thioctic acid has been researched along with Electron Transport Chain Deficiencies, Mitochondrial in 17 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitochondrial diseases are a group of rare multisystem disorders characterized by genetic heterogeneity and pleomorphic clinical manifestations." | 1.48 | Nutritional support in mitochondrial diseases: the state of the art. ( Cintoni, M; Mele, MC; Pizzoferrato, M; Rinninella, E; Servidei, S, 2018) |
| "Acrolein is a highly reactive unsaturated hazardous air pollutant of human health concern, particularly as a component of cigarette smoke." | 1.35 | Protective effect of lipoic acid against acrolein-induced cytotoxicity in IMR-90 human fibroblasts. ( Bai, Y; Jia, L; Zhai, L; Zhang, Z, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 10 (58.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rinninella, E | 1 |
| Pizzoferrato, M | 1 |
| Cintoni, M | 1 |
| Servidei, S | 1 |
| Mele, MC | 1 |
| Nicolson, GL | 1 |
| Lacasa Maseri, A | 1 |
| Yun Castilla, C | 1 |
| Mota Ybancos, JL | 1 |
| Rodríguez-Pombo, P | 1 |
| Mehrotra, A | 1 |
| Kanwal, A | 1 |
| Banerjee, SK | 1 |
| Sandhir, R | 1 |
| Kishita, Y | 1 |
| Pajak, A | 1 |
| Bolar, NA | 1 |
| Marobbio, CM | 1 |
| Maffezzini, C | 1 |
| Miniero, DV | 1 |
| Monné, M | 1 |
| Kohda, M | 1 |
| Stranneheim, H | 1 |
| Murayama, K | 1 |
| Naess, K | 1 |
| Lesko, N | 1 |
| Bruhn, H | 1 |
| Mourier, A | 1 |
| Wibom, R | 1 |
| Nennesmo, I | 1 |
| Jespers, A | 1 |
| Govaert, P | 1 |
| Ohtake, A | 1 |
| Van Laer, L | 1 |
| Loeys, BL | 1 |
| Freyer, C | 1 |
| Palmieri, F | 1 |
| Wredenberg, A | 1 |
| Okazaki, Y | 1 |
| Wedell, A | 1 |
| Jia, L | 2 |
| Zhang, Z | 1 |
| Zhai, L | 1 |
| Bai, Y | 1 |
| Orsucci, D | 1 |
| Filosto, M | 1 |
| Siciliano, G | 1 |
| Mancuso, M | 1 |
| Brenner, SR | 1 |
| Navarro-Sastre, A | 2 |
| Tort, F | 2 |
| Stehling, O | 1 |
| Uzarska, MA | 1 |
| Arranz, JA | 2 |
| Del Toro, M | 2 |
| Labayru, MT | 1 |
| Landa, J | 1 |
| Font, A | 2 |
| Garcia-Villoria, J | 1 |
| Merinero, B | 1 |
| Ugarte, M | 1 |
| Gutierrez-Solana, LG | 1 |
| Campistol, J | 2 |
| Garcia-Cazorla, A | 2 |
| Vaquerizo, J | 1 |
| Riudor, E | 2 |
| Briones, P | 2 |
| Elpeleg, O | 1 |
| Ribes, A | 2 |
| Lill, R | 1 |
| Pfeffer, G | 1 |
| Majamaa, K | 1 |
| Turnbull, DM | 1 |
| Thorburn, D | 1 |
| Chinnery, PF | 1 |
| Haack, TB | 1 |
| Rolinski, B | 1 |
| Haberberger, B | 1 |
| Zimmermann, F | 1 |
| Schum, J | 1 |
| Strecker, V | 1 |
| Graf, E | 1 |
| Athing, U | 1 |
| Hoppen, T | 1 |
| Wittig, I | 1 |
| Sperl, W | 1 |
| Freisinger, P | 1 |
| Mayr, JA | 1 |
| Strom, TM | 1 |
| Meitinger, T | 1 |
| Prokisch, H | 1 |
| Ferrer-Cortès, X | 1 |
| Bujan, N | 1 |
| Matalonga, L | 1 |
| Mythili, Y | 1 |
| Sudharsan, PT | 1 |
| Varalakshmi, P | 1 |
| Rodriguez, MC | 1 |
| MacDonald, JR | 1 |
| Mahoney, DJ | 1 |
| Parise, G | 1 |
| Beal, MF | 1 |
| Tarnopolsky, MA | 1 |
| Liu, Z | 1 |
| Sun, L | 1 |
| Miller, SS | 1 |
| Ames, BN | 1 |
| Cotman, CW | 1 |
| Liu, J | 2 |
| Ambrose, M | 1 |
| Goldstine, JV | 1 |
| Gatti, RA | 1 |
| Shen, W | 1 |
| Liu, K | 1 |
| Tian, C | 1 |
| Yang, L | 1 |
| Li, X | 1 |
| Ren, J | 1 |
| Packer, L | 1 |
| Head, E | 1 |
| Sharman, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blinded, Placebo-controlled Trial of Idebenone in the Prevention of Episodic Migraine[NCT04151472] | Phase 3 | 180 participants (Anticipated) | Interventional | 2021-12-08 | Recruiting | ||
| A Phase II, Monocenter, Single Arm Study To Assess The Safety and Efficacy Of Combination Deoxycytidine and Deoxythymidine For Mitochondrial Depletion Disorders[NCT04802707] | Phase 2 | 50 participants (Anticipated) | Interventional | 2021-10-18 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thioctic acid and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Electron transfer mediators and other metabolites and cofactors in the treatment of mitochondrial dysfunction.
Topics: Acidosis, Lactic; Animals; Antioxidants; Carnitine; Creatine; Dietary Supplements; Electron Transpor | 2009 |
Treatment for mitochondrial disorders.
Topics: Creatine; Dichloroacetic Acid; Humans; Mitochondrial Diseases; Randomized Controlled Trials as Topic | 2012 |
1 trial available for thioctic acid and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adolescent; Adult; Analysis of Variance; Antioxidants; Body Composition | 2007 |
14 other studies available for thioctic acid and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Nutritional support in mitochondrial diseases: the state of the art.
Topics: Arginine; Deglutition Disorders; Diet, High-Fat; Energy Metabolism; Humans; Mitochondria; Mitochondr | 2018 |
Mitochondrial dysfunction and chronic disease: treatment with natural supplements.
Topics: Carnitine; Dietary Supplements; Fatigue Syndrome, Chronic; Humans; Mitochondrial Diseases; NAD; Thio | 2014 |
[Severe pulmonary hypertension: initial manifestation of a new deficiency of the lipoic acid metabolism].
Topics: Biomarkers; Carrier Proteins; Fatal Outcome; Genetic Markers; Humans; Hypertension, Pulmonary; Infan | 2014 |
Mitochondrial modulators in experimental Huntington's disease: reversal of mitochondrial dysfunctions and cognitive deficits.
Topics: Acetylcarnitine; Animals; Cognition Disorders; Drug Therapy, Combination; Female; Huntington Disease | 2015 |
Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Calcium-Binding Proteins; Child, Preschool; DNA M | 2015 |
Protective effect of lipoic acid against acrolein-induced cytotoxicity in IMR-90 human fibroblasts.
Topics: Acrolein; Adenosine Triphosphate; Air Pollutants; Antioxidants; Cell Line; Cell Survival; Cytotoxins | 2009 |
Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs.
Topics: Brain Diseases, Metabolic; Chronic Disease; Disease Progression; DNA, Mitochondrial; Genetic Predisp | 2010 |
A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins.
Topics: Amino Acid Oxidoreductases; Carrier Proteins; Chromosomes, Human, Pair 2; Female; HeLa Cells; Homozy | 2011 |
Homozygous missense mutation in BOLA3 causes multiple mitochondrial dysfunctions syndrome in two siblings.
Topics: Amino Acid Sequence; Electron Transport; Female; Fibroblasts; Homozygote; Humans; Infant, Newborn; M | 2013 |
Protein expression profiles in patients carrying NFU1 mutations. Contribution to the pathophysiology of the disease.
Topics: Carrier Proteins; Electron Transport; Fibroblasts; Genotype; Homozygote; Humans; Infant; Mitochondri | 2013 |
dl-alpha-lipoic acid ameliorates cyclophosphamide induced cardiac mitochondrial injury.
Topics: Animals; Antineoplastic Agents, Alkylating; Cyclophosphamide; Electron Transport Chain Complex Prote | 2005 |
Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid.
Topics: Acrolein; Antioxidants; Cell Line; Cell Survival; Cytoprotection; Electron Transport Chain Complex P | 2007 |
Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells.
Topics: Antioxidants; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Ce | 2007 |
Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid.
Topics: Acetylcarnitine; Animals; Cell Line, Tumor; Insulinoma; Islets of Langerhans; Mitochondrial Diseases | 2008 |