thioctic acid has been researched along with Fatty Liver in 23 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Development of nonalcoholic fatty liver disease (NAFLD) occurs through initial steatosis and subsequent oxidative stress." | 1.40 | The effects of α-lipoic acid on liver oxidative stress and free fatty acid composition in methionine-choline deficient diet-induced NAFLD. ( de Luka, S; Ethuričić, I; Jorgačević, B; Mladenović, D; Ninković, M; Radosavljević, TS; Sobajić, S; Stanković, MN; Vukicevic, RJ, 2014) |
| "Non-alcoholic steatohepatitis (NASH) is a liver disease that causes fat accumulation, inflammation and fibrosis." | 1.38 | Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice. ( Kim, HS; Kim, JG; Kim, MK; Lee, IK; Lee, KU; Min, AK; Park, KG; Seo, HY, 2012) |
| "Similarly, treatment of the fatty liver cell model with alpha-lipoic acid reduced intracellular lipid accumulation in HepG2 cells, increased AMPK phosphorylation, and induced ATGL expression." | 1.38 | Alpha-lipoic acid induces adipose triglyceride lipase expression and decreases intracellular lipid accumulation in HepG2 cells. ( Chen, WL; Kuo, YT; Lee, HM; Lin, TH, 2012) |
| "Chronic ALA supplementation prevents NAFLD through multiple mechanisms by reducing steatosis, oxidative stress, immune activation and inflammation in the liver." | 1.38 | α-lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats. ( Hahm, JR; Jeon, BT; Jung, TS; Kim, SK; Roh, GS; Shin, HJ, 2012) |
| "Carnitine treatment increased the mRNA expression of carnitine palmitoyltransferase 1A and peroxisome proliferator-activated receptor-γ, and carnitine-lipoic acid further augmented the mRNA expression." | 1.37 | Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction. ( Cho, WK; Choi, HS; Hahm, JS; Jang, KS; Jeon, HJ; Jun, DW; Jun, JH; Kim, HJ; Kwon, HJ; Lee, HL; Lee, KN; Lee, MH; Lee, OY; Yoon, BC, 2011) |
| "Fatty liver is common in obese subjects with insulin resistance." | 1.35 | Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. ( Choi, HS; Hwang, JS; Jang, BK; Kim, HS; Kim, JB; Kim, MO; Kim, YD; Koh, EH; Lee, IK; Lee, KU; Min, AK; Park, HS; Park, JY; Park, KG; Yoon, TS, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (21.74) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 15 (65.22) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Zwierz, M | 1 |
| Chabowski, A | 1 |
| Sztolsztener, K | 1 |
| Lee, SY | 1 |
| Sung, JH | 1 |
| Sena, CM | 1 |
| Cipriano, MA | 1 |
| Botelho, MF | 1 |
| Seiça, RM | 1 |
| Xu, J | 1 |
| Gao, H | 1 |
| Song, L | 1 |
| Yang, W | 1 |
| Chen, C | 1 |
| Deng, Q | 1 |
| Huang, Q | 1 |
| Yang, J | 1 |
| Huang, F | 1 |
| Tian, YF | 1 |
| He, CT | 1 |
| Chen, YT | 1 |
| Hsieh, PS | 1 |
| Kathirvel, E | 1 |
| Morgan, K | 1 |
| French, SW | 1 |
| Morgan, TR | 1 |
| Stanković, MN | 1 |
| Mladenović, D | 1 |
| Ninković, M | 1 |
| Ethuričić, I | 1 |
| Sobajić, S | 1 |
| Jorgačević, B | 1 |
| de Luka, S | 1 |
| Vukicevic, RJ | 1 |
| Radosavljević, TS | 1 |
| Yang, Y | 1 |
| Li, W | 1 |
| Liu, Y | 1 |
| Sun, Y | 1 |
| Li, Y | 1 |
| Yao, Q | 1 |
| Li, J | 1 |
| Zhang, Q | 1 |
| Gao, Y | 1 |
| Gao, L | 1 |
| Zhao, J | 1 |
| Park, KG | 2 |
| Min, AK | 2 |
| Koh, EH | 1 |
| Kim, HS | 2 |
| Kim, MO | 1 |
| Park, HS | 1 |
| Kim, YD | 1 |
| Yoon, TS | 1 |
| Jang, BK | 1 |
| Hwang, JS | 1 |
| Kim, JB | 1 |
| Choi, HS | 2 |
| Park, JY | 1 |
| Lee, IK | 2 |
| Lee, KU | 2 |
| Podymova, SD | 1 |
| Davletshina, IV | 1 |
| Jun, DW | 1 |
| Cho, WK | 1 |
| Jun, JH | 1 |
| Kwon, HJ | 1 |
| Jang, KS | 1 |
| Kim, HJ | 1 |
| Jeon, HJ | 1 |
| Lee, KN | 1 |
| Lee, HL | 1 |
| Lee, OY | 1 |
| Yoon, BC | 1 |
| Hahm, JS | 1 |
| Lee, MH | 1 |
| Kim, MK | 1 |
| Seo, HY | 1 |
| Kim, JG | 1 |
| Valdecantos, MP | 2 |
| Pérez-Matute, P | 2 |
| González-Muniesa, P | 2 |
| Prieto-Hontoria, PL | 2 |
| Moreno-Aliaga, MJ | 2 |
| Martínez, JA | 2 |
| Kuo, YT | 1 |
| Lin, TH | 1 |
| Chen, WL | 1 |
| Lee, HM | 1 |
| Jung, TS | 1 |
| Kim, SK | 1 |
| Shin, HJ | 1 |
| Jeon, BT | 1 |
| Hahm, JR | 1 |
| Roh, GS | 1 |
| Kapoor, S | 1 |
| Kaya-Dagistanli, F | 1 |
| Tanriverdi, G | 1 |
| Altinok, A | 1 |
| Ozyazgan, S | 1 |
| Ozturk, M | 1 |
| HATAKEYAMA, T | 1 |
| KRUESKEMPER, HL | 1 |
| KORUS, W | 1 |
| NOMURA, T | 1 |
| Möller, E | 1 |
| Schmitt, R | 1 |
| Ishida, K | 1 |
2 trials available for thioctic acid and Fatty Liver
| Article | Year |
|---|---|
[Efficacy of using alpha-lipoic acid (berlition) in patients with nonalcoholic steatohepatitis].
Topics: Adult; Aged; Antioxidants; Dose-Response Relationship, Drug; Drug Administration Schedule; Energy Me | 2008 |
[A contribution to the treatment of chronic liver diseases (author's transl)].
Topics: Administration, Oral; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Chronic Disease; Cl | 1976 |
21 other studies available for thioctic acid and Fatty Liver
| Article | Year |
|---|---|
α-Lipoic acid - a promising agent for attenuating inflammation and preventing steatohepatitis in rats fed a high-fat diet.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Diet, High-Fat; Fatty Liver; Inflammation; Liver; Male | 2023 |
Gut-liver on a chip toward an in vitro model of hepatic steatosis.
Topics: Butyrates; Caco-2 Cells; Fatty Liver; Gastrointestinal Tract; Hep G2 Cells; Humans; Lab-On-A-Chip De | 2018 |
Lipoic Acid Prevents High-Fat Diet-Induced Hepatic Steatosis in Goto Kakizaki Rats by Reducing Oxidative Stress Through Nrf2 Activation.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Diet, High-Fat; Fatty Liver; Lipid Peroxidation; M | 2018 |
Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard.
Topics: Animals; Diet, High-Fat; Dietary Fats; Fatty Liver; Humans; Linseed Oil; Lipid Accumulation Product; | 2013 |
Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Cytokines; Disease Models, Animal; Endotoxemia; Fatty | 2013 |
Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease.
Topics: Acetylcarnitine; Adipose Tissue; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransfe | 2013 |
The effects of α-lipoic acid on liver oxidative stress and free fatty acid composition in methionine-choline deficient diet-induced NAFLD.
Topics: Animals; Choline; Diet; Fatty Acids, Nonesterified; Fatty Liver; Humans; Lipid Peroxidation; Liver; | 2014 |
Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway.
Topics: Adenylate Kinase; AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Fatty Liver; Male; Mice; M | 2014 |
Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways.
Topics: AMP-Activated Protein Kinases; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Activation; Fatty | 2008 |
Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Carnitine; Carnitine O-Palmitoyltransferase; Choline Def | 2011 |
Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline; Choline Deficiency; Cyto | 2012 |
Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3.
Topics: Animals; Antioxidants; Blotting, Western; Body Weight; Diet, High-Fat; Disease Models, Animal; Fatty | 2012 |
Lipoic acid administration prevents nonalcoholic steatosis linked to long-term high-fat feeding by modulating mitochondrial function.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Body Weight; Citric Acid Cycle; Diet, High-Fat; Enzy | 2012 |
Alpha-lipoic acid induces adipose triglyceride lipase expression and decreases intracellular lipid accumulation in HepG2 cells.
Topics: Active Transport, Cell Nucleus; AMP-Activated Protein Kinases; Cell Nucleus; Enzyme Activation; Fatt | 2012 |
α-lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats.
Topics: Acetyl-CoA Carboxylase; Adiponectin; Aldehydes; Animals; Azo Compounds; Blood Glucose; Blotting, Wes | 2012 |
Hepato-protective effects of alpha lipoic acid besides its role in preventing fatty liver disease.
Topics: Animals; Fatty Liver; Gene Expression Regulation; Immunity, Innate; Liver; Thioctic Acid | 2013 |
The effects of alpha lipoic acid on liver cells damages and apoptosis induced by polyunsaturated fatty acids.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Fatty Acids, Omega-6; Fatty Liver; Fibrosis; Hepatic St | 2013 |
[Studies on nutrition and hepatic injury. 4. Studies on experimental fatty liver; effects of addition of lipoic acid, orotic acid, lvsine, threonine, and fermented sovbeans].
Topics: Fatty Liver; Glycine max; Liver Diseases; Lysine; Nutritional Status; Orotic Acid; Thioctic Acid; Th | 1961 |
[The effect of lipoic acid on degradation of cortisone in experimental fatty liver].
Topics: Cortisone; Fatty Liver; Liver Diseases; Thioctic Acid | 1961 |
[HISTOLOGICAL STUDY ON NUCLEIC ACIDS OF THE LIVER IN DIETARY LIVER DISORDERS. 2. THE RESULTS IN THE GROUPS FED BUCKWHEAT WITH ANTI-FATTY LIVER AGENTS].
Topics: Animals; Caseins; Diet; Edible Grain; Fagopyrum; Fatty Liver; Folic Acid; Liver; Methionine; Mice; N | 1964 |
[Studies on the erythrocyte carbohydrate metabolism in various conditions].
Topics: Anabolic Agents; Animals; Erythrocytes; Ethanol; Fatty Liver; Galactose; Glucose; Hexoses; Humans; I | 1968 |