Page last updated: 2024-10-19

thioctic acid and Drug-Related Side Effects and Adverse Reactions

thioctic acid has been researched along with Drug-Related Side Effects and Adverse Reactions in 4 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.

Research Excerpts

Excerpt	Relevance	Reference
"Malondialdehyde was increased as an indicator of free radical formation in AK-induced group and decreased with ALA treatment."	1.42	The impact of alpha-lipoic acid on amikacin-induced nephrotoxicity. ( Asci, H; Bayram, D; Candan, IA; Cankara, FN; Ilhan, I; Saygin, M; Yesilot, S, 2015)
" ALA was not acutely toxic to rats (LD(50)>2000mg/kg bw, OECD method 425)."	1.33	Safety evaluation of alpha-lipoic acid (ALA). ( Cremer, DR; Lynch, B; Rabeler, R; Roberts, A, 2006)

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (25.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (50.00)	29.6817
2010's	1 (25.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Asci, H	1
Saygin, M	1
Cankara, FN	1
Bayram, D	1
Yesilot, S	1
Candan, IA	1
Ilhan, I	1
DE BENEDICTIS, G	1
CACUDI, G	1
Cremer, DR	1
Rabeler, R	1
Roberts, A	1
Lynch, B	1
Coleman, MD	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Dose Finding and Tolerability Study of Alpha-lipoic Acid in Patients at Risk for Paclitaxel Induced Peripheral Neuropathy[NCT01313117]			Phase 1/Phase 2	9 participants (Actual)	Interventional	2012-02-29	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cumulative Rate of Adverse Events

(NCT01313117)
Timeframe: 4 months

Intervention	participants (Number)
Alpha Lipoic Acid	9

Identification of the Optimal Dose of ALA Based on Acceptable Adverse Event(AE) Profile

Based on acceptable adverse event (AE) profile and continual reassessment method dose escalation. (NCT01313117)
Timeframe: 4 months

Intervention	mg (Number)
Alpha Lipoic Acid	500

Proportion of Patients Who Complete the Proposed Regimen of Daily ALA

(NCT01313117)
Timeframe: 4 months

Intervention	participants (Number)
Alpha Lipoic Acid	7

Other Studies

4 other studies available for thioctic acid and Drug-Related Side Effects and Adverse Reactions

Article	Year
The impact of alpha-lipoic acid on amikacin-induced nephrotoxicity. Renal failure, 2015, Volume: 37, Issue:1 Topics: Amikacin; Animals; Anti-Bacterial Agents; Antioxidants; Blood Urea Nitrogen; Creatinine; Disease Mod	2015
[Experimental research on the possible protective action of thioctic acid in acute isonicotinic acid hydrazide poisoning. II]. Giornale di clinica medica, 1959, Volume: 40, Issue:5 Topics: Drug-Related Side Effects and Adverse Reactions; Isoniazid; Thioctic Acid; Vitamin A; Vitamin K; Vit	1959
Safety evaluation of alpha-lipoic acid (ALA). Regulatory toxicology and pharmacology : RTP, 2006, Volume: 46, Issue:1 Topics: Animals; Antioxidants; Behavior, Animal; Body Weight; Drug-Related Side Effects and Adverse Reaction	2006
Improvement of patient tolerance to dapsone: current and future developments. Dermatology online journal, 2007, Oct-13, Volume: 13, Issue:4 Topics: Antioxidants; Cimetidine; Dapsone; Dermatologic Agents; Drug-Related Side Effects and Adverse Reacti	2007