thioctic acid has been researched along with Heart Diseases in 8 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Arsenic trioxide was predicted to induce fibrosis by AP1-driven TGFβ expression and MMP2-driven TGFβ activation." | 1.62 | Network model-based screen for FDA-approved drugs affecting cardiac fibrosis. ( Chandrabhatla, AS; Christiansen, SL; Holmes, JW; Nelson, AR; Saucerman, JJ; Zeigler, AC, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Zeigler, AC | 1 |
| Chandrabhatla, AS | 1 |
| Christiansen, SL | 1 |
| Nelson, AR | 1 |
| Holmes, JW | 1 |
| Saucerman, JJ | 1 |
| Jiang, S | 1 |
| Zhu, W | 1 |
| Li, C | 1 |
| Zhang, X | 1 |
| Lu, T | 1 |
| Ding, Z | 1 |
| Cao, K | 1 |
| Liu, L | 1 |
| Sridharan, V | 1 |
| Seawright, JW | 1 |
| Antonawich, FJ | 1 |
| Garnett, M | 1 |
| Cao, M | 1 |
| Singh, P | 1 |
| Boerma, M | 1 |
| Mukherjee, R | 1 |
| Banerjee, S | 1 |
| Joshi, N | 1 |
| Singh, PK | 1 |
| Baxi, D | 1 |
| Ramachandran, AV | 1 |
| Ghibu, S | 1 |
| Delemasure, S | 1 |
| Richard, C | 1 |
| Guilland, JC | 1 |
| Martin, L | 1 |
| Gambert, S | 1 |
| Rochette, L | 1 |
| Vergely, C | 1 |
| Litovitz, TL | 1 |
| Assadnazari, H | 1 |
| Zimmer, G | 1 |
| Freisleben, HJ | 1 |
| Werk, W | 1 |
| Leibfritz, D | 1 |
| Chekunova, MP | 1 |
| Minkina, NA | 1 |
| Suvorov, IM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for thioctic acid and Heart Diseases
| Article | Year |
|---|---|
The anecdotal antidotes.
Topics: Acetylcysteine; Adult; Aged; Animals; Antidotes; Child; Cimetidine; Female; Ferrocyanides; Folic Aci | 1984 |
7 other studies available for thioctic acid and Heart Diseases
| Article | Year |
|---|---|
Network model-based screen for FDA-approved drugs affecting cardiac fibrosis.
Topics: Aminobutyrates; Angiotensin Receptor Antagonists; Animals; Arsenic Trioxide; Biphenyl Compounds; Com | 2021 |
α-Lipoic acid attenuates LPS-induced cardiac dysfunction through a PI3K/Akt-dependent mechanism.
Topics: Animals; Cardiotonic Agents; Endotoxemia; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 bet | 2013 |
Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; CD2 Antigens; Disease Models, Anim | 2017 |
A combination of melatonin and alpha lipoic acid has greater cardioprotective effect than either of them singly against cadmium-induced oxidative damage.
Topics: Animals; Antioxidants; Ascorbic Acid; Biomarkers; Cadmium Chloride; Drug Synergism; Drug Therapy, Co | 2011 |
General oxidative stress during doxorubicin-induced cardiotoxicity in rats: absence of cardioprotection and low antioxidant efficiency of alpha-lipoic acid.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Ascitic Fluid; Ascorbic Acid; Body Weight; Cardi | 2012 |
Cardioprotective efficiency of dihydrolipoic acid in working rat hearts during hypoxia and reoxygenation. 31P nuclear magnetic resonance investigations.
Topics: Adenosine Triphosphate; Animals; Creatine Kinase; Heart; Heart Diseases; Hypoxia; In Vitro Technique | 1993 |
[Pathogenetic therapy procedures in cobalt lesions of the myocardium].
Topics: Acute Disease; Animals; Cobalt; Decanoates; Drug Evaluation, Preclinical; Heart Diseases; Male; Meth | 1978 |