thioctic acid has been researched along with Fibromyalgia in 2 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Fibromyalgia: A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Drug therapy for fibromyalgia is limited by incomplete efficacy and dose-limiting adverse effects (AEs)." | 7.30 | Combination analgesic development for enhanced clinical efficacy (the CADENCE trial): a double-blind, controlled trial of an alpha-lipoic acid-pregabalin combination for fibromyalgia pain. ( Gilron, I; Holden, RR; Milev, R; Robb, S; Towheed, T; Tu, D, 2023) |
| "Drug therapy for fibromyalgia is limited by incomplete efficacy and dose-limiting adverse effects (AEs)." | 3.30 | Combination analgesic development for enhanced clinical efficacy (the CADENCE trial): a double-blind, controlled trial of an alpha-lipoic acid-pregabalin combination for fibromyalgia pain. ( Gilron, I; Holden, RR; Milev, R; Robb, S; Towheed, T; Tu, D, 2023) |
| "Fibromyalgia is a common and challenging chronic pain disorder with few, if any, highly effective and well-tolerated treatments." | 3.01 | Double-blind, randomized, placebo-controlled crossover trial of alpha-lipoic acid for the treatment of fibromyalgia pain: the IMPALA trial. ( Gilron, I; Gray, C; Holden, R; Milev, R; Robb, S; Towheed, T; Tu, D; Wang, L; Ziegler, D, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gilron, I | 2 |
| Robb, S | 2 |
| Tu, D | 2 |
| Holden, RR | 1 |
| Milev, R | 2 |
| Towheed, T | 2 |
| Holden, R | 1 |
| Ziegler, D | 1 |
| Wang, L | 1 |
| Gray, C | 1 |
2 trials available for thioctic acid and Fibromyalgia
| Article | Year |
|---|---|
Combination analgesic development for enhanced clinical efficacy (the CADENCE trial): a double-blind, controlled trial of an alpha-lipoic acid-pregabalin combination for fibromyalgia pain.
Topics: Analgesics; Double-Blind Method; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Pain; Pregabalin; Th | 2023 |
Double-blind, randomized, placebo-controlled crossover trial of alpha-lipoic acid for the treatment of fibromyalgia pain: the IMPALA trial.
Topics: Cross-Over Studies; Double-Blind Method; Female; Fibromyalgia; Humans; Male; Thioctic Acid; Treatmen | 2021 |