thioctic acid has been researched along with Encephalopathy, Toxic in 10 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomized double-blind placebo-controlled prospective study included 64 patients with breast cancer who were randomized into control group (n = 32) which received 4 cycles of doxorubicin plus cyclophosphamide (every 21 days) followed by weekly doses of paclitaxel for 12 weeks plus placebo tablets once daily and ALA group (n = 32) which received the same chemotherapeutic regimen plus ALA 600 once daily for 6 months." | 9.51 | Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients. ( Elshafiey, RA; Elzawawy, S; Ghoneim, A; Mostafa, TM; Werida, RH, 2022) |
| "This randomized double-blind placebo-controlled prospective study included 64 patients with breast cancer who were randomized into control group (n = 32) which received 4 cycles of doxorubicin plus cyclophosphamide (every 21 days) followed by weekly doses of paclitaxel for 12 weeks plus placebo tablets once daily and ALA group (n = 32) which received the same chemotherapeutic regimen plus ALA 600 once daily for 6 months." | 5.51 | Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients. ( Elshafiey, RA; Elzawawy, S; Ghoneim, A; Mostafa, TM; Werida, RH, 2022) |
| " High attrition rates due to poor patient compliance and manner of dosage administration in this trial demonstrated a lack of feasibility for this intervention." | 2.79 | Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial. ( Dakhil, SR; Eng, C; Fisch, MJ; Forman, A; Gilman, P; Guo, Y; Jones, D; Mills, GM; Noga, SJ; Overman, MJ; Palmer, JL; Velasco, MR; Weiss, M, 2014) |
| "Ifosfamide (IFOS) which is a cytotoxic alkylating agent may cause central nervous system toxicity." | 1.40 | Effect of alpha lipoic acid on ifosfamide-induced central neurotoxicity in rats. ( Albayrak, A; Bilen, S; Fadillioglu, E; Ginis, Z; Kurt, SN; Ozturk, G, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mishra, MK | 1 |
| Wang, J | 1 |
| Mirzaei, R | 1 |
| Chan, R | 1 |
| Melo, H | 1 |
| Zhang, P | 1 |
| Ling, CC | 1 |
| Bruccoleri, A | 1 |
| Tang, L | 1 |
| Yong, VW | 1 |
| Werida, RH | 1 |
| Elshafiey, RA | 1 |
| Ghoneim, A | 1 |
| Elzawawy, S | 1 |
| Mostafa, TM | 1 |
| Yang, T | 1 |
| Xu, Z | 1 |
| Liu, W | 2 |
| Xu, B | 2 |
| Deng, Y | 2 |
| Yuan, Y | 1 |
| Yang, J | 1 |
| Chen, J | 1 |
| Zhao, S | 1 |
| Wang, T | 1 |
| Zou, H | 1 |
| Wang, Y | 1 |
| Gu, J | 1 |
| Liu, X | 1 |
| Bian, J | 1 |
| Liu, Z | 1 |
| Ozturk, G | 1 |
| Ginis, Z | 1 |
| Kurt, SN | 1 |
| Albayrak, A | 1 |
| Bilen, S | 1 |
| Fadillioglu, E | 1 |
| Guo, Y | 1 |
| Jones, D | 1 |
| Palmer, JL | 1 |
| Forman, A | 1 |
| Dakhil, SR | 1 |
| Velasco, MR | 1 |
| Weiss, M | 1 |
| Gilman, P | 1 |
| Mills, GM | 1 |
| Noga, SJ | 1 |
| Eng, C | 1 |
| Overman, MJ | 1 |
| Fisch, MJ | 1 |
| Yang, TY | 1 |
| Xu, ZF | 1 |
| Li, YH | 1 |
| Feng, S | 1 |
| Bist, R | 1 |
| Bhatt, DK | 1 |
| Nagesh Babu, G | 1 |
| Kumar, A | 1 |
| Singh, RL | 1 |
| Puerta, E | 1 |
| Hervias, I | 1 |
| Goñi-Allo, B | 1 |
| Zhang, SF | 1 |
| Jordán, J | 1 |
| Starkov, AA | 1 |
| Aguirre, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Alpha-Lipoic Acid Against Chemotherapy Induced Toxicities in Breast Cancer Patients[NCT03908528] | 64 participants (Actual) | Interventional | 2019-03-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for thioctic acid and Encephalopathy, Toxic
| Article | Year |
|---|---|
Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cardiotoxicity; Doxorubicin; Femal | 2022 |
Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cispl | 2014 |
8 other studies available for thioctic acid and Encephalopathy, Toxic
| Article | Year |
|---|---|
A Distinct
Topics: Animals; Antioxidants; Hibiscus; Iron; Mice; Multiple Sclerosis; Neurotoxicity Syndromes; Plant Extr | 2022 |
Oxidative stress accelerates synaptic glutamate dyshomeostasis and NMDARs disorder during methylmercury-induced neuronal apoptosis in rat cerebral cortex.
Topics: Animals; Antioxidants; Apoptosis; Cerebral Cortex; Glutamic Acid; Male; Methylmercury Compounds; Neu | 2020 |
Alpha-lipoic acid protects against cadmium-induced neuronal injury by inhibiting the endoplasmic reticulum stress eIF2α-ATF4 pathway in rat cortical neurons in vitro and in vivo.
Topics: Acetates; Activating Transcription Factor 4; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cadm | 2019 |
Effect of alpha lipoic acid on ifosfamide-induced central neurotoxicity in rats.
Topics: Animals; Antioxidants; Brain; Caspase 3; Catalase; Ifosfamide; Male; Malondialdehyde; Neurons; Neuro | 2014 |
Alpha-lipoic acid protects against methylmercury-induced neurotoxic effects via inhibition of oxidative stress in rat cerebral cortex.
Topics: Animals; Cerebral Cortex; Environmental Pollutants; Excitatory Amino Acid Transporter 1; Excitatory | 2015 |
The evaluation of effect of alpha-lipoic acid and vitamin E on the lipid peroxidation, gamma-amino butyric acid and serotonin level in the brain of mice (Mus musculus) acutely intoxicated with lindane.
Topics: Animals; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Insecticides | 2009 |
Chronic pretreatment with acetyl-L-carnitine and ±DL-α-lipoic acid protects against acute glutamate-induced neurotoxicity in rat brain by altering mitochondrial function.
Topics: Acetylcarnitine; Animals; Brain; Drug Therapy, Combination; Glutamic Acid; Male; Mitochondria; Neuro | 2011 |
Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity.
Topics: Animals; Antioxidants; Corpus Striatum; Dopamine; Electron Transport Complex I; Free Radicals; Hallu | 2010 |