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thioctic acid and Hyperglycemia, Postprandial

thioctic acid has been researched along with Hyperglycemia, Postprandial in 27 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Hyperglycemia, Postprandial: Abnormally high BLOOD GLUCOSE level after a meal.

Research Excerpts

ExcerptRelevanceReference
"The effects of 3-oxypyridine and succinic acid derivatives (emoxipine, reamberin and mexidol) on affective disorders in rats with alloxan diabetes were studied."7.81[Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes]. ( Faizullin, RM; Kalugina, AV; Miroshnichenko, IY; Pryakhina, KE; Rassokhina, LM; Volchegorskii, LA, 2015)
"The effects of original Russian preparations, derivatives of 3-hydroxypyridine and succinic acid (emoxipin, reamberin, mexidol), on the cellular composition of the cerebrocortical and diencephalic structures were studied and correlations of shifts in the cellular composition with changes in the severity of hyperglycemia in rats with alloxan diabetes were analyzed."7.79Cerebroprotective effects of emoxipin, reamberin, and mexidol in alloxan diabetes. ( Miroshnichenko, IY; Rassokhina, LM; Volchegorskii, IA, 2013)
"The effects of 3-oxypyridine and succinic acid derivatives (emoxipine, reamberin and mexidol) on affective disorders in rats with alloxan diabetes were studied."3.81[Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes]. ( Faizullin, RM; Kalugina, AV; Miroshnichenko, IY; Pryakhina, KE; Rassokhina, LM; Volchegorskii, LA, 2015)
"The effects of original Russian preparations, derivatives of 3-hydroxypyridine and succinic acid (emoxipin, reamberin, mexidol), on the cellular composition of the cerebrocortical and diencephalic structures were studied and correlations of shifts in the cellular composition with changes in the severity of hyperglycemia in rats with alloxan diabetes were analyzed."3.79Cerebroprotective effects of emoxipin, reamberin, and mexidol in alloxan diabetes. ( Miroshnichenko, IY; Rassokhina, LM; Volchegorskii, IA, 2013)
" In other rats, glucose, insulin, uric acid, and insulin sensitivity index, were determined before and after fructose or lipoic acid plus fructose."3.79A single oral dose of fructose induces some features of metabolic syndrome in rats: role of oxidative stress. ( Hong, E; Moreno, JA, 2013)
" Compared with control rats, D developed increased urinary excretion of albumin and transforming growth factor beta, renal insufficiency, glomerular mesangial matrix expansion, and glomerulosclerosis in association with depletion of glutathione and accumulation of malondialdehyde in renal cortex."3.71Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. ( Craven, PA; DeRubertis, FR; Liachenko, J; Melhem, MF, 2002)
"Male participants with and without type 1 diabetes were studied in the General Clinical Research Centre of the Albert Einstein College of Medicine."2.73Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes. ( Brownlee, M; Du, X; Edelstein, D, 2008)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.70)18.7374
1990's4 (14.81)18.2507
2000's9 (33.33)29.6817
2010's12 (44.44)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Zalewska, A1
Zięba, S1
Kostecka-Sochoń, P1
Matczuk, J1
Żendzian-Piotrowska, M1
Maciejczyk, M1
Gao, T1
Qian, S1
Shen, S1
Zhang, X1
Liu, J1
Jia, W1
Chen, Z1
Ye, J1
Volchegorskii, IA3
Rassokhina, LM4
Miroshnichenko, IY2
Yang, Y1
Li, W1
Liu, Y1
Li, Y1
Gao, L1
Zhao, JJ1
Coletta, C1
Módis, K1
Szczesny, B1
Brunyánszki, A1
Oláh, G1
Rios, EC1
Yanagi, K1
Ahmad, A1
Papapetropoulos, A1
Szabo, C1
Volchegorskii, LA1
Faizullin, RM1
Pryakhina, KE1
Kalugina, AV1
Du, X1
Edelstein, D1
Brownlee, M1
Poh, ZX1
Goh, KP1
Santos, JM1
Kowluru, RA1
Koliadich, MI1
Alekseev, MI1
Miroshnichenko, IIu1
Moreno, JA1
Hong, E1
Vorob'eva, OV1
Arambašić, J1
Mihailović, M1
Uskoković, A1
Dinić, S1
Grdović, N1
Marković, J1
Poznanović, G1
Bajec, D1
Vidaković, M1
Rochette, L1
Ghibu, S1
Richard, C1
Zeller, M1
Cottin, Y1
Vergely, C1
Guillonneau, C1
Charton, Y1
Ginot, YM1
Fouquier-d'Hérouël, MV1
Bertrand, M1
Lockhart, B1
Lestage, P1
Goldstein, S1
Midaoui, AE1
Elimadi, A1
Wu, L1
Haddad, PS1
de Champlain, J1
SCHIROSA, G1
PAGLIARO, L1
Vincent, AM1
McLean, LL1
Backus, C1
Feldman, EL1
Ross, CM1
Berkowitz, BA1
Roberts, R1
Stemmler, A1
Luan, H1
Gradianu, M1
Xiang, GD1
Sun, HL1
Zhao, LS1
Hou, J1
Yue, L1
Xu, L1
Hofmann, M1
Mainka, P1
Tritschler, H1
Fuchs, J1
Zimmer, G1
Ou, P1
Nourooz-Zadeh, J1
Tritschler, HJ2
Wolff, S1
Biewenga, G1
Haenen, GR1
Bast, A1
Konrad, T1
Vicini, P1
Kusterer, K1
Höflich, A1
Assadkhani, A1
Böhles, HJ1
Sewell, A1
Cobelli, C1
Usadel, KH1
Melhem, MF1
Craven, PA1
Liachenko, J1
DeRubertis, FR1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Role of the Glucosamine Pathway and Reactive Oxygen Species in the Pathogenesis of Diabetic Complications[NCT00703989]21 participants (Actual)Interventional2005-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for thioctic acid and Hyperglycemia, Postprandial

ArticleYear
A current update on the use of alpha lipoic acid in the management of type 2 diabetes mellitus.
    Endocrine, metabolic & immune disorders drug targets, 2009, Volume: 9, Issue:4

    Topics: Antioxidants; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Neuropath

2009
[Thioctic (alpha-lipoic) acid-spectrum of clinical use].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:10 Pt 1

    Topics: Antioxidants; Humans; Hyperglycemia; Oxidative Stress; Thioctic Acid

2011
Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential.
    Molecular nutrition & food research, 2013, Volume: 57, Issue:1

    Topics: Animals; Antioxidants; Cardiovascular Diseases; Chelating Agents; Diabetes Mellitus; Dietary Supplem

2013
The role of lipoic acid in the treatment of diabetic polyneuropathy.
    Drug metabolism reviews, 1997, Volume: 29, Issue:4

    Topics: Aldehydes; Animals; Blood Glucose; Diabetic Neuropathies; Gluconeogenesis; Glucose; Humans; Hypergly

1997

Trials

3 trials available for thioctic acid and Hyperglycemia, Postprandial

ArticleYear
Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
    Diabetologia, 2008, Volume: 51, Issue:10

    Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Cytochrome P-450 Enzyme System; Diabe

2008
[Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients].
    Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:11

    Topics: Antioxidants; Attention; Cognition; Cognition Disorders; Diabetes Complications; Diabetes Mellitus;

2011
The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycaemia during OGTT in impaired glucose tolerance.
    Clinical endocrinology, 2008, Volume: 68, Issue:5

    Topics: Adult; Antioxidants; Blood Glucose; Case-Control Studies; Endothelium, Vascular; Female; Free Radica

2008

Other Studies

20 other studies available for thioctic acid and Hyperglycemia, Postprandial

ArticleYear
α-Lipoic Acid Supplementation Salivary Glands in the Hyperglycaemic Rats.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2022, May-19, Volume: 56, Issue:S1

    Topics: Animals; Antioxidants; Diet, High-Fat; Dietary Supplements; Hyperglycemia; Oxidative Stress; Rats; R

2022
Reduction of mitochondrial 3-oxoacyl-ACP synthase (OXSM) by hyperglycemia is associated with deficiency of α-lipoic acid synthetic pathway in kidney of diabetic mice.
    Biochemical and biophysical research communications, 2019, 04-23, Volume: 512, Issue:1

    Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; 3T3-L1 Cells; Animals; Biosynthetic Pathways; Diabetes Me

2019
Cerebroprotective effects of emoxipin, reamberin, and mexidol in alloxan diabetes.
    Bulletin of experimental biology and medicine, 2013, Volume: 155, Issue:1

    Topics: Alloxan; Animals; Astrocytes; Cerebral Cortex; Diabetes Mellitus, Experimental; Diencephalon; Female

2013
Alpha-lipoic acid attenuates insulin resistance and improves glucose metabolism in high fat diet-fed mice.
    Acta pharmacologica Sinica, 2014, Volume: 35, Issue:10

    Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Diet, High-Fat; Down-Regulatio

2014
Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid.
    Molecular medicine (Cambridge, Mass.), 2015, Feb-18, Volume: 21

    Topics: Animals; Cell Line; Cyclic GMP-Dependent Protein Kinases; Cysteine; Diabetes Mellitus; Disease Model

2015
[Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2015, Volume: 101, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Depression; Diabetes Mellitus, Experimental; Humans; Hypergly

2015
Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid.
    Investigative ophthalmology & visual science, 2011, Nov-11, Volume: 52, Issue:12

    Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Progression; D

2011
[Antihypoxic effect of 3-hydroxypyridine and succinic acid derivatives and their nootropic action in alloxan diabetes].
    Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:12

    Topics: Alloxan; Animals; Conditioning, Classical; Diabetes Mellitus, Experimental; Diabetic Neuropathies; D

2011
A single oral dose of fructose induces some features of metabolic syndrome in rats: role of oxidative stress.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2013, Volume: 23, Issue:6

    Topics: Administration, Oral; Animals; Blood Glucose; Blood Pressure; Dose-Response Relationship, Drug; Fruc

2013
Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism.
    European journal of nutrition, 2013, Volume: 52, Issue:5

    Topics: Acetylglucosamine; Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimental;

2013
Synthesis and pharmacological evaluation of new 1,2-dithiolane based antioxidants.
    European journal of medicinal chemistry, 2003, Volume: 38, Issue:1

    Topics: Alloxan; Animals; Antioxidants; Body Temperature; Drug Evaluation, Preclinical; Hyperglycemia; Lipid

2003
Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production.
    American journal of hypertension, 2003, Volume: 16, Issue:3

    Topics: Animals; Antioxidants; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Glucose; Glycat

2003
[Thioctic acid in the therapy of hyperglycemic states].
    La Riforma medica, 1957, Jan-12, Volume: 71, Issue:2

    Topics: Humans; Hyperglycemia; Thioctic Acid; Vitamin A; Vitamin K; Vitamins

1957
Short-term hyperglycemia produces oxidative damage and apoptosis in neurons.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:6

    Topics: Aconitate Hydratase; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Catalase; Cells, Culture

2005
Insulin, AGE and hypertension.
    Journal of hypertension, 2005, Volume: 23, Issue:8

    Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; H

2005
Impaired apparent ion demand in experimental diabetic retinopathy: correction by lipoic Acid.
    Investigative ophthalmology & visual science, 2007, Volume: 48, Issue:10

    Topics: Animals; Antioxidants; Blood-Retinal Barrier; Capillary Permeability; Diabetes Mellitus, Experimenta

2007
Decrease of red cell membrane fluidity and -SH groups due to hyperglycemic conditions is counteracted by alpha-lipoic acid.
    Archives of biochemistry and biophysics, 1995, Dec-01, Volume: 324, Issue:1

    Topics: Dithiothreitol; Erythrocyte Membrane; Fluorescence Polarization; Glucose; Glucose Transporter Type 1

1995
Activation of aldose reductase in rat lens and metal-ion chelation by aldose reductase inhibitors and lipoic acid.
    Free radical research, 1996, Volume: 25, Issue:4

    Topics: 1-Octanol; Aldehyde Reductase; Animals; Ascorbic Acid; Chelating Agents; Copper; Enzyme Activation;

1996
alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes.
    Diabetes care, 1999, Volume: 22, Issue:2

    Topics: Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fasting; Glucose Tolerance Test; Glycat

1999
Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes.
    Journal of the American Society of Nephrology : JASN, 2002, Volume: 13, Issue:1

    Topics: Albuminuria; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephrop

2002