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thioctic acid and Diabetic Nephropathies

thioctic acid has been researched along with Diabetic Nephropathies in 37 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.

Research Excerpts

ExcerptRelevanceReference
"This study was designed to investigate the effects of combined administration of lipoic acid and pyridoxine on albuminuria, oxidative stress, blood pressure, serum advanced glycation end-products, nitric oxide (NO), and endothelin-1 in patients with diabetic nephropathy."9.17Effects of combined lipoic acid and pyridoxine on albuminuria, advanced glycation end-products, and blood pressure in diabetic nephropathy. ( Hedayati, M; Hosseinpanah, F; Nafar, M; Noori, N; Tabibi, H, 2013)
"This study was designed to investigate the effects of combined administration of lipoic acid and pyridoxine on albuminuria, oxidative stress, blood pressure, serum advanced glycation end-products, nitric oxide (NO), and endothelin-1 in patients with diabetic nephropathy."5.17Effects of combined lipoic acid and pyridoxine on albuminuria, advanced glycation end-products, and blood pressure in diabetic nephropathy. ( Hedayati, M; Hosseinpanah, F; Nafar, M; Noori, N; Tabibi, H, 2013)
" Compared with control rats, D developed increased urinary excretion of albumin and transforming growth factor beta, renal insufficiency, glomerular mesangial matrix expansion, and glomerulosclerosis in association with depletion of glutathione and accumulation of malondialdehyde in renal cortex."3.71Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. ( Craven, PA; DeRubertis, FR; Liachenko, J; Melhem, MF, 2002)
"This is a prospective parallel, randomized, double-blind, placebo-controlled trial to study the effects of α lipoic acid in combination with olmesartan medoxomil on blood glucose and oxidation indicators in patients with DN."3.11Effects of α lipoic acid combined with olmesartan medoxomil on blood glucose and oxidation indicators in patients with diabetic nephropathy: A protocol for a parallel, randomized, double-blind, controlled clinical trial. ( Chang, X; Dong, Y; Jiao, S; Li, H; Wu, Y, 2022)
"The aim of this study was to compare curative effects of valsartan alone or combined with alpha-lipoic acid (ALA) on inflammatory cytokine indices including hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α) and renal function indices including urinary albumin excretion rate (UAER), β2-microglobulin (β2-MG) and cystatin C (Cys C) of patients with early-stage diabetic kidney disease (DKD)."2.90Curative Effects of Valsartan Alone or Combined with Alpha-lipoic Acid on Inflammatory Cytokines and Renal Function in Early-stage Diabetic Kidney Disease. ( Jiang, Z; Li, X; Meng, F; Tan, Z, 2019)
" The purpose of this study was to evaluate the efficacy of valsartan combined with α-lipoic acid on renal function in patients with DN."2.72Effects of valsartan combined with α-lipoic acid on renal function in patients with diabetic nephropathy: a systematic review and meta-analysis. ( Cai, J; Jiang, D; Sun, F, 2021)
"Forty-nine patients (34 with Type 1 diabetes, 15 with Type 2 diabetes) had no antioxidant treatment and served as a control group."2.70Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study. ( Amiral, J; Borcea, V; Ehret, T; Gehrke, S; Henkels, M; Hofmann, M; Isermann, B; Morcos, M; Nawroth, PP; Schiekofer, S; Tritschler, H; Wahl, P; Ziegler, R, 2001)
" Therefore, the results of valsartan and amlodipine tablets combined with alpha-lipoic acid on total antioxidant capacity (T-AOC) need to be investigated."1.91Effects of Valsartan and Amlodipine Tablets Combined with α-Lipoic Acid on T-AOC, IL-6 and β2-MG Levels in Patients with Diabetic Nephropathy. ( Su, F; Xia, Q, 2023)
"Polyneuropathies were specified as toxic/metabolic with the prevalence of a demyelinating component within the main disease in 18 (67%) patients."1.38[Demyelinating polyneuropathies in patients with diabetes mellitus and chronic alcoholic intoxication]. ( Kovrazhkina, EA, 2012)
"Thioctic acid treatment was discontinued 2 days after admission."1.37Thioctic acid-induced acute cholestatic hepatitis. ( Castiglioni, T; Ridruejo, E; Silva, MO, 2011)
"Twenty-eight patients, 17 women and 11 men, aged 40-70 years, with distal sensory-motor diabetic neuropathy of the lower extremities were treated with berlition, an alpha-lipoic acid preparation, in dosage 600 mg daily during 3 months."1.35[Implication of alpha-lipoic acid preparations in the treatment of diabetic neuropathy]. ( Al'-Zamil', MKh; Brezheva, EV, 2008)
"We hypothesized that streptozotocin diabetes in rats and mice would result in an early reduction in podocyte density and that this reduction would be prevented by antioxidants."1.33Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: prevention by lipoic acid treatment. ( Brosius, FC; Saha, J; Siu, B; Smoyer, WE; Sullivan, KA, 2006)
"Patients with diabetic nephropathy showed higher NF-kappaB binding activity in Electrophoretic Mobility Shift Assays and stronger immunohistological staining for activated NF-kappaBp65 than patients without renal complications."1.30Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB. ( Abdel Khalek, AK; Amiral, J; Bierhaus, A; Borcea, V; Henkels, M; Hofmann, MA; Isermann, B; Joswig, M; Kanitz, M; Morcos, M; Nawroth, PP; Ritz, E; Schiekofer, S; Treusch, A; Tritschler, H; Wahl, P; Weiss, T; Ziegler, R, 1999)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.70)18.7374
1990's3 (8.11)18.2507
2000's14 (37.84)29.6817
2010's13 (35.14)24.3611
2020's6 (16.22)2.80

Authors

AuthorsStudies
Sun, F1
Jiang, D1
Cai, J1
Dugbartey, GJ1
Alornyo, KK1
N'guessan, BB1
Atule, S1
Mensah, SD1
Adjei, S1
Jiao, S1
Dong, Y1
Chang, X1
Wu, Y1
Li, H1
Zhang, HF1
Liu, HM1
Xiang, JY1
Zhou, XC1
Wang, D1
Chen, RY1
Tan, WL1
Liang, LQ1
Liu, LL1
Shi, MJ1
Zhang, F1
Xiao, Y1
Zhou, YX1
Zhang, T1
Tang, L1
Guo, B1
Wang, YY1
Su, F1
Xia, Q1
Jiang, Z1
Tan, Z1
Meng, F1
Li, X1
Kayhan Kuştepe, E1
Bahar, L1
Zayman, E1
Sucu, N1
Gül, S1
Gül, M1
Noori, N1
Tabibi, H1
Hosseinpanah, F1
Hedayati, M1
Nafar, M1
Safa, J1
Ardalan, MR1
Rezazadehsaatlou, M1
Mesgari, M1
Mahdavi, R1
Jadid, MP1
Mao, ZM1
Shen, SM1
Wan, YG1
Sun, W1
Chen, HL1
Huang, MM1
Yang, JJ1
Wu, W1
Tang, HT1
Tang, RM1
Sun, H1
Yao, W1
Tang, Y1
Zhuang, W1
Wu, D1
Huang, S1
Sheng, H1
Lee, SJ1
Kang, JG1
Ryu, OH1
Kim, CS1
Ihm, SH1
Choi, MG1
Yoo, HJ1
Kim, DS1
Kim, TW1
Kanter, M1
Sen, S1
Donmez, S1
Aktas, C1
Ustundag, S1
Erboga, M1
Li, XZ1
Yan, HD1
Wang, J1
Ridruejo, E1
Castiglioni, T1
Silva, MO1
Huk-Kolega, H1
Skibska, B1
Kleniewska, P1
Piechota, A1
Michalski, Ł1
Goraca, A1
Bertolotto, F1
Massone, A1
Kovrazhkina, EA1
Okuyucu, S1
Kocer, A1
Eryilmaz, M1
Kocaman, G1
Mıcılı, SC1
Ergur, BU1
Ozoğul, C1
Sarıoğlu, S1
Bağrıyanık, HA1
Tuğyan, K1
Pekcetin, C1
Sonmez, U1
Tekmen, I1
Erbil, G1
Akdoğan, GG1
Ozyurt, D1
Buldan, Z1
Nascimento, NR1
Costa-e-Forti, A1
Peter, AA1
Fonteles, MC1
Alderson, NL1
Chachich, ME1
Frizzell, N1
Canning, P1
Metz, TO1
Januszewski, AS1
Youssef, NN1
Stitt, AW1
Baynes, JW1
Thorpe, SR1
Bhatti, F1
Mankhey, RW1
Asico, L1
Quinn, MT1
Welch, WJ1
Maric, C1
Siu, B1
Saha, J1
Smoyer, WE1
Sullivan, KA1
Brosius, FC1
Chang, JW1
Lee, EK1
Kim, TH1
Min, WK1
Chun, S1
Lee, KU1
Kim, SB1
Park, JS1
Oksala, NK1
Lappalainen, J1
Laaksonen, DE1
Khanna, S1
Kaarniranta, K1
Sen, CK1
Atalay, M1
Tang, J1
Wingerchuk, DM1
Crum, BA1
Rubin, DI1
Demaerschalk, BM1
Winiarska, K1
Malinska, D1
Szymanski, K1
Dudziak, M1
Bryla, J1
Liu, F1
Zhang, Y1
Yang, M1
Liu, B1
Shen, YD1
Jia, WP1
Xiang, KS1
Al'-Zamil', MKh1
Brezheva, EV1
Kähler, W1
Kuklinski, B1
Rühlmann, C1
Plötz, C1
Hofmann, MA1
Schiekofer, S2
Isermann, B2
Kanitz, M1
Henkels, M2
Joswig, M1
Treusch, A1
Morcos, M2
Weiss, T1
Borcea, V2
Abdel Khalek, AK1
Amiral, J2
Tritschler, H2
Ritz, E1
Wahl, P2
Ziegler, R2
Bierhaus, A1
Nawroth, PP2
Ruhnau, KJ1
Meissner, HP1
Finn, JR1
Reljanovic, M1
Lobisch, M1
Schütte, K1
Nehrdich, D1
Tritschler, HJ1
Mehnert, H1
Ziegler, D1
Melhem, MF2
Craven, PA2
Derubertis, FR2
Gehrke, S1
Ehret, T1
Hofmann, M1
Liachenko, J1
Sauer, H1
Böninger, C1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Dose Finding and Tolerability Study of Alpha-lipoic Acid in Patients at Risk for Paclitaxel Induced Peripheral Neuropathy[NCT01313117]Phase 1/Phase 29 participants (Actual)Interventional2012-02-29Completed
Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups[NCT00328601]Phase 3170 participants Interventional2005-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cumulative Rate of Adverse Events

(NCT01313117)
Timeframe: 4 months

Interventionparticipants (Number)
Alpha Lipoic Acid9

Identification of the Optimal Dose of ALA Based on Acceptable Adverse Event(AE) Profile

Based on acceptable adverse event (AE) profile and continual reassessment method dose escalation. (NCT01313117)
Timeframe: 4 months

Interventionmg (Number)
Alpha Lipoic Acid500

Proportion of Patients Who Complete the Proposed Regimen of Daily ALA

(NCT01313117)
Timeframe: 4 months

Interventionparticipants (Number)
Alpha Lipoic Acid7

Reviews

2 reviews available for thioctic acid and Diabetic Nephropathies

ArticleYear
Effects of valsartan combined with α-lipoic acid on renal function in patients with diabetic nephropathy: a systematic review and meta-analysis.
    BMC endocrine disorders, 2021, Aug-31, Volume: 21, Issue:1

    Topics: Antihypertensive Agents; Antioxidants; Diabetic Nephropathies; Drug Therapy, Combination; Humans; Ki

2021
[Role of lipoic acid in health and disease].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2011, Volume: 31, Issue:183

    Topics: Antioxidants; Chelating Agents; Diabetic Nephropathies; Heavy Metal Poisoning; Humans; Mycoses; Pois

2011

Trials

12 trials available for thioctic acid and Diabetic Nephropathies

ArticleYear
Effects of α lipoic acid combined with olmesartan medoxomil on blood glucose and oxidation indicators in patients with diabetic nephropathy: A protocol for a parallel, randomized, double-blind, controlled clinical trial.
    Medicine, 2022, Apr-29, Volume: 101, Issue:17

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Glucose; Blood Pressure; Dia

2022
Curative Effects of Valsartan Alone or Combined with Alpha-lipoic Acid on Inflammatory Cytokines and Renal Function in Early-stage Diabetic Kidney Disease.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2019, Volume: 29, Issue:10

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; China; Cytokines; Diabetic Nephropathies; Drug The

2019
Effects of combined lipoic acid and pyridoxine on albuminuria, advanced glycation end-products, and blood pressure in diabetic nephropathy.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2013, Volume: 83, Issue:2

    Topics: Adult; Aged; Albuminuria; Arginine; Blood Pressure; Creatinine; Diabetic Nephropathies; Double-Blind

2013
Effects of alpha lipoic acid supplementation on serum levels of IL-8 and TNF-α in patient with ESRD undergoing hemodialysis.
    International urology and nephrology, 2014, Volume: 46, Issue:8

    Topics: Adult; Aged; Antioxidants; Diabetic Nephropathies; Dietary Supplements; Double-Blind Method; Female;

2014
Urinary exosomes as a novel biomarker for evaluation of α-lipoic acid's protective effect in early diabetic nephropathy.
    Journal of clinical laboratory analysis, 2017, Volume: 31, Issue:6

    Topics: Aged; Biomarkers; Diabetic Nephropathies; Exosomes; Female; Humans; Male; Middle Aged; Protective Ag

2017
Combination of alpha lipoic acid and superoxide dismutase leads to physiological and symptomatic improvements in diabetic neuropathy.
    Drugs in R&D, 2012, Mar-01, Volume: 12, Issue:1

    Topics: Aged; Ambulatory Care; Antioxidants; Diabetic Nephropathies; Female; Humans; Male; Neural Conduction

2012
Effects of alpha-lipoic acid on the plasma levels of asymmetric dimethylarginine in diabetic end-stage renal disease patients on hemodialysis: a pilot study.
    American journal of nephrology, 2007, Volume: 27, Issue:1

    Topics: Adult; Antioxidants; Arginine; Biomarkers; C-Reactive Protein; Cholesterol; Chromatography, High Pre

2007
Alpha-lipoic acid may improve symptomatic diabetic polyneuropathy.
    The neurologist, 2007, Volume: 13, Issue:3

    Topics: Administration, Oral; Aged; Antioxidants; Diabetic Nephropathies; Dose-Response Relationship, Drug;

2007
[Curative effect of alpha-lipoic acid on peripheral neuropathy in type 2 diabetes: a clinical study].
    Zhonghua yi xue za zhi, 2007, Oct-16, Volume: 87, Issue:38

    Topics: Aged; Antioxidants; Blood Glucose; C-Reactive Protein; Diabetes Mellitus, Type 2; Diabetic Nephropat

2007
[Diabetes mellitus--a free radical-associated disease. Results of adjuvant antioxidant supplementation].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1993, Volume: 48, Issue:5

    Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropat

1993
Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy.
    Diabetic medicine : a journal of the British Diabetic Association, 1999, Volume: 16, Issue:12

    Topics: Aged; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female;

1999
Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy.
    Diabetic medicine : a journal of the British Diabetic Association, 1999, Volume: 16, Issue:12

    Topics: Aged; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female;

1999
Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy.
    Diabetic medicine : a journal of the British Diabetic Association, 1999, Volume: 16, Issue:12

    Topics: Aged; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female;

1999
Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy.
    Diabetic medicine : a journal of the British Diabetic Association, 1999, Volume: 16, Issue:12

    Topics: Aged; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female;

1999
Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study.
    Diabetes research and clinical practice, 2001, Volume: 52, Issue:3

    Topics: Albuminuria; Antioxidants; Biomarkers; Blood Pressure; Diabetes Mellitus, Type 1; Diabetes Mellitus,

2001

Other Studies

23 other studies available for thioctic acid and Diabetic Nephropathies

ArticleYear
Supplementation of conventional anti-diabetic therapy with alpha-lipoic acid prevents early development and progression of diabetic nephropathy.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 149

    Topics: Animals; Antioxidants; Creatinine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabe

2022
Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation.
    Acta pharmacologica Sinica, 2023, Volume: 44, Issue:5

    Topics: Animals; beta Catenin; Cystic Fibrosis Transmembrane Conductance Regulator; Diabetes Mellitus, Type

2023
Effects of Valsartan and Amlodipine Tablets Combined with α-Lipoic Acid on T-AOC, IL-6 and β2-MG Levels in Patients with Diabetic Nephropathy.
    Alternative therapies in health and medicine, 2023, Volume: 29, Issue:5

    Topics: Amlodipine; Antihypertensive Agents; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Nephropathies

2023
A light microscopic investigation of the renoprotective effects of α-lipoic acid and α-tocopherol in an experimental diabetic rat model.
    Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2020, Volume: 95, Issue:4

    Topics: alpha-Tocopherol; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Ma

2020
Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to α-lipoic acid.
    Journal of ethnopharmacology, 2015, Sep-15, Volume: 173

    Topics: Abelmoschus; Animals; Antioxidants; Capsules; Diabetes Mellitus, Experimental; Diabetic Nephropathie

2015
Effects of alpha-lipoic acid on transforming growth factor beta1-p38 mitogen-activated protein kinase-fibronectin pathway in diabetic nephropathy.
    Metabolism: clinical and experimental, 2009, Volume: 58, Issue:5

    Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Blood Glucose; Blotting, W

2009
Protective effects of irbesartan and alpha lipoic acid in STZ-induced diabetic nephropathy in rats.
    Renal failure, 2010, Volume: 32, Issue:4

    Topics: Animals; Biphenyl Compounds; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Immuno

2010
[Extract of Ginkgo biloba and alpha-lipoic acid attenuate advanced glycation end products accumulation and RAGE expression in diabetic nephropathy rats].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2011, Volume: 31, Issue:4

    Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Ginkgo biloba; Glyca

2011
Thioctic acid-induced acute cholestatic hepatitis.
    The Annals of pharmacotherapy, 2011, Volume: 45, Issue:7-8

    Topics: Antioxidants; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Diabetes Mellitus,

2011
[Demyelinating polyneuropathies in patients with diabetes mellitus and chronic alcoholic intoxication].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:5

    Topics: Acute Disease; Alcoholism; Antioxidants; Diabetic Nephropathies; Electromyography; Humans; Polyneuro

2012
Thioctacid is effective for neuropathy symptoms and hyperglycemia control without pronounced electromyographic changes.
    Neurosciences (Riyadh, Saudi Arabia), 2012, Volume: 17, Issue:4

    Topics: Aged; Antioxidants; Diabetic Nephropathies; Electromyography; Female; Humans; Male; Middle Aged; Neu

2012
Effects of lipoic acid in an experimentally induced hypertensive and diabetic rat model.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2013, Volume: 35, Issue:5

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Hypertensi

2013
Free radical scavengers improve the impaired endothelium-dependent responses in aorta and kidneys of diabetic rabbits.
    Diabetes research and clinical practice, 2003, Volume: 61, Issue:3

    Topics: Animals; Aorta, Thoracic; Diabetic Angiopathies; Diabetic Nephropathies; Endothelium, Vascular; Free

2003
Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat.
    Diabetologia, 2004, Volume: 47, Issue:8

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, E

2004
Mechanisms of antioxidant and pro-oxidant effects of alpha-lipoic acid in the diabetic and nondiabetic kidney.
    Kidney international, 2005, Volume: 67, Issue:4

    Topics: Albuminuria; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephrop

2005
Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: prevention by lipoic acid treatment.
    BMC nephrology, 2006, Mar-15, Volume: 7

    Topics: Animals; Antioxidants; Cell Count; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Male; Mi

2006
Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney.
    Antioxidants & redox signaling, 2007, Volume: 9, Issue:4

    Topics: Analysis of Variance; Animals; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Nephropa

2007
Lipoic acid ameliorates oxidative stress and renal injury in alloxan diabetic rabbits.
    Biochimie, 2008, Volume: 90, Issue:3

    Topics: Animals; Antioxidants; Blood Glucose; Creatine; Diabetes Mellitus, Experimental; Diabetic Nephropath

2008
[Implication of alpha-lipoic acid preparations in the treatment of diabetic neuropathy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2008, Volume: 108, Issue:2

    Topics: Adult; Aged; Antioxidants; Diabetic Nephropathies; Dose-Response Relationship, Drug; Electromyograph

2008
Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB.
    Diabetologia, 1999, Volume: 42, Issue:2

    Topics: Adult; Albuminuria; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nep

1999
Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus.
    Journal of the American Society of Nephrology : JASN, 2001, Volume: 12, Issue:1

    Topics: Animals; Antioxidants; Collagen; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dietary Su

2001
Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes.
    Journal of the American Society of Nephrology : JASN, 2002, Volume: 13, Issue:1

    Topics: Albuminuria; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephrop

2002
[What is reliable in the therapy of diabetes mellitus?].
    Der Internist, 1970, Volume: 11, Issue:12

    Topics: Carbutamide; Chlorpropamide; Chronic Disease; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nep

1970