| Zeller, M | 1 |
| Cottin, Y | 1 |
| Vergely, C | 1 |
| Guillonneau, C | 1 |
| Charton, Y | 1 |
| Ginot, YM | 1 |
| Fouquier-d'Hérouël, MV | 1 |
| Bertrand, M | 1 |
| Lockhart, B | 1 |
| Lestage, P | 1 |
| Goldstein, S | 1 |
| Midaoui, AE | 1 |
| Elimadi, A | 1 |
| Wu, L | 1 |
| Haddad, PS | 1 |
| de Champlain, J | 1 |
| SCHIROSA, G | 1 |
| PAGLIARO, L | 1 |
| Vincent, AM | 1 |
| McLean, LL | 1 |
| Backus, C | 1 |
| Feldman, EL | 1 |
| Ross, CM | 1 |
| Berkowitz, BA | 1 |
| Roberts, R | 1 |
| Stemmler, A | 1 |
| Luan, H | 1 |
| Gradianu, M | 1 |
| Xiang, GD | 1 |
| Sun, HL | 1 |
| Zhao, LS | 1 |
| Hou, J | 1 |
| Yue, L | 1 |
| Xu, L | 1 |
| Hofmann, M | 1 |
| Mainka, P | 1 |
| Tritschler, H | 1 |
| Fuchs, J | 1 |
| Zimmer, G | 1 |
| Ou, P | 1 |
| Nourooz-Zadeh, J | 1 |
| Tritschler, HJ | 2 |
| Wolff, S | 1 |
| Biewenga, G | 1 |
| Haenen, GR | 1 |
| Bast, A | 1 |
| Konrad, T | 1 |
| Vicini, P | 1 |
| Kusterer, K | 1 |
| Höflich, A | 1 |
| Assadkhani, A | 1 |
| Böhles, HJ | 1 |
| Sewell, A | 1 |
| Cobelli, C | 1 |
| Usadel, KH | 1 |
| Melhem, MF | 1 |
| Craven, PA | 1 |
| Liachenko, J | 1 |
| DeRubertis, FR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of the Glucosamine Pathway and Reactive Oxygen Species in the Pathogenesis of Diabetic Complications[NCT00703989] | 21 participants (Actual) | Interventional | 2005-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for thioctic acid and Hyperglycemia, Postprandial
| Article | Year |
|---|---|
A current update on the use of alpha lipoic acid in the management of type 2 diabetes mellitus.
Topics: Antioxidants; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Neuropath | 2009 |
[Thioctic (alpha-lipoic) acid-spectrum of clinical use].
Topics: Antioxidants; Humans; Hyperglycemia; Oxidative Stress; Thioctic Acid | 2011 |
Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential.
Topics: Animals; Antioxidants; Cardiovascular Diseases; Chelating Agents; Diabetes Mellitus; Dietary Supplem | 2013 |
The role of lipoic acid in the treatment of diabetic polyneuropathy.
Topics: Aldehydes; Animals; Blood Glucose; Diabetic Neuropathies; Gluconeogenesis; Glucose; Humans; Hypergly | 1997 |
3 trials available for thioctic acid and Hyperglycemia, Postprandial
| Article | Year |
|---|---|
Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Cytochrome P-450 Enzyme System; Diabe | 2008 |
[Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients].
Topics: Antioxidants; Attention; Cognition; Cognition Disorders; Diabetes Complications; Diabetes Mellitus; | 2011 |
The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycaemia during OGTT in impaired glucose tolerance.
Topics: Adult; Antioxidants; Blood Glucose; Case-Control Studies; Endothelium, Vascular; Female; Free Radica | 2008 |
20 other studies available for thioctic acid and Hyperglycemia, Postprandial
| Article | Year |
|---|---|
α-Lipoic Acid Supplementation Salivary Glands in the Hyperglycaemic Rats.
Topics: Animals; Antioxidants; Diet, High-Fat; Dietary Supplements; Hyperglycemia; Oxidative Stress; Rats; R | 2022 |
Reduction of mitochondrial 3-oxoacyl-ACP synthase (OXSM) by hyperglycemia is associated with deficiency of α-lipoic acid synthetic pathway in kidney of diabetic mice.
Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; 3T3-L1 Cells; Animals; Biosynthetic Pathways; Diabetes Me | 2019 |
Cerebroprotective effects of emoxipin, reamberin, and mexidol in alloxan diabetes.
Topics: Alloxan; Animals; Astrocytes; Cerebral Cortex; Diabetes Mellitus, Experimental; Diencephalon; Female | 2013 |
Alpha-lipoic acid attenuates insulin resistance and improves glucose metabolism in high fat diet-fed mice.
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Diet, High-Fat; Down-Regulatio | 2014 |
Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid.
Topics: Animals; Cell Line; Cyclic GMP-Dependent Protein Kinases; Cysteine; Diabetes Mellitus; Disease Model | 2015 |
[Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes].
Topics: Animals; Anti-Anxiety Agents; Anxiety; Depression; Diabetes Mellitus, Experimental; Humans; Hypergly | 2015 |
Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Progression; D | 2011 |
[Antihypoxic effect of 3-hydroxypyridine and succinic acid derivatives and their nootropic action in alloxan diabetes].
Topics: Alloxan; Animals; Conditioning, Classical; Diabetes Mellitus, Experimental; Diabetic Neuropathies; D | 2011 |
A single oral dose of fructose induces some features of metabolic syndrome in rats: role of oxidative stress.
Topics: Administration, Oral; Animals; Blood Glucose; Blood Pressure; Dose-Response Relationship, Drug; Fruc | 2013 |
Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism.
Topics: Acetylglucosamine; Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; | 2013 |
Synthesis and pharmacological evaluation of new 1,2-dithiolane based antioxidants.
Topics: Alloxan; Animals; Antioxidants; Body Temperature; Drug Evaluation, Preclinical; Hyperglycemia; Lipid | 2003 |
Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production.
Topics: Animals; Antioxidants; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Glucose; Glycat | 2003 |
[Thioctic acid in the therapy of hyperglycemic states].
Topics: Humans; Hyperglycemia; Thioctic Acid; Vitamin A; Vitamin K; Vitamins | 1957 |
Short-term hyperglycemia produces oxidative damage and apoptosis in neurons.
Topics: Aconitate Hydratase; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Catalase; Cells, Culture | 2005 |
Insulin, AGE and hypertension.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; H | 2005 |
Impaired apparent ion demand in experimental diabetic retinopathy: correction by lipoic Acid.
Topics: Animals; Antioxidants; Blood-Retinal Barrier; Capillary Permeability; Diabetes Mellitus, Experimenta | 2007 |
Decrease of red cell membrane fluidity and -SH groups due to hyperglycemic conditions is counteracted by alpha-lipoic acid.
Topics: Dithiothreitol; Erythrocyte Membrane; Fluorescence Polarization; Glucose; Glucose Transporter Type 1 | 1995 |
Activation of aldose reductase in rat lens and metal-ion chelation by aldose reductase inhibitors and lipoic acid.
Topics: 1-Octanol; Aldehyde Reductase; Animals; Ascorbic Acid; Chelating Agents; Copper; Enzyme Activation; | 1996 |
alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes.
Topics: Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fasting; Glucose Tolerance Test; Glycat | 1999 |
Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes.
Topics: Albuminuria; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephrop | 2002 |