thioctic acid has been researched along with Hepatocellular Carcinoma in 17 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Many clinical and epidemiological studies show that mild hyperhomocysteinemia is associated with premature vascular disease." | 3.73 | Elimination of high amounts of extracellular homocysteine in human cell lines. ( Hultberg, B, 2005) |
| "Hepatocellular carcinoma is the most frequent primary liver cancer worldwide." | 1.48 | Integrated transcriptomic and proteomic analyses reveal ɑ-lipoic acid-regulated cell proliferation via Grb2-mediated signalling in hepatic cancer cells. ( Lu, J; Sun, X; Wang, R; Wang, X; Wen, Y; Xu, J; Yang, L; Zhang, M, 2018) |
| "Fatty liver is common in obese subjects with insulin resistance." | 1.35 | Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. ( Choi, HS; Hwang, JS; Jang, BK; Kim, HS; Kim, JB; Kim, MO; Kim, YD; Koh, EH; Lee, IK; Lee, KU; Min, AK; Park, HS; Park, JY; Park, KG; Yoon, TS, 2008) |
| "However, identical exposure of HepG2 hepatoma cells produced no inhibition of these cytokine responses." | 1.35 | Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption. ( Halvorsen, SW; Monroe, RK, 2009) |
| "Glutathione synthesis in hepatoma cell cultures is probably more sensitive to a low cysteine level than HeLa cell cultures, and the presence of copper ions further decreases the availability of cysteine probably by increasing the disulfide binding to cysteine residues in extracellular proteins, which causes a further decrease of total glutathione." | 1.34 | Traces of copper ions deplete glutathione in human hepatoma cell cultures with low cysteine content. ( Andersson, A; Hultberg, B; Hultberg, M; Isaksson, A, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Li, J | 1 |
| Tuo, D | 1 |
| Guo, G | 1 |
| Gan, J | 1 |
| Yang, L | 1 |
| Wang, X | 1 |
| Xu, J | 1 |
| Wen, Y | 1 |
| Zhang, M | 1 |
| Lu, J | 1 |
| Wang, R | 1 |
| Sun, X | 1 |
| Giordano, E | 1 |
| Davalos, A | 1 |
| Nicod, N | 1 |
| Visioli, F | 1 |
| Roberts, JL | 1 |
| He, B | 1 |
| Erickson, A | 1 |
| Moreau, R | 1 |
| Ikuta, N | 1 |
| Chikamoto, K | 1 |
| Asano, Y | 1 |
| Yasui, Y | 1 |
| Yokokawa, H | 1 |
| Terao, K | 1 |
| Rimbach, G | 1 |
| Matsugo, S | 1 |
| Park, KG | 1 |
| Min, AK | 1 |
| Koh, EH | 1 |
| Kim, HS | 1 |
| Kim, MO | 1 |
| Park, HS | 1 |
| Kim, YD | 1 |
| Yoon, TS | 1 |
| Jang, BK | 1 |
| Hwang, JS | 1 |
| Kim, JB | 1 |
| Choi, HS | 1 |
| Park, JY | 1 |
| Lee, IK | 1 |
| Lee, KU | 1 |
| Walden, HR | 1 |
| Kirby, JA | 1 |
| Yeaman, SJ | 1 |
| Gray, J | 1 |
| Jones, DE | 1 |
| Palmer, JM | 1 |
| Monroe, RK | 1 |
| Halvorsen, SW | 1 |
| Filatova, NA | 1 |
| Kirpichnikova, KM | 1 |
| Aksenov, ND | 1 |
| Vakhromova, EA | 1 |
| Gamaleĭ, IA | 1 |
| Guerriero, E | 1 |
| Sorice, A | 1 |
| Capone, F | 1 |
| Costantini, S | 1 |
| Palladino, P | 1 |
| D'ischia, M | 1 |
| Castello, G | 1 |
| LEE, SJ | 1 |
| KAO, MS | 1 |
| HUANG, PC | 1 |
| SUNG, JL | 1 |
| MOORE, EC | 1 |
| REICHARD, P | 1 |
| Hultberg, B | 2 |
| Simbula, G | 1 |
| Columbano, A | 1 |
| Ledda-Columbano, GM | 1 |
| Sanna, L | 1 |
| Deidda, M | 1 |
| Diana, A | 1 |
| Pibiri, M | 1 |
| Hultberg, M | 1 |
| Isaksson, A | 1 |
| Andersson, A | 1 |
| Shi, DY | 1 |
| Liu, HL | 1 |
| Stern, JS | 1 |
| Yu, PZ | 1 |
| Liu, SL | 1 |
| Schultz, A | 1 |
| Sasaki, M | 1 |
| Natelson, S | 1 |
17 other studies available for thioctic acid and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Aberrant expression of cuproptosis‑related gene LIPT1 is associated with metabolic dysregulation of fatty acid and prognosis in hepatocellular carcinoma.
Topics: Apoptosis; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Copper; Fa | 2023 |
Integrated transcriptomic and proteomic analyses reveal ɑ-lipoic acid-regulated cell proliferation via Grb2-mediated signalling in hepatic cancer cells.
Topics: Carcinoma, Hepatocellular; Cell Proliferation; Disease-Free Survival; Female; Gene Expression Regula | 2018 |
Hydroxytyrosol attenuates tunicamycin-induced endoplasmic reticulum stress in human hepatocarcinoma cells.
Topics: Antioxidants; Carcinoma, Hepatocellular; Endoplasmic Reticulum Stress; Glutathione; Hep G2 Cells; He | 2014 |
Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-α-lipoic acid, in human hepatocellular carcinoma cells.
Topics: Adaptor Proteins, Signal Transducing; Apolipoprotein B-100; Carcinoma, Hepatocellular; Carrier Prote | 2016 |
Time Course Effect of R-Alpha-Lipoic Acid on Cellular Metabolomics in Cultured Hepatoma Cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Glucose; Humans; Liver Neop | 2017 |
Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways.
Topics: AMP-Activated Protein Kinases; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Activation; Fatty | 2008 |
Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway.
Topics: Adenosine Triphosphate; Animals; Autoimmunity; Caproates; Carcinoma, Hepatocellular; Cell Line; Cell | 2008 |
Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption.
Topics: 2,6-Dichloroindophenol; Antioxidants; Cadmium Chloride; Carcinoma, Hepatocellular; Cell Line, Tumor; | 2009 |
[Decrease in tumorigenic activity of murine hepatoma cells after treatment with antioxidants and melatonin].
Topics: Acetylcysteine; Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Cycle; Flow Cytometry; Humans | 2011 |
Effects of lipoic acid, caffeic acid and a synthesized lipoyl-caffeic conjugate on human hepatoma cell lines.
Topics: Antineoplastic Agents; Antioxidants; Caffeic Acids; Carcinoma, Hepatocellular; Cell Proliferation; C | 2011 |
THE EFFECT OF THIOCTIC ACID ON BLOOD ALPHA-KETO ACID LEVELS IN LIVER DISEASES.
Topics: Blood Chemical Analysis; Carcinoma, Hepatocellular; Chromatography; Hepatic Encephalopathy; Hepatiti | 1963 |
ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOTIDES. VI. THE CYTIDINE DIPHOSPHATE REDUCTASE SYSTEM FROM NOVIKOFF HEPATOMA.
Topics: Adenosine Triphosphate; Animals; Bacterial Proteins; Carcinoma, Hepatocellular; Cytosine Nucleotides | 1964 |
Elimination of high amounts of extracellular homocysteine in human cell lines.
Topics: Adenosine; Antioxidants; Arteriosclerosis; Carcinoma, Hepatocellular; Cell Line, Tumor; HeLa Cells; | 2005 |
Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Ascorbic Acid; bcl-2-Associated X Protein; Carcino | 2007 |
Traces of copper ions deplete glutathione in human hepatoma cell cultures with low cysteine content.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Copper; Cysteine; Glutathione; HeLa Cells; Humans; Merc | 2007 |
Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Enzyme Acti | 2008 |
Comparison of the ribonucleotide with the canavanine reductase system.
Topics: Amino Acid Oxidoreductases; Animals; Canavanine; Carcinoma, Hepatocellular; Cell Division; Cells, Cu | 1974 |