thioctic acid has been researched along with Down Syndrome in 2 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lott, IT | 1 |
| Doran, E | 1 |
| Nguyen, VQ | 1 |
| Tournay, A | 1 |
| Head, E | 1 |
| Gillen, DL | 1 |
| Gualandri, W | 1 |
| Gualandri, L | 1 |
| Demartini, G | 1 |
| Esposti, R | 1 |
| Marthyn, P | 1 |
| Volontè, S | 1 |
| Stangoni, L | 1 |
| Borgonovo, M | 1 |
| Fraschini, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Alpha Lipoic Acid on the Incidence and Severity of Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients[NCT05023863] | Phase 2/Phase 3 | 70 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for thioctic acid and Down Syndrome
| Article | Year |
|---|---|
Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation.
Topics: alpha-Tocopherol; Alzheimer Disease; Antioxidants; Ascorbic Acid; Down Syndrome; Drug Combinations; | 2011 |
1 other study available for thioctic acid and Down Syndrome
| Article | Year |
|---|---|
Redox balance in patients with Down's syndrome before and after dietary supplementation with alpha-lipoic acid and L-cysteine.
Topics: Adolescent; Child; Child, Preschool; Cysteine; Dietary Supplements; Down Syndrome; Female; Humans; I | 2003 |