thioctic acid has been researched along with Diabetic Retinopathy in 22 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A daily dosage of 600 mg ALA does not prevent the occurrence of CSME in IDDM patients." | 2.76 | Alpha-lipoic acid for the prevention of diabetic macular edema. ( Gerss, J; Hammes, HP; Haritoglou, C; Kampik, A; Ulbig, MW, 2011) |
| "ALA can prevent the dry eye by down regulating the expression of matrix metalloproteinase-9 in the corneal epithelial cells and activating the antioxidant status of the ocular surface." | 2.66 | Alpha-lipoic acid: A possible pharmacological agent for treating dry eye disease and retinopathy in diabetes. ( Ajith, TA, 2020) |
| " The effect is increased significantly, especially in the sensory sphere (tactile, temperature and pain sensitivity), when the drug is used in combination with curantyl in dosage 50 mg twice daily for 3 months." | 1.35 | [The use of dipyridamole (curantyl) in combination with alpha-lipoic acid in the treatment of diabetic neuropathy with retinopathy]. ( Al-Zamil, MKh, 2008) |
| " Our results demonstrate that the long-term administration of alpha-lipoic acid has beneficial effects on the development of diabetic retinopathy via inhibition of accumulation of oxidatively modified DNA and nitrotyrosine in the retina." | 1.32 | Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. ( Kowluru, RA; Odenbach, S, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.09) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 7 (31.82) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Sajadimajd, S | 1 |
| Khosravifar, M | 1 |
| Bahrami, G | 1 |
| Ajith, TA | 1 |
| Oraebosi, MI | 1 |
| Olurishe, TO | 1 |
| Anafi, SB | 1 |
| Bisalla, M | 1 |
| Nebbioso, M | 2 |
| Pranno, F | 1 |
| Pescosolido, N | 2 |
| Chen, CL | 1 |
| Cheng, WS | 1 |
| Chen, JL | 1 |
| Chiang, CH | 1 |
| Berkowitz, BA | 3 |
| Grady, EM | 1 |
| Khetarpal, N | 1 |
| Patel, A | 1 |
| Roberts, R | 3 |
| Kan, E | 1 |
| Alici, Ö | 1 |
| Kan, EK | 1 |
| Ayar, A | 1 |
| Johnsen-Soriano, S | 1 |
| Garcia-Pous, M | 1 |
| Arnal, E | 1 |
| Sancho-Tello, M | 1 |
| Garcia-Delpech, S | 1 |
| Miranda, M | 1 |
| Bosch-Morell, F | 1 |
| Diaz-Llopis, M | 1 |
| Navea, A | 1 |
| Romero, FJ | 1 |
| Al-Zamil, MKh | 1 |
| Haritoglou, C | 1 |
| Gerss, J | 1 |
| Hammes, HP | 2 |
| Kampik, A | 1 |
| Ulbig, MW | 1 |
| Santos, JM | 1 |
| Kowluru, RA | 2 |
| Federici, M | 1 |
| Rusciano, D | 1 |
| Evangelista, M | 1 |
| Abiko, T | 1 |
| Abiko, A | 1 |
| Clermont, AC | 1 |
| Shoelson, B | 1 |
| Horio, N | 1 |
| Takahashi, J | 1 |
| Adamis, AP | 1 |
| King, GL | 1 |
| Bursell, SE | 1 |
| Odenbach, S | 1 |
| Dene, BA | 1 |
| Maritim, AC | 1 |
| Sanders, RA | 1 |
| Watkins, JB | 1 |
| Lin, J | 1 |
| Bierhaus, A | 1 |
| Bugert, P | 1 |
| Dietrich, N | 1 |
| Feng, Y | 1 |
| Vom Hagen, F | 1 |
| Nawroth, P | 1 |
| Brownlee, M | 1 |
| Luan, H | 2 |
| Stemmler, A | 1 |
| Gradianu, M | 1 |
| Packer, L | 1 |
| Kähler, W | 1 |
| Kuklinski, B | 1 |
| Rühlmann, C | 1 |
| Plötz, C | 1 |
| Kutschera, E | 1 |
| Sauer, H | 1 |
| Böninger, C | 1 |
3 reviews available for thioctic acid and Diabetic Retinopathy
| Article | Year |
|---|---|
Alpha-lipoic acid: A possible pharmacological agent for treating dry eye disease and retinopathy in diabetes.
Topics: Animals; Diabetic Retinopathy; Dry Eye Syndromes; Humans; Oxidative Stress; Retina; Thioctic Acid | 2020 |
Lipoic acid in animal models and clinical use in diabetic retinopathy.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Humans; Thioctic Acid | 2013 |
Antioxidant properties of lipoic acid and its therapeutic effects in prevention of diabetes complications and cataracts.
Topics: Animals; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Cataract; Diabetes Mellitus, Experim | 1994 |
3 trials available for thioctic acid and Diabetic Retinopathy
| Article | Year |
|---|---|
Alpha-lipoic acid for the prevention of diabetic macular edema.
Topics: Administration, Oral; Adult; Aged; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes | 2011 |
Oxidative stress in preretinopathic diabetes subjects and antioxidants.
Topics: Adult; Aged; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Electroretinography; Fem | 2012 |
[Diabetes mellitus--a free radical-associated disease. Results of adjuvant antioxidant supplementation].
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropat | 1993 |
16 other studies available for thioctic acid and Diabetic Retinopathy
| Article | Year |
|---|---|
Anti-Diabetic Effects of Isolated Lipids from Natural Sources through Modulation of Angiogenesis.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Fatty Acids, Omega-3; Humans; Linsee | 2022 |
Chronopharmacology of the alpha-lipoic acid/nifedipine/glimepiride combination in the amelioration of retinopathy in rats.
Topics: Animals; Antioxidants; Circadian Rhythm; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Nife | 2021 |
Potential of nonoral α-lipoic acid aqueous formulations to reduce ocular microvascular complications in a streptozotocin-induced diabetic rat model.
Topics: Administration, Ophthalmic; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Retinop | 2013 |
Oxidative stress and light-evoked responses of the posterior segment in a mouse model of diabetic retinopathy.
Topics: Animals; Antioxidants; Choroid; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Female; Light | 2015 |
Effects of alpha-lipoic acid on retinal ganglion cells, retinal thicknesses, and VEGF production in an experimental model of diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Male; Mice, Inbred BAL | 2017 |
Early lipoic acid intake protects retina of diabetic mice.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Drug Administration Sc | 2008 |
[The use of dipyridamole (curantyl) in combination with alpha-lipoic acid in the treatment of diabetic neuropathy with retinopathy].
Topics: Adult; Aged; Antioxidants; Diabetic Neuropathies; Diabetic Retinopathy; Dipyridamole; Drug Therapy, | 2008 |
Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Progression; D | 2011 |
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation.
Topics: alpha-Tocopherol; Animals; Antioxidants; Blood Flow Velocity; Diabetes Mellitus, Experimental; Diabe | 2003 |
Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats.
Topics: Animals; Cell Death; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Male; Oxidative Stress; | 2004 |
Effects of antioxidant treatment on normal and diabetic rat retinal enzyme activities.
Topics: Animals; Antioxidants; beta Carotene; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Drug Co | 2005 |
Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Male; NF-kappa B; Rats; Rats, Wistar | 2006 |
alpha-lipoic acid corrects late-phase supernormal retinal oxygenation response in experimental diabetic retinopathy.
Topics: Animals; Antioxidants; Carbon Dioxide; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Hypero | 2006 |
Impaired apparent ion demand in experimental diabetic retinopathy: correction by lipoic Acid.
Topics: Animals; Antioxidants; Blood-Retinal Barrier; Capillary Permeability; Diabetes Mellitus, Experimenta | 2007 |
[Problems of diabetic retinopathy].
Topics: Age Factors; Anabolic Agents; Diabetic Retinopathy; Diet Therapy; Dietary Fats; Humans; Hypophysecto | 1970 |
[What is reliable in the therapy of diabetes mellitus?].
Topics: Carbutamide; Chlorpropamide; Chronic Disease; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nep | 1970 |