thioctic acid has been researched along with Disease Models, Animal in 248 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mirtazapine (MIRT) is a multi-target antidepressant used in treatment of severe depression with promising efficacy, but also with important side effects, mainly sedation and weight gain." | 8.12 | Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. ( Chaves Filho, AJM; Cunha, NL; De Oliveira, GMF; Gadelha Filho, CVJ; Jucá, PM; Macedo, DS; Oliveira, TQ; Soares, MVR; Vasconcelos, SMM; Viana, GA; Vieira, CFX, 2022) |
| "w", given orally) of sodium R-lipoate (NaRLA) and enzymatically-modified isoquercitrin (EMIQ) in alleviating both local/systemic non-immunological anaphylactic reactions and stress-induced gastric ulceration in mice, in comparison with sulfasalazine (SSZ) as a reference drug." | 8.02 | Sodium R-lipoate and enzymatically-modified isoquercitrin suppressed IgE-independent anaphylactic reactions and stress-induced gastric ulceration in mice. ( Mohammed, HA; Ramadan, G; Waheed, G, 2021) |
| "Niacin has been widely used as an antihyperlipidemic drug, but the flushing effect restricted its clinical application." | 7.96 | Discovery of a novel niacin-lipoic acid dimer N2L attenuating atherosclerosis and dyslipidemia with non-flushing effects. ( Cai, W; Chen, J; Jiang, Y; Jin, M; Liu, P; Pi, R; Yan, J; Yao, M, 2020) |
| "Metformin or/and α-LA attenuated the severity of the DSS-induced colitis through improving the reductions in body weights, the DAI, the colonic oxidative stress markers, TNF-α, and NF-κB levels, and the morphological mucosal damage scores." | 7.88 | New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats. ( Elaidy, SM; Essawy, SS; Hassan, MS; Samman, FS, 2018) |
| "Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones." | 7.85 | α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria. ( Beck, JN; Bose, N; Chi, T; Damodar, S; Gerona, RR; Hall, D; Kahn, A; Kapahi, P; Killilea, DW; O'Leary, MN; Parihar, J; Ramanathan, A; Sahota, A; Stoller, ML; Tischfield, J; Yang, M; Yang, S; Zee, J; Zee, T, 2017) |
| "The therapeutic impact of DHL-HisZn on mast-cell-mediated type I hypersensitivity was evaluated by a mast-cell degranulation assay using bone marrow-derived mast cells and by a mouse model of ovalbumin (OVA)-induced allergic rhinitis." | 7.85 | Therapeutic potential of α-lipoic acid derivative, sodium zinc histidine dithiooctanamide, in a mouse model of allergic rhinitis. ( Chen, CL; Goto, S; Hsu, LW; Inomata, M; Kitano, S; Lai, CY; Nakano, T; Takaoka, Y, 2017) |
| "Mechanical and cold allodynia were reduced by thioctic acid injection." | 7.81 | The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model. ( Chung, EY; Kahng, J; Kim, TK; Kim, YS; Moon, JY, 2015) |
| "The oxidative stress plays an important signaling role in pilocarpine-induced seizures, and antioxidant drugs might be considered as therapeutical tools in this pathology." | 7.77 | Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; Feng, D; Jordán, J, 2011) |
| "To evaluate whether alpha-lipoic acid (LA) inhibits lens opacity of naphthalene-induced cataract by altering post-translational modifications (PTMs) and protecting the chaperone activity of alpha-crystallins." | 7.76 | alpha-Lipoic acid alters post-translational modifications and protects the chaperone activity of lens alpha-crystallin in naphthalene-induced cataract. ( Chen, Y; Fang, Y; Jang, Y; Wei, L; Wu, X; Yan, G; Yi, L; Zhou, X, 2010) |
| "In the present study, we investigated the effects of lipoic acid (LA) in the brain oxidative stress caused by pilocarpine-induced seizures in adult rats." | 7.76 | Lipoic acid alters delta-aminolevulinic dehydratase, glutathione peroxidase and Na+,K+-ATPase activities and glutathione-reduced levels in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM, 2010) |
| "Galactosamine, a selective hepatotoxin, produces in rats histologic alterations, which show the characteristics of severe human viral hepatitis." | 7.67 | Effect of coenzyme-A, NAD, alpha lipoic-acid and cocarboxylase on survival of rats with galactosamine-induced severe hepatitis. ( Rajacic, Z; Thölen, H; Zimmerli, W, 1985) |
| "Schizophrenia is a chronic mental disorder reported to compromise about 1% of the world's population." | 5.48 | Advantages of the Alpha-lipoic Acid Association with Chlorpromazine in a Model of Schizophrenia Induced by Ketamine in Rats: Behavioral and Oxidative Stress evidences. ( Cysne Filho, FMS; de Almeida, JC; de Sousa, CNS; Diniz, DDS; Macêdo, D; Patrocínio, CFV; Patrocínio, MCA; Sampaio, LRL; Vasconcelos, SMM, 2018) |
| " The present study aimed to investigate the effects of the typical antipsychotic chlorpromazine (CP) alone or combined with the natural antioxidant alpha-lipoic acid (ALA) on changes in the hippocampal average spectral power induced by ketamine (KET)." | 5.46 | Electroencephalographic study of chlorpromazine alone or combined with alpha-lipoic acid in a model of schizophrenia induced by ketamine in rats. ( Barbosa, TM; Borges, LTN; Gularte, VN; Lima, RF; Macêdo, D; Matos, NCB; Oliveira, MN; Patrocínio, MCA; Sampaio, LRL; Vale, OCD; Vasconcelos, SMM, 2017) |
| "Chronic hepatitis is recognized as a worldwide health problem that gradually progresses towards cirrhosis and hepatocellular carcinoma." | 5.43 | Curcumin, Silybin Phytosome(®) and α-R-Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production. ( Ali, SO; Darwish, HA; Ismail, NA, 2016) |
| "5 improved most of the parameters evaluated in this study without causing motor impairment demonstrating, thus, that possibly when combined with ALA a lower dose of CLZ is required." | 5.42 | Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and neurotrophic mechanisms. ( de Lucena, DF; de Sousa, CN; Gama, CS; Lima, LL; Macêdo, D; Oliveira, Tde Q; Vasconcelos, GS; Vasconcelos, SM; Ximenes, NC, 2015) |
| "Inflammation was induced by injection of 0." | 5.36 | Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA. ( El-Desoky, K; El-Ghareib, MA; El-Masry, SA; El-Shitany, NA, 2010) |
| "The risk of seizures increases to the extent that the injury is associated with sub-arachnoid hemorrhage and hematoma." | 5.32 | Lipoic acid pretreatment attenuates ferric chloride-induced seizures in the rat. ( Lee, JK; Meyerhoff, JL; Rittase, BW; Tsang, AY; Yourick, DL, 2004) |
| "Mirtazapine (MIRT) is a multi-target antidepressant used in treatment of severe depression with promising efficacy, but also with important side effects, mainly sedation and weight gain." | 4.12 | Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. ( Chaves Filho, AJM; Cunha, NL; De Oliveira, GMF; Gadelha Filho, CVJ; Jucá, PM; Macedo, DS; Oliveira, TQ; Soares, MVR; Vasconcelos, SMM; Viana, GA; Vieira, CFX, 2022) |
| "w", given orally) of sodium R-lipoate (NaRLA) and enzymatically-modified isoquercitrin (EMIQ) in alleviating both local/systemic non-immunological anaphylactic reactions and stress-induced gastric ulceration in mice, in comparison with sulfasalazine (SSZ) as a reference drug." | 4.02 | Sodium R-lipoate and enzymatically-modified isoquercitrin suppressed IgE-independent anaphylactic reactions and stress-induced gastric ulceration in mice. ( Mohammed, HA; Ramadan, G; Waheed, G, 2021) |
| "Niacin has been widely used as an antihyperlipidemic drug, but the flushing effect restricted its clinical application." | 3.96 | Discovery of a novel niacin-lipoic acid dimer N2L attenuating atherosclerosis and dyslipidemia with non-flushing effects. ( Cai, W; Chen, J; Jiang, Y; Jin, M; Liu, P; Pi, R; Yan, J; Yao, M, 2020) |
| "Metformin or/and α-LA attenuated the severity of the DSS-induced colitis through improving the reductions in body weights, the DAI, the colonic oxidative stress markers, TNF-α, and NF-κB levels, and the morphological mucosal damage scores." | 3.88 | New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats. ( Elaidy, SM; Essawy, SS; Hassan, MS; Samman, FS, 2018) |
| "The therapeutic impact of DHL-HisZn on mast-cell-mediated type I hypersensitivity was evaluated by a mast-cell degranulation assay using bone marrow-derived mast cells and by a mouse model of ovalbumin (OVA)-induced allergic rhinitis." | 3.85 | Therapeutic potential of α-lipoic acid derivative, sodium zinc histidine dithiooctanamide, in a mouse model of allergic rhinitis. ( Chen, CL; Goto, S; Hsu, LW; Inomata, M; Kitano, S; Lai, CY; Nakano, T; Takaoka, Y, 2017) |
| " We examined the inhibitory effects of a selective phosphodiesterase-3 inhibitor, cilostazol (CZ), and two antioxidants, enzymatically modified isoquercitrin (EMIQ) and α-lipoic acid (ALA), against dextran sulphate sodium (DSS)-induced colitis." | 3.85 | Anti-inflammatory effects of the selective phosphodiesterase 3 inhibitor, cilostazol, and antioxidants, enzymatically-modified isoquercitrin and α-lipoic acid, reduce dextran sulphate sodium-induced colorectal mucosal injury in mice. ( Abe, H; Hayashi, SM; Kangawa, Y; Kihara, T; Miyashita, T; Nakamura, M; Seto, Y; Shibutani, M; Yoshida, T, 2017) |
| "Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones." | 3.85 | α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria. ( Beck, JN; Bose, N; Chi, T; Damodar, S; Gerona, RR; Hall, D; Kahn, A; Kapahi, P; Killilea, DW; O'Leary, MN; Parihar, J; Ramanathan, A; Sahota, A; Stoller, ML; Tischfield, J; Yang, M; Yang, S; Zee, J; Zee, T, 2017) |
| "Mechanical and cold allodynia were reduced by thioctic acid injection." | 3.81 | The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model. ( Chung, EY; Kahng, J; Kim, TK; Kim, YS; Moon, JY, 2015) |
| " There were significant differences in the lumen area, neointima area, percent area stenosis, fibrin score, and inflammation score among the four groups [2." | 3.80 | Effect of polymer-free TiO2 stent coated with abciximab or alpha lipoic acid in porcine coronary restenosis model. ( Ahn, Y; Bae, IH; Cho, DL; Hong, YJ; Jeong, HY; Jeong, MH; Kim, HS; Kim, JH; Kim, JM; Kim, YS; Lim, KS; Park, DS; Park, JK; Park, KH; Sim, DS; Song, SJ; Yang, EJ, 2014) |
| "The effect of original domestic derivatives of 3-oxypiridine and succinic acid (emoxipine, reamberin and mexidol) on the resistance to acute brain ischemia was studied in an experimental mouse models." | 3.80 | [The effect of 3-oxypyridine and succinic acid derivatives on the resistance to acute cerebral ischemia]. ( Faĭzullin, RM; Kalugina, AV; Malkin, MP; Miroshnichenko, II; Priakhina, KE; Rassokhina, LM; Volchegorskiĭ, IA, 2014) |
| "The oxidative stress plays an important signaling role in pilocarpine-induced seizures, and antioxidant drugs might be considered as therapeutical tools in this pathology." | 3.77 | Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; Feng, D; Jordán, J, 2011) |
| "In the present study, we investigated the effects of lipoic acid (LA) in the brain oxidative stress caused by pilocarpine-induced seizures in adult rats." | 3.76 | Lipoic acid alters delta-aminolevulinic dehydratase, glutathione peroxidase and Na+,K+-ATPase activities and glutathione-reduced levels in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM, 2010) |
| "To evaluate whether alpha-lipoic acid (LA) inhibits lens opacity of naphthalene-induced cataract by altering post-translational modifications (PTMs) and protecting the chaperone activity of alpha-crystallins." | 3.76 | alpha-Lipoic acid alters post-translational modifications and protects the chaperone activity of lens alpha-crystallin in naphthalene-induced cataract. ( Chen, Y; Fang, Y; Jang, Y; Wei, L; Wu, X; Yan, G; Yi, L; Zhou, X, 2010) |
| " This study aimed to evaluate the potential beneficial effect of ALA on trinitrobenzenesulfonic acid (TNBS)-induced gut ileitis and colitis in rats." | 3.74 | Alpha-lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats. ( Alican, I; Ercan, F; Jahovic, N; Kolgazi, M; Yüksel, M, 2007) |
| " Amatoxin, a peptide contained in several mushroom species, accounts for the majority of severe mushroom poisonings by binding to RNA polymerase II irreversibly, leading to severe hepatonecrosis." | 3.74 | Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model. ( Betten, DP; Clark, RF; Favata, M; Hernandez, M; Richardson, WH; Riffenburgh, RH; Tanen, DA; Tong, TC, 2007) |
| "Chronic systemic exposure of mice, rats, and Drosophila to D-galactose causes the acceleration of senescence and has been used as an aging model." | 3.73 | Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. ( Cui, X; Hu, Y; Li, X; Liu, J; Long, J; Packer, L; Zhang, Q; Zuo, P, 2006) |
| "Hypertension was induced in Sprague-Dawley rats by infusing angiotensin II (200 ng/kg per min) through osmotic pumps for 12 days." | 3.72 | NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells. ( de Champlain, J; El Midaoui, A; Laplante, MA; Wu, R, 2003) |
| "Galactosamine, a selective hepatotoxin, produces in rats histologic alterations, which show the characteristics of severe human viral hepatitis." | 3.67 | Effect of coenzyme-A, NAD, alpha lipoic-acid and cocarboxylase on survival of rats with galactosamine-induced severe hepatitis. ( Rajacic, Z; Thölen, H; Zimmerli, W, 1985) |
| "A wide variety of models of Huntington's disease have been developed including yeast, Caenorhabditis elegans, Drosophila melanogaster and mouse." | 2.42 | Experimental therapeutics in Huntington's disease: are models useful for therapeutic trials? ( Bates, GP; Hockly, E, 2003) |
| "CPZ provoked demyelination, enhanced oxidative stress, and stimulated neuroinflammation." | 1.91 | Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination. ( Ahmed, KA; Ibrahim Fouad, G, 2023) |
| "Liver fibrosis was induced via thioacetamide (TAA) intoxication in rats; TAA-intoxicated rats were treated with either silymarin or ALA." | 1.56 | α-Lipoic acid modulates liver fibrosis: A cross talk between TGF-β1, autophagy, and apoptosis. ( El-Lakkany, NM; El-Maadawy, WH; Hammam, OA; Seif El-Din, SH, 2020) |
| "Total sleep deprivation (TSD) apparatus was used to induce SD (for 24 h)." | 1.56 | The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats. ( Mohammadi-Mahdiabadi-Hasani, MH; Nasehi, M; Nasiri Khalili, MA; Rezaie, M; Vaseghi, S; Zarrindast, MR, 2020) |
| "Given the aging population, the treatment of vascular dementia (VaD) is becoming increasingly important." | 1.51 | Effects of α-lipoic acid on chronic cerebrovascular hypoperfusion in an animal model of vascular dementia. ( Han, CY; Lee, HS; Lee, S; Park, JH; Young Park, H, 2019) |
| "Lung injury was performed with a single dose of MTX (20 mg/kg) to groups 2 and 3." | 1.48 | Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats. ( Arpag, H; Atilla, N; Aydemir, Y; Cakir, T; Gül, M; Polat, C; Sayan, M; Yiğitcan, B; Þehirli, Ö, 2018) |
| "Diseases caused by atherosclerosis are the leading causes of death in postmenopausal women, owing to the loss of estradiol." | 1.48 | Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice. ( Liu, P; Shen, D; Shen, T; Sun, H; Tian, L, 2018) |
| "Schizophrenia is a chronic mental disorder reported to compromise about 1% of the world's population." | 1.48 | Advantages of the Alpha-lipoic Acid Association with Chlorpromazine in a Model of Schizophrenia Induced by Ketamine in Rats: Behavioral and Oxidative Stress evidences. ( Cysne Filho, FMS; de Almeida, JC; de Sousa, CNS; Diniz, DDS; Macêdo, D; Patrocínio, CFV; Patrocínio, MCA; Sampaio, LRL; Vasconcelos, SMM, 2018) |
| " This study aimed to investigate the effects of mirtazapine (MIRT) alone and combined with alpha-lipoic acid (ALA) against corticosterone (CORT) induced behavioral and oxidative alterations." | 1.46 | Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone. ( de Oliveira, AA; de Sousa, CNS; de Sousa, LC; Honório Júnior, JER; Macedo, D; Maes, M; Medeiros, IDS; Oliveira, TQ; Patrocínio, CFV; Vasconcelos, GS; Vasconcelos, SMM, 2017) |
| " The present study aimed to investigate the effects of the typical antipsychotic chlorpromazine (CP) alone or combined with the natural antioxidant alpha-lipoic acid (ALA) on changes in the hippocampal average spectral power induced by ketamine (KET)." | 1.46 | Electroencephalographic study of chlorpromazine alone or combined with alpha-lipoic acid in a model of schizophrenia induced by ketamine in rats. ( Barbosa, TM; Borges, LTN; Gularte, VN; Lima, RF; Macêdo, D; Matos, NCB; Oliveira, MN; Patrocínio, MCA; Sampaio, LRL; Vale, OCD; Vasconcelos, SMM, 2017) |
| " Group II was intraperitoneally administered saline solution at the same dosage and over the same period." | 1.46 | Effect of alpha-lipoic acid on endometrial implants in an experimental rat model. ( Bayraktar, S; Özcan, O; Özgür, T; Pınar, N; Soylu Karapınar, O, 2017) |
| "Chronic hepatitis is recognized as a worldwide health problem that gradually progresses towards cirrhosis and hepatocellular carcinoma." | 1.43 | Curcumin, Silybin Phytosome(®) and α-R-Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production. ( Ali, SO; Darwish, HA; Ismail, NA, 2016) |
| "Inflammation was decreased and recovery time was shortened in the ALA + RT group compared with the RT group." | 1.43 | Effect of alpha-lipoic acid on radiation-induced small intestine injury in mice. ( Choi, BH; Choi, HS; Hahm, JR; Jeong, BK; Jeong, H; Jung, JH; Jung, MH; Kang, KM; Kim, JH; Song, JH; Woo, SH, 2016) |
| " This study was designed to evaluate the efficacy of CMX-2043 in an animal model of myocardial IRI and to establish effective dosing conditions." | 1.43 | CMX-2043 Efficacy in a Rat Model of Cardiac Ischemia-Reperfusion Injury. ( Baguisi, A; Beeuwkes, R; Casale, RA; Kates, SA; Lader, AS; Stewart, K, 2016) |
| "5 improved most of the parameters evaluated in this study without causing motor impairment demonstrating, thus, that possibly when combined with ALA a lower dose of CLZ is required." | 1.42 | Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and neurotrophic mechanisms. ( de Lucena, DF; de Sousa, CN; Gama, CS; Lima, LL; Macêdo, D; Oliveira, Tde Q; Vasconcelos, GS; Vasconcelos, SM; Ximenes, NC, 2015) |
| "Amikacin (AK) is an antibacterial drug, but it has remarkable nephrotoxic and ototoxic side effects due to increase in reactive oxygen radicals." | 1.42 | The impact of alpha-lipoic acid on amikacin-induced nephrotoxicity. ( Asci, H; Bayram, D; Candan, IA; Cankara, FN; Ilhan, I; Saygin, M; Yesilot, S, 2015) |
| "Alzheimer's disease is a progressive neurodegenerative disease that entails impairments of memory, thinking and behavior and culminates into brain atrophy." | 1.39 | Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease. ( Akopian, G; Brinton, RD; Cadenas, E; Sancheti, H; Walsh, JP; Yin, F, 2013) |
| "Ulcerative colitis affects many people worldwide." | 1.39 | Role of α-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: studies on inflammation, oxidative stress, DNA damage and fibrosis. ( Jena, GB; Trivedi, PP, 2013) |
| "In order to suppress cancer growth, however, multiple proteins involved in these pathways have to be targeted simultaneously." | 1.38 | Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice. ( Abolhassani, M; Baronzio, G; Bonte, J; Campion, F; Fichtner, I; Fiorentini, G; Guais, A; Israël, M; Sanders, E; Schwartz, L, 2012) |
| "X-linked adrenoleukodystrophy is a neurodegenerative condition caused by loss of function of the peroxisomal ABCD1 transporter, in which oxidative stress plays a pivotal role." | 1.38 | Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy. ( Andreu, AL; Bianchi, P; Ferrer, I; Fourcade, S; Galino, J; López-Erauskin, J; Muñoz-Pinedo, C; Pujol, A, 2012) |
| "Non-alcoholic steatohepatitis (NASH) is a liver disease that causes fat accumulation, inflammation and fibrosis." | 1.38 | Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice. ( Kim, HS; Kim, JG; Kim, MK; Lee, IK; Lee, KU; Min, AK; Park, KG; Seo, HY, 2012) |
| " Eight full-thickness bladder strips were isolated from each of 4 treated and 4 control rabbit bladders, and a dose-response curve to H(2)O(2) (0." | 1.37 | Differential effects of coenzyme Q10 and α-lipoic acid on two models of in vitro oxidative damage to the rabbit urinary bladder. ( Leggett, RE; Levin, RM; Li, HT; Schuler, C, 2011) |
| " Combination of α-lipoic acid efficiently halting deleterious toxic effects of L-dopa, revealed normalization of catalepsy score in addition to amelioration of neurochemical parameters and apparent preservation of striatal ultrastructure integrity, indicating benefit of both symptomatic and neuroprotective therapy." | 1.37 | Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and L-dopa toxicity. ( Abdin, AA; Sarhan, NI, 2011) |
| "Carnitine treatment increased the mRNA expression of carnitine palmitoyltransferase 1A and peroxisome proliferator-activated receptor-γ, and carnitine-lipoic acid further augmented the mRNA expression." | 1.37 | Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction. ( Cho, WK; Choi, HS; Hahm, JS; Jang, KS; Jeon, HJ; Jun, DW; Jun, JH; Kim, HJ; Kwon, HJ; Lee, HL; Lee, KN; Lee, MH; Lee, OY; Yoon, BC, 2011) |
| "Inflammation was induced by injection of 0." | 1.36 | Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA. ( El-Desoky, K; El-Ghareib, MA; El-Masry, SA; El-Shitany, NA, 2010) |
| " In conclusion, mGST in combination with GSH has a synergistic effect in reducing airway inflammation compared to the individual antioxidants and has potential for the treatment of asthma." | 1.36 | Mutated glutathione S-transferase in combination with reduced glutathione shows a synergistic effect in ameliorating oxidative stress and airway inflammation. ( Arora, N; Nair, S; Singh, BP; Tripathi, P, 2010) |
| "In alloxan-treated mice (a model of type 1 diabetes), drugs were administered orally once daily for 6 days post-alloxan treatment." | 1.35 | Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment. ( Jiang, J; Larrick, JW; Wang, Y; Yu, P; Zeng, X; Zhang, Z, 2009) |
| "Treatment with coenzyme Q10 plus alpha-lipoic acid significantly restored contractile responses to all forms of stimulation." | 1.35 | The beneficial effect of coenzyme Q10 and lipoic acid on obstructive bladder dysfunction in the rabbit. ( Chuang, SM; Huang, CH; Hydery, T; Juan, YS; Kogan, B; Levin, RM; Li, S; Mannikarottu, A; Schuler, C, 2008) |
| " Chronic administration of either LA or NAC improved cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight." | 1.32 | The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. ( Banks, WA; Butterfield, DA; Dogrukol-Ak, D; Drake, J; Eyerman, E; Farr, SA; Morley, JE; Poon, HF, 2003) |
| "The risk of seizures increases to the extent that the injury is associated with sub-arachnoid hemorrhage and hematoma." | 1.32 | Lipoic acid pretreatment attenuates ferric chloride-induced seizures in the rat. ( Lee, JK; Meyerhoff, JL; Rittase, BW; Tsang, AY; Yourick, DL, 2004) |
| "Formation of lens opacities in vitro was correlated with lactate dehydrogenase (LDH) leakage into the incubation medium." | 1.29 | Modelling cortical cataractogenesis 17: in vitro effect of a-lipoic acid on glucose-induced lens membrane damage, a model of diabetic cataractogenesis. ( Handelman, GJ; Kilic, F; Packer, L; Serbinova, E; Trevithick, JR, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (0.81) | 18.7374 |
| 1990's | 3 (1.21) | 18.2507 |
| 2000's | 63 (25.40) | 29.6817 |
| 2010's | 158 (63.71) | 24.3611 |
| 2020's | 22 (8.87) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 2 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Liao, S | 1 |
| Yang, W | 1 |
| Yu, T | 1 |
| Dai, L | 1 |
| Liu, X | 3 |
| Zhang, J | 5 |
| Zhao, J | 1 |
| Liu, C | 1 |
| Oliveira, TQ | 2 |
| Chaves Filho, AJM | 1 |
| Jucá, PM | 1 |
| Soares, MVR | 1 |
| Cunha, NL | 1 |
| Vieira, CFX | 1 |
| Gadelha Filho, CVJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Repeated Antioxidant Supplementation of Embryo Culture Media on Blastocyst Utilization and Expansion Rate Under Two Different O2 Concentrations[NCT05919186] | 293 participants (Actual) | Interventional | 2021-10-12 | Completed | |||
| Assessment of Metformin as Adjuvant Therapy in Patients With Ulcerative Colitis[NCT04750135] | Phase 2 | 40 participants (Anticipated) | Interventional | 2021-02-07 | Not yet recruiting | ||
| Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD:A Randomized, Double Blind, Placebo-controlled, Multicentric Trial.[NCT04284059] | Phase 4 | 504 participants (Anticipated) | Interventional | 2021-02-25 | Recruiting | ||
| Effect of Alpha Lipoic Acid on Non-alcoholic Fatty Liver Diseases: A Randomized Placebo-controlled Clinical Trial[NCT04475276] | Phase 4 | 120 participants (Anticipated) | Interventional | 2021-02-23 | Recruiting | ||
| The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| The Effect of Alpha Lipoic Acid on the Incidence and Severity of Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients[NCT05023863] | Phase 2/Phase 3 | 70 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| Alpha-lipoic Acid Adjunctive Therapy in Schizophrenia: A Randomized, Double-blind, Placebo-controlled Trial[NCT03788759] | Phase 2/Phase 3 | 48 participants (Actual) | Interventional | 2019-09-01 | Completed | ||
| Double Blind, Placebo Controlled, Cross Over Study to Investigate the Effectiveness and Safety of Eluxadoline in the Treatment of Diabetic Diarrhea[NCT04313088] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2022-07-01 | Withdrawn (stopped due to This study did not enroll any subjects) | ||
| A Double-Blind, Randomized, Placebo-Controlled Trial To Evaluate The Efficacy Of Intravenous Immunoglobulin Therapy In Treatment Induced Neuropathy Of Diabetes[NCT02915263] | Phase 2 | 13 participants (Actual) | Interventional | 2017-09-11 | Terminated (stopped due to Funding withdrawn in the midst of the COVID pandemic) | ||
| NAC Attack, A Phase III, Multicenter, Randomized, Parallel, Double Masked, Placebo-Controlled Study Evaluating the Efficacy and Safety of Oral N-Acetylcysteine in Patients With Retinitis Pigmentosa[NCT05537220] | Phase 3 | 438 participants (Anticipated) | Interventional | 2023-10-11 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The standardized autonomic nervous system testing evaluates the heart rate variability to paced breathing.~Heart rate variability is reported in beats per minutes. The outcome measure is the heart rate variability at the final visit (7 weeks after initial infusion) minus the heart rate variability of the baseline visit. A positive result indicates an increase in heart rate variability (a better outcome), a negative result indicates a decrease in heart rate variability (a worse outcome)." (NCT02915263)
Timeframe: 7 weeks after first infusion
| Intervention | beats/minute (Mean) |
|---|---|
| 0.9% Sodium Chloride | -2.1 |
| IGIV-C | -2.5 |
"The visual analog scale (VAS) of pain allows for quantification of neuropathic pain.~The VAS pain scale is a line with markings that range from 0 (no pain) to 10 (worse pain), with whole digit intervals (thus an 11 point scale).~This outcome measure is the VAS pain score at the final visit (7 weeks after first infusion) minus the VAS pain score at the baseline visit. A positive result indicates that pain increased over the course of the study (a worse outcome), a negative result indicates that pain improved over the course of the trial (a better outcome)." (NCT02915263)
Timeframe: 7 weeks after first infusion
| Intervention | units on a scale (Mean) |
|---|---|
| 0.9% Sodium Chloride | 1.1 |
| IGIV-C | 1.6 |
"Skin biopsies will be evaluated by measuring the Intra-epidermal nerve fiber density.~Nerve fiber density is measured in the number of nerve fibers per millimeter. This outcome measure is the nerve fiber density at the final visit (7 weeks after the initial infusion) minus the nerve fiber density from the baseline visit. A positive result indicates that nerve fiber density increased over the course of the study (a better outcome), a negative result indicates that nerve fiber density decreased over the course of the trial (a worse outcome)." (NCT02915263)
Timeframe: 7 weeks after first infusion
| Intervention | fibers/mm (Mean) |
|---|---|
| 0.9% Sodium Chloride | -0.6 |
| IGIV-C | -0.3 |
"The Utah Early Neuropathy Scale (UENS) was developed specifically to detect and quantify early small-fiber sensory neuropathy and to recognize modest changes in sensory severity and distribution.~The UENS scale ranges from 0 (no neuropathy) to 42 (severe small fiber neuropathy). The outcome measure is the UENS score from 7 weeks (final evaluation) minus the UENS score from the baseline visit. A positive value indicates that neuropathy worsened over the course of the trial (a worse outcome), a negative score indicates that neuropathy improved over the course of the trial (a better outcome)." (NCT02915263)
Timeframe: 7 weeks after first infusion.
| Intervention | units on a scale (Mean) |
|---|---|
| 0.9% Sodium Chloride | 1.5 |
| IGIV-C | 3.9 |
11 reviews available for thioctic acid and Disease Models, Animal
| Article | Year |
|---|---|
Role of lipoic acid in multiple sclerosis.
Topics: Animals; Antioxidants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; | 2022 |
Renal-Protective Roles of Lipoic Acid in Kidney Disease.
Topics: Acute Kidney Injury; Animals; Antioxidants; Disease Models, Animal; Kidney; Renal Insufficiency, Chr | 2023 |
Alpha Lipoic Acid: A Therapeutic Strategy that Tend to Limit the Action of Free Radicals in Transplantation.
Topics: Animals; Clinical Trials as Topic; Disease Models, Animal; Free Radicals; Humans; Reperfusion Injury | 2018 |
Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis: A Review.
Topics: Acetylcarnitine; Animals; Ascorbic Acid; Biotin; Caffeine; Creatine; Curcumin; Dietary Supplements; | 2018 |
Effects of alpha lipoic acid and its derivative "andrographolid-lipoic acid-1" on ulcerative colitis: A systematic review with meta-analysis of animal studies.
Topics: Animals; Antioxidants; Colitis, Ulcerative; Disease Models, Animal; Mice; Rats; Thioctic Acid | 2019 |
Lipoic acid biosynthesis defects.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Acyltransferases; Amino Acid Oxidoreductases; Ani | 2014 |
Lipoic Acid: its antioxidant and anti-inflammatory role and clinical applications.
Topics: Aging; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Clinical Trials as Topic; Dis | 2015 |
Xenobiotics and loss of tolerance in primary biliary cholangitis.
Topics: Acetaminophen; Animals; Autoantibodies; Autoantigens; Chemical and Drug Induced Liver Injury; Cholan | 2016 |
Experimental therapeutics in Huntington's disease: are models useful for therapeutic trials?
Topics: Acetamides; Animals; Antioxidants; Creatine; Disease Models, Animal; Evaluation Studies as Topic; Hu | 2003 |
Lipoic acid as a potential first agent for protection from mycotoxins and treatment of mycotoxicosis.
Topics: Air Pollution, Indoor; Animals; Antioxidants; Biomedical Research; Disease Models, Animal; Drug Eval | 2003 |
Alpha-lipoic acid, an anti-obesity agent?
Topics: AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Disease Models, Animal; Humans; Lipid M | 2004 |
1 trial available for thioctic acid and Disease Models, Animal
| Article | Year |
|---|---|
Nutritional Interventions that Slow the Age-Associated Decline in Renal Function in a Canine Geriatric Model for Elderly Humans.
Topics: Absorptiometry, Photon; Aged; Aging; Animals; Arginine; Biomarkers; Body Weight; Carnitine; Cross-Se | 2016 |
236 other studies available for thioctic acid and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Establishment of a Drug Screening Model for Cardiac Complications of Acute Renal Failure.
Topics: Acute Kidney Injury; Animals; Animals, Genetically Modified; Cardio-Renal Syndrome; Cardiovascular D | 2021 |
Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Cognitive Dysfunction; Corticosteron | 2022 |
α-Lipoic Acid Has the Potential to Normalize Copper Metabolism, Which Is Dysregulated in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2022 |
Alpha-lipoic acid improved motor function in MPTP-induced Parkinsonian mice by reducing neuroinflammation in the nigral and spinal cord.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopaminergic Neurons; | 2022 |
Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination.
Topics: Animals; Carvedilol; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C | 2023 |
Protective effect and mechanism of alpha-lipoic acid on partial hepatic ischemia-reperfusion injury in adult male rats.
Topics: Animals; Chemokine CXCL2; Cytoprotection; Disease Models, Animal; Free Radical Scavengers; Glutathio | 2019 |
A Novel Paclitaxel Conjugate with Higher Efficiency and Lower Toxicity: A New Drug Candidate for Cancer Treatment.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferat | 2019 |
"Imitative" click chemistry to form a sticking xerogel for the portable therapy of bacteria-infected wounds.
Topics: Animals; Biocompatible Materials; Click Chemistry; Disease Models, Animal; Mice; Staphylococcal Infe | 2019 |
α-Lipoic acid modulates liver fibrosis: A cross talk between TGF-β1, autophagy, and apoptosis.
Topics: Animals; Apoptosis; Autophagy; Biomarkers; Disease Models, Animal; Liver Cirrhosis; Male; Oxidative | 2020 |
Protective Effects of α-Lipoic Acid on Vascular Oxidative Stress in Rats with Hyperuricemia.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Catalase; Disease Models, Animal; Dose-Response Relation | 2019 |
Discovery of a novel niacin-lipoic acid dimer N2L attenuating atherosclerosis and dyslipidemia with non-flushing effects.
Topics: Animals; Atherosclerosis; Cell Line; Cricetulus; Dimerization; Disease Models, Animal; Drug Design; | 2020 |
Alpha lipoic acid and vitamin E improve atorvastatin-induced mitochondrial dysfunctions in rats.
Topics: Adenosine Triphosphate; Administration, Oral; Animals; Atorvastatin; Case-Control Studies; Disease M | 2020 |
The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats.
Topics: Animals; Avoidance Learning; Behavior, Animal; Disease Models, Animal; Locomotion; Male; Memory; Mem | 2020 |
Alpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Angiotensin II; Animals; Animals, Newborn; Aorta; Apoptosis; | 2020 |
Intratympanic administration of alpha-lipoic acid-loaded pluronic F-127 nanoparticles ameliorates acute hearing loss.
Topics: Animals; Antioxidants; Cell Death; Cell Line; Cell Nucleus; Disease Models, Animal; Hearing Loss; Ma | 2021 |
The Effect of Alpha Lipoic Acid on the Recovery of Sciatic Nerve Injury in Rats: A Prospective Randomized Controlled Trial.
Topics: Animals; Disease Models, Animal; Functional Status; Male; Peripheral Nerve Injuries; Prospective Stu | 2021 |
Maternal intake of alpha-lipoic acid prevents development of symptoms associated with a fructose-rich diet in the male offspring in Wistar rats.
Topics: Animals; Diet; Disease Models, Animal; Female; Fructose; Maternal Exposure; Pregnancy; Prenatal Expo | 2021 |
Antioxidative effects of alpha-lipoic acid in spinal cord injury An experimental rat model.
Topics: Animals; Antioxidants; Disease Models, Animal; Methylprednisolone; Rats; Rats, Sprague-Dawley; Rats, | 2021 |
Topics: Animals; Bacterial Proteins; Cell Membrane; Disease Models, Animal; Fatty Acids, Unsaturated; Host-P | 2021 |
Sodium R-lipoate and enzymatically-modified isoquercitrin suppressed IgE-independent anaphylactic reactions and stress-induced gastric ulceration in mice.
Topics: Administration, Oral; Anaphylaxis; Animals; Anti-Allergic Agents; Cell Degranulation; Disease Models | 2021 |
Alpha lipoic acid priming enhances the hepatoprotective effect of adipose derived stem cells in CCl4 induced hepatic injury in-vitro.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Inju | 2021 |
The neuroprotective effects of alpha-lipoic acid on an experimental model of Alzheimer's disease in PC12 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Neuroprotective Agents; P | 2022 |
Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Glutathione; Humans; Interleukin-1beta; Lung; Lung In | 2018 |
Effect of alpha-lipoic acid on endometrial implants in an experimental rat model.
Topics: Animals; Antioxidants; Autografts; Disease Models, Animal; Endometriosis; Endometrium; Female; Oxida | 2017 |
Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone.
Topics: Animals; Antidepressive Agents, Tricyclic; Antioxidants; Brain; Brain-Derived Neurotrophic Factor; C | 2017 |
Alpha-lipoic Acid suppresses P2X receptor activities and visceral hypersensitivity to colorectal distention in diabetic rats.
Topics: Animals; Colon; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Fem | 2017 |
Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and
Topics: Animals; Anti-Obesity Agents; Antioxidants; Astrocytes; Biological Transport; Brain; Brain Chemistry | 2017 |
Therapeutic potential of α-lipoic acid derivative, sodium zinc histidine dithiooctanamide, in a mouse model of allergic rhinitis.
Topics: Allergens; Alum Compounds; Animals; Antioxidants; Cell Degranulation; Cytokines; Disease Models, Ani | 2017 |
The α-lipoic acid improves high-fat diet-induced cerebral damage through inhibition of oxidative stress and inflammatory reaction.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Brain Diseases; Diet, High-Fat; Disease Models, A | 2017 |
α-Lipoic Acid Promotes Neurological Recovery After Ischemic Stroke by Activating the Nrf2/HO-1 Pathway to Attenuate Oxidative Damage.
Topics: Animals; Brain; Brain Edema; Cell Hypoxia; Cell Survival; Cells, Cultured; Disease Models, Animal; G | 2017 |
Alpha Lipoamide Ameliorates Motor Deficits and Mitochondrial Dynamics in the Parkinson's Disease Model Induced by 6-Hydroxydopamine.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apomorphine; Cell Death; Disease Models, Animal; Dopa | 2018 |
A Lipoylated Metabolic Protein Released by Staphylococcus aureus Suppresses Macrophage Activation.
Topics: Animals; Bacterial Proteins; Bone Marrow; Cell Culture Techniques; Cytokines; Dihydrolipoamide Dehyd | 2017 |
Lipoic acid alleviates L‑DOPA‑induced dyskinesia in 6‑OHDA parkinsonian rats via anti‑oxidative stress.
Topics: Animals; Antioxidants; Caspase 3; Disease Models, Animal; Dopaminergic Neurons; Dyskinesia, Drug-Ind | 2018 |
α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice.
Topics: Alzheimer Disease; Animals; Cell Death; Disease Models, Animal; Female; Inflammation; Lipid Peroxida | 2018 |
Antioxidants improve IVF outcome and subsequent embryo development in the mouse.
Topics: Acetylcarnitine; Acetylcysteine; Animals; Antioxidants; Blastocyst; Culture Media; Disease Models, A | 2017 |
Advantages of the Alpha-lipoic Acid Association with Chlorpromazine in a Model of Schizophrenia Induced by Ketamine in Rats: Behavioral and Oxidative Stress evidences.
Topics: Animals; Antioxidants; Antipsychotic Agents; Chlorpromazine; Disease Models, Animal; Drug Therapy, C | 2018 |
Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model.
Topics: Animals; CD3 Complex; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; G | 2018 |
New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats.
Topics: Animals; Antioxidants; Body Weight; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Male; M | 2018 |
Rux largely restores lungs in Iraq PM-exposed mice, Up-regulating regulatory T-cells (Tregs).
Topics: Afghan Campaign 2001-; Animals; Disease Models, Animal; Interleukin-15; Iraq; Lung Injury; Mice; Par | 2018 |
α-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Cell Line; Disease Models, An | 2018 |
Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice.
Topics: Animals; Aorta; Atherosclerosis; Disease Models, Animal; Endothelial Cells; Female; Humans; Hydrogen | 2018 |
The Role of Alpha-Lipoic Acid in the Pathomechanism of Acute Ischemic Stroke.
Topics: Animals; Behavior, Animal; Brain Edema; Cell Line; Cyclooxygenase 2; Disease Models, Animal; Infarct | 2018 |
Alpha-lipoic acid reduces retinal cell death in diabetic mice.
Topics: Administration, Oral; AMP-Activated Protein Kinases; Animals; Cell Death; Cells, Cultured; Diabetes | 2018 |
Effects of Alpha Lipoic Acid on Loss of Myelin Sheath of Sciatic Nerve in Experimentally Induced Diabetic Rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Anima | 2018 |
α-Lipoic Acid Reduces Iron-induced Toxicity and Oxidative Stress in a Model of Iron Overload.
Topics: Animals; Autophagy; Cell Line; Disease Models, Animal; Ferric Compounds; Glutathione; Heme Oxygenase | 2019 |
The antioxidant α-lipoic acid attenuates intermittent hypoxia-related renal injury in a mouse model of sleep apnea.
Topics: Animals; Antioxidants; Disease Models, Animal; Hypoxia; Inflammation; Kidney; Kidney Diseases; Male; | 2019 |
Mitigation of Radiation-induced Pneumonitis and Lung Fibrosis using Alpha-lipoic Acid and Resveratrol.
Topics: Animals; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Female; Humans; Mice; Pulm | 2020 |
Effects of α-lipoic acid on chronic cerebrovascular hypoperfusion in an animal model of vascular dementia.
Topics: Animals; Carotid Stenosis; Cognitive Dysfunction; Dementia, Vascular; Disease Models, Animal; Drug A | 2019 |
Alpha lipoic acid inhibits oxidative stress-induced apoptosis by modulating of Nrf2 signalling pathway after traumatic brain injury.
Topics: Animals; Antioxidants; Apoptosis; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Heme Oxy | 2019 |
The effect of n-3 long-chain polyunsaturated fatty acids and lipoic acid on the heart in the ovariectomized rat model of menopause.
Topics: Animals; Antioxidants; Biomarkers; Dietary Supplements; Disease Models, Animal; Fatty Acids, Omega-3 | 2019 |
Hepatoprotective Actions of Ascorbic Acid, Alpha Lipoic Acid and Silymarin or Their Combination Against Acetaminophen-Induced Hepatotoxicity in Rats.
Topics: Acetaminophen; Animals; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Disease Models, Anima | 2019 |
Alpha lipoic acid and metformin alleviates experimentally induced insulin resistance and cognitive deficit by modulation of TLR2 signalling.
Topics: Animals; Anti-Inflammatory Agents; Cognition Disorders; Disease Models, Animal; Insulin; Insulin Res | 2019 |
Autophagy Enhancing Contributes to the Organ Protective Effect of Alpha-Lipoic Acid in Septic Rats.
Topics: Animals; Apoptosis; Autophagy; Cytokines; Disease Models, Animal; Inflammation; Male; NF-kappa B; Pr | 2019 |
Alpha-lipoic acid protects against 6-hydroxydopamine-induced neurotoxicity in a rat model of hemi-parkinsonism.
Topics: Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Dose-Response Relationship, Drug; F | 2013 |
Ibuprofen and lipoic acid conjugate neuroprotective activity is mediated by Ngb/Akt intracellular signaling pathway in Alzheimer's disease rat model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Brain; Cyclic AMP Response Element-Bin | 2013 |
α-Lipoic acid reduces infarct size and preserves cardiac function in rat myocardial ischemia/reperfusion injury through activation of PI3K/Akt/Nrf2 pathway.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Nucleus; Creatine Kinase; Disease Models, Animal; Gene | 2013 |
Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines release.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cytokines; Disease Models, Animal; I | 2013 |
Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Cytokines; Disease Models, Animal; Endotoxemia; Fatty | 2013 |
Role of α-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: studies on inflammation, oxidative stress, DNA damage and fibrosis.
Topics: Animals; Antioxidants; Blood Cells; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Ani | 2013 |
Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Glucose; Insulin; Mice; Mice | 2013 |
Dietary α-lipoic acid prevents UVB-induced corneal and conjunctival degeneration through multiple effects.
Topics: Animals; Antioxidants; Cell Survival; Conjunctiva; Conjunctival Diseases; Cornea; Corneal Diseases; | 2013 |
Evaluation of lipoic acid topical application on rats skin wound healing.
Topics: Animals; Antioxidants; Disease Models, Animal; Lipid Peroxidation; Male; Nanocapsules; Rats; Rats, W | 2013 |
Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease.
Topics: Acetylcarnitine; Adipose Tissue; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransfe | 2013 |
Lipoic acid treatment after brain injury: study of the glial reaction.
Topics: Animals; Antioxidants; Astrocytes; Blood-Brain Barrier; Brain; Brain Injuries; Disease Models, Anima | 2013 |
Lipoic acid analogs with enhanced pharmacological activity.
Topics: Animals; Dipeptides; Disease Models, Animal; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Spra | 2014 |
Mitochondrial cofactors in experimental Huntington's disease: behavioral, biochemical and histological evaluation.
Topics: Acetylcarnitine; Animals; Antioxidants; Behavior, Animal; Brain; Chromatography, Thin Layer; Disease | 2014 |
Alpha-lipoic acid restores tear production in an animal model of dry eye.
Topics: Animals; Antioxidants; Ascorbic Acid; Chromatography, High Pressure Liquid; Conjunctiva; Cornea; Die | 2014 |
Amelioration of behavioural, biochemical, and neurophysiological deficits by combination of monosodium glutamate with resveratrol/alpha-lipoic acid/coenzyme Q10 in rat model of cisplatin-induced peripheral neuropathy.
Topics: Animals; Behavior, Animal; Catalase; Disease Models, Animal; Drug Therapy, Combination; Glutathione; | 2013 |
Co-administration of resveratrol and lipoic acid, or their synthetic combination, enhances neuroprotection in a rat model of ischemia/reperfusion.
Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Humans; Male; Rats; Rats, Sprague-Daw | 2014 |
Lipoic acid, but not tempol, preserves vascular compliance and decreases medial calcification in a model of elastocalcinosis.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Compliance; Cyclic N-Oxides; Disease Models, Animal; Mal | 2014 |
Preventive effect of α-lipoic acid on prepulse inhibition deficits in a juvenile two-hit model of schizophrenia.
Topics: Aging; Animals; Disease Models, Animal; Female; Male; Mice, Inbred C57BL; Prefrontal Cortex; Pregnan | 2014 |
Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.
Topics: Aging; Alzheimer Disease; Animals; Disease Models, Animal; Docosahexaenoic Acids; Gene Expression Re | 2014 |
Effect of polymer-free TiO2 stent coated with abciximab or alpha lipoic acid in porcine coronary restenosis model.
Topics: Abciximab; Animals; Antibodies, Monoclonal; Coronary Restenosis; Disease Models, Animal; Drug-Elutin | 2014 |
Evaluation of the protective effect of α-lipoic acid on cisplatin ototoxicity using distortion-product otoacoustic emission measurements: an experimental animal study.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cisplatin; Cochlea; Disease Models, Animal; Ear, Middl | 2014 |
Treatment with α-lipoic acid enhances the bone healing after femoral fracture model of rats.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fem | 2014 |
Hypermetabolic state in the 7-month-old triple transgenic mouse model of Alzheimer's disease and the effect of lipoic acid: a 13C-NMR study.
Topics: Alzheimer Disease; Animals; Carbon Isotopes; Dietary Supplements; Disease Models, Animal; Glucose; H | 2014 |
Alpha-lipoic acid affects the oxidative stress in various brain structures in mice with methionine and choline deficiency.
Topics: Animals; Brain; Catalase; Cerebral Cortex; Choline Deficiency; Corpus Striatum; Disease Models, Anim | 2015 |
Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression and protects mouse brain against focal ischemia.
Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; M | 2014 |
The impact of alpha-lipoic acid on amikacin-induced nephrotoxicity.
Topics: Amikacin; Animals; Anti-Bacterial Agents; Antioxidants; Blood Urea Nitrogen; Creatinine; Disease Mod | 2015 |
Alpha lipoic acid attenuates radiation-induced thyroid injury in rats.
Topics: Animals; Antioxidants; Cytokines; Disease Models, Animal; Fibrosis; Male; Oxidative Stress; Radiatio | 2014 |
The effects of α-lipoic acid on aortic injury and hypertension in the rat remnant kidney (5/6 nephrectomy) model.
Topics: Administration, Oral; Animals; Antioxidants; Aorta, Abdominal; Blood Pressure; Dietary Supplements; | 2015 |
Advanced glycation end products are mitogenic signals and trigger cell cycle reentry of neurons in Alzheimer's disease brain.
Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Cell Cycle; Cells, Cultured; Cyclin D1; Disease Model | 2015 |
[The effect of 3-oxypyridine and succinic acid derivatives on obsessive-compulsive activity of mice in marble-burying test].
Topics: Amitriptyline; Animals; Behavior, Animal; Disease Models, Animal; Female; Humans; Hypnotics and Seda | 2014 |
Α‑lipoic acid protects against cerebral ischemia/reperfusion-induced injury in rats.
Topics: Animals; Antioxidants; Apoptosis; Brain Edema; Brain Ischemia; Brain-Derived Neurotrophic Factor; Ca | 2015 |
Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid.
Topics: Animals; Cell Line; Cyclic GMP-Dependent Protein Kinases; Cysteine; Diabetes Mellitus; Disease Model | 2015 |
The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, | 2015 |
[The effect of 3-oxypyridine and succinic acid derivatives on the resistance to acute cerebral ischemia].
Topics: Acute Disease; Animals; Brain Ischemia; Disease Models, Animal; Female; Male; Meglumine; Mice; Picol | 2014 |
Effects of alpha lipoic acid on intra-abdominal adhesion: an experimental study in a rat model.
Topics: Animals; Antioxidants; Cecum; Disease Models, Animal; Female; Glutathione; Infusions, Parenteral; La | 2015 |
Effects of pentoxifylline and alpha lipoic acid on methotrexate-induced damage in liver and kidney of rats.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; G | 2015 |
Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and neurotrophic mechanisms.
Topics: Analysis of Variance; Animals; Antioxidants; Antipsychotic Agents; Brain; Brain-Derived Neurotrophic | 2015 |
The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Apoptosis; Bromelains; Cells, Cultured; Disease M | 2015 |
Evidence for protective effect of lipoic acid and desvenlafaxine on oxidative stress in a model depression in mice.
Topics: Animals; Antidepressive Agents; Antioxidants; Corpus Striatum; Corticosterone; Depressive Disorder; | 2016 |
Mitochondrial modulators improve lipid composition and attenuate memory deficits in experimental model of Huntington's disease.
Topics: Acetylcarnitine; Animals; Behavior, Animal; Brain; Cholesterol; Chromatography, Thin Layer; Cognitio | 2015 |
Curcumin, Silybin Phytosome(®) and α-R-Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Curcumin; Cytokines; Disease | 2016 |
Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine.
Topics: Acetylcarnitine; Aging; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Coenzymes | 2016 |
Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model.
Topics: Animals; Antioxidants; CD11b Antigen; Cerebral Cortex; Cytokines; Disease Models, Animal; Encephalit | 2015 |
Comparative Biochemical and Motor Function Analysis of Alpha Lipoic Acid and N-Acetyl Cysteine Treatment on Rats with Experimental Spinal Cord Injury.
Topics: Animals; Cysteine; Disease Models, Animal; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; | 2016 |
Lipoic acid improves neuronal insulin signalling and rescues cognitive function regulating VGlut1 expression in high-fat-fed rats: Implications for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cognition; Dietary Fats; Disease Models, Animal; Gene Expression Regulat | 2016 |
Lipoicmethylenedioxyphenol Reduces Experimental Atherosclerosis through Activation of Nrf2 Signaling.
Topics: Animals; Atherosclerosis; Blood Vessels; Chemotaxis, Leukocyte; Disease Models, Animal; Disease Prog | 2016 |
Lipoic acid does not improve renal function markers in 5/6 nephrectomy model: possible role of Nrf2 inactivation.
Topics: Animals; Disease Models, Animal; Kidney; Male; Nephrectomy; NF-E2-Related Factor 2; Rats; Rats, Wist | 2016 |
Effect of alpha-lipoic acid on radiation-induced small intestine injury in mice.
Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Gamma | 2016 |
Chondroprotective effects of alpha-lipoic acid in a rat model of osteoarthritis.
Topics: Animals; Disease Models, Animal; Male; NF-kappa B; Osteoarthritis; Oxidative Stress; Rats; Rats, Spr | 2016 |
CMX-2043 Efficacy in a Rat Model of Cardiac Ischemia-Reperfusion Injury.
Topics: Administration, Oral; Animals; Arrhythmias, Cardiac; Cardiovascular Agents; Cytoprotection; Dipeptid | 2016 |
Evaluation of Electrophysiological Effects of Melatonin and Alpha Lipoic Acid in Rats with Streptozotocine Induced Diabetic Neuropathy.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Diabetic Neuropathies; Disease Models, Animal; E | 2016 |
Protein Disulfide Levels and Lens Elasticity Modulation: Applications for Presbyopia.
Topics: Accommodation, Ocular; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Disulf | 2016 |
Functional and structural changes of the urinary bladder following spinal cord injury; treatment with alpha lipoic acid.
Topics: Animals; Antioxidants; Disease Models, Animal; Male; Rats; Rats, Wistar; Spinal Cord Injuries; Thioc | 2017 |
Alpha-Lipoic Acid Alleviates Acute Inflammation and Promotes Lipid Mobilization During the Inflammatory Response in White Adipose Tissue of Mice.
Topics: Adipose Tissue, White; Animals; Disease Models, Animal; Energy Metabolism; Fatty Acids, Nonesterifie | 2016 |
α-lipoic acid exerts neuroprotective effects on neuronal cells by upregulating the expression of PCNA via the P53 pathway in neurodegenerative conditions.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Electron Transport Co | 2016 |
The influence of lipoic acid on caveolin-1-regulated antioxidative enzymes in the mouse model of acute ulcerative colitis.
Topics: Acute Disease; Animals; Antioxidants; Caveolin 1; Colitis, Ulcerative; Colon; Cytokines; Dextran Sul | 2016 |
Staphylococcus aureus Tissue Infection During Sepsis Is Supported by Differential Use of Bacterial or Host-Derived Lipoic Acid.
Topics: Adaptation, Physiological; Animals; Disease Models, Animal; Female; Mice; Mutagenesis, Site-Directed | 2016 |
Electroencephalographic study of chlorpromazine alone or combined with alpha-lipoic acid in a model of schizophrenia induced by ketamine in rats.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Brain; Chlorpromazine; Disease Models, Animal; | 2017 |
An injectable collagen/poly(γ-glutamic acid) hydrogel as a scaffold of stem cells and α-lipoic acid for enhanced protection against renal dysfunction.
Topics: Animals; Cell Survival; Cisplatin; Collagen; Disease Models, Animal; Hydrogels; Kidney Diseases; Mes | 2017 |
UPEI-400, a conjugate of lipoic acid and scopoletin, mediates neuroprotection in a rat model of ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Male; Neuroprotective Agents; Rats; Rats, Sprague-D | 2017 |
Inhibitory effects of alpha-lipoic acid on oxidative stress in the rostral ventrolateral medulla in rats with salt-induced hypertension.
Topics: Animals; Antioxidants; Blood Pressure; Diet; Disease Models, Animal; Hypertension; Male; Medulla Obl | 2017 |
Effects of Lipoic Acid Supplementation on Activities of Cyclooxygenases and Levels of Prostaglandins E
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dinoprost; Dinoprostone; Disea | 2016 |
Monitoring treatment of acute kidney injury with damage biomarkers.
Topics: Acute Kidney Injury; Animals; Biomarkers; Cisplatin; Disease Models, Animal; Glomerular Filtration R | 2017 |
Effects of alpha lipoic acid on ischemia-reperfusion injury in rat hindlimb ischemia model.
Topics: Animals; Antioxidants; Disease Models, Animal; Hindlimb; Infusions, Parenteral; Ischemia; Male; Musc | 2016 |
Anti-inflammatory effects of the selective phosphodiesterase 3 inhibitor, cilostazol, and antioxidants, enzymatically-modified isoquercitrin and α-lipoic acid, reduce dextran sulphate sodium-induced colorectal mucosal injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cilostazol; Colitis; Dextran Sulfate; Disease Model | 2017 |
Tang-Luo-Ning Improves Mitochondrial Antioxidase Activity in Dorsal Root Ganglia of Diabetic Rats: A Proteomics Study.
Topics: Animals; Blood Glucose; Chromatography, Ion Exchange; Diabetes Mellitus, Experimental; Disease Model | 2017 |
α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria.
Topics: Amino Acid Transport Systems, Basic; Amino Acid Transport Systems, Neutral; Animals; Cystine; Cystin | 2017 |
Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; CD2 Antigens; Disease Models, Anim | 2017 |
The effects of lipoic acid on redox status in brain regions and systemic circulation in streptozotocin-induced sporadic Alzheimer's disease model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cerebral Cortex; Disease Models, An | 2017 |
Mutated glutathione-S-transferase reduced airway inflammation by limiting oxidative stress and Th2 response.
Topics: Animals; Binding Sites; Bronchoalveolar Lavage Fluid; Circular Dichroism; Disease Models, Animal; En | 2008 |
The beneficial effect of coenzyme Q10 and lipoic acid on obstructive bladder dysfunction in the rabbit.
Topics: Analysis of Variance; Animals; Blotting, Western; Disease Models, Animal; Dose-Response Relationship | 2008 |
The evaluation of effect of alpha-lipoic acid and vitamin E on the lipid peroxidation, gamma-amino butyric acid and serotonin level in the brain of mice (Mus musculus) acutely intoxicated with lindane.
Topics: Animals; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Insecticides | 2009 |
Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine.
Topics: Animals; Antioxidants; Azoles; Disease Models, Animal; Intestinal Diseases; Intestine, Small; Isoind | 2008 |
Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat.
Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cells, Cultured; Cisplatin; Disease Models, | 2008 |
Protective effect of sulfhydryl-containing antioxidants against ischemia/reperfusion injury of prepubertal rat intestine.
Topics: Acetylcysteine; Animals; Antioxidants; Constriction; Disease Models, Animal; Glutathione Peroxidase; | 2009 |
Influence of alpha lipoic acid on antioxidant status in D-galactosamine-induced hepatic injury.
Topics: Analysis of Variance; Animals; Antioxidants; Biomarkers; Catalase; Chemical and Drug Induced Liver I | 2008 |
Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim | 2009 |
Lipoic acid and 6-formylpterin reduce potentiation of noise-induced hearing loss by carbon monoxide: preliminary investigation.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Hair Cells, Auditory; Hearing Loss, Noise-Induced; | 2008 |
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease.
Topics: Acetylcarnitine; Aging; Alzheimer Disease; Animals; Antioxidants; Apolipoprotein E4; Brain; Cerebrov | 2009 |
Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment.
Topics: Alloxan; Animals; Blood Glucose; Cytoprotection; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2009 |
ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture.
Topics: Animals; Blotting, Western; Caspases; Cells, Cultured; Disease Models, Animal; Electrophoresis, Poly | 2010 |
Alpha-lipoic acid attenuates cisplatin-induced tubulointerstitial injuries through inhibition of mitochondrial bax translocation in rats.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blood Urea Nitrogen; Caspase 3; Caspas | 2009 |
Effects of lipoic acid on oxidative stress in rat striatum after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Catalase; Convulsants; Corpus Striatum; Disease Models, Animal; Drug Interact | 2010 |
Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Cyclooxygenase Inhi | 2010 |
Lipoic acid alters delta-aminolevulinic dehydratase, glutathione peroxidase and Na+,K+-ATPase activities and glutathione-reduced levels in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Convulsants; Disease Models, Animal; Down-Regulation; Enzymes; Glutathione; G | 2010 |
Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats.
Topics: Acute Lung Injury; Animals; Cecum; Disease Models, Animal; Interleukin-6; Ligation; Male; NF-kappa B | 2010 |
Effect of alpha lipoic acid in a porcine in-stent restenosis model.
Topics: Administration, Oral; Animals; Cell Proliferation; Cells, Cultured; Coronary Restenosis; Disease Mod | 2009 |
Lipoic acid effects on established atherosclerosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Atherosclerosis; Blood Glucose; B | 2010 |
Mutated glutathione S-transferase in combination with reduced glutathione shows a synergistic effect in ameliorating oxidative stress and airway inflammation.
Topics: Animals; Antioxidants; Asthma; Disease Models, Animal; Drug Synergism; Glutathione; Glutathione Tran | 2010 |
Ibuprofen and lipoic acid diamides as potential codrugs with neuroprotective activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxid | 2010 |
Neuropathy in a rat model of mild diabetes induced by multiple low doses of streptozotocin: effects of the antioxidant stobadine in comparison with a high-dose alpha-lipoic acid treatment.
Topics: Animals; Antioxidants; Carbolines; Diabetic Neuropathies; Disease Models, Animal; Humans; Male; Neur | 2010 |
Dyslipidemic high-fat diet affects adversely bone metabolism in mice associated with impaired antioxidant capacity.
Topics: Animals; Antioxidants; Bone and Bones; Bone Resorption; Collagen Type I; Dietary Fats; Disease Model | 2011 |
Differential effects of coenzyme Q10 and α-lipoic acid on two models of in vitro oxidative damage to the rabbit urinary bladder.
Topics: Animals; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Follow-Up Studies; Hydroxy | 2011 |
Anti-apoptotic and neuroprotective effects of α-lipoic acid on spinal cord ischemia-reperfusion injury in rabbits.
Topics: Animals; Apoptosis; Disease Models, Animal; Male; Nerve Degeneration; Neuroprotective Agents; Rabbit | 2010 |
Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Ca(2+) Mg(2+)-ATPase; Disease Models, Animal; Hippocampus; Male; Oxidative St | 2011 |
alpha-Lipoic acid alters post-translational modifications and protects the chaperone activity of lens alpha-crystallin in naphthalene-induced cataract.
Topics: Acetylation; alpha-Crystallins; Animals; Antioxidants; Cataract; Chromatography, High Pressure Liqui | 2010 |
α-Lipoic acid prevents neointimal hyperplasia via induction of p38 mitogen-activated protein kinase/Nur77-mediated apoptosis of vascular smooth muscle cells and accelerates postinjury reendothelialization.
Topics: Animals; Apoptosis; Cardiovascular Agents; Disease Models, Animal; Endothelial Cells; Endothelium, V | 2010 |
Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress.
Topics: Aged; Animals; Antioxidants; Apoptosis; Biopsy; Case-Control Studies; Cell Line; Colon; Diabetes Com | 2011 |
Neuroprotective effects of alpha-lipoic acid in experimental spinal cord injury in rats.
Topics: Analysis of Variance; Animals; Disease Models, Animal; DNA Fragmentation; Glutathione; Luminescent M | 2010 |
α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Cotton Fiber; Disease Models, Animal; | 2011 |
Differential efficiency of simvastatin and lipoic acid treatments on Bothrops jararaca envenomation-induced acute kidney injury in mice.
Topics: Acute Kidney Injury; Aminopeptidases; Animals; Anticholesteremic Agents; Antioxidants; Bothrops; Cro | 2011 |
Anti-oxidative effect of lipoic Acid in spinal cord ischemia/reperfusion.
Topics: Analysis of Variance; Animals; Antioxidants; Disease Models, Animal; Free Radical Scavengers; Glutat | 2011 |
α-Lipoic acid suppresses the development of DNFB-induced atopic dermatitis-like symptoms in NC/Nga mice.
Topics: Administration, Oral; Animals; Antioxidants; CD4-Positive T-Lymphocytes; Cell Proliferation; Dermati | 2011 |
New lipoic acid derivative drug sodium zinc dihydrolipoylhistidinate prevents cardiac dysfunction in an isolated perfused rat heart model.
Topics: Animals; Cardiotonic Agents; Cells, Cultured; Disease Models, Animal; Heart; Histidine; Male; Membra | 2011 |
Modulatory effects of vitamin E, acetyl-L-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.
Topics: Alzheimer Disease; Animals; Antioxidants; Biomarkers; Brain; Carnitine; Cholinesterase Inhibitors; D | 2012 |
Alpha-lipoic acid rebalances redox and immune-testicular milieu in septic rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Infertility, Male; | 2011 |
Lipoic acid decreases inflammation and confers neuroprotection in experimental autoimmune optic neuritis.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation M | 2011 |
Oxidative stress: key player in gastrointestinal complications of diabetes.
Topics: Animals; Antioxidants; Apoptosis; Cell Line; Colon; Diabetes Complications; Disease Models, Animal; | 2011 |
Lipoic acid prevents steroid-induced osteonecrosis in rabbits.
Topics: Animals; Biomarkers; Cholesterol; Cytoprotection; Disease Models, Animal; Endothelins; Femur; Glutat | 2012 |
Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Citrates; Disease Mo | 2012 |
The effect of alpha-lipoic acid in the prevention of peritoneal adhesions.
Topics: Animals; Antioxidants; Disease Models, Animal; Hydroxyproline; Male; Malondialdehyde; Oxidative Stre | 2011 |
[Cerebroprotective effect of 3-oxypyridine and succinic acid derivatives in acute phase of alloxan-induced diabetes mellitus in rats].
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Anim | 2011 |
Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and L-dopa toxicity.
Topics: Animals; Antiparkinson Agents; Apoptosis; Disease Models, Animal; Levodopa; Mitochondria; Neurons; N | 2011 |
Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion.
Topics: Animals; Brain Ischemia; Cell Death; Disease Models, Animal; Ethidium; Fluoresceins; Gerbillinae; Gl | 2012 |
Dihydrolipoyl histidinate zinc complex, a new antioxidant, attenuates hepatic ischemia-reperfusion injury in rats.
Topics: Alanine Transaminase; Animals; Antimycin A; Antioxidants; Aspartate Aminotransferases; Biomarkers; B | 2011 |
Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Carnitine; Carnitine O-Palmitoyltransferase; Choline Def | 2011 |
Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline; Choline Deficiency; Cyto | 2012 |
The effects of alpha lipoic acid on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit.
Topics: Animals; Antioxidants; Apoptosis; Basilar Artery; Cerebrovascular Circulation; Disease Models, Anima | 2011 |
Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Animals; Apoptosis; Caspas | 2012 |
UPEI-100, a conjugate of lipoic acid and apocynin, mediates neuroprotection in a rat model of ischemia/reperfusion.
Topics: Acetophenones; Animals; Biomarkers; Disease Models, Animal; Glutathione Disulfide; Infarction, Middl | 2012 |
Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3.
Topics: Animals; Antioxidants; Blotting, Western; Body Weight; Diet, High-Fat; Disease Models, Animal; Fatty | 2012 |
The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis.
Topics: Animals; Autoantibodies; Autoantigens; Biomimetic Materials; Cattle; Cells, Cultured; Cytokines; Dih | 2012 |
Oxidative stress in 5/6 nephrectomized rat model: effect of alpha-lipoic acid.
Topics: Animals; Antioxidants; Disease Models, Animal; Kidney; Kidney Failure, Chronic; Kidney Function Test | 2012 |
Effect of alpha-lipoic acid on memory, oxidation, and lifespan in SAMP8 mice.
Topics: Alzheimer Disease; Animals; Antioxidants; Brain; Disease Models, Animal; Glutathione Peroxidase; Glu | 2012 |
Protective effects of a novel synthetic α-lipoic acid-decursinol hybrid compound in experimentally induced transient cerebral ischemia.
Topics: Animals; Disease Models, Animal; Gerbillinae; Ischemic Attack, Transient; Male; Neuroprotective Agen | 2012 |
Sodium butyrate potentiates carbon tetrachloride-induced acute liver injury in mice.
Topics: Acetylcysteine; Animals; Butyrates; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical a | 2012 |
Effects of alpha-lipoic acid in an animal model of mania induced by D-amphetamine.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Brain; Brain-Derived Neurotrophic Factor; Central Nervo | 2012 |
Effects of lipoic acid in an experimentally induced hypertensive and diabetic rat model.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Hypertensi | 2013 |
Role of catalase and superoxide dismutase activities on oxidative stress in the brain of a phenylketonuria animal model and the effect of lipoic acid.
Topics: Animals; Brain; Catalase; Disease Models, Animal; DNA Damage; Enzyme Inhibitors; Female; Lipid Perox | 2013 |
Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy.
Topics: Acetylcysteine; Adenosine Triphosphate; Adrenoleukodystrophy; Age Factors; Analysis of Variance; Ani | 2012 |
Lipoic acid in combination with a chelator ameliorates lead-induced peroxidative damages in rat kidney.
Topics: Acetylglucosaminidase; Animals; Catalase; Chelating Agents; Disease Models, Animal; Drug Therapy, Co | 2002 |
The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice.
Topics: Acetylcysteine; Age Factors; Amyloid beta-Peptides; Animals; Antioxidants; Appetitive Behavior; Beha | 2003 |
NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta; Blood Pressure; Disease Model | 2003 |
Acute glucose deprivation leads to apoptosis in a cell model of acute diabetic neuropathy.
Topics: Animals; Antioxidants; Apoptosis; Benzamides; Caspase 3; Caspases; Cell Count; Cell Hypoxia; Cell Su | 2003 |
Effect of alpha lipoic acid on intracerebroventricular streptozotocin model of cognitive impairment in rats.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Avoidance Learning; Behavior, Animal; Brain; Bra | 2003 |
A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Dr | 2003 |
Selective modulation of antioxidant enzyme activities in host tissues during Rickettsia conorii infection.
Topics: Animals; Antioxidants; Boutonneuse Fever; Brain; Colony Count, Microbial; Disease Models, Animal; En | 2004 |
Therapeutic efficacy of lipoic acid in combination with dimercaptosuccinic acid against lead-induced renal tubular defects and on isolated brush-border enzyme activities.
Topics: 5-Aminolevulinate Synthetase; Animals; Antioxidants; Biomarkers; Body Weight; Chelating Agents; Dise | 2004 |
Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Division; Dermatitis | 2004 |
Lipoic acid pretreatment attenuates ferric chloride-induced seizures in the rat.
Topics: Animals; Antioxidants; Chlorides; Disease Models, Animal; Electroencephalography; Ferric Compounds; | 2004 |
Regulation of ischemic cell death by the lipoic acid-palladium complex, Poly MVA, in gerbils.
Topics: Animals; Antioxidants; Behavior, Animal; Cell Death; Disease Models, Animal; Dose-Response Relations | 2004 |
[Effects of DL-alpha-lipoic acid on the experimentally induced diabetic cataract in rats].
Topics: Animals; Antioxidants; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Disease Models, Ani | 2004 |
Protective effect of DL-alpha-lipoic acid in cyclophosphamide induced oxidative injury in rat testis.
Topics: Animals; Antineoplastic Agents, Alkylating; Antioxidants; Body Weight; Cyclophosphamide; Disease Mod | 2004 |
Neuroprotection by alpha-lipoic acid in streptozotocin-induced diabetes.
Topics: Animals; Antioxidants; Biomarkers; Brain Chemistry; Diabetes Mellitus, Experimental; Diabetic Neurop | 2004 |
Mechanisms of antioxidant and pro-oxidant effects of alpha-lipoic acid in the diabetic and nondiabetic kidney.
Topics: Albuminuria; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephrop | 2005 |
Effects of alpha-lipoic acid on kinin B1 and B2 receptor binding sites in the spinal cord of chronically angiotensin-treated rats.
Topics: Angiotensin II; Animals; Binding Sites; Blood Glucose; Blood Pressure; Body Weight; Chronic Disease; | 2005 |
Alpha-lipoic acid inhibits fractalkine expression and prevents neointimal hyperplasia after balloon injury in rat carotid artery.
Topics: Angioplasty, Balloon; Animals; Antioxidants; Blotting, Northern; Blotting, Western; Carotid Artery D | 2006 |
Protective role of eicosapentaenoate-lipoate (EPA-LA) derivative in combating oxidative hepatocellular injury in hypercholesterolemic atherogenesis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Atherosclerosis; Cholesterol; Deoxyguanosine; Disease Models, | 2006 |
Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Dementia; Disease Models, Animal; Galactose; | 2006 |
Alpha-lipoic acid modulates ovarian surface epithelial cell growth.
Topics: Animals; Apoptosis; Cell Growth Processes; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, An | 2006 |
Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Cell Differentiatio | 2006 |
Antioxidants reduce cone cell death in a model of retinitis pigmentosa.
Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Cell Death; Disease Models, Animal; Electror | 2006 |
Alpha-lipoic acid suppresses the development of collagen-induced arthritis and protects against bone destruction in mice.
Topics: Animals; Antioxidants; Arthritis, Experimental; Cytokines; Disease Models, Animal; Dose-Response Rel | 2007 |
Protective effect of alpha-lipoic acid in experimental spermatic cord torsion.
Topics: Animals; Antioxidants; Disease Models, Animal; Free Radical Scavengers; Glutathione; Injections, Int | 2007 |
Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase 2; Dinoprostone; Disease Models, Ani | 2007 |
Alpha-lipoic acid may be a clinically useful therapy in interstitial cystitis.
Topics: Animals; Antioxidants; Cystitis, Interstitial; Disease Models, Animal; Humans; Inflammation; Mice; R | 2007 |
Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa.
Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Cell Death; Codon, Nonsense; Cyclic Nucleoti | 2007 |
Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model.
Topics: Acetylcysteine; Alanine Transaminase; Amanitins; Animals; Antidotes; Aspartate Aminotransferases; Ch | 2007 |
Therapeutic efficacy of DL-alpha-lipoic acid on cyclosporine A induced renal alterations.
Topics: Animals; Biomarkers; Cyclosporine; Disease Models, Animal; Enzymes; Kidney; Kidney Diseases; Male; P | 2007 |
Hepatocellular injury of nonischemic liver tissue after selective clamping in rats--protective action by pharmacological pretreatment with lipoic acid.
Topics: Animals; Antioxidants; Constriction; Disease Models, Animal; Ischemia; Lipid Peroxidation; Liver; Li | 2007 |
Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Caspase 3; Caspase 9; | 2007 |
Alpha-lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Colon; Disease Models, Animal; Gastrointes | 2007 |
Genetic and pharmacologic manipulation of oxidative stress after neonatal hypoxia-ischemia.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Disease Models, Animal; | 2008 |
The effect of lipoic acid on lipid peroxidation and visual evoked potentials (VEPs) in rats exposed to chronic restraint stress.
Topics: Analysis of Variance; Animals; Antioxidants; Disease Models, Animal; Evoked Potentials, Visual; Lipi | 2007 |
The protective effect of alpha-lipoic acid in experimental ovarian ischaemia-reperfusion injury.
Topics: Animals; Disease Models, Animal; Female; Malondialdehyde; Nitric Oxide; Ovary; Rats; Rats, Wistar; R | 2007 |
The effect of lipoic acid on antioxidant status and lipid peroxidation in rats exposed to chronic restraint stress.
Topics: Animals; Antioxidants; Brain; Catalase; Disease Models, Animal; Glutathione Peroxidase; Lipid Peroxi | 2008 |
Alpha lipoic acid attenuates microvascular endothelial cell hyperpermeability by inhibiting the intrinsic apoptotic signaling.
Topics: Analysis of Variance; Animals; Apoptosis; Capillary Permeability; Caspase 3; Cell Membrane Permeabil | 2008 |
Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Body Weight; Cholesterol; Dietary Supplements; Disease | 2008 |
Atherosclerosis in Japanese quail and the effect of lipoic acid.
Topics: Animals; Aorta; Arteriosclerosis; Coturnix; Delayed-Action Preparations; Diet, Atherogenic; Dietary | 1983 |
Modelling cortical cataractogenesis 17: in vitro effect of a-lipoic acid on glucose-induced lens membrane damage, a model of diabetic cataractogenesis.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glucose; In Vitr | 1995 |
Metabolic effects of thioctic acid in rodent models of insulin resistance and diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Disease Models, Animal; Fructose; Glucose; H | 1998 |
Modelling cortical cataractogenesis XX. In vitro effect of alpha-lipoic acid on glutathione concentrations in lens in model diabetic cataractogenesis.
Topics: Animals; Cataract; Culture Techniques; Diabetes Complications; Diabetes Mellitus; Disease Models, An | 1998 |
Effect of alpha-lipoic acid supplementation on oxidative protein damage in the streptozotocin-diabetic rat.
Topics: Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Free Radical | 2000 |
Effect of combined supplementation with vitamin E and alpha-lipoic acid on myocardial performance during in vivo ischaemia-reperfusion.
Topics: Animals; Antioxidants; Benzene Derivatives; Blood Pressure; Dietary Supplements; Disease Models, Ani | 2000 |
Lipoic acid reduces ischemia-reperfusion injury in animal models.
Topics: Adenosine Triphosphatases; Animals; Creatine Kinase; Disease Models, Animal; Heart; Hindlimb; In Vit | 2000 |
Contribution of dithiol ligands to in vitro and in vivo trypanocidal activities of dithiaarsanes and investigation of ligand exchange in an aqueous solution.
Topics: Animals; Arsenicals; Cysteamine; Dansyl Compounds; Disease Models, Animal; Female; Mice; Parasitic S | 2000 |
Alpha-lipoic acid treatment ameliorates metabolic parameters, blood pressure, vascular reactivity and morphology of vessels already damaged by streptozotocin-diabetes.
Topics: Animals; Antioxidants; Aorta; Blood Pressure; Carbohydrate Metabolism; Diabetes Mellitus, Experiment | 2000 |
Efficacy of antioxidant therapies in transient focal ischemia in mice.
Topics: Administration, Oral; Animals; Antioxidants; Body Weight; Brain; Cerebral Hemorrhage; Cerebrovascula | 2001 |
Dietary lipoic acid supplementation prevents fructose-induced hypertension in rats.
Topics: Aldehydes; Animals; Aorta; Blood Glucose; Blood Pressure; Dietary Supplements; Disease Models, Anima | 2000 |
Lipoic acid improves survival in transgenic mouse models of Huntington's disease.
Topics: Animals; Antioxidants; Benzenesulfonates; Body Weight; Brain; Disease Models, Animal; Food, Formulat | 2001 |
Beneficial effects of alpha-lipoic acid plus vitamin E on neurological deficit, reactive gliosis and neuronal remodeling in the penumbra of the ischemic rat brain.
Topics: Animals; Astrocytes; Brain; Disease Models, Animal; Free Radical Scavengers; GAP-43 Protein; Glial F | 2002 |
Effect of coenzyme-A, NAD, alpha lipoic-acid and cocarboxylase on survival of rats with galactosamine-induced severe hepatitis.
Topics: Animals; Coenzyme A; Disease Models, Animal; Female; Galactosamine; Hepatitis; Liver Function Tests; | 1985 |