thioctic acid has been researched along with Disease Exacerbation in 16 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model." | 7.81 | Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( Ayar, A; Çolak, R; Kan, E; Kiliçkan, E, 2015) |
| "The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model." | 3.81 | Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( Ayar, A; Çolak, R; Kan, E; Kiliçkan, E, 2015) |
| "Multiple sclerosis is an immune-mediated disease that produces chronic inflammation and neural degeneration." | 2.52 | [Antioxidant use as dietary therapy in patients with multiple sclerosis]. ( Flores-Aldana, M; González-González, L; Hernández-Girón, C; Macías-Morales, N; Pérez-Cortéz, JG, 2015) |
| " Dosage of the drug was 600 mg daily." | 1.39 | [Efficacy of thiolepta in diabetic polyneuropathy: results of the study ETIKA]. ( Fokina, AS; Golovacheva, VA; Kochetov, AG; Strokov, IA, 2013) |
| "There were no differences in reactive hyperemia in any of the groups with PL or AOC." | 1.38 | Vascular function and the role of oxidative stress in heart failure, heart transplant, and beyond. ( Barrett-O'Keefe, Z; Fjeldstad, AS; Ives, SJ; McDaniel, J; Nativi, JN; Richardson, RS; Stehlik, J; Witman, MA; Wray, DW; Zhao, J, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 11 (68.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zara, S | 2 |
| De Colli, M | 1 |
| Rapino, M | 2 |
| Pacella, S | 1 |
| Nasuti, C | 2 |
| Sozio, P | 2 |
| Di Stefano, A | 2 |
| Cataldi, A | 2 |
| Strokov, IA | 1 |
| Fokina, AS | 1 |
| Golovacheva, VA | 1 |
| Kochetov, AG | 1 |
| Kan, E | 1 |
| Kiliçkan, E | 1 |
| Ayar, A | 1 |
| Çolak, R | 1 |
| González-González, L | 1 |
| Pérez-Cortéz, JG | 1 |
| Flores-Aldana, M | 1 |
| Macías-Morales, N | 1 |
| Hernández-Girón, C | 1 |
| Ziegler, D | 1 |
| Low, PA | 1 |
| Freeman, R | 1 |
| Tritschler, H | 1 |
| Vinik, AI | 1 |
| Ying, Z | 1 |
| Chen, M | 1 |
| Xie, X | 1 |
| Wang, X | 1 |
| Kherada, N | 1 |
| Desikan, R | 1 |
| Mihai, G | 1 |
| Burns, P | 1 |
| Sun, Q | 1 |
| Rajagopalan, S | 1 |
| Brenner, SR | 1 |
| De Araújo, DP | 1 |
| Lobato, Rde F | 1 |
| Cavalcanti, JR | 1 |
| Sampaio, LR | 1 |
| Araújo, PV | 1 |
| Silva, MC | 1 |
| Neves, KR | 1 |
| Fonteles, MM | 1 |
| Sousa, FC | 1 |
| Vasconcelos, SM | 1 |
| Santos, JM | 1 |
| Kowluru, RA | 1 |
| Witman, MA | 1 |
| Fjeldstad, AS | 1 |
| McDaniel, J | 1 |
| Ives, SJ | 1 |
| Zhao, J | 1 |
| Barrett-O'Keefe, Z | 1 |
| Nativi, JN | 1 |
| Stehlik, J | 1 |
| Wray, DW | 1 |
| Richardson, RS | 1 |
| Alderson, NL | 1 |
| Chachich, ME | 1 |
| Frizzell, N | 1 |
| Canning, P | 1 |
| Metz, TO | 1 |
| Januszewski, AS | 1 |
| Youssef, NN | 1 |
| Stitt, AW | 1 |
| Baynes, JW | 1 |
| Thorpe, SR | 1 |
| Wepner, U | 1 |
| Naruse, K | 1 |
| Nakamura, J | 1 |
| Lee, KM | 1 |
| Park, KG | 1 |
| Kim, YD | 1 |
| Lee, HJ | 1 |
| Kim, HT | 1 |
| Cho, WH | 1 |
| Kim, HS | 1 |
| Han, SW | 1 |
| Koh, GY | 1 |
| Park, JY | 1 |
| Lee, KU | 1 |
| Kim, JG | 1 |
| Lee, IK | 1 |
| Hager, K | 1 |
| Kenklies, M | 1 |
| McAfoose, J | 1 |
| Engel, J | 1 |
| Münch, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blinded, Placebo-controlled Trial of Idebenone in the Prevention of Episodic Migraine[NCT04151472] | Phase 3 | 180 participants (Anticipated) | Interventional | 2021-12-08 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for thioctic acid and Disease Exacerbation
| Article | Year |
|---|---|
[Antioxidant use as dietary therapy in patients with multiple sclerosis].
Topics: Animals; Antioxidants; Disease Progression; Humans; Multiple Sclerosis; Myelin Sheath; Oxidative Str | 2015 |
The contributions of antioxidant activity of lipoic acid in reducing neurogenerative progression of Parkinson's disease: a review.
Topics: Animals; Antioxidants; Apoptosis; Disease Progression; Humans; Nerve Degeneration; Oxidative Stress; | 2011 |
[Pathogenesis and progression of neuropathies in diabetic patients with endothelial dysfunction].
Topics: Aldehyde Reductase; Animals; Antioxidants; C-Peptide; Diabetes Mellitus; Diabetic Neuropathies; Dise | 2005 |
2 trials available for thioctic acid and Disease Exacerbation
| Article | Year |
|---|---|
Predictors of improvement and progression of diabetic polyneuropathy following treatment with α-lipoic acid for 4 years in the NATHAN 1 trial.
Topics: Antioxidants; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Progression; Female; Follow- | 2016 |
Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis.
Topics: Aged; Alzheimer Disease; Antioxidants; Cholinesterase Inhibitors; Cognition Disorders; Disease Progr | 2007 |
11 other studies available for thioctic acid and Disease Exacerbation
| Article | Year |
|---|---|
Ibuprofen and lipoic acid conjugate neuroprotective activity is mediated by Ngb/Akt intracellular signaling pathway in Alzheimer's disease rat model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Brain; Cyclic AMP Response Element-Bin | 2013 |
[Efficacy of thiolepta in diabetic polyneuropathy: results of the study ETIKA].
Topics: Antioxidants; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropat | 2013 |
Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice.
Topics: Animals; Antioxidants; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Pr | 2015 |
Lipoicmethylenedioxyphenol Reduces Experimental Atherosclerosis through Activation of Nrf2 Signaling.
Topics: Animals; Atherosclerosis; Blood Vessels; Chemotaxis, Leukocyte; Disease Models, Animal; Disease Prog | 2016 |
Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs.
Topics: Brain Diseases, Metabolic; Chronic Disease; Disease Progression; DNA, Mitochondrial; Genetic Predisp | 2010 |
Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ε-mediated metalloproteinase 2 and 9 levels in β-amyloid infused Alzheimer's disease rat model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Cyclooxygenase Inhibitors; Disea | 2011 |
Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Progression; D | 2011 |
Vascular function and the role of oxidative stress in heart failure, heart transplant, and beyond.
Topics: Aged; Antioxidants; Ascorbic Acid; Brachial Artery; Case-Control Studies; Cross-Sectional Studies; D | 2012 |
Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, E | 2004 |
[Evidence-based management of diabetic polyneuropathy. "Burning feet" alarm signal].
Topics: Amines; Combined Modality Therapy; Cyclohexanecarboxylic Acids; Diabetic Foot; Diabetic Neuropathies | 2004 |
Alpha-lipoic acid inhibits fractalkine expression and prevents neointimal hyperplasia after balloon injury in rat carotid artery.
Topics: Angioplasty, Balloon; Animals; Antioxidants; Blotting, Northern; Blotting, Western; Carotid Artery D | 2006 |