thioctic acid has been researched along with Disease Models, Animal in 248 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (0.81) | 18.7374 |
| 1990's | 3 (1.21) | 18.2507 |
| 2000's | 63 (25.40) | 29.6817 |
| 2010's | 158 (63.71) | 24.3611 |
| 2020's | 22 (8.87) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Dai, L; Liao, S; Liu, C; Liu, X; Yang, W; Yu, T; Zhang, J; Zhao, J | 1 |
| Chaves Filho, AJM; Cunha, NL; De Oliveira, GMF; Gadelha Filho, CVJ; Jucá, PM; Macedo, DS; Oliveira, TQ; Soares, MVR; Vasconcelos, SMM; Viana, GA; Vieira, CFX | 1 |
| Kirss, S; Laks, K; Metsla, K; Palgi, M; Palumaa, P; Palumaa, T; Sildnik, G; Tõugu, V | 1 |
| Cao, Y; Jia, Z; Long, X; Shang, H; Xie, H; Yang, X | 1 |
| Gao, Y; Wang, M; Yang, G; Zhang, J; Zhang, X; Zhang, Y; Zhao, Y | 1 |
| Ahmed, KA; Ibrahim Fouad, G | 1 |
| Kamt, SF; Liu, J; Yan, LJ | 1 |
| Deng, FS; Jiang, L; Li, JS; Ren, Y; Wang, LH | 1 |
| Falah, M; Rayan, A; Rayan, M | 1 |
| Cui, Z; Huang, B; Jing, D; Li, Z; Liang, Y; Liu, X; Tan, L; Wang, X; Wu, S; Yang, X; Yeung, KWK; Zheng, D; Zheng, Y; Zhu, S | 1 |
| El-Lakkany, NM; El-Maadawy, WH; Hammam, OA; Seif El-Din, SH | 1 |
| Cheng, S; Ma, L; Wang, L; Xiang, W; Zhou, Y | 1 |
| Cai, W; Chen, J; Jiang, Y; Jin, M; Liu, P; Pi, R; Yan, J; Yao, M | 1 |
| Eser Faki, H; Tras, B; Uney, K | 1 |
| Mohammadi-Mahdiabadi-Hasani, MH; Nasehi, M; Nasiri Khalili, MA; Rezaie, M; Vaseghi, S; Zarrindast, MR | 1 |
| Dong, Z; Ge, J; Hu, K; Li, W; Sun, A; Sun, X; Wu, J; Yin, L | 1 |
| Jang, SY; Jung, SY; Kim, DK; Koo, H; Yang, KJ; Yi, G; Yoo, J | 1 |
| Akpinar, P; Aktas, I; Erkanli Senturk, G; Ersoy Canillioglu, Y; Kurt Oktay, KN; Unlu Ozkan, F | 1 |
| Beltramo, D; Francini, F; Garay, MI; Lagares, C; Moreira-Espinoza, MJ; Pasqualini, ME; Quiroga, P; Rabaglino, MB | 1 |
| Aktas, A; Ercan, S; Kemaloglu, MS | 1 |
| Alonzo, F; Chen, X; Laczkovich, I; Teoh, WP | 1 |
| Mohammed, HA; Ramadan, G; Waheed, G | 1 |
| Butt, H; Latief, N; Naseer, N; Riazuddin, S; Yaqub, F | 1 |
| Hu, F; Huang, X; Li, X; Long, D; Luo, F; Pei, X; Xing, S | 1 |
| Arpag, H; Atilla, N; Aydemir, Y; Cakir, T; Gül, M; Polat, C; Sayan, M; Yiğitcan, B; Þehirli, Ö | 1 |
| Bayraktar, S; Özcan, O; Özgür, T; Pınar, N; Soylu Karapınar, O | 1 |
| de Oliveira, AA; de Sousa, CNS; de Sousa, LC; Honório Júnior, JER; Macedo, D; Maes, M; Medeiros, IDS; Oliveira, TQ; Patrocínio, CFV; Vasconcelos, GS; Vasconcelos, SMM | 1 |
| Feng, Y; Hu, J; Qin, X; Song, ZY; Sun, Q; Xu, GY; Yang, PP; Zhang, HH | 1 |
| Cadenas, E; Liu, Z; Patil, I; Sancheti, H; Yin, F | 1 |
| Chen, CL; Goto, S; Hsu, LW; Inomata, M; Kitano, S; Lai, CY; Nakano, T; Takaoka, Y | 1 |
| Liu, Y; Sun, T; Wang, H; Wang, L; Xia, H; Yang, Y; Zhang, L; Zhang, Q | 1 |
| Han, X; Lv, C; Maharjan, S; Mao, Z; Sun, Y; Wang, Q; Wang, S; Xin, Y; Zhang, B | 1 |
| Chen, YH; Gou, Y; Li, HW; Li, Y; Lin, X; Tang, L; Wen, M; Zhang, Y; Zhou, B | 1 |
| Alonzo, F; Grayczyk, JP; Harvey, CJ; Laczkovich, I | 1 |
| Lin, JY; Liu, ZG; Wang, MH; Wang, XJ; Xie, CL; Zhang, SF | 1 |
| Fan, YG; Guo, C; Guo, SQ; Guo, T; Wang, DW; Wang, S; Wang, ZY; Xu, SF; Yang, YY; Zhang, S; Zhang, YH | 1 |
| Gardner, DK; Truong, T | 1 |
| Ambrosi, N; Caro, F; Casadei, D; Chuluyan, E; Guerrieri, D; Haeublein, G; Incardona, C; Sanchez, F | 1 |
| Cysne Filho, FMS; de Almeida, JC; de Sousa, CNS; Diniz, DDS; Macêdo, D; Patrocínio, CFV; Patrocínio, MCA; Sampaio, LRL; Vasconcelos, SMM | 1 |
| Aktas, O; Albrecht, P; Berndt, C; Dietrich, M; Fischer, D; Hartung, HP; Helling, N; Heskamp, A; Hildebrandt, T; Hilla, A; Issberner, A; Kohne, Z; Küry, P | 1 |
| Elaidy, SM; Essawy, SS; Hassan, MS; Samman, FS | 1 |
| Cross, AH; Evans, E; Piccio, L | 1 |
| Antonawich, F; Cox, C; Garnett, M; Golightly, MG; Hamidi, SA; Harrington, A; Huang, PH; Levine, L; Li, J; Lin, D; McClain, S; Miller, E; Qamar, N; Razi, R; Rueb, T; Schmidt, M; Szema, AM; Zimmerman, T | 1 |
| Cheng, J; Feng, H; Jiang, H; Liang, W; Wang, S; Wang, T; Wang, X; Wang, Y; Yang, Y; Zhang, C | 1 |
| Liu, P; Shen, D; Shen, T; Sun, H; Tian, L | 1 |
| Han, X; Lv, C; Mao, Z; Sun, Y; Wang, Q; Wang, S; Xin, Y; Zhang, B | 1 |
| Cho, GJ; Choi, MY; Choi, WS; Hong, EK; Kang, SS; Kim, HJ; Kim, M; Kim, YS; Lee, DH; Roh, GS | 1 |
| Demir, CF; Kuloglu, T; Tasci, I | 1 |
| Abdolghaffari, AH; Abdollahi, M; Moeinian, M; Momtaz, S; Nikfar, S | 1 |
| Amenta, F; Avola, R; Brundo, MV; Camiolo, G; Copat, C; Di Raimondo, F; Di Rosa, M; Ferrante, M; Giallongo, C; Li Volti, G; Musumeci, G; Palumbo, GA; Parrinello, NL; Romano, A; Salvaggio, A; Tibullo, D; Vicario, N | 1 |
| Abuyassin, B; Ayas, NT; Badran, M; Laher, I | 1 |
| Amini, P; Azmoonfar, R; Khodamoradi, E; Motevaseli, E; Musa, AE; Najafi, M; Rezaeyan, A; Shabeeb, D; Tavassoli, A; Yahyapour, R | 1 |
| Han, CY; Lee, HS; Lee, S; Park, JH; Young Park, H | 1 |
| Chen, Z; Fu, C; Wang, H; Xia, D; Zhai, X; Zhu, M | 1 |
| Andrade, AS; Behling, CS; Benfato, MS; Hackenhaar, FS; Marinho, PM; Putti, JS; Salomon, TB | 1 |
| Abdulrazzaq, AM; Abu Khalil, AA; Alhussainy, TM; Badr, M; Gammoh, O; Ghanim, BY; Qinna, NA | 1 |
| Ahuja, S; Akhtar, A; Sah, SP; Uniyal, A | 1 |
| Gong, X; Ji, K; Jia, J; Li, G; Luan, T; Yang, Z; Zang, B; Zhao, Y | 1 |
| Jalali-Nadoushan, M; Roghani, M | 1 |
| Cataldi, A; De Colli, M; Di Stefano, A; Nasuti, C; Pacella, S; Rapino, M; Sozio, P; Zara, S | 1 |
| Cao, F; Cheng, L; Deng, C; Ma, L; Sun, Z; Tong, G; Yi, D; Yi, W; Zhang, J; Zhao, B | 1 |
| Bosch-Morell, F; Mérida, S; Miranda, M; Muriach, M; Navea, A; Sancho-Tello, M | 1 |
| Chen, YT; He, CT; Hsieh, PS; Tian, YF | 1 |
| Jena, GB; Trivedi, PP | 1 |
| Akopian, G; Brinton, RD; Cadenas, E; Sancheti, H; Walsh, JP; Yin, F | 1 |
| Chang, HH; Chang, LS; Chen, BY; Huang, TP; Lin, DP; Liu, HJ; Lo, YL; Luk, CP | 1 |
| Alves, JA; Bianchin, MD; Freitas, JS; Guterres, SS; Isoppo, M; Külkamp-Guerreiro, IC; Piovezan, AP; Pohlmann, AR; Souza, MN | 1 |
| French, SW; Kathirvel, E; Morgan, K; Morgan, TR | 1 |
| Barcia, C; Garcia Esparza, A; Paradells, S; Rocamonde, B; Soria, JM | 1 |
| Baguisi, A; Beeuwkes, R; Casale, RA; Kates, SA | 1 |
| Mehrotra, A; Sandhir, R | 1 |
| Andrade, AS; Behling, CS; Benfato, MS; Hackenhaar, FS; Mahl, CD; Putti, J; Salomon, TB | 1 |
| Bhadri, N; Madakasira Guggilla, H; Razdan, R; Sanji, T | 1 |
| Abd-El-Aziz, AS; Connell, BJ; Khan, BV; Kucukkaya, I; Rajagopal, D; Saleh, MC; Saleh, TM | 1 |
| Bassi, E; Bortolotto, LA; Laurindo, FR; Liberman, M; Martinatti, MK | 1 |
| Feichtinger, RG; Mayr, JA; Ribes, A; Sperl, W; Tort, F | 1 |
| Deslauriers, J; Grignon, S; Racine, W; Sarret, P | 1 |
| Alaverdyan, M; Chan, P; Chen, PP; Cole, GM; Frautschy, SA; Gant, DJ; Kiosea, NC; Ma, QL; Nazari, S; Nothias, F; Teng, E; Ubeda, OJ; Yang, F; Zuo, X | 1 |
| Ahn, Y; Bae, IH; Cho, DL; Hong, YJ; Jeong, HY; Jeong, MH; Kim, HS; Kim, JH; Kim, JM; Kim, YS; Lim, KS; Park, DS; Park, JK; Park, KH; Sim, DS; Song, SJ; Yang, EJ | 1 |
| Basoglu, MS; Katilmis, H; Ozkul, Y; Ozturkcan, S; Songu, M | 1 |
| Akoz, A; Akpinar, E; Aksakal, AM; Aydin, A; Bayir, Y; Ferah, I; Halici, Z; Karaman, A; Kovaci, H; Selli, J | 1 |
| Cadenas, E; Díaz Brinton, R; Kanamori, K; Lin, AL; Patil, I; Sancheti, H; Zhang, W | 1 |
| de Luka, S; Jorgacevic, B; Mladenovic, D; Radosavljevic, T; Stevanovic, I; Veskovic, M | 1 |
| Fu, B; He, T; Li, P; Li, Y; Wang, X; Zhang, C; Zhang, J; Zhang, X; Zhang, Y; Zhao, Y; Zhu, X | 1 |
| Asci, H; Bayram, D; Candan, IA; Cankara, FN; Ilhan, I; Saygin, M; Yesilot, S | 1 |
| Hahm, JR; Jeong, BK; Jung, J; Jung, JH; Jung, MH; Kang, KM; Kim, JH; Kim, SK; Woo, SH | 1 |
| Akokay, P; Çilaker Mıcılı, S; Ergür, BU; Yılmaz, O | 1 |
| Kuhla, A; Kuhla, B; Ludwig, SC; Münch, G; Vollmar, B | 1 |
| Faĭzullin, RM; Miroshnichenko, IIu; Priakhina, KE; Rassokhina, LM; Volchegorskiĭ, IA | 1 |
| Deng, H; Ji, A; Liu, L; Liu, X; Wu, Z; Xu, Q; Zhang, J; Zuo, X | 1 |
| de Andrade, KQ; dos Santos, JC; Goulart, MO; Moura, FA | 1 |
| Ahmad, A; Brunyánszki, A; Coletta, C; Módis, K; Oláh, G; Papapetropoulos, A; Rios, EC; Szabo, C; Szczesny, B; Yanagi, K | 1 |
| Chung, EY; Kahng, J; Kim, TK; Kim, YS; Moon, JY | 1 |
| Faĭzullin, RM; Kalugina, AV; Malkin, MP; Miroshnichenko, II; Priakhina, KE; Rassokhina, LM; Volchegorskiĭ, IA | 1 |
| Allahverdi, E; Deprem, T; Diken Allahverdi, T; Günerhan, Y; Köksal, N; Merhan, O; Sülü, B; Vural, S; Yayla, S | 1 |
| Armagan, HH; Armagan, I; Bayram, D; Candan, IA; Celik, E; Uğuz, AC; Yigit, A | 1 |
| de Lucena, DF; de Sousa, CN; Gama, CS; Lima, LL; Macêdo, D; Oliveira, Tde Q; Vasconcelos, GS; Vasconcelos, SM; Ximenes, NC | 1 |
| Agostinis, C; Bulla, R; De Leo, R; De Seta, F; Zauli, G; Zorzet, S | 1 |
| Araújo, FY; da Silva, JC; de Oliveira, GV; de Sousa, CN; Gomes, PX; Leal, LK; Macêdo, D; Silva, MC; Vasconcelos, GS; Vasconcelos, SM; Ximenes, NC | 1 |
| Mehrotra, A; Sandhir, R; Sood, A | 1 |
| Ali, SO; Darwish, HA; Ismail, NA | 1 |
| Cotman, CW; de Rivera, C; Milgram, NW; Snigdha, S | 1 |
| Bourdette, D; Chaudhary, P; Galipeau, D; Marracci, G; Morris, B; Pocius, E | 1 |
| Choi, J; Dubrovsky, AM; Leung, PS; Wang, J; Yang, G | 1 |
| Bavbek, M; Bodur, E; Bozkurt, I; Gurcan, O; Gurcay, AG; Kazanci, A; Senturk, S; Turkoglu, OF | 1 |
| Moreno-Aliaga, MJ; Ramirez, MJ; Rodriguez-Perdigon, M; Solas, M | 1 |
| Burns, P; Chen, M; Desikan, R; Kherada, N; Mihai, G; Rajagopalan, S; Sun, Q; Wang, X; Xie, X; Ying, Z | 1 |
| Dal Lin, FT; Hauser, AB; Lo, SM; Nakao, LS; Pecoits-Filho, R; Soares, MF | 1 |
| Choi, BH; Choi, HS; Hahm, JR; Jeong, BK; Jeong, H; Jung, JH; Jung, MH; Kang, KM; Kim, JH; Song, JH; Woo, SH | 1 |
| Fu, Z; Liu, M; Sun, H; Wang, J | 1 |
| Baguisi, A; Beeuwkes, R; Casale, RA; Kates, SA; Lader, AS; Stewart, K | 1 |
| Degirmenci, E; Oguzhanoglu, A; Seyit, DA | 1 |
| Garner, MH; Garner, WH | 1 |
| Akakın, D; Biber, N; Ekiz, A; Erşahin, M; Hakan, T; Kıran, D; Öğünç, AV; Özdemir-Kumral, ZN; Özsavcı, D; Şener, G; Toklu, HZ; Tuğtepe, H; Yeğen, BÇ | 1 |
| Gao, S; Guo, J; Liu, Z; Yang, X; Zhao, R | 1 |
| Li, DW; Sun, WP; Wang, YD; Zhou, SY | 1 |
| Fichna, J; Piechota-Polanczyk, A; Piekielny, D; Zielińska, M | 1 |
| Alonzo, F; Grayczyk, JP; Zorzoli, A | 1 |
| Bobe, G; Hall, JA; Jewell, DE; Obare, E; Panickar, KS; Yerramilli, M | 1 |
| Barbosa, TM; Borges, LTN; Gularte, VN; Lima, RF; Macêdo, D; Matos, NCB; Oliveira, MN; Patrocínio, MCA; Sampaio, LRL; Vale, OCD; Vasconcelos, SMM | 1 |
| Cho, MY; Cho, SH; Go, MJ; Kang, ES; Kim, YH; Lee, CH; Lim, YT; Noh, JR | 1 |
| Connell, BJ; Rajagopal, D; Saleh, MC; Saleh, TM | 1 |
| Huang, YP; Jin, HY; Yu, HP | 1 |
| Abu-Samak, M; Al Hanbali, OA; Al-Matubsi, HY; Oriquat, GA; Salim, MD | 1 |
| Buckley, NA; Davidson, T; Endre, ZH; Pianta, TJ; Succar, L | 1 |
| Aydın, A; Yıldırım, AM | 1 |
| Abe, H; Hayashi, SM; Kangawa, Y; Kihara, T; Miyashita, T; Nakamura, M; Seto, Y; Shibutani, M; Yoshida, T | 1 |
| Gao, Y; Gong, Y; Guan, S; Xie, P; Yi, W; Zhang, T; Zhou, H | 1 |
| Beck, JN; Bose, N; Chi, T; Damodar, S; Gerona, RR; Hall, D; Kahn, A; Kapahi, P; Killilea, DW; O'Leary, MN; Parihar, J; Ramanathan, A; Sahota, A; Stoller, ML; Tischfield, J; Yang, M; Yang, S; Zee, J; Zee, T | 1 |
| Antonawich, FJ; Boerma, M; Cao, M; Garnett, M; Seawright, JW; Singh, P; Sridharan, V | 1 |
| Aydın, S; Belce, A; Çakatay, U; Cebe, T; Çelikten, M; Erdoğan, ME; Kansu, AD; Mengi, M; Yanar, K | 1 |
| Arora, N; Singh, BP; Tripathi, P | 1 |
| Chuang, SM; Huang, CH; Hydery, T; Juan, YS; Kogan, B; Levin, RM; Li, S; Mannikarottu, A; Schuler, C | 1 |
| Bhatt, DK; Bist, R | 1 |
| Gundogdu, G; Guven, A; Korkmaz, A; Kul, M; Onguru, O; Ozturk, H; Topal, T; Tunc, T | 1 |
| Bunch, JR; Jajoo, S; Mukherjea, D; Ramkumar, V; Rybak, LP; Turner, JG; Whitworth, C | 1 |
| Güven, A; Korkmaz, A; Kul, M; Ongürü, O; Oter, S; Sarici, U; Topal, T; Tunc, T | 1 |
| Arunsundar, M; Balaji, R; Krishnakumar, E; Ravichandiran, V; Shanmugarajan, TS; Sivaraman, D; Somasundaram, I | 1 |
| Atwood, CS; Casadesus, G; Pappolla, MA; Perry, G; Siedlak, SL; Smith, MA; Webber, KM | 1 |
| Fechter, LD; Fulton, S; Gearhart, C; Nelson-Miller, A; Pouyatos, B | 1 |
| Aliev, G; Alvarez, LM; Ames, BN; Fischbach, K; Gasimov, E; Lamanna, JC; Liu, J; Obrenovich, ME; Puchowicz, M; Shenk, JC; Xu, K | 1 |
| Jiang, J; Larrick, JW; Wang, Y; Yu, P; Zeng, X; Zhang, Z | 1 |
| Abdul Majid, AS; Del Soldato, P; Fawcett, RJ; Ji, D; Osborne, NN; Sparatore, A | 1 |
| Bae, SY; Kwon, YJ; Lee, YM; Pyo, HJ; Won, NH | 1 |
| de Freitas, RM; Ferreira, PM; Militão, GC | 1 |
| El-Desoky, K; El-Ghareib, MA; El-Masry, SA; El-Shitany, NA | 1 |
| de Freitas, RM | 1 |
| Albayrak, M; Altunkaynak, BZ; Cadirci, E; Gundogdu, C; Halici, M; Halici, Z; Odabasoglu, F; Suleyman, H; Unal, B; Uyanik, MH | 1 |
| Ahn, Y; Bae, EH; Cho, DL; Hong, YJ; Jeong, MH; Kang, JC; Kim, JH; Kim, KS; Kim, YS; Lim, SY; Park, IK; Sim, DS; Song, SJ | 1 |
| Chung, Y; Deiuliis, J; Desikan, R; Farrar, B; Kampfrath, T; Khan, B; Kherada, N; Parthasarathy, S; Rajagopalan, S; Simonetti, O; Sun, Q; Villamena, F; Ying, Z | 1 |
| Arora, N; Nair, S; Singh, BP; Tripathi, P | 1 |
| Cantalamessa, F; Cataldi, A; D'Aurizio, E; Di Stefano, A; Iannitelli, A; Nasuti, C; Sozio, P; Zara, S | 1 |
| Gajdosíková, A; Goldenberg, Z; Jariabka, P; Klobucníková, K; Kucera, P; Kyselová, Z; Skalská, S; Stefek, M; Stolc, S; Traubner, P | 1 |
| Cui, J; Le, GW; Li, YX; Shi, YH; Wang, B; Wang, ZP; Xiao, Y | 1 |
| Leggett, RE; Levin, RM; Li, HT; Schuler, C | 1 |
| Baykaner, MK; Börcek, AO; Doğulu, F; Durdağ, E; Emmez, H; Kale, A; Kiliç, N; Tönge, M; Uçankuş, LN; Yildirim, Z | 1 |
| de Freitas, RM; Feng, D; Jordán, J | 1 |
| Chen, Y; Fang, Y; Jang, Y; Wei, L; Wu, X; Yan, G; Yi, L; Zhou, X | 1 |
| Choi, HS; Choi, YK; Do, JY; Kim, HJ; Kim, JY; Kim, SY; Kwon, TK; Lee, HJ; Lee, IK; Lee, KU; Lee, MO; Lee, SJ; Oh, CJ; Park, IS; Park, KG | 1 |
| Anitha, M; Blatt, R; Chandrasekharan, B; Jones, DP; Kooby, D; Mwangi, S; Shahnavaz, N; Sitaraman, SV; Srinivasan, S; Staley, C | 1 |
| Akakin, D; Biber, N; Celik, H; Cetinel, S; Cikler, E; Ersahin, M; Erzik, C; Hakan, T; Ogunc, AV; Sener, G; Toklu, HZ | 1 |
| Atalay, F; Aygun, H; Bayir, Y; Cadirci, E; Cakir, A; Halici, M; Halici, Z; Odabasoglu, F; Suleyman, H | 1 |
| Alponti, RF; Barone, JM; Frezzatti, R; Silveira, PF; Zambotti-Villela, L | 1 |
| Afrooz, MR; Dadadshi, A; Hajipour, B; Hosseinian, MM; Khodadadi, A; Shaafi, S | 1 |
| Ahn, HJ; Jang, AH; Kim, GD; Kim, TH; Park, CS; Park, YS | 1 |
| Hagiwara, S; Koga, H; Noguchi, T; Saikawa, T; Takahashi, N; Teshima, Y | 1 |
| Ahmed, HH | 1 |
| Abd-Allah, AR; Abdel-Hamied, HE; Al-Shabanah, OA; Ashour, AE; Korashy, HM | 1 |
| Bourdette, D; Chaudhary, P; Galipeau, D; Marracci, G; Morris, B; Yu, X | 1 |
| Farrugia, G; Kashyap, P | 1 |
| Li, KH; Lu, BB | 1 |
| Abolhassani, M; Baronzio, G; Bonte, J; Campion, F; Fichtner, I; Fiorentini, G; Guais, A; Israël, M; Sanders, E; Schwartz, L | 1 |
| Ersöz, N; Korkmaz, A; Öter, Ş; Özerhan, İH; Özler, M; Topal, T | 1 |
| Miroshnichenko, IIu; Rassokhina, LM; Volchegorskiĭ, IA | 1 |
| Abdin, AA; Sarhan, NI | 1 |
| Reymann, KG; Röhnert, P; Schröder, UH; Striggow, F; Täger, M; Ziabreva, I | 1 |
| Hagiwara, S; Inomata, M; Iwashita, Y; Kitano, S; Masuda, T; Noguchi, T; Ohta, M | 1 |
| Cho, WK; Choi, HS; Hahm, JS; Jang, KS; Jeon, HJ; Jun, DW; Jun, JH; Kim, HJ; Kwon, HJ; Lee, HL; Lee, KN; Lee, MH; Lee, OY; Yoon, BC | 1 |
| Kim, HS; Kim, JG; Kim, MK; Lee, IK; Lee, KU; Min, AK; Park, KG; Seo, HY | 1 |
| Erdi, MF; Esen, H; Guney, O; Kiyici, A | 1 |
| Dai, Z; He, L; Liu, B; Luo, XJ; Ma, QL; Peng, J; Zhang, HF; Zhang, YS | 1 |
| Connell, BJ; Khan, BV; Rajagopal, D; Saleh, MC; Saleh, TM | 1 |
| González-Muniesa, P; Martínez, JA; Moreno-Aliaga, MJ; Pérez-Matute, P; Prieto-Hontoria, PL; Valdecantos, MP | 1 |
| Akashi, K; Ansari, AA; Gershwin, ME; Harada, K; Hisamoto, S; Ishibashi, H; Kikuchi, K; Leung, PS; Nakamura, M; Nakanuma, Y; Niiro, H; Shimoda, S; Tsuneyama, K | 1 |
| Ding, X; Liu, H; Xu, X; Yu, X; Zhu, J; Zou, J | 1 |
| Banks, WA; Ercal, N; Farr, SA; Morley, JE; Price, TO | 1 |
| Ahn, JH; Choi, JH; Hwang, IK; Kim, IH; Kim, JD; Lee, CH; Lee, JC; Lee, SK; Lee, TH; Park, JH; Won, MH; Yan, BC; Yim, Y; Yoo, KY | 1 |
| Jiang, R; Lu, H; Peng, X; Wan, J; Xie, J; Zhang, L | 1 |
| Carvalho, AF; Cordeiro, RC; Hyphantis, TN; Macêdo, DS; McIntyre, RS; Medeiros, CD; Morais, TA; Quevedo, J; Santos, JV; Sousa, FC | 1 |
| Akdoğan, GG; Bağrıyanık, HA; Buldan, Z; Erbil, G; Ergur, BU; Mıcılı, SC; Ozoğul, C; Ozyurt, D; Pekcetin, C; Sarıoğlu, S; Sonmez, U; Tekmen, I; Tuğyan, K | 1 |
| Coelho, JG; Dalazen, GR; Dutra-Filho, CS; Jacques, CE; Moraes, TB; Rosa, AP; Terra, M | 1 |
| Andreu, AL; Bianchi, P; Ferrer, I; Fourcade, S; Galino, J; López-Erauskin, J; Muñoz-Pinedo, C; Pujol, A | 1 |
| Nagaraj, M; Sivaprasad, R; Varalakshmi, P | 1 |
| Banks, WA; Butterfield, DA; Dogrukol-Ak, D; Drake, J; Eyerman, E; Farr, SA; Morley, JE; Poon, HF | 1 |
| de Champlain, J; El Midaoui, A; Laplante, MA; Wu, R | 1 |
| Honma, H; Podratz, JL; Windebank, AJ | 1 |
| Bates, GP; Hockly, E | 1 |
| Gupta, YK; Sharma, M | 1 |
| Cabral, FR; do Vale, OC; Fonteles, DS; Fonteles, MC | 1 |
| Baggs, RB; Rydkina, E; Sahni, SK; Santucci, LA; Silverman, DJ; Turpin, LC | 1 |
| Malarkodi, SP; Sivaprasad, TR; Varalakshmi, P | 1 |
| Avery, MA; Benson, SC; Chittiboyina, A; Ellis, CN; Ho, CI; Kurtz, TW; Meingassner, J; Pershadsingh, HA; Varani, J; Venkatraman, MS | 1 |
| Lee, JK; Meyerhoff, JL; Rittase, BW; Tsang, AY; Yourick, DL | 1 |
| Rogers, SA | 1 |
| Antonawich, FJ; Fiore, SM; Welicky, LM | 1 |
| Sun, L; Zhang, JS | 1 |
| Mythili, Y; Prahalathan, C; Selvakumar, E; Varalakshmi, P | 1 |
| Baydas, G; Donder, E; Kiliboz, M; Nedzvetskii, VS; Sonkaya, E; Tuzcu, M; Yasar, A | 1 |
| Doggrell, SA | 1 |
| Asico, L; Bhatti, F; Mankhey, RW; Maric, C; Quinn, MT; Welch, WJ | 1 |
| Couture, R; de Champlain, J; El Midaoui, A; Ongali, B; Petcu, M | 1 |
| Cho, WH; Han, SW; Kim, HS; Kim, HT; Kim, JG; Kim, YD; Koh, GY; Lee, HJ; Lee, IK; Lee, KM; Lee, KU; Park, JY; Park, KG | 1 |
| Kumar, SA; Sudhahar, V; Varalakshmi, P | 1 |
| Cui, X; Hu, Y; Li, X; Liu, J; Long, J; Packer, L; Zhang, Q; Zuo, P | 2 |
| Allison, BM; Benson, EA; Goebl, MG; Harrington, MA; Limbil, TL; Vig-Varga, E | 1 |
| Campochiaro, PA; Komeima, K; Lu, L; Rogers, BS | 1 |
| Cho, KJ; Cho, YS; Lee, CK; Lee, EY; Lee, HR; Lee, KU; Moon, HB; Moon, SH; Park, JY; Yoo, B | 1 |
| Aragão, AA; Barbosa, PH; de Sandes Kimura, O; de Vasconcelos, PR; Guimarães, SB; Santos, JM | 1 |
| Ho, SY; Ho, YS; Lai, CS; Liu, HI; Pan, MH; Tai, C; Wang, YJ | 1 |
| Kawalski, H; Koszutski, T; Kudela, G; Pastuszka, A; Slusarczyk, K | 1 |
| Campochiaro, PA; Komeima, K; Rogers, BS | 1 |
| Betten, DP; Clark, RF; Favata, M; Hernandez, M; Richardson, WH; Riffenburgh, RH; Tanen, DA; Tong, TC | 1 |
| Amudha, G; Josephine, A; Mythili, Y; Sundarapandiyan, R; Varalakshmi, P | 1 |
| Albrecht-Schöck, S; Duenschede, F; Dutkowski, P; Junginger, T; Kiemer, AK; Kneist, W; Korenkov, M; Miesner, I; Schad, A; Westermann, S | 1 |
| Albrecht-Schöck, S; Duenschede, F; Erbes, K; Ewald, P; Gockel, I; Junginger, T; Kiemer, AK; Kircher, A; Miesmer, I; Riegler, N; Schad, A; Westermann, S | 1 |
| Alican, I; Ercan, F; Jahovic, N; Kolgazi, M; Yüksel, M | 1 |
| Christen, S; Ferriero, DM; Sheldon, RA | 1 |
| Ağar, A; Akpinar, D; Alicigüzel, Y; Derin, N; Sahin, M; Yargiçoğlu, P | 1 |
| Basarali, K; Büyükbas, S; Cosar, E; Köken, G; Sahin, FK; Toy, H | 1 |
| Ağar, A; Akpinar, D; Alicigüzel, Y; Derin, N; Yargiçoğlu, P | 1 |
| Childs, EW; Holder-Haynes, JG; Hunter, FA; Tharakan, B | 1 |
| Bird, KE; Frei, B; Hagen, TM; LeBoeuf, RC; McMillen, TS; Zhang, WJ | 1 |
| Shih, JC | 1 |
| Handelman, GJ; Kilic, F; Packer, L; Serbinova, E; Trevithick, JR | 1 |
| Black, K; Donnelly, R; Qu, X; Seale, JP | 1 |
| Handelman, GJ; Kilic, F; Packer, L; Traber, K; Trevithick, JR; Tsang, K | 1 |
| Akçay, T; Cakatay, U; Kayali, R; Sivas, A; Telci, A | 1 |
| Coombes, JS; Demirel, HA; Hamilton, KL; Jessup, J; Ji, LL; Naito, H; Packer, L; Powers, SK; Sen, CK; Shanely, RA; Vincent, HK | 1 |
| Freisleben, HJ | 1 |
| Loiseau, PM; Lubert, P; Wolf, JG | 1 |
| Aktan, F; Canbolat, O; Elbeğ, S; Karasu, C; Koçak, G; Ozoğul, C; Yildizoglu-Ari, N | 1 |
| Cipolla, MJ; Clark, WM; Lessov, NS; Lowery, SL; Rinker, LG | 1 |
| Ford, CA; Gadag, V; Longerich, L; Parai, S; Vasdev, S | 1 |
| Andreassen, OA; Beal, MF; Dedeoglu, A; Ferrante, RJ | 1 |
| Garcia-Estrada, J; Gomez-Pinedo, U; Gonzalez-Castañeda, RE; Gonzalez-Perez, O; Huerta, M; Luquin, S; Navarro-Ruiz, A; Sanchez-Almaraz, E | 1 |
| Rajacic, Z; Thölen, H; Zimmerli, W | 1 |
11 review(s) available for thioctic acid and Disease Models, Animal
| Article | Year |
|---|---|
Role of lipoic acid in multiple sclerosis.
Topics: Animals; Antioxidants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Mice; Multiple Sclerosis; Thioctic Acid | 2022 |
Renal-Protective Roles of Lipoic Acid in Kidney Disease.
Topics: Acute Kidney Injury; Animals; Antioxidants; Disease Models, Animal; Kidney; Renal Insufficiency, Chronic; Thioctic Acid | 2023 |
Alpha Lipoic Acid: A Therapeutic Strategy that Tend to Limit the Action of Free Radicals in Transplantation.
Topics: Animals; Clinical Trials as Topic; Disease Models, Animal; Free Radicals; Humans; Reperfusion Injury; Thioctic Acid; Transplantation | 2018 |
Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis: A Review.
Topics: Acetylcarnitine; Animals; Ascorbic Acid; Biotin; Caffeine; Creatine; Curcumin; Dietary Supplements; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids, Unsaturated; Folic Acid; Ginkgo biloba; Humans; Multiple Sclerosis; Niacin; Pantothenic Acid; Plant Preparations; Probiotics; Pyridoxine; Resveratrol; Riboflavin; Tea; Thiamine; Thioctic Acid; Ubiquinone; Vitamin A; Vitamin B 12; Vitamin D; Vitamin E; Vitamins | 2018 |
Effects of alpha lipoic acid and its derivative "andrographolid-lipoic acid-1" on ulcerative colitis: A systematic review with meta-analysis of animal studies.
Topics: Animals; Antioxidants; Colitis, Ulcerative; Disease Models, Animal; Mice; Rats; Thioctic Acid | 2019 |
Lipoic acid biosynthesis defects.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Acyltransferases; Amino Acid Oxidoreductases; Animals; Carrier Proteins; Dihydrolipoamide Dehydrogenase; Disease Models, Animal; Humans; Lipid Metabolism, Inborn Errors; Multienzyme Complexes; Sulfurtransferases; Thioctic Acid; Transferases | 2014 |
Lipoic Acid: its antioxidant and anti-inflammatory role and clinical applications.
Topics: Aging; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Clinical Trials as Topic; Disease Models, Animal; Humans; Inflammation; Oxidative Stress; Pain; Reactive Oxygen Species; Thioctic Acid; Vitamin E | 2015 |
Xenobiotics and loss of tolerance in primary biliary cholangitis.
Topics: Acetaminophen; Animals; Autoantibodies; Autoantigens; Chemical and Drug Induced Liver Injury; Cholangitis; Dihydrolipoyllysine-Residue Acetyltransferase; Disease Models, Animal; Humans; Immune Tolerance; Mice; Mitochondria; Mitochondrial Proteins; Molecular Mimicry; Thioctic Acid; Xenobiotics | 2016 |
Experimental therapeutics in Huntington's disease: are models useful for therapeutic trials?
Topics: Acetamides; Animals; Antioxidants; Creatine; Disease Models, Animal; Evaluation Studies as Topic; Huntingtin Protein; Huntington Disease; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neuroprotective Agents; Nuclear Proteins; Peptides; Point Mutation; Riluzole; Thioctic Acid; Trinucleotide Repeats; Ubiquinone | 2003 |
Lipoic acid as a potential first agent for protection from mycotoxins and treatment of mycotoxicosis.
Topics: Air Pollution, Indoor; Animals; Antioxidants; Biomedical Research; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Inhalation Exposure; Mycotoxicosis; Mycotoxins; Sick Building Syndrome; Thioctic Acid; Xenobiotics | 2003 |
Alpha-lipoic acid, an anti-obesity agent?
Topics: AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Disease Models, Animal; Humans; Lipid Metabolism; Metformin; Multienzyme Complexes; Obesity; Protein Serine-Threonine Kinases; Rats; Rats, Inbred OLETF; Rats, Sprague-Dawley; Thioctic Acid | 2004 |
1 trial(s) available for thioctic acid and Disease Models, Animal
| Article | Year |
|---|---|
Nutritional Interventions that Slow the Age-Associated Decline in Renal Function in a Canine Geriatric Model for Elderly Humans.
Topics: Absorptiometry, Photon; Aged; Aging; Animals; Arginine; Biomarkers; Body Weight; Carnitine; Cross-Sectional Studies; Diet; Dietary Proteins; Dietary Supplements; Disease Models, Animal; Dogs; Female; Fish Oils; Fruit; Geriatric Assessment; Glomerular Filtration Rate; Humans; Kidney; Male; Thioctic Acid; Vegetables | 2016 |
236 other study(ies) available for thioctic acid and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Establishment of a Drug Screening Model for Cardiac Complications of Acute Renal Failure.
Topics: Acute Kidney Injury; Animals; Animals, Genetically Modified; Cardio-Renal Syndrome; Cardiovascular Diseases; Digoxin; Disease Models, Animal; Drug Evaluation, Preclinical; Enalapril; Epithelial Cells; Humans; Kidney Tubules; Larva; Metronidazole; Regional Blood Flow; Thioctic Acid; Treatment Outcome; Zebrafish | 2021 |
Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Cognitive Dysfunction; Corticosterone; Depression; Disease Models, Animal; Hippocampus; Male; Mice; Mirtazapine; Thioctic Acid; Weight Gain | 2022 |
α-Lipoic Acid Has the Potential to Normalize Copper Metabolism, Which Is Dysregulated in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Cell Line; Copper; Disease Models, Animal; Drosophila melanogaster; Humans; Neurons; Thioctic Acid | 2022 |
Alpha-lipoic acid improved motor function in MPTP-induced Parkinsonian mice by reducing neuroinflammation in the nigral and spinal cord.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopaminergic Neurons; Mice; Mice, Inbred C57BL; Microglia; Neuroinflammatory Diseases; NF-kappa B; Parkinson Disease; Spinal Cord; Substantia Nigra; Thioctic Acid; Tumor Necrosis Factor-alpha | 2022 |
Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination.
Topics: Animals; Carvedilol; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neurodegenerative Diseases; Rats; Thioctic Acid | 2023 |
Protective effect and mechanism of alpha-lipoic acid on partial hepatic ischemia-reperfusion injury in adult male rats.
Topics: Animals; Chemokine CXCL2; Cytoprotection; Disease Models, Animal; Free Radical Scavengers; Glutathione; Liver; Liver Diseases; Male; Nitric Oxide Synthase Type II; Oxidative Stress; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Superoxide Dismutase; Thioctic Acid; Transcription Factor RelA | 2019 |
A Novel Paclitaxel Conjugate with Higher Efficiency and Lower Toxicity: A New Drug Candidate for Cancer Treatment.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Paclitaxel; Thioctic Acid; Xenograft Model Antitumor Assays | 2019 |
"Imitative" click chemistry to form a sticking xerogel for the portable therapy of bacteria-infected wounds.
Topics: Animals; Biocompatible Materials; Click Chemistry; Disease Models, Animal; Mice; Staphylococcal Infections; Staphylococcus aureus; Static Electricity; Thioctic Acid; Transdermal Patch; Wound Healing; Wound Infection | 2019 |
α-Lipoic acid modulates liver fibrosis: A cross talk between TGF-β1, autophagy, and apoptosis.
Topics: Animals; Apoptosis; Autophagy; Biomarkers; Disease Models, Animal; Liver Cirrhosis; Male; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Silymarin; Thioacetamide; Thioctic Acid; Transforming Growth Factor beta1 | 2020 |
Protective Effects of α-Lipoic Acid on Vascular Oxidative Stress in Rats with Hyperuricemia.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Catalase; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione Peroxidase; Hyperuricemia; Male; Malondialdehyde; Oxidative Stress; Rats; Superoxide Dismutase; Thioctic Acid; Vascular System Injuries | 2019 |
Discovery of a novel niacin-lipoic acid dimer N2L attenuating atherosclerosis and dyslipidemia with non-flushing effects.
Topics: Animals; Atherosclerosis; Cell Line; Cricetulus; Dimerization; Disease Models, Animal; Drug Design; Dyslipidemias; Female; Flushing; Human Umbilical Vein Endothelial Cells; Humans; Hypolipidemic Agents; Lipids; Male; Mice; Mice, Knockout, ApoE; Molecular Docking Simulation; Niacin; Rats; Thioctic Acid | 2020 |
Alpha lipoic acid and vitamin E improve atorvastatin-induced mitochondrial dysfunctions in rats.
Topics: Adenosine Triphosphate; Administration, Oral; Animals; Atorvastatin; Case-Control Studies; Disease Models, Animal; Kidney; Male; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Rats; Rats, Wistar; Thioctic Acid; Treatment Outcome; Vitamin E | 2020 |
The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats.
Topics: Animals; Avoidance Learning; Behavior, Animal; Disease Models, Animal; Locomotion; Male; Memory; Memory Disorders; Nootropic Agents; Rats, Wistar; Sleep; Sleep Deprivation; Social Behavior; Thioctic Acid | 2020 |
Alpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Angiotensin II; Animals; Animals, Newborn; Aorta; Apoptosis; Base Sequence; Cardiotonic Agents; Constriction, Pathologic; Disease Models, Animal; Fibrosis; Heart Failure; Heart Ventricles; Hypertrophy, Left Ventricular; Male; Membrane Proteins; Mice, Inbred C57BL; Mitochondria; Mitochondrial Proteins; Myocytes, Cardiac; Nuclear Respiratory Factor 1; Pressure; Rats; Signal Transduction; Thioctic Acid | 2020 |
Intratympanic administration of alpha-lipoic acid-loaded pluronic F-127 nanoparticles ameliorates acute hearing loss.
Topics: Animals; Antioxidants; Cell Death; Cell Line; Cell Nucleus; Disease Models, Animal; Hearing Loss; Male; Mice, Inbred C57BL; Nanoparticles; NF-E2-Related Factor 2; Poloxamer; Thioctic Acid; Tympanic Membrane | 2021 |
The Effect of Alpha Lipoic Acid on the Recovery of Sciatic Nerve Injury in Rats: A Prospective Randomized Controlled Trial.
Topics: Animals; Disease Models, Animal; Functional Status; Male; Peripheral Nerve Injuries; Prospective Studies; Rats; Rats, Sprague-Dawley; Recovery of Function; Sciatic Nerve; Thioctic Acid | 2021 |
Maternal intake of alpha-lipoic acid prevents development of symptoms associated with a fructose-rich diet in the male offspring in Wistar rats.
Topics: Animals; Diet; Disease Models, Animal; Female; Fructose; Maternal Exposure; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Thioctic Acid | 2021 |
Antioxidative effects of alpha-lipoic acid in spinal cord injury An experimental rat model.
Topics: Animals; Antioxidants; Disease Models, Animal; Methylprednisolone; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spinal Cord Injuries; Thioctic Acid | 2021 |
Topics: Animals; Bacterial Proteins; Cell Membrane; Disease Models, Animal; Fatty Acids, Unsaturated; Host-Pathogen Interactions; Lipase; Lipogenesis; Lipoylation; Mice; Organ Specificity; Skin; Staphylococcal Infections; Staphylococcus aureus; Thioctic Acid | 2021 |
Sodium R-lipoate and enzymatically-modified isoquercitrin suppressed IgE-independent anaphylactic reactions and stress-induced gastric ulceration in mice.
Topics: Administration, Oral; Anaphylaxis; Animals; Anti-Allergic Agents; Cell Degranulation; Disease Models, Animal; Gastric Mucosa; Histamine Release; Humans; Male; Mast Cells; Mice; p-Methoxy-N-methylphenethylamine; Quercetin; Specific Pathogen-Free Organisms; Stomach Ulcer; Stress, Psychological; Sulfasalazine; Thioctic Acid | 2021 |
Alpha lipoic acid priming enhances the hepatoprotective effect of adipose derived stem cells in CCl4 induced hepatic injury in-vitro.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Coculture Techniques; Combined Modality Therapy; Disease Models, Animal; Hepatocytes; Humans; Mesenchymal Stem Cell Transplantation; Primary Cell Culture; Protective Agents; Rats; Thioctic Acid | 2021 |
The neuroprotective effects of alpha-lipoic acid on an experimental model of Alzheimer's disease in PC12 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Neuroprotective Agents; PC12 Cells; Rats; Thioctic Acid | 2022 |
Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Glutathione; Humans; Interleukin-1beta; Lung; Lung Injury; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Thioctic Acid; Tumor Necrosis Factor-alpha | 2018 |
Effect of alpha-lipoic acid on endometrial implants in an experimental rat model.
Topics: Animals; Antioxidants; Autografts; Disease Models, Animal; Endometriosis; Endometrium; Female; Oxidative Stress; Rats; Rats, Wistar; Thioctic Acid; Treatment Outcome | 2017 |
Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone.
Topics: Animals; Antidepressive Agents, Tricyclic; Antioxidants; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Depressive Disorder; Disease Models, Animal; Drug Combinations; Glutathione; Hippocampus; Lipid Peroxidation; Male; Mianserin; Mice; Mirtazapine; Nitrites; Thioctic Acid | 2017 |
Alpha-lipoic Acid suppresses P2X receptor activities and visceral hypersensitivity to colorectal distention in diabetic rats.
Topics: Animals; Colon; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; Neurons; Pain Measurement; Physical Stimulation; Rats, Sprague-Dawley; Receptors, Purinergic P2X; Receptors, Purinergic P2X2; Receptors, Purinergic P2X3; Rectum; Streptozocin; Thioctic Acid | 2017 |
Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and
Topics: Animals; Anti-Obesity Agents; Antioxidants; Astrocytes; Biological Transport; Brain; Brain Chemistry; Carbon-13 Magnetic Resonance Spectroscopy; Diet, High-Fat; Disease Models, Animal; Gene Expression Regulation; Glucose; Glucose Transporter Type 3; Glucose Transporter Type 4; Insulin Resistance; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neurons; Obesity; Positron Emission Tomography Computed Tomography; Thioctic Acid | 2017 |
Therapeutic potential of α-lipoic acid derivative, sodium zinc histidine dithiooctanamide, in a mouse model of allergic rhinitis.
Topics: Allergens; Alum Compounds; Animals; Antioxidants; Cell Degranulation; Cytokines; Disease Models, Animal; Female; Histidine; Immunoglobulin E; Immunoglobulin G; Male; Mast Cells; Mice, Inbred BALB C; Ovalbumin; Rats, Inbred Lew; Rhinitis, Allergic; Spleen; T-Lymphocytes, Regulatory; Thioctic Acid | 2017 |
The α-lipoic acid improves high-fat diet-induced cerebral damage through inhibition of oxidative stress and inflammatory reaction.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Brain Diseases; Diet, High-Fat; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Oxidative Stress; Phosphorylation; Thioctic Acid | 2017 |
α-Lipoic Acid Promotes Neurological Recovery After Ischemic Stroke by Activating the Nrf2/HO-1 Pathway to Attenuate Oxidative Damage.
Topics: Animals; Brain; Brain Edema; Cell Hypoxia; Cell Survival; Cells, Cultured; Disease Models, Animal; Glutathione Peroxidase; Heme Oxygenase-1; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Stroke; Superoxide Dismutase; Thioctic Acid | 2017 |
Alpha Lipoamide Ameliorates Motor Deficits and Mitochondrial Dynamics in the Parkinson's Disease Model Induced by 6-Hydroxydopamine.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apomorphine; Cell Death; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Exploratory Behavior; Forelimb; Male; Mesencephalon; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Motor Activity; Motor Disorders; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Sympatholytics; Thioctic Acid | 2018 |
A Lipoylated Metabolic Protein Released by Staphylococcus aureus Suppresses Macrophage Activation.
Topics: Animals; Bacterial Proteins; Bone Marrow; Cell Culture Techniques; Cytokines; Dihydrolipoamide Dehydrogenase; Disease Models, Animal; DNA, Bacterial; Female; Host-Parasite Interactions; Immune Evasion; Immunity, Innate; Macrophage Activation; Macrophages; Mice; Pyruvate Dehydrogenase Complex; Recombinant Proteins; Sequence Deletion; Staphylococcal Infections; Staphylococcus aureus; Thioctic Acid; Toll-Like Receptor 1; Toll-Like Receptor 2; Virulence Factors | 2017 |
Lipoic acid alleviates L‑DOPA‑induced dyskinesia in 6‑OHDA parkinsonian rats via anti‑oxidative stress.
Topics: Animals; Antioxidants; Caspase 3; Disease Models, Animal; Dopaminergic Neurons; Dyskinesia, Drug-Induced; Female; Levodopa; Oxidative Stress; Parkinson Disease; Poly(ADP-ribose) Polymerases; Rats; Reactive Oxygen Species; Substantia Nigra; Thioctic Acid | 2018 |
α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice.
Topics: Alzheimer Disease; Animals; Cell Death; Disease Models, Animal; Female; Inflammation; Lipid Peroxidation; Mice, Transgenic; Oxidative Stress; Point Mutation; tau Proteins; Tauopathies; Thioctic Acid | 2018 |
Antioxidants improve IVF outcome and subsequent embryo development in the mouse.
Topics: Acetylcarnitine; Acetylcysteine; Animals; Antioxidants; Blastocyst; Culture Media; Disease Models, Animal; Embryo Culture Techniques; Embryonic Development; Female; Fertilization in Vitro; Hydrogen Peroxide; In Vitro Oocyte Maturation Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Oocyte Retrieval; Oocytes; Oxidative Stress; Oxygen; Spermatozoa; Thioctic Acid; Treatment Outcome | 2017 |
Advantages of the Alpha-lipoic Acid Association with Chlorpromazine in a Model of Schizophrenia Induced by Ketamine in Rats: Behavioral and Oxidative Stress evidences.
Topics: Animals; Antioxidants; Antipsychotic Agents; Chlorpromazine; Disease Models, Animal; Drug Therapy, Combination; Hippocampus; Ketamine; Lipid Peroxidation; Male; Memory, Short-Term; Motor Activity; Nitriles; Oxidative Stress; Prepulse Inhibition; Random Allocation; Rats, Wistar; Schizophrenia; Thioctic Acid | 2018 |
Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model.
Topics: Animals; CD3 Complex; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Glutathione; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Nerve Degeneration; Nystagmus, Optokinetic; Protein Carbonylation; Retina; Thioctic Acid; Tomography, Optical Coherence; Vision Disorders; Vitamin B Complex | 2018 |
New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats.
Topics: Animals; Antioxidants; Body Weight; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Male; Metformin; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar; Survival Rate; Thioctic Acid; Tumor Necrosis Factor-alpha | 2018 |
Rux largely restores lungs in Iraq PM-exposed mice, Up-regulating regulatory T-cells (Tregs).
Topics: Afghan Campaign 2001-; Animals; Disease Models, Animal; Interleukin-15; Iraq; Lung Injury; Mice; Particulate Matter; Ruthenium; T-Lymphocytes, Regulatory; Thioctic Acid; Up-Regulation | 2018 |
α-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Cell Line; Disease Models, Animal; Drosophila melanogaster; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Male; MAP Kinase Signaling System; Mice; Neuroprotective Agents; Oxidative Stress; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Superoxide Dismutase-1; Thioctic Acid | 2018 |
Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice.
Topics: Animals; Aorta; Atherosclerosis; Disease Models, Animal; Endothelial Cells; Female; Humans; Hydrogen Peroxide; Mice; Mice, Knockout; Ovariectomy; Thioctic Acid | 2018 |
The Role of Alpha-Lipoic Acid in the Pathomechanism of Acute Ischemic Stroke.
Topics: Animals; Behavior, Animal; Brain Edema; Cell Line; Cyclooxygenase 2; Disease Models, Animal; Infarction, Middle Cerebral Artery; Intercellular Adhesion Molecule-1; Interleukin-10; Interleukin-1beta; Lipopolysaccharides; Male; Microglia; Neuroprotective Agents; NF-kappa B; Rats; Rats, Sprague-Dawley; Stroke; Thioctic Acid; Tumor Necrosis Factor-alpha | 2018 |
Alpha-lipoic acid reduces retinal cell death in diabetic mice.
Topics: Administration, Oral; AMP-Activated Protein Kinases; Animals; Cell Death; Cells, Cultured; Diabetes Mellitus, Experimental; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; N-Acetylglucosaminyltransferases; Retina; Streptozocin; Thioctic Acid | 2018 |
Effects of Alpha Lipoic Acid on Loss of Myelin Sheath of Sciatic Nerve in Experimentally Induced Diabetic Rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Male; Myelin Sheath; Neural Conduction; Rats; Rats, Wistar; Sciatic Nerve; Thioctic Acid | 2018 |
α-Lipoic Acid Reduces Iron-induced Toxicity and Oxidative Stress in a Model of Iron Overload.
Topics: Animals; Autophagy; Cell Line; Disease Models, Animal; Ferric Compounds; Glutathione; Heme Oxygenase-1; Humans; Iron Chelating Agents; Iron Overload; Oxidative Stress; Quaternary Ammonium Compounds; Reactive Oxygen Species; Superoxide Dismutase; Thioctic Acid; Zebrafish | 2019 |
The antioxidant α-lipoic acid attenuates intermittent hypoxia-related renal injury in a mouse model of sleep apnea.
Topics: Animals; Antioxidants; Disease Models, Animal; Hypoxia; Inflammation; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Sleep Apnea, Obstructive; Thioctic Acid | 2019 |
Mitigation of Radiation-induced Pneumonitis and Lung Fibrosis using Alpha-lipoic Acid and Resveratrol.
Topics: Animals; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Female; Humans; Mice; Pulmonary Fibrosis; Radiation; Radiation Pneumonitis; Resveratrol; Thioctic Acid | 2020 |
Effects of α-lipoic acid on chronic cerebrovascular hypoperfusion in an animal model of vascular dementia.
Topics: Animals; Carotid Stenosis; Cognitive Dysfunction; Dementia, Vascular; Disease Models, Animal; Drug Administration Schedule; Injections, Intraperitoneal; Male; Maze Learning; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Thioctic Acid; TOR Serine-Threonine Kinases; Treatment Outcome | 2019 |
Alpha lipoic acid inhibits oxidative stress-induced apoptosis by modulating of Nrf2 signalling pathway after traumatic brain injury.
Topics: Animals; Antioxidants; Apoptosis; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Heme Oxygenase-1; Male; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction; Thioctic Acid; Up-Regulation | 2019 |
The effect of n-3 long-chain polyunsaturated fatty acids and lipoic acid on the heart in the ovariectomized rat model of menopause.
Topics: Animals; Antioxidants; Biomarkers; Dietary Supplements; Disease Models, Animal; Fatty Acids, Omega-3; Female; Heart; Menopause; Ovariectomy; Oxidative Stress; Rats; Rats, Wistar; Thioctic Acid | 2019 |
Hepatoprotective Actions of Ascorbic Acid, Alpha Lipoic Acid and Silymarin or Their Combination Against Acetaminophen-Induced Hepatotoxicity in Rats.
Topics: Acetaminophen; Animals; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Male; Oxidative Stress; Protective Factors; Rats; Rats, Sprague-Dawley; Silymarin; Thioctic Acid | 2019 |
Alpha lipoic acid and metformin alleviates experimentally induced insulin resistance and cognitive deficit by modulation of TLR2 signalling.
Topics: Animals; Anti-Inflammatory Agents; Cognition Disorders; Disease Models, Animal; Insulin; Insulin Resistance; Interleukin-6; Lipid Peroxidation; Lipids; Male; Maze Learning; Memory; Metformin; Mice; Signal Transduction; Thioctic Acid; Toll-Like Receptor 2; Zymosan | 2019 |
Autophagy Enhancing Contributes to the Organ Protective Effect of Alpha-Lipoic Acid in Septic Rats.
Topics: Animals; Apoptosis; Autophagy; Cytokines; Disease Models, Animal; Inflammation; Male; NF-kappa B; Protective Agents; Rats; Rats, Sprague-Dawley; Sepsis; Signal Transduction; Survival Rate; Thioctic Acid; Weight Loss | 2019 |
Alpha-lipoic acid protects against 6-hydroxydopamine-induced neurotoxicity in a rat model of hemi-parkinsonism.
Topics: Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Laterality; Malondialdehyde; Neurons; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rotation; Substantia Nigra; Thioctic Acid | 2013 |
Ibuprofen and lipoic acid conjugate neuroprotective activity is mediated by Ngb/Akt intracellular signaling pathway in Alzheimer's disease rat model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Brain; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Disease Progression; Globins; Humans; Ibuprofen; Male; Memory; Nerve Tissue Proteins; Neuroglobin; Neuroprotective Agents; Peptide Fragments; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Thioctic Acid | 2013 |
α-Lipoic acid reduces infarct size and preserves cardiac function in rat myocardial ischemia/reperfusion injury through activation of PI3K/Akt/Nrf2 pathway.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Nucleus; Creatine Kinase; Disease Models, Animal; Gene Expression Regulation; Heme Oxygenase-1; L-Lactate Dehydrogenase; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Neutrophils; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Thioctic Acid; Transcription, Genetic; Tumor Necrosis Factor-alpha; Ventricular Function, Left | 2013 |
Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines release.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cytokines; Disease Models, Animal; Inflammation; Lipopolysaccharides; Male; Rats; Rats, Inbred Lew; Th1 Cells; Thioctic Acid; Uveitis | 2013 |
Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Cytokines; Disease Models, Animal; Endotoxemia; Fatty Liver; Fructose; Glutathione; Inflammation Mediators; Insulin; Lipopolysaccharides; Liver; Male; Malondialdehyde; Pancreas; Pancreatitis; Rats; Rats, Sprague-Dawley; Superoxides; Thioctic Acid; Toll-Like Receptor 4; Triglycerides | 2013 |
Role of α-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: studies on inflammation, oxidative stress, DNA damage and fibrosis.
Topics: Animals; Antioxidants; Blood Cells; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Fibrosis; Inflammation Mediators; Intestinal Absorption; Lipopolysaccharides; Male; Mice; Micronuclei, Chromosome-Defective; Organ Size; Oxidative Stress; Permeability; Random Allocation; Thioctic Acid; Tight Junctions | 2013 |
Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Glucose; Insulin; Mice; Mice, Inbred C57BL; Molecular Mimicry; Neuronal Plasticity; Synapses; Thioctic Acid | 2013 |
Dietary α-lipoic acid prevents UVB-induced corneal and conjunctival degeneration through multiple effects.
Topics: Animals; Antioxidants; Cell Survival; Conjunctiva; Conjunctival Diseases; Cornea; Corneal Diseases; Dietary Supplements; Disease Models, Animal; Female; Immunohistochemistry; Mice; Mice, Inbred CBA; Oxidative Stress; Thioctic Acid; Treatment Outcome; Ultraviolet Rays | 2013 |
Evaluation of lipoic acid topical application on rats skin wound healing.
Topics: Animals; Antioxidants; Disease Models, Animal; Lipid Peroxidation; Male; Nanocapsules; Rats; Rats, Wistar; Reactive Oxygen Species; Skin; Thioctic Acid; Time Factors; Wound Healing | 2013 |
Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease.
Topics: Acetylcarnitine; Adipose Tissue; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Body Weight; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Insulin Resistance; Liver; Male; Mice; Mice, Inbred BALB C; Mitochondria; Non-alcoholic Fatty Liver Disease; Organ Size; Oxidative Stress; Thioctic Acid | 2013 |
Lipoic acid treatment after brain injury: study of the glial reaction.
Topics: Animals; Antioxidants; Astrocytes; Blood-Brain Barrier; Brain; Brain Injuries; Disease Models, Animal; Inflammation; Male; Microglia; Neuroprotective Agents; Rats; Thioctic Acid | 2013 |
Lipoic acid analogs with enhanced pharmacological activity.
Topics: Animals; Dipeptides; Disease Models, Animal; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Structure-Activity Relationship; Thioctic Acid | 2014 |
Mitochondrial cofactors in experimental Huntington's disease: behavioral, biochemical and histological evaluation.
Topics: Acetylcarnitine; Animals; Antioxidants; Behavior, Animal; Brain; Chromatography, Thin Layer; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Glutathione; Huntington Disease; Lipid Peroxidation; Maze Learning; Motor Activity; Nitro Compounds; Propionates; Psychomotor Performance; Rats; Rats, Wistar; Rotarod Performance Test; Thioctic Acid | 2014 |
Alpha-lipoic acid restores tear production in an animal model of dry eye.
Topics: Animals; Antioxidants; Ascorbic Acid; Chromatography, High Pressure Liquid; Conjunctiva; Cornea; Dietary Supplements; Disease Models, Animal; Dry Eye Syndromes; Epithelium, Corneal; Estradiol; Fatty Acids, Omega-3; Female; Glutathione; Lacrimal Apparatus; Malondialdehyde; Microscopy, Electron, Scanning; Nitrates; Nitrites; Ovariectomy; Oxidative Stress; Progesterone; Radioimmunoassay; Rats; Rats, Wistar; Tears; Thioctic Acid | 2014 |
Amelioration of behavioural, biochemical, and neurophysiological deficits by combination of monosodium glutamate with resveratrol/alpha-lipoic acid/coenzyme Q10 in rat model of cisplatin-induced peripheral neuropathy.
Topics: Animals; Behavior, Animal; Catalase; Disease Models, Animal; Drug Therapy, Combination; Glutathione; Lipid Peroxidation; Neural Conduction; Neuroprotective Agents; Peripheral Nervous System Diseases; Psychomotor Performance; Rats; Resveratrol; Sciatic Neuropathy; Sodium Glutamate; Stilbenes; Thioctic Acid; Ubiquinone | 2013 |
Co-administration of resveratrol and lipoic acid, or their synthetic combination, enhances neuroprotection in a rat model of ischemia/reperfusion.
Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Humans; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Resveratrol; Stilbenes; Stroke; Thioctic Acid | 2014 |
Lipoic acid, but not tempol, preserves vascular compliance and decreases medial calcification in a model of elastocalcinosis.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Compliance; Cyclic N-Oxides; Disease Models, Animal; Male; Rabbits; Spin Labels; Thioctic Acid; Vascular Calcification; Vascular Resistance; Vasoconstriction | 2014 |
Preventive effect of α-lipoic acid on prepulse inhibition deficits in a juvenile two-hit model of schizophrenia.
Topics: Aging; Animals; Disease Models, Animal; Female; Male; Mice, Inbred C57BL; Prefrontal Cortex; Pregnancy; Receptors, Dopamine; Reflex, Startle; Schizophrenia; Thioctic Acid | 2014 |
Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.
Topics: Aging; Alzheimer Disease; Animals; Disease Models, Animal; Docosahexaenoic Acids; Gene Expression Regulation; Hippocampus; Learning Disabilities; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Movement Disorders; Psychomotor Performance; Reaction Time; Substantia Nigra; Synapses; tau Proteins; Thioctic Acid | 2014 |
Effect of polymer-free TiO2 stent coated with abciximab or alpha lipoic acid in porcine coronary restenosis model.
Topics: Abciximab; Animals; Antibodies, Monoclonal; Coronary Restenosis; Disease Models, Animal; Drug-Eluting Stents; Fibrin; Hyperplasia; Immunoglobulin Fab Fragments; Inflammation; Male; Neointima; Percutaneous Coronary Intervention; Polymers; Swine; Thioctic Acid; Time Factors; Titanium; Treatment Outcome | 2014 |
Evaluation of the protective effect of α-lipoic acid on cisplatin ototoxicity using distortion-product otoacoustic emission measurements: an experimental animal study.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cisplatin; Cochlea; Disease Models, Animal; Ear, Middle; Guinea Pigs; Hearing Loss; Injections; Injections, Intraperitoneal; Male; Otoacoustic Emissions, Spontaneous; Protective Agents; Thioctic Acid; Time Factors; Vestibule, Labyrinth | 2014 |
Treatment with α-lipoic acid enhances the bone healing after femoral fracture model of rats.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Femoral Fractures; Fracture Healing; Gene Expression Regulation; Rats; Rats, Wistar; RNA, Messenger; Thioctic Acid; Tomography, X-Ray Computed; Transforming Growth Factor beta; Treatment Outcome | 2014 |
Hypermetabolic state in the 7-month-old triple transgenic mouse model of Alzheimer's disease and the effect of lipoic acid: a 13C-NMR study.
Topics: Alzheimer Disease; Animals; Carbon Isotopes; Dietary Supplements; Disease Models, Animal; Glucose; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Sweetening Agents; Thioctic Acid; Vitamin B Complex | 2014 |
Alpha-lipoic acid affects the oxidative stress in various brain structures in mice with methionine and choline deficiency.
Topics: Animals; Brain; Catalase; Cerebral Cortex; Choline Deficiency; Corpus Striatum; Disease Models, Animal; Glutathione; Hippocampus; Hypothalamus; Lipid Peroxidation; Male; Malondialdehyde; Methionine; Mice; Mice, Inbred C57BL; Nitric Oxide; Oxidative Stress; Superoxide Dismutase; Thioctic Acid | 2015 |
Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression and protects mouse brain against focal ischemia.
Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Mice; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Sirtuin 1; Superoxide Dismutase; Thioctic Acid; Up-Regulation | 2014 |
The impact of alpha-lipoic acid on amikacin-induced nephrotoxicity.
Topics: Amikacin; Animals; Anti-Bacterial Agents; Antioxidants; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Female; Kidney; Kidney Function Tests; Malondialdehyde; Rats; Rats, Wistar; Renal Insufficiency; Thioctic Acid; Treatment Outcome | 2015 |
Alpha lipoic acid attenuates radiation-induced thyroid injury in rats.
Topics: Animals; Antioxidants; Cytokines; Disease Models, Animal; Fibrosis; Male; Oxidative Stress; Radiation Injuries; Radiation Injuries, Experimental; Radiation-Protective Agents; Rats; Thioctic Acid; Thyroid Gland | 2014 |
The effects of α-lipoic acid on aortic injury and hypertension in the rat remnant kidney (5/6 nephrectomy) model.
Topics: Administration, Oral; Animals; Antioxidants; Aorta, Abdominal; Blood Pressure; Dietary Supplements; Disease Models, Animal; Hypertension; Kidney; Kidney Failure, Chronic; Male; Rats; Rats, Wistar; Thioctic Acid; Vascular System Injuries | 2015 |
Advanced glycation end products are mitogenic signals and trigger cell cycle reentry of neurons in Alzheimer's disease brain.
Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Cell Cycle; Cells, Cultured; Cyclin D1; Disease Models, Animal; DNA Replication; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Glycation End Products, Advanced; Humans; In Situ Hybridization, Fluorescence; Male; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neurons; Oxidative Stress; Signal Transduction; Thioctic Acid | 2015 |
[The effect of 3-oxypyridine and succinic acid derivatives on obsessive-compulsive activity of mice in marble-burying test].
Topics: Amitriptyline; Animals; Behavior, Animal; Disease Models, Animal; Female; Humans; Hypnotics and Sedatives; Male; Meglumine; Mice; Motor Activity; Obsessive-Compulsive Disorder; Picolines; Psychotropic Drugs; Succinates; Thioctic Acid | 2014 |
Α‑lipoic acid protects against cerebral ischemia/reperfusion-induced injury in rats.
Topics: Animals; Antioxidants; Apoptosis; Brain Edema; Brain Ischemia; Brain-Derived Neurotrophic Factor; Caspases; Cerebral Infarction; Disease Models, Animal; Male; Malondialdehyde; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Reperfusion Injury; Superoxide Dismutase; Thioctic Acid | 2015 |
Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid.
Topics: Animals; Cell Line; Cyclic GMP-Dependent Protein Kinases; Cysteine; Diabetes Mellitus; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Energy Metabolism; Hydrogen Sulfide; Hyperglycemia; Male; Metabolic Networks and Pathways; Mice; Mitochondria; Neovascularization, Physiologic; Oxygen Consumption; Proto-Oncogene Proteins c-akt; Rats; Sulfurtransferases; Thioctic Acid; Vasodilator Agents | 2015 |
The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Inflammation; Neuralgia; Pain Measurement; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Thioctic Acid; Vincristine | 2015 |
[The effect of 3-oxypyridine and succinic acid derivatives on the resistance to acute cerebral ischemia].
Topics: Acute Disease; Animals; Brain Ischemia; Disease Models, Animal; Female; Male; Meglumine; Mice; Picolines; Pyridines; Succinates; Thioctic Acid | 2014 |
Effects of alpha lipoic acid on intra-abdominal adhesion: an experimental study in a rat model.
Topics: Animals; Antioxidants; Cecum; Disease Models, Animal; Female; Glutathione; Infusions, Parenteral; Laparotomy; Malondialdehyde; Peritoneal Diseases; Rats; Rats, Wistar; Thioctic Acid; Tissue Adhesions | 2015 |
Effects of pentoxifylline and alpha lipoic acid on methotrexate-induced damage in liver and kidney of rats.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Kidney Diseases; Male; Methotrexate; Pentoxifylline; Rats; Rats, Sprague-Dawley; Thioctic Acid | 2015 |
Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and neurotrophic mechanisms.
Topics: Analysis of Variance; Animals; Antioxidants; Antipsychotic Agents; Brain; Brain-Derived Neurotrophic Factor; Clozapine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Exploratory Behavior; Glutathione; Interpersonal Relations; Ketamine; Lipid Peroxidation; Male; Malondialdehyde; Maze Learning; Mice; Nitrites; Random Allocation; Reflex, Startle; Schizophrenia; Thioctic Acid | 2015 |
The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Apoptosis; Bromelains; Cells, Cultured; Disease Models, Animal; Endometriosis; Endothelial Cells; Female; Humans; Inflammation; Mice; Mice, SCID; Microscopy, Fluorescence; Thioctic Acid; Tumor Necrosis Factor-alpha; Uterus; Vascular Cell Adhesion Molecule-1 | 2015 |
Evidence for protective effect of lipoic acid and desvenlafaxine on oxidative stress in a model depression in mice.
Topics: Animals; Antidepressive Agents; Antioxidants; Corpus Striatum; Corticosterone; Depressive Disorder; Desvenlafaxine Succinate; Disease Models, Animal; Drug Therapy, Combination; Female; Glutathione; Hippocampus; Lipid Peroxidation; Mice; Oxidative Stress; Prefrontal Cortex; Random Allocation; Superoxide Dismutase; Thioctic Acid | 2016 |
Mitochondrial modulators improve lipid composition and attenuate memory deficits in experimental model of Huntington's disease.
Topics: Acetylcarnitine; Animals; Behavior, Animal; Brain; Cholesterol; Chromatography, Thin Layer; Cognition; Disease Models, Animal; Drug Therapy, Combination; Female; Huntington Disease; Lipid Metabolism; Membrane Fluidity; Memory; Mitochondria; Mitochondrial Membranes; Motor Activity; Nitro Compounds; Nootropic Agents; Phospholipids; Propionates; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Thioctic Acid | 2015 |
Curcumin, Silybin Phytosome(®) and α-R-Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Curcumin; Cytokines; Disease Models, Animal; Hepatitis, Chronic; Male; Oxidative Stress; Rats; Rats, Wistar; Silybin; Silymarin; Thioacetamide; Thioctic Acid | 2016 |
Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine.
Topics: Acetylcarnitine; Aging; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Coenzymes; Cognition; Cognition Disorders; Dietary Supplements; Disease Models, Animal; Dogs; Female; Male; Memory, Long-Term; Thioctic Acid | 2016 |
Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model.
Topics: Animals; Antioxidants; CD11b Antigen; Cerebral Cortex; Cytokines; Disease Models, Animal; Encephalitis; Encephalomyelitis, Autoimmune, Experimental; Female; Galectin 3; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Statistics, Nonparametric; Thioctic Acid; Time Factors | 2015 |
Comparative Biochemical and Motor Function Analysis of Alpha Lipoic Acid and N-Acetyl Cysteine Treatment on Rats with Experimental Spinal Cord Injury.
Topics: Animals; Cysteine; Disease Models, Animal; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries; Thioctic Acid | 2016 |
Lipoic acid improves neuronal insulin signalling and rescues cognitive function regulating VGlut1 expression in high-fat-fed rats: Implications for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cognition; Dietary Fats; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Insulin; Insulin Receptor Substrate Proteins; Male; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Thioctic Acid; Vesicular Glutamate Transport Protein 1 | 2016 |
Lipoicmethylenedioxyphenol Reduces Experimental Atherosclerosis through Activation of Nrf2 Signaling.
Topics: Animals; Atherosclerosis; Blood Vessels; Chemotaxis, Leukocyte; Disease Models, Animal; Disease Progression; Male; Mice; NF-E2-Related Factor 2; Oxidative Stress; Phenol; Rabbits; Signal Transduction; Thioctic Acid | 2016 |
Lipoic acid does not improve renal function markers in 5/6 nephrectomy model: possible role of Nrf2 inactivation.
Topics: Animals; Disease Models, Animal; Kidney; Male; Nephrectomy; NF-E2-Related Factor 2; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Thioctic Acid | 2016 |
Effect of alpha-lipoic acid on radiation-induced small intestine injury in mice.
Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Gamma Rays; Inflammation; Intestine, Small; Male; Mice; Mice, Inbred BALB C; Oxidative Stress; Radiation Injuries, Experimental; Radiation-Protective Agents; Thioctic Acid | 2016 |
Chondroprotective effects of alpha-lipoic acid in a rat model of osteoarthritis.
Topics: Animals; Disease Models, Animal; Male; NF-kappa B; Osteoarthritis; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction; Thioctic Acid | 2016 |
CMX-2043 Efficacy in a Rat Model of Cardiac Ischemia-Reperfusion Injury.
Topics: Administration, Oral; Animals; Arrhythmias, Cardiac; Cardiovascular Agents; Cytoprotection; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Intravenous; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats, Sprague-Dawley; Thioctic Acid | 2016 |
Evaluation of Electrophysiological Effects of Melatonin and Alpha Lipoic Acid in Rats with Streptozotocine Induced Diabetic Neuropathy.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Diabetic Neuropathies; Disease Models, Animal; Evoked Potentials, Somatosensory; Male; Melatonin; Rats; Rats, Wistar; Streptozocin; Thioctic Acid | 2016 |
Protein Disulfide Levels and Lens Elasticity Modulation: Applications for Presbyopia.
Topics: Accommodation, Ocular; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Disulfides; Elastic Modulus; Lens, Crystalline; Mass Spectrometry; Mice; Mice, Inbred C57BL; Presbyopia; Refraction, Ocular; Thioctic Acid; Tissue Culture Techniques | 2016 |
Functional and structural changes of the urinary bladder following spinal cord injury; treatment with alpha lipoic acid.
Topics: Animals; Antioxidants; Disease Models, Animal; Male; Rats; Rats, Wistar; Spinal Cord Injuries; Thioctic Acid; Urinary Bladder; Urinary Bladder Diseases | 2017 |
Alpha-Lipoic Acid Alleviates Acute Inflammation and Promotes Lipid Mobilization During the Inflammatory Response in White Adipose Tissue of Mice.
Topics: Adipose Tissue, White; Animals; Disease Models, Animal; Energy Metabolism; Fatty Acids, Nonesterified; Gene Expression Regulation; Inflammation; Lipid Metabolism; Lipid Mobilization; Lipopolysaccharides; Male; Mice; NF-kappa B; Thioctic Acid | 2016 |
α-lipoic acid exerts neuroprotective effects on neuronal cells by upregulating the expression of PCNA via the P53 pathway in neurodegenerative conditions.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Electron Transport Complex I; Gene Expression Regulation; Humans; MPTP Poisoning; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinson Disease, Secondary; PC12 Cells; Proliferating Cell Nuclear Antigen; Rats; Reactive Oxygen Species; Thioctic Acid; Tumor Suppressor Protein p53 | 2016 |
The influence of lipoic acid on caveolin-1-regulated antioxidative enzymes in the mouse model of acute ulcerative colitis.
Topics: Acute Disease; Animals; Antioxidants; Caveolin 1; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Inflammation Mediators; Male; Mice, Inbred C57BL; Peroxidase; Thioctic Acid | 2016 |
Staphylococcus aureus Tissue Infection During Sepsis Is Supported by Differential Use of Bacterial or Host-Derived Lipoic Acid.
Topics: Adaptation, Physiological; Animals; Disease Models, Animal; Female; Mice; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Sepsis; Staphylococcal Infections; Staphylococcus aureus; Thioctic Acid | 2016 |
Electroencephalographic study of chlorpromazine alone or combined with alpha-lipoic acid in a model of schizophrenia induced by ketamine in rats.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Brain; Chlorpromazine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Electrocorticography; Electrodes, Implanted; Ketamine; Male; Random Allocation; Rats, Wistar; Schizophrenia; Thioctic Acid; Time Factors | 2017 |
An injectable collagen/poly(γ-glutamic acid) hydrogel as a scaffold of stem cells and α-lipoic acid for enhanced protection against renal dysfunction.
Topics: Animals; Cell Survival; Cisplatin; Collagen; Disease Models, Animal; Hydrogels; Kidney Diseases; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Polyglutamic Acid; Thioctic Acid; Tissue Scaffolds | 2017 |
UPEI-400, a conjugate of lipoic acid and scopoletin, mediates neuroprotection in a rat model of ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Scopoletin; Stroke; Thioctic Acid | 2017 |
Inhibitory effects of alpha-lipoic acid on oxidative stress in the rostral ventrolateral medulla in rats with salt-induced hypertension.
Topics: Animals; Antioxidants; Blood Pressure; Diet; Disease Models, Animal; Hypertension; Male; Medulla Oblongata; Mitochondria; Models, Biological; NADPH Oxidases; Oxidative Stress; Rats; Reactive Oxygen Species; Salts; Thioctic Acid | 2017 |
Effects of Lipoic Acid Supplementation on Activities of Cyclooxygenases and Levels of Prostaglandins E
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dinoprost; Dinoprostone; Disease Models, Animal; Female; Glutathione; Liver; Placenta; Pregnancy; Pregnancy in Diabetics; Pregnancy, Animal; Prostaglandin-Endoperoxide Synthases; Rats; Thioctic Acid | 2016 |
Monitoring treatment of acute kidney injury with damage biomarkers.
Topics: Acute Kidney Injury; Animals; Biomarkers; Cisplatin; Disease Models, Animal; Glomerular Filtration Rate; Kidney; Male; Predictive Value of Tests; Rats, Sprague-Dawley; Thioctic Acid; Time Factors; Urinalysis | 2017 |
Effects of alpha lipoic acid on ischemia-reperfusion injury in rat hindlimb ischemia model.
Topics: Animals; Antioxidants; Disease Models, Animal; Hindlimb; Infusions, Parenteral; Ischemia; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Thioctic Acid | 2016 |
Anti-inflammatory effects of the selective phosphodiesterase 3 inhibitor, cilostazol, and antioxidants, enzymatically-modified isoquercitrin and α-lipoic acid, reduce dextran sulphate sodium-induced colorectal mucosal injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cilostazol; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Oligonucleotide Array Sequence Analysis; Phosphodiesterase 3 Inhibitors; Quercetin; Tetrazoles; Thioctic Acid | 2017 |
Tang-Luo-Ning Improves Mitochondrial Antioxidase Activity in Dorsal Root Ganglia of Diabetic Rats: A Proteomics Study.
Topics: Animals; Blood Glucose; Chromatography, Ion Exchange; Diabetes Mellitus, Experimental; Disease Models, Animal; Drugs, Chinese Herbal; Ganglia, Spinal; Glycated Hemoglobin; Male; Mass Spectrometry; Mitochondria; Mitochondrial Proteins; Neural Conduction; Oxidoreductases; Peptides; Proteomics; Rats, Sprague-Dawley; Streptozocin; Thioctic Acid | 2017 |
α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria.
Topics: Amino Acid Transport Systems, Basic; Amino Acid Transport Systems, Neutral; Animals; Cystine; Cystinuria; Disease Models, Animal; Kidney; Mice; Mice, Knockout; Solubility; Thioctic Acid; Urolithiasis; X-Ray Microtomography | 2017 |
Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; CD2 Antigens; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Heart Diseases; Heart Ventricles; Male; Mitochondria, Heart; Organometallic Compounds; Palladium; Radiation Injuries; Rats; Rats, Sprague-Dawley; Thioctic Acid | 2017 |
The effects of lipoic acid on redox status in brain regions and systemic circulation in streptozotocin-induced sporadic Alzheimer's disease model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cerebral Cortex; Disease Models, Animal; Glucose Transporter Type 2; Glucose Transporter Type 3; Hippocampus; Oxidation-Reduction; Oxidative Stress; Streptozocin; Thioctic Acid | 2017 |
Mutated glutathione-S-transferase reduced airway inflammation by limiting oxidative stress and Th2 response.
Topics: Animals; Binding Sites; Bronchoalveolar Lavage Fluid; Circular Dichroism; Disease Models, Animal; Enzyme Activation; Glutathione Transferase; Immunoglobulin E; Inflammation; Lung Diseases; Mice; Mice, Inbred BALB C; Mutation; Ovalbumin; Oxidative Stress; Th2 Cells; Thioctic Acid | 2008 |
The beneficial effect of coenzyme Q10 and lipoic acid on obstructive bladder dysfunction in the rabbit.
Topics: Analysis of Variance; Animals; Blotting, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Immunohistochemistry; Male; Muscle Contraction; Muscle, Smooth; Probability; Rabbits; Random Allocation; Sensitivity and Specificity; Thioctic Acid; Ubiquinone; Urinary Bladder Neck Obstruction | 2008 |
The evaluation of effect of alpha-lipoic acid and vitamin E on the lipid peroxidation, gamma-amino butyric acid and serotonin level in the brain of mice (Mus musculus) acutely intoxicated with lindane.
Topics: Animals; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Insecticides; Lipid Peroxidation; Male; Mice; Neuroprotective Agents; Neurotoxicity Syndromes; Serotonin; Thioctic Acid; Vitamin E | 2009 |
Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine.
Topics: Animals; Antioxidants; Azoles; Disease Models, Animal; Intestinal Diseases; Intestine, Small; Isoindoles; Male; Organoselenium Compounds; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Thioctic Acid | 2008 |
Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat.
Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cells, Cultured; Cisplatin; Disease Models, Animal; Down-Regulation; Hair Cells, Auditory; Hearing Loss, Sensorineural; Isoenzymes; Male; NADPH Oxidases; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Thioctic Acid; TRPV Cation Channels | 2008 |
Protective effect of sulfhydryl-containing antioxidants against ischemia/reperfusion injury of prepubertal rat intestine.
Topics: Acetylcysteine; Animals; Antioxidants; Constriction; Disease Models, Animal; Glutathione Peroxidase; Ileum; Lipid Peroxidation; Male; Malondialdehyde; Mesenteric Artery, Superior; Oxidative Stress; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sexual Development; Sulfhydryl Compounds; Superoxide Dismutase; Thioctic Acid; Thioglycolates; Thiophenes | 2009 |
Influence of alpha lipoic acid on antioxidant status in D-galactosamine-induced hepatic injury.
Topics: Analysis of Variance; Animals; Antioxidants; Biomarkers; Catalase; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Galactosamine; Glutathione; Glutathione Peroxidase; Injections, Intraperitoneal; Lipid Peroxidation; Liver; Liver Diseases; Male; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thioctic Acid | 2008 |
Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Antioxidants; Cognition; Disease Models, Animal; Immunohistochemistry; Maze Learning; Mice; Mice, Transgenic; Oxidative Stress; Thioctic Acid | 2009 |
Lipoic acid and 6-formylpterin reduce potentiation of noise-induced hearing loss by carbon monoxide: preliminary investigation.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Hair Cells, Auditory; Hearing Loss, Noise-Induced; Male; Pterins; Rats; Thioctic Acid | 2008 |
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease.
Topics: Acetylcarnitine; Aging; Alzheimer Disease; Animals; Antioxidants; Apolipoprotein E4; Brain; Cerebrovascular Circulation; Cognition; Dietary Supplements; Disease Models, Animal; Humans; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Thioctic Acid | 2009 |
Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment.
Topics: Alloxan; Animals; Blood Glucose; Cytoprotection; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Diterpenes; Fasting; Glucose Transporter Type 4; Hypoglycemic Agents; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Mice; Thioctic Acid | 2009 |
ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture.
Topics: Animals; Blotting, Western; Caspases; Cells, Cultured; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Electroretinography; Fluorescent Antibody Technique, Indirect; Glial Fibrillary Acidic Protein; Glutathione; Hydrogen Peroxide; Hydrogen Sulfide; Latanoprost; Nitric Oxide Synthase Type I; Oxidative Stress; Prostaglandins F, Synthetic; Rats; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thioctic Acid; Thy-1 Antigens | 2010 |
Alpha-lipoic acid attenuates cisplatin-induced tubulointerstitial injuries through inhibition of mitochondrial bax translocation in rats.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blood Urea Nitrogen; Caspase 3; Caspase 9; Cisplatin; Creatinine; Disease Models, Animal; Kidney Tubules; Male; Mitochondria; Necrosis; Nephritis, Interstitial; Rats; Rats, Sprague-Dawley; Sodium; Thioctic Acid; Translocation, Genetic | 2009 |
Effects of lipoic acid on oxidative stress in rat striatum after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Catalase; Convulsants; Corpus Striatum; Disease Models, Animal; Drug Interactions; Epilepsy; Glutathione Peroxidase; Lipid Peroxidation; Male; Nerve Degeneration; Neuroprotective Agents; Nitrites; Oxidative Stress; Pilocarpine; Rats; Rats, Wistar; Superoxide Dismutase; Superoxide Dismutase-1; Thioctic Acid | 2010 |
Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation; Indomethacin; Inflammation; Interleukin-10; Male; Nitric Oxide; Oxidative Stress; Rats; RNA, Messenger; Thioctic Acid | 2010 |
Lipoic acid alters delta-aminolevulinic dehydratase, glutathione peroxidase and Na+,K+-ATPase activities and glutathione-reduced levels in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Convulsants; Disease Models, Animal; Down-Regulation; Enzymes; Glutathione; Glutathione Peroxidase; Male; Neuroprotective Agents; Oxidative Stress; Pilocarpine; Porphobilinogen Synthase; Rats; Rats, Wistar; Seizures; Sodium-Potassium-Exchanging ATPase; Spectrophotometry; Thioctic Acid | 2010 |
Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats.
Topics: Acute Lung Injury; Animals; Cecum; Disease Models, Animal; Interleukin-6; Ligation; Male; NF-kappa B; Punctures; Rats; Rats, Wistar; Sepsis; Thioctic Acid; Tumor Necrosis Factor-alpha | 2010 |
Effect of alpha lipoic acid in a porcine in-stent restenosis model.
Topics: Administration, Oral; Animals; Cell Proliferation; Cells, Cultured; Coronary Restenosis; Disease Models, Animal; Drug-Eluting Stents; Female; Hyperplasia; Muscle, Smooth, Vascular; Neointima; Stents; Swine; Thioctic Acid | 2009 |
Lipoic acid effects on established atherosclerosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Atherosclerosis; Blood Glucose; Blotting, Western; Cell Adhesion; Chemotaxis, Leukocyte; Cholesterol, Dietary; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Endothelium, Vascular; Humans; Hyperlipidemias; Immunohistochemistry; Insulin; Jurkat Cells; Leukocytes, Mononuclear; Lipoproteins; Male; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Thioctic Acid; Transcription Factor RelA | 2010 |
Mutated glutathione S-transferase in combination with reduced glutathione shows a synergistic effect in ameliorating oxidative stress and airway inflammation.
Topics: Animals; Antioxidants; Asthma; Disease Models, Animal; Drug Synergism; Glutathione; Glutathione Transferase; Inflammation; Lung Diseases; Mice; Mice, Inbred BALB C; Mutant Proteins; Mutation; Ovalbumin; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Thioctic Acid | 2010 |
Ibuprofen and lipoic acid diamides as potential codrugs with neuroprotective activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Brain; Chemistry, Pharmaceutical; Diamide; Disease Models, Animal; Drug Combinations; Drug Stability; Free Radical Scavengers; Ibuprofen; Male; Neuroprotective Agents; Prodrugs; Rats; Rats, Wistar; Thioctic Acid | 2010 |
Neuropathy in a rat model of mild diabetes induced by multiple low doses of streptozotocin: effects of the antioxidant stobadine in comparison with a high-dose alpha-lipoic acid treatment.
Topics: Animals; Antioxidants; Carbolines; Diabetic Neuropathies; Disease Models, Animal; Humans; Male; Neural Conduction; Rats; Rats, Wistar; Streptozocin; Thioctic Acid; Treatment Outcome | 2010 |
Dyslipidemic high-fat diet affects adversely bone metabolism in mice associated with impaired antioxidant capacity.
Topics: Animals; Antioxidants; Bone and Bones; Bone Resorption; Collagen Type I; Dietary Fats; Disease Models, Animal; Down-Regulation; Femur; Hyperlipidemias; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred C57BL; Osteoblasts; Osteoclasts; Oxidative Stress; Peptides; Random Allocation; Thioctic Acid; Tumor Necrosis Factor-alpha | 2011 |
Differential effects of coenzyme Q10 and α-lipoic acid on two models of in vitro oxidative damage to the rabbit urinary bladder.
Topics: Animals; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Follow-Up Studies; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Muscle Contraction; Muscle, Smooth; Oxidative Stress; Rabbits; Reperfusion Injury; Thioctic Acid; Ubiquinone; Urinary Bladder Neck Obstruction; Vitamins | 2011 |
Anti-apoptotic and neuroprotective effects of α-lipoic acid on spinal cord ischemia-reperfusion injury in rabbits.
Topics: Animals; Apoptosis; Disease Models, Animal; Male; Nerve Degeneration; Neuroprotective Agents; Rabbits; Rats; Reperfusion Injury; Spinal Cord; Spinal Cord Ischemia; Thioctic Acid | 2010 |
Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Ca(2+) Mg(2+)-ATPase; Disease Models, Animal; Hippocampus; Male; Oxidative Stress; Pilocarpine; Porphobilinogen Synthase; Rats; Rats, Wistar; Seizures; Sodium-Potassium-Exchanging ATPase; Thioctic Acid; Ubiquinone | 2011 |
alpha-Lipoic acid alters post-translational modifications and protects the chaperone activity of lens alpha-crystallin in naphthalene-induced cataract.
Topics: Acetylation; alpha-Crystallins; Animals; Antioxidants; Cataract; Chromatography, High Pressure Liquid; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Female; Lens, Crystalline; Methylation; Molecular Chaperones; Naphthalenes; Oxidation-Reduction; Phosphorylation; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Thioctic Acid | 2010 |
α-Lipoic acid prevents neointimal hyperplasia via induction of p38 mitogen-activated protein kinase/Nur77-mediated apoptosis of vascular smooth muscle cells and accelerates postinjury reendothelialization.
Topics: Animals; Apoptosis; Cardiovascular Agents; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Hyperplasia; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Receptor Subfamily 4, Group A, Member 1; p38 Mitogen-Activated Protein Kinases; Platelet Aggregation; Rats; Thioctic Acid; Wound Healing | 2010 |
Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress.
Topics: Aged; Animals; Antioxidants; Apoptosis; Biopsy; Case-Control Studies; Cell Line; Colon; Diabetes Complications; Disease Models, Animal; Electric Stimulation; Enteric Nervous System; Female; Gastrointestinal Diseases; Humans; Male; Mice; Middle Aged; Muscle Contraction; Muscle Relaxation; Oxidative Stress; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species; Signal Transduction; Thioctic Acid | 2011 |
Neuroprotective effects of alpha-lipoic acid in experimental spinal cord injury in rats.
Topics: Analysis of Variance; Animals; Disease Models, Animal; DNA Fragmentation; Glutathione; Luminescent Measurements; Male; Malondialdehyde; Neurologic Examination; Neuroprotective Agents; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Reactive Oxygen Species; Spinal Cord Injuries; Thioctic Acid | 2010 |
α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Cotton Fiber; Disease Models, Animal; Edema; Enzymes; Hindlimb; Inflammation; Linoleic Acid; Lipid Peroxidation; Male; Rats; Rats, Wistar; Thioctic Acid | 2011 |
Differential efficiency of simvastatin and lipoic acid treatments on Bothrops jararaca envenomation-induced acute kidney injury in mice.
Topics: Acute Kidney Injury; Aminopeptidases; Animals; Anticholesteremic Agents; Antioxidants; Bothrops; Crotalid Venoms; Disease Models, Animal; Kidney; Kidney Function Tests; Male; Mice; Oxidative Stress; Simvastatin; Snake Bites; Thioctic Acid; Treatment Outcome | 2011 |
Anti-oxidative effect of lipoic Acid in spinal cord ischemia/reperfusion.
Topics: Analysis of Variance; Animals; Antioxidants; Disease Models, Animal; Free Radical Scavengers; Glutathione Peroxidase; Male; Random Allocation; Rats; Rats, Wistar; Reperfusion; Spinal Cord Ischemia; Superoxide Dismutase; Thioctic Acid; Treatment Outcome | 2011 |
α-Lipoic acid suppresses the development of DNFB-induced atopic dermatitis-like symptoms in NC/Nga mice.
Topics: Administration, Oral; Animals; Antioxidants; CD4-Positive T-Lymphocytes; Cell Proliferation; Dermatitis, Atopic; Dinitrofluorobenzene; Disease Models, Animal; Immunoglobulin E; Interferon-gamma; Interleukin-4; Male; Mice; Mice, Inbred Strains; Thioctic Acid | 2011 |
New lipoic acid derivative drug sodium zinc dihydrolipoylhistidinate prevents cardiac dysfunction in an isolated perfused rat heart model.
Topics: Animals; Cardiotonic Agents; Cells, Cultured; Disease Models, Animal; Heart; Histidine; Male; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Perfusion; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thioctic Acid | 2011 |
Modulatory effects of vitamin E, acetyl-L-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.
Topics: Alzheimer Disease; Animals; Antioxidants; Biomarkers; Brain; Carnitine; Cholinesterase Inhibitors; Dietary Supplements; Disease Models, Animal; Donepezil; Enzyme-Linked Immunosorbent Assay; Homocysteine; Indans; Insulin-Like Growth Factor I; Interleukin-1beta; Male; Piperidines; Rats; Rats, Sprague-Dawley; Thioctic Acid; Tumor Necrosis Factor-alpha; Vitamin E | 2012 |
Alpha-lipoic acid rebalances redox and immune-testicular milieu in septic rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Infertility, Male; Lipopolysaccharides; Male; Oxidation-Reduction; Oxidative Stress; Rats; Testis; Thioctic Acid | 2011 |
Lipoic acid decreases inflammation and confers neuroprotection in experimental autoimmune optic neuritis.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation Mediators; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Optic Neuritis; Thioctic Acid | 2011 |
Oxidative stress: key player in gastrointestinal complications of diabetes.
Topics: Animals; Antioxidants; Apoptosis; Cell Line; Colon; Diabetes Complications; Disease Models, Animal; Enteric Nervous System; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Mice; Oxidative Stress; Reactive Oxygen Species; Thioctic Acid | 2011 |
Lipoic acid prevents steroid-induced osteonecrosis in rabbits.
Topics: Animals; Biomarkers; Cholesterol; Cytoprotection; Disease Models, Animal; Endothelins; Femur; Glutathione; Lipoproteins, HDL; Lipoproteins, LDL; Male; Malondialdehyde; Methylprednisolone; Methylprednisolone Acetate; Osteonecrosis; Oxidative Stress; Protective Agents; Rabbits; Thioctic Acid; Time Factors | 2012 |
Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Citrates; Disease Models, Animal; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred C57BL; Neoplasms; Octreotide; Reproducibility of Results; Thioctic Acid; Treatment Outcome | 2012 |
The effect of alpha-lipoic acid in the prevention of peritoneal adhesions.
Topics: Animals; Antioxidants; Disease Models, Animal; Hydroxyproline; Male; Malondialdehyde; Oxidative Stress; Peritoneum; Rats; Rats, Sprague-Dawley; Thioctic Acid; Tissue Adhesions | 2011 |
[Cerebroprotective effect of 3-oxypyridine and succinic acid derivatives in acute phase of alloxan-induced diabetes mellitus in rats].
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Hippocampus; Learning; Lipid Metabolism; Lipid Peroxidation; Male; Meglumine; Motor Activity; Neurons; Neuroprotective Agents; Nootropic Agents; Picolines; Pyridines; Rats; Succinates; Succinic Acid; Thioctic Acid | 2011 |
Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and L-dopa toxicity.
Topics: Animals; Antiparkinson Agents; Apoptosis; Disease Models, Animal; Levodopa; Mitochondria; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rats; Rotenone; Thioctic Acid; Uncoupling Agents | 2011 |
Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion.
Topics: Animals; Brain Ischemia; Cell Death; Disease Models, Animal; Ethidium; Fluoresceins; Gerbillinae; Glial Fibrillary Acidic Protein; Glucose; Glycoproteins; Hippocampus; Hypoxia; Lectins; Neurons; Neuroprotective Agents; Organ Culture Techniques; Oxidation-Reduction; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Rhodamines; Sulfhydryl Compounds; Thioctic Acid; Versicans | 2012 |
Dihydrolipoyl histidinate zinc complex, a new antioxidant, attenuates hepatic ischemia-reperfusion injury in rats.
Topics: Alanine Transaminase; Animals; Antimycin A; Antioxidants; Aspartate Aminotransferases; Biomarkers; Biphenyl Compounds; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Histidine; Liver; Liver Diseases; Male; Malondialdehyde; Mice; Oxidative Stress; Picrates; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Thioctic Acid; Time Factors | 2011 |
Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Carnitine; Carnitine O-Palmitoyltransferase; Choline Deficiency; Disease Models, Animal; DNA, Mitochondrial; Fatty Acids, Nonesterified; Fatty Liver; Gene Expression Regulation; Hep G2 Cells; Humans; Liver; Lysosomes; Membrane Potential, Mitochondrial; Methionine; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Oxidative Stress; PPAR gamma; Rats; Rats, Inbred OLETF; Rats, Long-Evans; RNA, Messenger; Thioctic Acid; Time Factors | 2011 |
Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline; Choline Deficiency; Cytochrome P-450 CYP2E1; Diet; Disease Models, Animal; Endoplasmic Reticulum Stress; Fatty Liver; Humans; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Thiobarbituric Acid Reactive Substances; Thioctic Acid | 2012 |
The effects of alpha lipoic acid on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit.
Topics: Animals; Antioxidants; Apoptosis; Basilar Artery; Cerebrovascular Circulation; Disease Models, Animal; Endothelial Cells; Free Radicals; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hydrogen Peroxide; Male; Malondialdehyde; Muscle, Smooth, Vascular; Oxidative Stress; Rabbits; Subarachnoid Hemorrhage; Superoxide Dismutase; Thioctic Acid; Treatment Outcome; Vasodilation; Vasospasm, Intracranial | 2011 |
Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Animals; Apoptosis; Caspase 3; Cells, Cultured; Creatine Kinase; Disease Models, Animal; Heart; In Vitro Techniques; Male; Malondialdehyde; Mitochondrial Proteins; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thioctic Acid | 2012 |
UPEI-100, a conjugate of lipoic acid and apocynin, mediates neuroprotection in a rat model of ischemia/reperfusion.
Topics: Acetophenones; Animals; Biomarkers; Disease Models, Animal; Glutathione Disulfide; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Male; Mitochondria; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke; Superoxide Dismutase; Thioctic Acid | 2012 |
Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3.
Topics: Animals; Antioxidants; Blotting, Western; Body Weight; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Lipid Peroxidation; Liver; Male; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Organ Size; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Sirtuin 1; Sirtuin 3; Thioctic Acid | 2012 |
The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis.
Topics: Animals; Autoantibodies; Autoantigens; Biomimetic Materials; Cattle; Cells, Cultured; Cytokines; Dihydrolipoyllysine-Residue Acetyltransferase; Disease Models, Animal; Humans; Immune Tolerance; Immunization; Immunodominant Epitopes; Killer Cells, Natural; Liver Cirrhosis, Biliary; Lymphocyte Depletion; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Proteins; Natural Killer T-Cells; Peptide Fragments; Serum Albumin, Bovine; Thioctic Acid | 2012 |
Oxidative stress in 5/6 nephrectomized rat model: effect of alpha-lipoic acid.
Topics: Animals; Antioxidants; Disease Models, Animal; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Male; Nephrectomy; Nephritis; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thioctic Acid | 2012 |
Effect of alpha-lipoic acid on memory, oxidation, and lifespan in SAMP8 mice.
Topics: Alzheimer Disease; Animals; Antioxidants; Brain; Disease Models, Animal; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxidation; Longevity; Malondialdehyde; Maze Learning; Memory; Mice; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Thioctic Acid | 2012 |
Protective effects of a novel synthetic α-lipoic acid-decursinol hybrid compound in experimentally induced transient cerebral ischemia.
Topics: Animals; Disease Models, Animal; Gerbillinae; Ischemic Attack, Transient; Male; Neuroprotective Agents; Thioctic Acid | 2012 |
Sodium butyrate potentiates carbon tetrachloride-induced acute liver injury in mice.
Topics: Acetylcysteine; Animals; Butyrates; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Liver; Male; Mice; Oxidative Stress; Thioctic Acid | 2012 |
Effects of alpha-lipoic acid in an animal model of mania induced by D-amphetamine.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Brain; Brain-Derived Neurotrophic Factor; Central Nervous System Stimulants; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Glutathione; Lipid Peroxidation; Lithium Chloride; Male; Malondialdehyde; Mice; Motor Activity; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Thioctic Acid | 2012 |
Effects of lipoic acid in an experimentally induced hypertensive and diabetic rat model.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Hypertension; Male; Nephrectomy; Rats; Rats, Wistar; Streptozocin; Thioctic Acid | 2013 |
Role of catalase and superoxide dismutase activities on oxidative stress in the brain of a phenylketonuria animal model and the effect of lipoic acid.
Topics: Animals; Brain; Catalase; Disease Models, Animal; DNA Damage; Enzyme Inhibitors; Female; Lipid Peroxidation; Male; Oxidative Stress; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Rats, Wistar; Superoxide Dismutase; Thioctic Acid | 2013 |
Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy.
Topics: Acetylcysteine; Adenosine Triphosphate; Adrenoleukodystrophy; Age Factors; Analysis of Variance; Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Brain; Buthionine Sulfoximine; Cell Death; Chromatin; Cyclophilins; Disease Models, Animal; Enzyme Inhibitors; Fibroblasts; Flow Cytometry; Galactose; Gene Expression Regulation; Glucose; Glutathione; Humans; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Neuroprotective Agents; Oligopeptides; Oxidative Stress; Peptidyl-Prolyl Isomerase F; Permeability; Reactive Oxygen Species; Thioctic Acid; Time Factors; Tubulin; Vitamin E | 2012 |
Lipoic acid in combination with a chelator ameliorates lead-induced peroxidative damages in rat kidney.
Topics: Acetylglucosaminidase; Animals; Catalase; Chelating Agents; Disease Models, Animal; Drug Therapy, Combination; gamma-Glutamyltransferase; Glutathione; Glutathione Peroxidase; Kidney; Lead Poisoning; Lipid Peroxidation; Lipid Peroxides; Male; Rats; Rats, Wistar; Succimer; Superoxide Dismutase; Thioctic Acid | 2002 |
The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice.
Topics: Acetylcysteine; Age Factors; Amyloid beta-Peptides; Animals; Antioxidants; Appetitive Behavior; Behavior, Animal; Blood-Brain Barrier; Brain; Cognition; Disease Models, Animal; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred Strains; Mice, Neurologic Mutants; Oxidative Stress; Specific Pathogen-Free Organisms; Thioctic Acid; Treatment Outcome | 2003 |
NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Hypertension; Losartan; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Cardiovascular; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Rats; Rats, Sprague-Dawley; Superoxides; Thioctic Acid; Vasoconstrictor Agents | 2003 |
Acute glucose deprivation leads to apoptosis in a cell model of acute diabetic neuropathy.
Topics: Animals; Antioxidants; Apoptosis; Benzamides; Caspase 3; Caspases; Cell Count; Cell Hypoxia; Cell Survival; Cells, Cultured; Diabetic Neuropathies; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Embryo, Mammalian; Ganglia, Spinal; Glucose; Imides; Immunohistochemistry; In Situ Nick-End Labeling; Microscopy, Electron; Nerve Growth Factor; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Thioctic Acid; Time Factors | 2003 |
Effect of alpha lipoic acid on intracerebroventricular streptozotocin model of cognitive impairment in rats.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Avoidance Learning; Behavior, Animal; Brain; Brain Chemistry; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Injections, Intraventricular; Male; Malondialdehyde; Maze Learning; Motor Activity; Oxidative Stress; Rats; Rats, Wistar; Reaction Time; Streptozocin; Thioctic Acid | 2003 |
A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Infusions, Intra-Arterial; Male; Oxidative Stress; Rats; Rats, Wistar; Reperfusion Injury; Thioctic Acid | 2003 |
Selective modulation of antioxidant enzyme activities in host tissues during Rickettsia conorii infection.
Topics: Animals; Antioxidants; Boutonneuse Fever; Brain; Colony Count, Microbial; Disease Models, Animal; Endothelium; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Lung; Male; Mice; Rickettsia conorii; Superoxide Dismutase; Testis; Thioctic Acid | 2004 |
Therapeutic efficacy of lipoic acid in combination with dimercaptosuccinic acid against lead-induced renal tubular defects and on isolated brush-border enzyme activities.
Topics: 5-Aminolevulinate Synthetase; Animals; Antioxidants; Biomarkers; Body Weight; Chelating Agents; Disease Models, Animal; Drug Therapy, Combination; Kidney Cortex; Kidney Diseases; Kidney Tubules; Lead Poisoning; Male; Microvilli; Organ Size; Organometallic Compounds; Rats; Rats, Wistar; Succimer; Thioctic Acid | 2004 |
Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Division; Dermatitis, Allergic Contact; Disease Models, Animal; Haplorhini; Humans; Interleukin-2; Keratinocytes; Mice; PPAR gamma; T-Lymphocytes; Thiazoles; Thioctic Acid | 2004 |
Lipoic acid pretreatment attenuates ferric chloride-induced seizures in the rat.
Topics: Animals; Antioxidants; Chlorides; Disease Models, Animal; Electroencephalography; Ferric Compounds; Male; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Thioctic Acid | 2004 |
Regulation of ischemic cell death by the lipoic acid-palladium complex, Poly MVA, in gerbils.
Topics: Animals; Antioxidants; Behavior, Animal; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Male; Nesting Behavior; Neurons; Palladium; Thioctic Acid | 2004 |
[Effects of DL-alpha-lipoic acid on the experimentally induced diabetic cataract in rats].
Topics: Animals; Antioxidants; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glutathione; Rats; Specific Pathogen-Free Organisms; Thioctic Acid | 2004 |
Protective effect of DL-alpha-lipoic acid in cyclophosphamide induced oxidative injury in rat testis.
Topics: Animals; Antineoplastic Agents, Alkylating; Antioxidants; Body Weight; Cyclophosphamide; Disease Models, Animal; Dose-Response Relationship, Drug; Glucosephosphate Dehydrogenase; Injections, Intraperitoneal; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Organ Size; Oxidative Stress; Rats; Rats, Wistar; Testis; Thioctic Acid | 2004 |
Neuroprotection by alpha-lipoic acid in streptozotocin-induced diabetes.
Topics: Animals; Antioxidants; Biomarkers; Brain Chemistry; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Gliosis; Injections, Intraperitoneal; Male; Neuroprotective Agents; Rats; Rats, Wistar; Thioctic Acid | 2004 |
Mechanisms of antioxidant and pro-oxidant effects of alpha-lipoic acid in the diabetic and nondiabetic kidney.
Topics: Albuminuria; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Kidney; Kidney Tubules; Oxidants; Rats; Reference Values; Thioctic Acid | 2005 |
Effects of alpha-lipoic acid on kinin B1 and B2 receptor binding sites in the spinal cord of chronically angiotensin-treated rats.
Topics: Angiotensin II; Animals; Binding Sites; Blood Glucose; Blood Pressure; Body Weight; Chronic Disease; Diet; Disease Models, Animal; Insulin; Rats; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Spinal Cord; Superoxides; Thioctic Acid | 2005 |
Alpha-lipoic acid inhibits fractalkine expression and prevents neointimal hyperplasia after balloon injury in rat carotid artery.
Topics: Angioplasty, Balloon; Animals; Antioxidants; Blotting, Northern; Blotting, Western; Carotid Artery Diseases; Cells, Cultured; Chemokine CX3CL1; Chemokines, CX3C; Disease Models, Animal; Disease Progression; DNA; Gene Expression; Hyperplasia; Male; Membrane Proteins; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Thioctic Acid; Tunica Intima | 2006 |
Protective role of eicosapentaenoate-lipoate (EPA-LA) derivative in combating oxidative hepatocellular injury in hypercholesterolemic atherogenesis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Atherosclerosis; Cholesterol; Deoxyguanosine; Disease Models, Animal; Eicosapentaenoic Acid; Hypercholesterolemia; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Male; Rats; Rats, Wistar; Superoxide Dismutase; Thioctic Acid; Treatment Outcome | 2006 |
Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Dementia; Disease Models, Animal; Galactose; Glutathione Peroxidase; Hippocampus; Male; Malondialdehyde; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Superoxide Dismutase; Thioctic Acid | 2006 |
Alpha-lipoic acid modulates ovarian surface epithelial cell growth.
Topics: Animals; Apoptosis; Cell Growth Processes; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Epithelial Cells; Female; Mice; Mice, Inbred C57BL; NF-kappa B; Ovarian Neoplasms; Ovary; Thioctic Acid; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2006 |
Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Drug Administration Schedule; Free Radical Scavengers; Free Radicals; Galactose; Hippocampus; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Stem Cells; Thioctic Acid | 2006 |
Antioxidants reduce cone cell death in a model of retinitis pigmentosa.
Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Cell Death; Disease Models, Animal; Electroretinography; Metalloporphyrins; Mice; Mice, Inbred C57BL; Oxidative Stress; Oxygen; Retina; Retinal Cone Photoreceptor Cells; Retinitis Pigmentosa; Thioctic Acid | 2006 |
Alpha-lipoic acid suppresses the development of collagen-induced arthritis and protects against bone destruction in mice.
Topics: Animals; Antioxidants; Arthritis, Experimental; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Male; Mice; NF-kappa B; Osteoclasts; Random Allocation; Synovial Fluid; Thioctic Acid | 2007 |
Protective effect of alpha-lipoic acid in experimental spermatic cord torsion.
Topics: Animals; Antioxidants; Disease Models, Animal; Free Radical Scavengers; Glutathione; Injections, Intraperitoneal; Lipid Peroxidation; Male; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Spermatic Cord Torsion; Thiobarbituric Acid Reactive Substances; Thioctic Acid | 2007 |
Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Drug Interactions; Female; Inflammation; Lipopolysaccharides; Mice; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thioctic Acid | 2007 |
Alpha-lipoic acid may be a clinically useful therapy in interstitial cystitis.
Topics: Animals; Antioxidants; Cystitis, Interstitial; Disease Models, Animal; Humans; Inflammation; Mice; Rats; Thioctic Acid | 2007 |
Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa.
Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Cell Death; Codon, Nonsense; Cyclic Nucleotide Phosphodiesterases, Type 6; Disease Models, Animal; Drug Administration Schedule; Electroretinography; Exons; Heterozygote; Homozygote; Injections, Intraperitoneal; Kinetics; Mice; Mice, Mutant Strains; Mutation, Missense; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells; Retinitis Pigmentosa; Rhodopsin; RNA, Messenger; Thioctic Acid | 2007 |
Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model.
Topics: Acetylcysteine; Alanine Transaminase; Amanitins; Animals; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cimetidine; Disease Models, Animal; Male; Mice; Mushroom Poisoning; Penicillin G; Random Allocation; Silybin; Silymarin; Thioctic Acid | 2007 |
Therapeutic efficacy of DL-alpha-lipoic acid on cyclosporine A induced renal alterations.
Topics: Animals; Biomarkers; Cyclosporine; Disease Models, Animal; Enzymes; Kidney; Kidney Diseases; Male; Protective Agents; Rats; Rats, Wistar; Thioctic Acid; Time Factors | 2007 |
Hepatocellular injury of nonischemic liver tissue after selective clamping in rats--protective action by pharmacological pretreatment with lipoic acid.
Topics: Animals; Antioxidants; Constriction; Disease Models, Animal; Ischemia; Lipid Peroxidation; Liver; Liver Diseases; Male; Rats; Reperfusion Injury; Thioctic Acid | 2007 |
Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Disease Models, Animal; Glutathione Transferase; Ischemia; Ischemic Preconditioning; Isoenzymes; Lipid Peroxidation; Liver; Male; Necrosis; Protective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred BN; Reperfusion Injury; Thioctic Acid; Time Factors | 2007 |
Alpha-lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Colon; Disease Models, Animal; Gastrointestinal Agents; Glutathione; Ileitis; Ileum; Lipid Peroxidation; Malondialdehyde; Neutrophil Infiltration; Neutrophils; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thioctic Acid; Trinitrobenzenesulfonic Acid | 2007 |
Genetic and pharmacologic manipulation of oxidative stress after neonatal hypoxia-ischemia.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hypoxia-Ischemia, Brain; Mice; Mice, Transgenic; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1; Thioctic Acid | 2008 |
The effect of lipoic acid on lipid peroxidation and visual evoked potentials (VEPs) in rats exposed to chronic restraint stress.
Topics: Analysis of Variance; Animals; Antioxidants; Disease Models, Animal; Evoked Potentials, Visual; Lipid Peroxidation; Male; Nitric Oxide; Photic Stimulation; Rats; Restraint, Physical; Stress, Psychological; Thiobarbituric Acid Reactive Substances; Thioctic Acid | 2007 |
The protective effect of alpha-lipoic acid in experimental ovarian ischaemia-reperfusion injury.
Topics: Animals; Disease Models, Animal; Female; Malondialdehyde; Nitric Oxide; Ovary; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Thioctic Acid; Xanthine Oxidase | 2007 |
The effect of lipoic acid on antioxidant status and lipid peroxidation in rats exposed to chronic restraint stress.
Topics: Animals; Antioxidants; Brain; Catalase; Disease Models, Animal; Glutathione Peroxidase; Lipid Peroxidation; Male; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Restraint, Physical; Retina; Stress, Psychological; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Thioctic Acid | 2008 |
Alpha lipoic acid attenuates microvascular endothelial cell hyperpermeability by inhibiting the intrinsic apoptotic signaling.
Topics: Analysis of Variance; Animals; Apoptosis; Capillary Permeability; Caspase 3; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Cytochromes c; Disease Models, Animal; Endothelial Cells; Lung; Membrane Potential, Mitochondrial; Probability; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sensitivity and Specificity; Signal Transduction; Thioctic Acid | 2008 |
Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Body Weight; Cholesterol; Dietary Supplements; Disease Models, Animal; Female; Inflammation; Mice; Receptors, LDL; Thioctic Acid; Triglycerides | 2008 |
Atherosclerosis in Japanese quail and the effect of lipoic acid.
Topics: Animals; Aorta; Arteriosclerosis; Coturnix; Delayed-Action Preparations; Diet, Atherogenic; Dietary Proteins; Disease Models, Animal; Female; Glycine max; Male; Thioctic Acid | 1983 |
Modelling cortical cataractogenesis 17: in vitro effect of a-lipoic acid on glucose-induced lens membrane damage, a model of diabetic cataractogenesis.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glucose; In Vitro Techniques; L-Lactate Dehydrogenase; Rats; Rats, Wistar; Thioctic Acid | 1995 |
Metabolic effects of thioctic acid in rodent models of insulin resistance and diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Disease Models, Animal; Fructose; Glucose; Hyperinsulinism; Insulin Resistance; Male; Rats; Rats, Sprague-Dawley; Thioctic Acid; Triglycerides | 1998 |
Modelling cortical cataractogenesis XX. In vitro effect of alpha-lipoic acid on glutathione concentrations in lens in model diabetic cataractogenesis.
Topics: Animals; Cataract; Culture Techniques; Diabetes Complications; Diabetes Mellitus; Disease Models, Animal; Female; Glucose; Glutathione; Lactic Acid; Lens, Crystalline; Oxidation-Reduction; Rats; Rats, Wistar; Stereoisomerism; Thioctic Acid | 1998 |
Effect of alpha-lipoic acid supplementation on oxidative protein damage in the streptozotocin-diabetic rat.
Topics: Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Free Radicals; Male; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Streptozocin; Thioctic Acid | 2000 |
Effect of combined supplementation with vitamin E and alpha-lipoic acid on myocardial performance during in vivo ischaemia-reperfusion.
Topics: Animals; Antioxidants; Benzene Derivatives; Blood Pressure; Dietary Supplements; Disease Models, Animal; Female; Free Radicals; Heart; Lipid Peroxidation; Myocardial Contraction; Myocardial Reperfusion Injury; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Thiobarbituric Acid Reactive Substances; Thioctic Acid; Ventricular Function; Vitamin E | 2000 |
Lipoic acid reduces ischemia-reperfusion injury in animal models.
Topics: Adenosine Triphosphatases; Animals; Creatine Kinase; Disease Models, Animal; Heart; Hindlimb; In Vitro Techniques; Male; Muscle Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Phosphocreatine; Rats; Rats, Sprague-Dawley; Thioctic Acid | 2000 |
Contribution of dithiol ligands to in vitro and in vivo trypanocidal activities of dithiaarsanes and investigation of ligand exchange in an aqueous solution.
Topics: Animals; Arsenicals; Cysteamine; Dansyl Compounds; Disease Models, Animal; Female; Mice; Parasitic Sensitivity Tests; Structure-Activity Relationship; Sulfhydryl Compounds; Thioctic Acid; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2000 |
Alpha-lipoic acid treatment ameliorates metabolic parameters, blood pressure, vascular reactivity and morphology of vessels already damaged by streptozotocin-diabetes.
Topics: Animals; Antioxidants; Aorta; Blood Pressure; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Disease Models, Animal; Lipid Metabolism; Lipid Peroxidation; Male; Muscle, Smooth, Vascular; Oxidative Stress; Rats; Rats, Wistar; Streptozocin; Thioctic Acid; Time Factors | 2000 |
Efficacy of antioxidant therapies in transient focal ischemia in mice.
Topics: Administration, Oral; Animals; Antioxidants; Body Weight; Brain; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Ginkgo biloba; Injections, Subcutaneous; Ischemic Attack, Transient; Male; Mice; Mice, Inbred C57BL; Phytotherapy; Plant Extracts; Plants, Medicinal; Thioctic Acid; Treatment Outcome | 2001 |
Dietary lipoic acid supplementation prevents fructose-induced hypertension in rats.
Topics: Aldehydes; Animals; Aorta; Blood Glucose; Blood Pressure; Dietary Supplements; Disease Models, Animal; Fructose; Hypertension; Insulin; Kidney; Rats; Rats, Inbred WKY; Thioctic Acid | 2000 |
Lipoic acid improves survival in transgenic mouse models of Huntington's disease.
Topics: Animals; Antioxidants; Benzenesulfonates; Body Weight; Brain; Disease Models, Animal; Food, Formulated; Huntington Disease; Male; Mice; Mice, Transgenic; Neuroprotective Agents; Oxidative Stress; Survival; Thioctic Acid; Treatment Outcome | 2001 |
Beneficial effects of alpha-lipoic acid plus vitamin E on neurological deficit, reactive gliosis and neuronal remodeling in the penumbra of the ischemic rat brain.
Topics: Animals; Astrocytes; Brain; Disease Models, Animal; Free Radical Scavengers; GAP-43 Protein; Glial Fibrillary Acidic Protein; Gliosis; Hypoxia-Ischemia, Brain; Male; Microglia; Nerve Degeneration; Neuronal Plasticity; Oxidative Stress; Rats; Rats, Wistar; Recovery of Function; Synaptophysin; Thioctic Acid; Thromboembolism; Vitamin E | 2002 |
Effect of coenzyme-A, NAD, alpha lipoic-acid and cocarboxylase on survival of rats with galactosamine-induced severe hepatitis.
Topics: Animals; Coenzyme A; Disease Models, Animal; Female; Galactosamine; Hepatitis; Liver Function Tests; NAD; Rats; Rats, Inbred Strains; Thiamine Pyrophosphate; Thioctic Acid | 1985 |