thioctic acid has been researched along with Diabetes Mellitus, Type 2 in 104 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the clinical value of alprostadil combined with the α-lipoic acid in treating type 2 diabetes mellitus with erectile dysfunction (DMED)." | 9.22 | Study on the clinical value of alprostadil combined with α-lipoic acid in treatment of type 2 diabetes mellitus patients with erectile dysfunction. ( Huang, FC; Huang, Q; Li, JR; Liu, C; Zhang, HY; Zhang, L, 2016) |
| "We investigated the clinical value of alprostadil combined with the α-lipoic acid in treating type 2 diabetes mellitus with erectile dysfunction (DMED)." | 5.22 | Study on the clinical value of alprostadil combined with α-lipoic acid in treatment of type 2 diabetes mellitus patients with erectile dysfunction. ( Huang, FC; Huang, Q; Li, JR; Liu, C; Zhang, HY; Zhang, L, 2016) |
| " Indeed, bimoclomol--a heat shock protein co-inducer being developed for treatment of diabetic neuropathy--and lipoic acid--suspected to be a heat shock protein inducer--have each demonstrated favorable effects on the insulin sensitivity of obese rodents, and parenteral lipoic acid is reported to improve the insulin sensitivity of type 2 diabetics." | 3.73 | Induction of heat shock proteins may combat insulin resistance. ( McCarty, MF, 2006) |
| "To evaluate the effect of alpha-lipoic acid (LA) combined with transient intensive insulin therapy on adipokine level in patients with type 2 diabetic perineuropathy (DPN)." | 2.78 | [Effect of alpha-lipoic acid combined with transient intensive insulin therapy on adipokine level in patients with type 2 diabetic perineuropathy]. ( Song, MQ; Yang, L; Zang, SF, 2013) |
| " A randomized controlled trial was conducted to investigate whether CSII in combination with rosiglitazone, metformin, or α-lipoic acid separately brings about extra benefits." | 2.78 | Short-term continuous subcutaneous insulin infusion combined with insulin sensitizers rosiglitazone, metformin, or antioxidant α-lipoic acid in patients with newly diagnosed type 2 diabetes mellitus. ( Chen, A; Deng, W; Fang, D; Huang, Z; Li, H; Li, Y; Liu, J; Liu, L; Wan, X; Wei, G, 2013) |
| "A daily dosage of 600 mg ALA does not prevent the occurrence of CSME in IDDM patients." | 2.76 | Alpha-lipoic acid for the prevention of diabetic macular edema. ( Gerss, J; Hammes, HP; Haritoglou, C; Kampik, A; Ulbig, MW, 2011) |
| "A total of 30 subjects with type 2 diabetes were included in this randomized, controlled, double-blinded, parallel group study." | 2.75 | Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial. ( Francesconi, M; Gouya, G; Heinisch, BB; Mittermayer, F; Pleiner, J; Schaller, G; Wolzt, M, 2010) |
| "Forty-nine patients (34 with Type 1 diabetes, 15 with Type 2 diabetes) had no antioxidant treatment and served as a control group." | 2.70 | Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study. ( Amiral, J; Borcea, V; Ehret, T; Gehrke, S; Henkels, M; Hofmann, M; Isermann, B; Morcos, M; Nawroth, PP; Schiekofer, S; Tritschler, H; Wahl, P; Ziegler, R, 2001) |
| "placebo treatment on insulin sensitivity was compared." | 2.69 | Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. ( Augustin, HJ; Dietze, GJ; Hermann, R; Jacob, S; Maerker, E; Renn, W; Rett, K; Ruus, P; Tritschler, HJ, 1999) |
| "Diabetic polyneuropathy is a serious complication in patients with diabetes mellitus." | 2.69 | Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy. ( Amini, P; Frommeyer, R; Haak, E; Haak, T; Kusterer, K; Tritschler, HJ; Usadel, KH, 2000) |
| "Type 2 diabetes is a common metabolic disorder characterized by resistance to the actions of insulin to stimulate skeletal muscle glucose disposal." | 2.52 | Natural supplements for improving insulin sensitivity and glucose uptake in skeletal muscle. ( Dirks-Naylor, AJ; Kouzi, SA; Nuzum, DS; Yang, S, 2015) |
| "In patients with type 2 diabetes, recent studies have reported that intravenous (i." | 2.41 | Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. ( Evans, JL; Goldfine, ID, 2000) |
| "The incidence of NIDDM is highest in economically developed nations, particularly the U." | 2.41 | Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes. ( McDonald, RB; Ruhe, RC, 2001) |
| " Therefore, the results of valsartan and amlodipine tablets combined with alpha-lipoic acid on total antioxidant capacity (T-AOC) need to be investigated." | 1.91 | Effects of Valsartan and Amlodipine Tablets Combined with α-Lipoic Acid on T-AOC, IL-6 and β2-MG Levels in Patients with Diabetic Nephropathy. ( Su, F; Xia, Q, 2023) |
| "Correlation between type 2 diabetes and other abnormalities such as obesity with redox balance disturbance was analyzed in many reports." | 1.72 | The Effect of α-Lipoic Acid on Oxidative Stress in Adipose Tissue of Rats with Obesity-Induced Insulin Resistance. ( Chabowski, A; Dajnowicz-Brzezik, P; Maciejczyk, M; Zalewska, A; Żebrowska, E, 2022) |
| " The dosage of alpha-lipoic acid was determined for each of the groups." | 1.72 | EFFECTS OF ALPHA-LIPOIC ACID ON GLYCEMIC STATUS IN 2 TYPE DIABETES PATIENTS WITH СHRONIC CORONARY SYNDROME. ( Altunina, N; Bondarchuk, O, 2022) |
| "Alprostadil is a commonly used vasodilator, and alpha lipoic acid is an antioxidant, which can effectively reduce oxidative stress responses and delay the progression of diabetes mellitus and its complications." | 1.56 | The clinical effectiveness and safety of alprostadil combined with alpha lipoic acid in the treatment of diabetic peripheral neuropathy: A protocol for systematic review and meta-analysis. ( Fang, C; Fang, X; Guan, H; Han, P; Li, L; Qiu, S; Ye, M; Zhang, L, 2020) |
| "A total of 36 cases with type 2 diabetes with microalbuminuria and fasting plasma glucose (FPG) levels less than 9 mmol/L and glycated hemoglobin A1c (HbA1c) ≤9." | 1.40 | Alleviation of podocyte injury: the possible pathway implicated in anti-inflammation of alpha-lipoic acid in type 2 diabetics. ( Bao, XH; Chen, Y; Xu, J; Yang, CL; Ye, SD, 2014) |
| " Dosage of the drug was 600 mg daily." | 1.39 | [Efficacy of thiolepta in diabetic polyneuropathy: results of the study ETIKA]. ( Fokina, AS; Golovacheva, VA; Kochetov, AG; Strokov, IA, 2013) |
| "A 63-year-old man with type 2 diabetes, hypertension, hypothyroidism, and stage 2 chronic renal failure was referred to the outpatient liver clinic with fever, asthenia, nausea, and pruritus." | 1.37 | Thioctic acid-induced acute cholestatic hepatitis. ( Castiglioni, T; Ridruejo, E; Silva, MO, 2011) |
| " Improved endothelial function due to alpha-LA was at least partially attributed to recoupling of eNOS and increased NO bioavailability and represents a pharmacological approach to prevent major complications associated with type 2 diabetes." | 1.35 | Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats. ( Boarder, MR; Fernandes, R; Louro, T; Nunes, E; Proença, T; Seiça, RM; Sena, CM, 2008) |
| " Chronic administration of the hydrophobic/hydrophilic antioxidant alpha -lipoic-acid (ALA, 100 mg/kg, i." | 1.32 | Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats. ( Al-Mulla, F; Al-Saleh, E; Bitar, MS; Pilcher, CW; Wahid, S, 2004) |
| "Patients with diabetic nephropathy showed higher NF-kappaB binding activity in Electrophoretic Mobility Shift Assays and stronger immunohistological staining for activated NF-kappaBp65 than patients without renal complications." | 1.30 | Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB. ( Abdel Khalek, AK; Amiral, J; Bierhaus, A; Borcea, V; Henkels, M; Hofmann, MA; Isermann, B; Joswig, M; Kanitz, M; Morcos, M; Nawroth, PP; Ritz, E; Schiekofer, S; Treusch, A; Tritschler, H; Wahl, P; Weiss, T; Ziegler, R, 1999) |
| "Twenty patients with NIDDM received TA (500 mg/ 500 ml NaCl, 0." | 1.29 | Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. ( Augustin, HJ; Dietze, GJ; Henriksen, EJ; Jacob, S; Tritschler, HJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (14.42) | 18.2507 |
| 2000's | 20 (19.23) | 29.6817 |
| 2010's | 47 (45.19) | 24.3611 |
| 2020's | 22 (21.15) | 2.80 |
| Authors | Studies |
|---|---|
| Jeffrey, S | 1 |
| Isaac Samraj, P | 1 |
| Sundara Raj, B | 1 |
| Dugbartey, GJ | 2 |
| Alornyo, KK | 2 |
| N'guessan, BB | 1 |
| Atule, S | 1 |
| Mensah, SD | 1 |
| Adjei, S | 1 |
| Derosa, G | 2 |
| D'Angelo, A | 2 |
| Preti, PS | 1 |
| Maffioli, P | 2 |
| Halabitska, IM | 1 |
| Babinets, LS | 1 |
| Vysotskyi, VI | 1 |
| Dajnowicz-Brzezik, P | 1 |
| Żebrowska, E | 1 |
| Maciejczyk, M | 1 |
| Zalewska, A | 1 |
| Chabowski, A | 1 |
| Wonje, QL | 1 |
| Adams, I | 1 |
| Diaba, DE | 1 |
| Roszkowska, AM | 1 |
| Spinella, R | 1 |
| Oliverio, GW | 1 |
| Postorino, EI | 1 |
| Signorino, GA | 1 |
| Rusciano, D | 2 |
| Aragona, P | 1 |
| Zhang, HF | 1 |
| Liu, HM | 1 |
| Xiang, JY | 1 |
| Zhou, XC | 1 |
| Wang, D | 1 |
| Chen, RY | 1 |
| Tan, WL | 1 |
| Liang, LQ | 1 |
| Liu, LL | 1 |
| Shi, MJ | 1 |
| Zhang, F | 1 |
| Xiao, Y | 1 |
| Zhou, YX | 1 |
| Zhang, T | 1 |
| Tang, L | 1 |
| Guo, B | 1 |
| Wang, YY | 1 |
| Altunina, N | 1 |
| Bondarchuk, O | 1 |
| Su, F | 1 |
| Xia, Q | 1 |
| Guarano, A | 1 |
| Capozzi, A | 1 |
| Cristodoro, M | 1 |
| Di Simone, N | 1 |
| Lello, S | 1 |
| Orellana-Donoso, M | 1 |
| López-Chaparro, M | 1 |
| Barahona-Vásquez, M | 1 |
| Santana-Machuca, A | 1 |
| Bruna-Mejias, A | 1 |
| Nova-Baeza, P | 1 |
| Valenzuela-Fuenzalida, JJ | 1 |
| Won, JC | 2 |
| Kwon, HS | 1 |
| Moon, SS | 1 |
| Chun, SW | 1 |
| Kim, CH | 1 |
| Park, IB | 1 |
| Kim, IJ | 1 |
| Lee, J | 1 |
| Cha, BY | 1 |
| Park, TS | 2 |
| El-Nahas, MR | 1 |
| Elkannishy, G | 1 |
| Abdelhafez, H | 1 |
| Elkhamisy, ET | 1 |
| El-Sehrawy, AA | 1 |
| Yan, T | 1 |
| Zhang, Z | 3 |
| Li, D | 1 |
| Pagano, G | 1 |
| Pallardó, FV | 1 |
| Lyakhovich, A | 1 |
| Tiano, L | 1 |
| Fittipaldi, MR | 1 |
| Toscanesi, M | 1 |
| Trifuoggi, M | 1 |
| Didangelos, T | 1 |
| Karlafti, E | 1 |
| Kotzakioulafi, E | 1 |
| Kontoninas, Z | 1 |
| Margaritidis, C | 1 |
| Giannoulaki, P | 1 |
| Kantartzis, K | 1 |
| Lu, Y | 1 |
| Li, W | 1 |
| Li, Y | 3 |
| Lian, X | 1 |
| Guan, H | 1 |
| Ye, M | 1 |
| Fang, C | 1 |
| Zhang, L | 2 |
| Han, P | 1 |
| Qiu, S | 1 |
| Fang, X | 1 |
| Li, L | 1 |
| Nádró, B | 1 |
| Lőrincz, H | 1 |
| Molnár, Á | 1 |
| Szentpéteri, A | 1 |
| Zöld, E | 1 |
| Seres, I | 1 |
| Páll, D | 1 |
| Paragh, G | 1 |
| Kempler, P | 1 |
| Harangi, M | 1 |
| Sztanek, F | 1 |
| Behl, T | 1 |
| Gupta, A | 1 |
| Sehgal, A | 1 |
| Sharma, S | 1 |
| Singh, S | 1 |
| Sharma, N | 1 |
| Diaconu, CC | 1 |
| Rahdar, A | 1 |
| Hafeez, A | 1 |
| Bhatia, S | 1 |
| Al-Harrasi, A | 1 |
| Bungau, S | 1 |
| Davidson, EP | 2 |
| Coppey, LJ | 2 |
| Shevalye, H | 1 |
| Obrosov, A | 1 |
| Kardon, RH | 1 |
| Yorek, MA | 2 |
| Baumgartner, S | 1 |
| Mensink, RP | 1 |
| Haenen, GR | 1 |
| Bast, A | 1 |
| Binder, CJ | 1 |
| Bekers, O | 1 |
| Husche, C | 1 |
| Lütjohann, D | 1 |
| Plat, J | 1 |
| Dworacka, M | 2 |
| Chukanova, G | 1 |
| Iskakova, S | 2 |
| Kurmambayev, Y | 2 |
| Wesołowska, A | 2 |
| Frycz, BA | 1 |
| Jagodziński, PP | 1 |
| Dworacki, G | 2 |
| Mrakic-Sposta, S | 1 |
| Vezzoli, A | 1 |
| Maderna, L | 1 |
| Gregorini, F | 1 |
| Montorsi, M | 1 |
| Moretti, S | 1 |
| Greco, F | 1 |
| Cova, E | 1 |
| Gussoni, M | 1 |
| Sena, CM | 3 |
| Cipriano, MA | 1 |
| Botelho, MF | 1 |
| Seiça, RM | 3 |
| Dolinar, K | 1 |
| Jan, V | 1 |
| Pavlin, M | 1 |
| Chibalin, AV | 1 |
| Pirkmajer, S | 1 |
| Karkabounas, S | 1 |
| Papadopoulos, N | 1 |
| Anastasiadou, C | 1 |
| Gubili, C | 1 |
| Peschos, D | 1 |
| Daskalou, T | 1 |
| Fikioris, N | 1 |
| Simos, YV | 1 |
| Kontargiris, E | 1 |
| Gianakopoulos, X | 1 |
| Ragos, V | 1 |
| Chatzidimitriou, M | 1 |
| Castro, MC | 2 |
| Villagarcía, HG | 1 |
| Massa, ML | 2 |
| Francini, F | 2 |
| Hassanien, M | 1 |
| Elawamy, A | 1 |
| Kamel, EZ | 1 |
| Khalifa, WA | 1 |
| Abolfadl, GM | 1 |
| Roushdy, ASI | 1 |
| El Zohne, RA | 1 |
| Makarem, YS | 1 |
| Feng, B | 1 |
| Yan, XF | 1 |
| Xue, JL | 1 |
| Xu, L | 2 |
| Wang, H | 1 |
| Ibrahimpasic, K | 1 |
| Strokov, IA | 2 |
| Fokina, AS | 1 |
| Golovacheva, VA | 1 |
| Kochetov, AG | 1 |
| Yang, L | 1 |
| Zang, SF | 1 |
| Song, MQ | 1 |
| Redmer, J | 1 |
| Longmier, E | 1 |
| Wedel, P | 1 |
| Huang, Z | 1 |
| Wan, X | 1 |
| Liu, J | 2 |
| Deng, W | 1 |
| Chen, A | 1 |
| Liu, L | 1 |
| Wei, G | 1 |
| Li, H | 1 |
| Fang, D | 1 |
| Sergienko, VA | 1 |
| Segin, VB | 1 |
| Samir, A | 1 |
| Sergienko, AA | 1 |
| Bao, XH | 1 |
| Xu, J | 1 |
| Chen, Y | 2 |
| Yang, CL | 1 |
| Ye, SD | 1 |
| Gębka, A | 1 |
| Serkies-Minuth, E | 1 |
| Raczyńska, D | 1 |
| Krzyżagórska, E | 1 |
| Zhao, L | 1 |
| Hu, FX | 1 |
| Kouzi, SA | 1 |
| Yang, S | 1 |
| Nuzum, DS | 1 |
| Dirks-Naylor, AJ | 1 |
| Yan, H | 1 |
| Zhang, G | 1 |
| Sun, Y | 1 |
| Yu, P | 1 |
| Wang, Y | 2 |
| Naito, Y | 1 |
| Ikuta, N | 1 |
| Okano, A | 1 |
| Okamoto, H | 1 |
| Nakata, D | 1 |
| Terao, K | 1 |
| Matsumoto, K | 1 |
| Kajiwara, N | 1 |
| Yasui, H | 1 |
| Yoshikawa, Y | 1 |
| Okanović, A | 1 |
| Prnjavorac, B | 1 |
| Jusufović, E | 1 |
| Sejdinović, R | 1 |
| Holmes, A | 1 |
| Garcia-Alcala, H | 1 |
| Santos Vichido, CI | 1 |
| Islas Macedo, S | 1 |
| Genestier-Tamborero, CN | 1 |
| Minutti-Palacios, M | 1 |
| Hirales Tamez, O | 1 |
| García, C | 1 |
| Ziegler, D | 6 |
| Low, PA | 1 |
| Freeman, R | 1 |
| Tritschler, H | 5 |
| Vinik, AI | 1 |
| Landgraf, BJ | 1 |
| McCarthy, EL | 1 |
| Booker, SJ | 1 |
| Zhang, HY | 1 |
| Huang, FC | 1 |
| Huang, Q | 1 |
| Liu, C | 1 |
| Li, JR | 1 |
| Romano, D | 1 |
| Han, Y | 1 |
| Wang, M | 1 |
| Shen, J | 1 |
| Zhao, M | 1 |
| Huang, J | 1 |
| Chen, Z | 1 |
| Hu, Y | 1 |
| Bureković, A | 1 |
| Terzić, M | 1 |
| Alajbegović, S | 1 |
| Vukojević, Z | 1 |
| Hadzić, N | 1 |
| Stirban, A | 1 |
| Poh, ZX | 1 |
| Goh, KP | 1 |
| Mittermayer, F | 2 |
| Pleiner, J | 2 |
| Francesconi, M | 2 |
| Wolzt, M | 2 |
| Heinisch, BB | 1 |
| Schaller, G | 1 |
| Gouya, G | 1 |
| Cummings, BP | 1 |
| Stanhope, KL | 1 |
| Graham, JL | 1 |
| Evans, JL | 2 |
| Baskin, DG | 1 |
| Griffen, SC | 1 |
| Havel, PJ | 1 |
| Bitar, MS | 2 |
| Ayed, AK | 1 |
| Abdel-Halim, SM | 1 |
| Isenovic, ER | 1 |
| Al-Mulla, F | 2 |
| Kanorskiĭ, SG | 1 |
| Kanorskaia, IuS | 1 |
| Golbidi, S | 1 |
| Ebadi, SA | 1 |
| Laher, I | 1 |
| de Oliveira, AM | 1 |
| Rondó, PH | 1 |
| Luzia, LA | 1 |
| D'Abronzo, FH | 1 |
| Illison, VK | 1 |
| Ansar, H | 1 |
| Mazloom, Z | 1 |
| Kazemi, F | 1 |
| Hejazi, N | 1 |
| Ridruejo, E | 1 |
| Castiglioni, T | 1 |
| Silva, MO | 1 |
| Rahman, ST | 1 |
| Merchant, N | 1 |
| Haque, T | 1 |
| Wahi, J | 1 |
| Bhaheetharan, S | 1 |
| Ferdinand, KC | 1 |
| Khan, BV | 1 |
| Haritoglou, C | 1 |
| Gerss, J | 1 |
| Hammes, HP | 1 |
| Kampik, A | 1 |
| Ulbig, MW | 1 |
| Nebbioso, M | 1 |
| Federici, M | 1 |
| Evangelista, M | 1 |
| Pescosolido, N | 1 |
| Porasuphatana, S | 1 |
| Suddee, S | 1 |
| Nartnampong, A | 1 |
| Konsil, J | 1 |
| Harnwong, B | 1 |
| Santaweesuk, A | 1 |
| Prieto-Hontoria, PL | 1 |
| Pérez-Matute, P | 1 |
| Fernández-Galilea, M | 1 |
| Alfredo Martínez, J | 1 |
| Moreno-Aliaga, MJ | 1 |
| Lee, JE | 1 |
| Yi, CO | 1 |
| Jeon, BT | 1 |
| Shin, HJ | 1 |
| Kim, SK | 1 |
| Jung, TS | 1 |
| Choi, JY | 1 |
| Roh, GS | 1 |
| Schinella, G | 1 |
| Gagliardino, JJ | 1 |
| Dicter, N | 1 |
| Madar, Z | 1 |
| Tirosh, O | 1 |
| Gruzman, A | 1 |
| Hidmi, A | 1 |
| Katzhendler, J | 1 |
| Haj-Yehie, A | 1 |
| Sasson, S | 1 |
| Wahid, S | 1 |
| Pilcher, CW | 1 |
| Al-Saleh, E | 1 |
| Lee, WJ | 1 |
| Song, KH | 1 |
| Koh, EH | 1 |
| Kim, HS | 1 |
| Park, HS | 1 |
| Kim, MS | 1 |
| Kim, SW | 1 |
| Lee, KU | 1 |
| Park, JY | 1 |
| Ross, CM | 1 |
| McCarty, MF | 1 |
| Henriksen, EJ | 4 |
| Jin, HY | 1 |
| Joung, SJ | 1 |
| Park, JH | 1 |
| Baek, HS | 1 |
| Vossler, S | 1 |
| Füllert, S | 1 |
| Schneider, F | 1 |
| Haak, E | 2 |
| Haak, T | 2 |
| Samigullin, R | 1 |
| Tooke, JE | 1 |
| Konrad, T | 2 |
| Nunes, E | 2 |
| Louro, T | 2 |
| Proença, T | 2 |
| Fernandes, R | 1 |
| Boarder, MR | 1 |
| Liu, F | 1 |
| Zhang, Y | 1 |
| Yang, M | 1 |
| Liu, B | 1 |
| Shen, YD | 1 |
| Jia, WP | 1 |
| Xiang, KS | 1 |
| Jacob, S | 4 |
| Schiemann, AL | 1 |
| Simon, I | 1 |
| Clancy, DE | 1 |
| Tritschler, HJ | 7 |
| Jung, WI | 1 |
| Augustin, HJ | 3 |
| Dietze, GJ | 3 |
| Kähler, W | 1 |
| Kuklinski, B | 1 |
| Rühlmann, C | 1 |
| Plötz, C | 1 |
| Hanefeld, M | 2 |
| Ruhnau, KJ | 3 |
| Meissner, HP | 2 |
| Lobisch, M | 4 |
| Schütte, K | 3 |
| Gries, FA | 2 |
| Schatz, H | 1 |
| Conrad, F | 1 |
| Ulrich, H | 1 |
| Reichel, G | 2 |
| Köbberling, J | 1 |
| Hompesch, M | 1 |
| Hofmann, MA | 1 |
| Schiekofer, S | 2 |
| Isermann, B | 2 |
| Kanitz, M | 1 |
| Henkels, M | 2 |
| Joswig, M | 1 |
| Treusch, A | 1 |
| Morcos, M | 2 |
| Weiss, T | 1 |
| Borcea, V | 3 |
| Abdel Khalek, AK | 1 |
| Amiral, J | 2 |
| Ritz, E | 1 |
| Wahl, P | 3 |
| Ziegler, R | 3 |
| Bierhaus, A | 1 |
| Nawroth, PP | 3 |
| Vicini, P | 1 |
| Kusterer, K | 2 |
| Höflich, A | 1 |
| Assadkhani, A | 1 |
| Böhles, HJ | 1 |
| Sewell, A | 1 |
| Cobelli, C | 1 |
| Usadel, KH | 2 |
| Nourooz-Zadeh, J | 1 |
| Wolff, SP | 1 |
| Klevesath, M | 1 |
| Hofmann, M | 2 |
| Urich, H | 1 |
| Halliwell, B | 1 |
| Kozlova, NA | 1 |
| Mozolevskiĭ, IuV | 1 |
| Miasoedov, SP | 1 |
| Iakhno, NN | 1 |
| Ruus, P | 1 |
| Hermann, R | 1 |
| Maerker, E | 1 |
| Renn, W | 1 |
| Rett, K | 3 |
| Hasche, H | 1 |
| Kerum, G | 1 |
| Malessa, R | 1 |
| Reljanovic, M | 2 |
| Schuette, K | 1 |
| Möller, W | 1 |
| Mehnert, H | 2 |
| Häring, HU | 1 |
| Finn, JR | 1 |
| Nehrdich, D | 1 |
| Amini, P | 1 |
| Frommeyer, R | 1 |
| Gehrke, S | 1 |
| Ehret, T | 1 |
| Heitzer, T | 1 |
| Finckh, B | 1 |
| Albers, S | 1 |
| Krohn, K | 1 |
| Kohlschütter, A | 1 |
| Meinertz, T | 1 |
| Goldfine, ID | 1 |
| Ruhe, RC | 1 |
| McDonald, RB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS) in Perioperative Stress Response[NCT05663164] | 30 participants (Actual) | Interventional | 2022-10-01 | Completed | |||
| Ozone Therapy in Clinical, Psychological and Neurophysiological Pain Alleviation in Patients With Diabetic Neuropathy[NCT05000463] | 60 participants (Anticipated) | Interventional | 2022-02-25 | Not yet recruiting | |||
| The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| Treatment With Alpha-lipoic Acid Over 16 Weeks in Type 2 Diabetic Patients With Symptomatic Polyneuropathy Who Responded to Initial 4-week High-dose Loading[NCT02439879] | Phase 4 | 45 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| Dose Finding and Tolerability Study of Alpha-lipoic Acid in Patients at Risk for Paclitaxel Induced Peripheral Neuropathy[NCT01313117] | Phase 1/Phase 2 | 9 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups[NCT00328601] | Phase 3 | 170 participants | Interventional | 2005-02-28 | Completed | ||
| Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment[NCT04881851] | 90 participants (Anticipated) | Interventional | 2015-05-07 | Recruiting | |||
| The Effect of Alpha Lipoic Acid on the Incidence and Severity of Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients[NCT05023863] | Phase 2/Phase 3 | 70 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total symptoms score is a summation of presence, severity, and duration of the four main positive neuropathic sensory symptoms: lancinating/stabbing pain, burning pain, paresthesia, and asleep numbness (NCT02439879)
Timeframe: 20 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Alpha Lipoic Acid Treatment | 2.5 |
| Alpha Lipoic Acid Withdrawal | 3.1 |
(NCT01313117)
Timeframe: 4 months
| Intervention | participants (Number) |
|---|---|
| Alpha Lipoic Acid | 9 |
Based on acceptable adverse event (AE) profile and continual reassessment method dose escalation. (NCT01313117)
Timeframe: 4 months
| Intervention | mg (Number) |
|---|---|
| Alpha Lipoic Acid | 500 |
(NCT01313117)
Timeframe: 4 months
| Intervention | participants (Number) |
|---|---|
| Alpha Lipoic Acid | 7 |
16 reviews available for thioctic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Therapeutic Benefits of Alpha-Lipoic Acid Supplementation in Diabetes Mellitus: A Narrative Review.
Topics: Antioxidants; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Oxidative Stress; Thioctic Aci | 2022 |
Alpha Lipoic Acid Efficacy in PCOS Treatment: What Is the Truth?
Topics: Antioxidants; Diabetes Mellitus, Type 2; Female; Humans; Inositol; Insulin; Insulin Resistance; Metf | 2023 |
Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis.
Topics: Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Neuralgia; Thioctic Acid | 2023 |
Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures.
Topics: Aging; Animals; Antioxidants; Cardiovascular Diseases; Carnitine; Cell Line; Diabetes Mellitus, Type | 2020 |
[Clinical Characteristics of Lipoic Acid-mediated Insulin Autoimmune Syndrome in Two Patients with Type 2 Diabetes Mellitus].
Topics: Autoimmune Diseases; Diabetes Mellitus, Type 2; Humans; Thioctic Acid | 2020 |
A spotlight on underlying the mechanism of AMPK in diabetes complications.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Diabetes Complications; Diabetes Mellitus, Type 2 | 2021 |
Alpha-lipoic acid and its protective role in fructose induced endocrine-metabolic disturbances.
Topics: Animals; Diabetes Mellitus, Type 2; Endocrine System; Fructose; Humans; Obesity; Oxidative Stress; T | 2019 |
Natural supplements for improving insulin sensitivity and glucose uptake in skeletal muscle.
Topics: Biotin; Cinnamomum zeylanicum; Diabetes Mellitus, Type 2; Dietary Supplements; Glucose; Humans; Insu | 2015 |
Radical S-Adenosylmethionine Enzymes in Human Health and Disease.
Topics: Carbon-Carbon Lyases; Diabetes Mellitus, Type 2; Gene Expression; Heart Defects, Congenital; Histone | 2016 |
Drugs for the treatment of diabetes complications. Zycose: a new player in the field?
Topics: 4-Aminobenzoic Acid; Animals; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus, T | 2008 |
A current update on the use of alpha lipoic acid in the management of type 2 diabetes mellitus.
Topics: Antioxidants; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Neuropath | 2009 |
Antioxidants in the treatment of diabetes.
Topics: Antioxidants; Ascorbic Acid; Carnitine; Clinical Trials as Topic; Diabetes Complications; Diabetes M | 2011 |
Exercise training and the antioxidant alpha-lipoic acid in the treatment of insulin resistance and type 2 diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Exercise Therapy; Humans; Insulin Resistance; Musc | 2006 |
Thioctic acid--effects on insulin sensitivity and glucose-metabolism.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Glucose; Humans; Hypoglycemic Agents; Insulin; Th | 1999 |
Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes.
Topics: Administration, Oral; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; | 2000 |
Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes.
Topics: Antioxidants; Blood Glucose; Cardiovascular Diseases; Developed Countries; Diabetes Complications; D | 2001 |
39 trials available for thioctic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Evaluation of the Effect on Sexual Performance of a Nutraceutical Combination Containing Alpha Lipoic Acid,
Topics: Adolescent; Adult; Diabetes Mellitus, Type 2; Dietary Supplements; Erectile Dysfunction; Female; Gin | 2022 |
γ-Linolenic Acid versus α-Lipoic Acid for Treating Painful Diabetic Neuropathy in Adults: A 12-Week, Double-Placebo, Randomized, Noninferiority Trial.
Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; gamma-Linolenic Acid; Humans; Male; | 2020 |
Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study.
Topics: Administration, Oral; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Female; | 2020 |
Efficacy and Safety of the Combination of Superoxide Dismutase, Alpha Lipoic Acid, Vitamin B12, and Carnitine for 12 Months in Patients with Diabetic Neuropathy.
Topics: Aged; Carnitine; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Drug Combina | 2020 |
The effects of vitamin E or lipoic acid supplementation on oxyphytosterols in subjects with elevated oxidative stress: a randomized trial.
Topics: Adolescent; Adult; Aged; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Humans; Male; Middl | 2017 |
Effects of α-Lipoic Acid, Carnosine, and Thiamine Supplementation in Obese Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study.
Topics: Administration, Oral; Blood Glucose; Carnosine; Diabetes Mellitus, Type 2; Dietary Supplements; Doub | 2018 |
Perineural Platelet-Rich Plasma for Diabetic Neuropathic Pain, Could It Make a Difference?
Topics: Adult; Analgesics; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Glycemic Control; Human | 2020 |
Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment.
Topics: Antioxidants; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Glycated Hemo | 2013 |
[Effect of alpha-lipoic acid combined with transient intensive insulin therapy on adipokine level in patients with type 2 diabetic perineuropathy].
Topics: Adiponectin; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; H | 2013 |
Short-term continuous subcutaneous insulin infusion combined with insulin sensitizers rosiglitazone, metformin, or antioxidant α-lipoic acid in patients with newly diagnosed type 2 diabetes mellitus.
Topics: Adult; Aged; Antioxidants; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Drug Therapy, | 2013 |
Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes.
Topics: Adult; Aged; Antioxidants; Case-Control Studies; Contrast Sensitivity; Diabetes Mellitus, Type 1; Di | 2014 |
[Correction of endothelial dysfunction in patients with essential hypertension and type 2 diabetes].
Topics: Adult; Blood Glucose; Carotid Arteries; Carotid Intima-Media Thickness; Diabetes Complications; Diab | 2014 |
α-Lipoic acid treatment of aged type 2 diabetes mellitus complicated with acute cerebral infarction.
Topics: Acute Disease; Aged; Aging; Antioxidants; Ascorbic Acid; Blood Glucose; Cerebral Infarction; Diabete | 2014 |
Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading.
Topics: Administration, Oral; Adolescent; Adult; Analgesics; Antioxidants; Diabetes Mellitus, Type 2; Diabet | 2015 |
Predictors of improvement and progression of diabetic polyneuropathy following treatment with α-lipoic acid for 4 years in the NATHAN 1 trial.
Topics: Antioxidants; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Progression; Female; Follow- | 2016 |
Study on the clinical value of alprostadil combined with α-lipoic acid in treatment of type 2 diabetes mellitus patients with erectile dysfunction.
Topics: Adult; Alprostadil; Diabetes Mellitus, Type 2; Erectile Dysfunction; Humans; Male; Middle Aged; Peni | 2016 |
A Clinical Trial about a Food Supplement Containing α-Lipoic Acid on Oxidative Stress Markers in Type 2 Diabetic Patients.
Topics: Adult; Biomarkers; Blood Glucose; Body Mass Index; Body Weight; C-Reactive Protein; Carnosine; Diabe | 2016 |
Differential efficacy of methylcobalamin and alpha-lipoic acid treatment on symptoms of diabetic peripheral neuropathy.
Topics: Aged; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Humans; Male; Middle A | 2018 |
Treatment with alpha-lipoic acid reduces asymmetric dimethylarginine in patients with type 2 diabetes mellitus.
Topics: Arginine; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Male; Middle Aged; Thiocti | 2010 |
Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial.
Topics: Acetylcholine; Antioxidants; Diabetes Mellitus, Type 2; Double-Blind Method; Endothelium, Vascular; | 2010 |
The effects of lipoic acid and α-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aged; alpha-Tocopherol; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blind Method; | 2011 |
Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients.
Topics: Adult; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glutathione Peroxidase; Human | 2011 |
The impact of lipoic acid on endothelial function and proteinuria in quinapril-treated diabetic patients with stage I hypertension: results from the QUALITY study.
Topics: Adult; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cross-Over Studies; Di | 2012 |
Alpha-lipoic acid for the prevention of diabetic macular edema.
Topics: Administration, Oral; Adult; Aged; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes | 2011 |
Oxidative stress in preretinopathic diabetes subjects and antioxidants.
Topics: Adult; Aged; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Electroretinography; Fem | 2012 |
Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled study.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Adult; Antioxidants; Biomarkers; Blood Glucose; C | 2012 |
Pharmacodynamic effects of orally administered dexlipotam on endothelial function in type 2-diabetic patients.
Topics: Adult; Aged; Antioxidants; Blood Flow Velocity; Brachial Artery; Diabetes Mellitus, Type 2; Double-B | 2007 |
[Curative effect of alpha-lipoic acid on peripheral neuropathy in type 2 diabetes: a clinical study].
Topics: Aged; Antioxidants; Blood Glucose; C-Reactive Protein; Diabetes Mellitus, Type 2; Diabetic Nephropat | 2007 |
Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid.
Topics: Aged; Aging; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; | 1995 |
[Diabetes mellitus--a free radical-associated disease. Results of adjuvant antioxidant supplementation].
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropat | 1993 |
Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study).
Topics: Adolescent; Adult; Aged; Antioxidants; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Neuropath | 1995 |
Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study).
Topics: Adolescent; Adult; Aged; Antioxidants; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Neuropath | 1995 |
Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study).
Topics: Adolescent; Adult; Aged; Antioxidants; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Neuropath | 1995 |
Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study).
Topics: Adolescent; Adult; Aged; Antioxidants; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Neuropath | 1995 |
Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN Study). Deutsche Kardiale Autonome Neuropathie.
Topics: Autonomic Nervous System Diseases; Blood Pressure; Body Weight; Confounding Factors, Epidemiologic; | 1997 |
[The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy].
Topics: Analysis of Variance; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Human | 1999 |
Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial.
Topics: Administration, Oral; Anthropometry; Diabetes Mellitus, Type 2; Female; Free Radical Scavengers; Glu | 1999 |
Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy.
Topics: Administration, Oral; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind M | 1999 |
Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy.
Topics: Administration, Oral; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind M | 1999 |
Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy.
Topics: Administration, Oral; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind M | 1999 |
Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy.
Topics: Administration, Oral; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind M | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy.
Topics: Aged; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female; | 1999 |
Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy.
Topics: Aged; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female; | 1999 |
Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy.
Topics: Aged; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female; | 1999 |
Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy.
Topics: Aged; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female; | 1999 |
Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy.
Topics: Antioxidants; Blood Flow Velocity; Capillaries; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2000 |
Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study.
Topics: Albuminuria; Antioxidants; Biomarkers; Blood Pressure; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 2001 |
49 other studies available for thioctic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Supplementation of conventional anti-diabetic therapy with alpha-lipoic acid prevents early development and progression of diabetic nephropathy.
Topics: Animals; Antioxidants; Creatinine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabe | 2022 |
POSSIBILITIES OF METABOLIC AND FUNCTIONAL DISORDERS CORRECTION IN OSTEOARTHRITIS WITH COMPLEX COMORBIDITY.
Topics: Comorbidity; Diabetes Mellitus, Type 2; Humans; Osteoarthritis; Quality of Life; Thioctic Acid; Trea | 2022 |
The Effect of α-Lipoic Acid on Oxidative Stress in Adipose Tissue of Rats with Obesity-Induced Insulin Resistance.
Topics: Adipose Tissue; Animals; Antioxidants; Body Weight; Diabetes Mellitus, Type 2; Diet, High-Fat; Insul | 2022 |
Alpha-lipoic acid treatment improves adverse cardiac remodelling in the diabetic heart - The role of cardiac hydrogen sulfide-synthesizing enzymes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Hydr | 2022 |
Effects of the Topical Use of the Natural Antioxidant Alpha-Lipoic Acid on the Ocular Surface of Diabetic Patients with Dry Eye Symptoms.
Topics: Antioxidants; Diabetes Mellitus, Type 2; Dry Eye Syndromes; Humans; Tears; Thioctic Acid | 2022 |
Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation.
Topics: Animals; beta Catenin; Cystic Fibrosis Transmembrane Conductance Regulator; Diabetes Mellitus, Type | 2023 |
EFFECTS OF ALPHA-LIPOIC ACID ON GLYCEMIC STATUS IN 2 TYPE DIABETES PATIENTS WITH СHRONIC CORONARY SYNDROME.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; | 2022 |
Effects of Valsartan and Amlodipine Tablets Combined with α-Lipoic Acid on T-AOC, IL-6 and β2-MG Levels in Patients with Diabetic Nephropathy.
Topics: Amlodipine; Antihypertensive Agents; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Nephropathies | 2023 |
NGF receptors and PI3K/AKT pathway involved in glucose fluctuation-induced damage to neurons and α-lipoic acid treatment.
Topics: Animals; Apoptosis; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Nerve Tissue Pr | 2020 |
The clinical effectiveness and safety of alprostadil combined with alpha lipoic acid in the treatment of diabetic peripheral neuropathy: A protocol for systematic review and meta-analysis.
Topics: Alprostadil; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Drug Therapy, Combinati | 2020 |
Effects of alpha-lipoic acid treatment on serum progranulin levels and inflammatory markers in diabetic neuropathy.
Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Progranulins; Prospective Studies; Thiocti | 2021 |
Impaired Corneal Sensation and Nerve Loss in a Type 2 Rat Model of Chronic Diabetes Is Reversible With Combination Therapy of Menhaden Oil, α-Lipoic Acid, and Enalapril.
Topics: Adiponectin; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Cornea; Diabetes Mell | 2017 |
New arguments for beneficial effects of alpha-lipoic acid on the cardiovascular system in the course of type 2 diabetes.
Topics: Animals; Antioxidants; Aorta; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2018 |
R(+)-Thioctic Acid Effects on Oxidative Stress and Peripheral Neuropathy in Type II Diabetic Patients: Preliminary Results by Electron Paramagnetic Resonance and Electroneurography.
Topics: Aged; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Electric Stimulation; Electron | 2018 |
Lipoic Acid Prevents High-Fat Diet-Induced Hepatic Steatosis in Goto Kakizaki Rats by Reducing Oxidative Stress Through Nrf2 Activation.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Diet, High-Fat; Fatty Liver; Lipid Peroxidation; M | 2018 |
Nucleosides block AICAR-stimulated activation of AMPK in skeletal muscle and cancer cells.
Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Ascorbic Acid; Cell Lin | 2018 |
The protective effects of α-lipoic acid on kidneys in type 2 diabetic Goto-Kakisaki rats via reducing oxidative stress.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glu | 2013 |
[Efficacy of thiolepta in diabetic polyneuropathy: results of the study ETIKA].
Topics: Antioxidants; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropat | 2013 |
Targeting diabetes: the benefits of an integrative approach.
Topics: Acupuncture Therapy; Antioxidants; Cinnamomum zeylanicum; Complementary Therapies; Diabetes Mellitus | 2013 |
[The effect of long-chain polyunsaturated higher ω-3 fatty acids, benfotiamine and α-lipoic acid on the lipid metabolism in patients with diabetes mellitus type 2 and cardiovascular autonomic neuropathy].
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; D | 2013 |
Alleviation of podocyte injury: the possible pathway implicated in anti-inflammation of alpha-lipoic acid in type 2 diabetics.
Topics: Adult; Albumins; Anti-Inflammatory Agents; Blood Glucose; Blood Pressure; Case-Control Studies; Chem | 2014 |
Alpha-lipoic acid modifies circulating angiogenic factors in patients with type 2 diabetes mellitus.
Topics: Aged; Angiogenesis Inducing Agents; Case-Control Studies; Chemokine CCL2; Comorbidity; Coronary Arte | 2015 |
Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signalling pathway.
Topics: Andrographis; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diterpenes; Dose- | 2015 |
Isomeric effects of anti-diabetic α-lipoic acid with γ-cyclodextrin.
Topics: Adiponectin; Adipose Tissue, White; Animals; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical | 2015 |
Alpha-lipoic acid reduces body weight and regulates triglycerides in obese patients with diabetes mellitus.
Topics: Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Female; Humans; Male; Metformin; Middle Aged; O | 2015 |
Effect of combination therapy consisting of enalapril, α-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat.
Topics: Animals; Cornea; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Neuropathies; | 2015 |
The role of alpha-lipoic acid in diabetic polyneuropathy treatment.
Topics: Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Hu | 2008 |
Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: amelioration by the antioxidant, alpha-lipoic acid.
Topics: Adiponectin; Animal Feed; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Fats; Dyslipide | 2010 |
Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism.
Topics: Acetophenones; Aging; Androstadienes; Animals; Antioxidants; Aorta; Apoptosis; Diabetes Mellitus, Ty | 2010 |
[Atrial fibrillation in patients with type 2 diabetes mellitus: specific features of development and antirecurrence therapy].
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antioxidants; Atrial Fi | 2010 |
Thioctic acid-induced acute cholestatic hepatitis.
Topics: Antioxidants; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Diabetes Mellitus, | 2011 |
Effects of lipoic acid on AMPK and adiponectin in adipose tissue of low- and high-fat-fed rats.
Topics: Adiponectin; Adipose Tissue, Brown; Adipose Tissue, White; Adiposity; AMP-Activated Protein Kinases; | 2013 |
α-Lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima Fatty rats.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Cardiomyop | 2012 |
Lipoic acid prevents liver metabolic changes induced by administration of a fructose-rich diet.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Diet; Fructose; Gene Expression Regulation; Insuli | 2013 |
Alpha-lipoic acid inhibits glycogen synthesis in rat soleus muscle via its oxidative activity and the uncoupling of mitochondria.
Topics: Animals; Antioxidants; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Culture Techniques; Diabe | 2002 |
Synthesis and characterization of new and potent alpha-lipoic acid derivatives.
Topics: Animals; Biological Transport; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Esters; Glucose; | 2004 |
Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats.
Topics: Animals; Antioxidants; Biological Transport; Diabetes Mellitus, Type 2; Glucose; Insulin; Insulin Re | 2004 |
Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Enzyme Activation; Fatty Acids; G | 2005 |
Insulin, AGE and hypertension.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; H | 2005 |
Induction of heat shock proteins may combat insulin resistance.
Topics: Diabetes Mellitus, Type 2; Enzyme Activation; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP72 | 2006 |
The effect of alpha-lipoic acid on symptoms and skin blood flow in diabetic neuropathy.
Topics: Antioxidants; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Humans; Injections, Intraven | 2007 |
Endothelial dysfunction in type 2 diabetes: effect of antioxidants.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Endothelium, Vascular; Rats; Thioctic Acid | 2007 |
Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats.
Topics: Aging; Animals; Antioxidants; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2008 |
Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid.
Topics: Aged; Blood Glucose; Blood Pressure; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Type 2; Fasti | 1996 |
alpha-Lipoic acid in NIDDM patients with cardiac autonomic neuropathy.
Topics: Autonomic Nervous System Diseases; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Researc | 1997 |
Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB.
Topics: Adult; Albuminuria; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nep | 1999 |
alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes.
Topics: Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fasting; Glucose Tolerance Test; Glycat | 1999 |
alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria.
Topics: Albuminuria; Antioxidants; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female | 1999 |
Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress.
Topics: Acetylcholine; Antioxidants; Ascorbic Acid; Blood Flow Velocity; Diabetes Mellitus, Type 2; Endothel | 2001 |