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thioctic acid and Huntington Disease

thioctic acid has been researched along with Huntington Disease in 5 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Research Excerpts

ExcerptRelevanceReference
"A wide variety of models of Huntington's disease have been developed including yeast, Caenorhabditis elegans, Drosophila melanogaster and mouse."2.42Experimental therapeutics in Huntington's disease: are models useful for therapeutic trials? ( Bates, GP; Hockly, E, 2003)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mehrotra, A3
Sandhir, R3
Kanwal, A1
Banerjee, SK1
Sood, A1
Bates, GP1
Hockly, E1
Andreassen, OA1
Ferrante, RJ1
Dedeoglu, A1
Beal, MF1

Reviews

1 review available for thioctic acid and Huntington Disease

ArticleYear
Experimental therapeutics in Huntington's disease: are models useful for therapeutic trials?
    Current opinion in neurology, 2003, Volume: 16, Issue:4

    Topics: Acetamides; Animals; Antioxidants; Creatine; Disease Models, Animal; Evaluation Studies as Topic; Hu

2003

Other Studies

4 other studies available for thioctic acid and Huntington Disease

ArticleYear
Mitochondrial cofactors in experimental Huntington's disease: behavioral, biochemical and histological evaluation.
    Behavioural brain research, 2014, Mar-15, Volume: 261

    Topics: Acetylcarnitine; Animals; Antioxidants; Behavior, Animal; Brain; Chromatography, Thin Layer; Disease

2014
Mitochondrial modulators in experimental Huntington's disease: reversal of mitochondrial dysfunctions and cognitive deficits.
    Neurobiology of aging, 2015, Volume: 36, Issue:6

    Topics: Acetylcarnitine; Animals; Cognition Disorders; Drug Therapy, Combination; Female; Huntington Disease

2015
Mitochondrial modulators improve lipid composition and attenuate memory deficits in experimental model of Huntington's disease.
    Molecular and cellular biochemistry, 2015, Volume: 410, Issue:1-2

    Topics: Acetylcarnitine; Animals; Behavior, Animal; Brain; Cholesterol; Chromatography, Thin Layer; Cognitio

2015
Lipoic acid improves survival in transgenic mouse models of Huntington's disease.
    Neuroreport, 2001, Oct-29, Volume: 12, Issue:15

    Topics: Animals; Antioxidants; Benzenesulfonates; Body Weight; Brain; Disease Models, Animal; Food, Formulat

2001
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