thioctic acid and Huntington Disease
thioctic acid has been researched along with Huntington Disease in 5 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"A wide variety of models of Huntington's disease have been developed including yeast, Caenorhabditis elegans, Drosophila melanogaster and mouse." | 2.42 | Experimental therapeutics in Huntington's disease: are models useful for therapeutic trials? ( Bates, GP; Hockly, E, 2003) |
Research
Studies (5)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (40.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Mehrotra, A | 3 |
Sandhir, R | 3 |
Kanwal, A | 1 |
Banerjee, SK | 1 |
Sood, A | 1 |
Bates, GP | 1 |
Hockly, E | 1 |
Andreassen, OA | 1 |
Ferrante, RJ | 1 |
Dedeoglu, A | 1 |
Beal, MF | 1 |
Reviews
1 review available for thioctic acid and Huntington Disease
Article | Year |
---|---|
Experimental therapeutics in Huntington's disease: are models useful for therapeutic trials?
Topics: Acetamides; Animals; Antioxidants; Creatine; Disease Models, Animal; Evaluation Studies as Topic; Hu | 2003 |
Other Studies
4 other studies available for thioctic acid and Huntington Disease
Article | Year |
---|---|
Mitochondrial cofactors in experimental Huntington's disease: behavioral, biochemical and histological evaluation.
Topics: Acetylcarnitine; Animals; Antioxidants; Behavior, Animal; Brain; Chromatography, Thin Layer; Disease | 2014 |
Mitochondrial modulators in experimental Huntington's disease: reversal of mitochondrial dysfunctions and cognitive deficits.
Topics: Acetylcarnitine; Animals; Cognition Disorders; Drug Therapy, Combination; Female; Huntington Disease | 2015 |
Mitochondrial modulators improve lipid composition and attenuate memory deficits in experimental model of Huntington's disease.
Topics: Acetylcarnitine; Animals; Behavior, Animal; Brain; Cholesterol; Chromatography, Thin Layer; Cognitio | 2015 |
Lipoic acid improves survival in transgenic mouse models of Huntington's disease.
Topics: Animals; Antioxidants; Benzenesulfonates; Body Weight; Brain; Disease Models, Animal; Food, Formulat | 2001 |