thioctic acid has been researched along with Diabetes Mellitus, Type 1 in 33 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Type 1 diabetes is associated with increased platelet reactivity." | 2.77 | Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients. ( Crea, F; Ghirlanda, G; Lanza, GA; Manto, A; Mollo, R; Navarese, EP; Pitocco, D; Rizzo, P; Scalone, G; Scavone, G; Zaccardi, F, 2012) |
| "A daily dosage of 600 mg ALA does not prevent the occurrence of CSME in IDDM patients." | 2.76 | Alpha-lipoic acid for the prevention of diabetic macular edema. ( Gerss, J; Hammes, HP; Haritoglou, C; Kampik, A; Ulbig, MW, 2011) |
| "Male participants with and without type 1 diabetes were studied in the General Clinical Research Centre of the Albert Einstein College of Medicine." | 2.73 | Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes. ( Brownlee, M; Du, X; Edelstein, D, 2008) |
| "46 patients with type 1 diabetes and different forms of autonomic neuropathy, of mean age 38." | 2.71 | Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study). ( Dakovska, L; Koev, D; Tankova, T, 2004) |
| "Forty-nine patients (34 with Type 1 diabetes, 15 with Type 2 diabetes) had no antioxidant treatment and served as a control group." | 2.70 | Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study. ( Amiral, J; Borcea, V; Ehret, T; Gehrke, S; Henkels, M; Hofmann, M; Isermann, B; Morcos, M; Nawroth, PP; Schiekofer, S; Tritschler, H; Wahl, P; Ziegler, R, 2001) |
| "The objective of this study was to determine the impact of prolonged gastric emptying in patients with insulin dependent diabetes mellitus (IDDM) on the bioavailability of the R(+)- and S(-)-thioctic acid (TA) enantiomers." | 2.69 | Gastric emptying in patients with insulin dependent diabetes mellitus and bioavailability of thioctic acid-enantiomers. ( Gleiter, CH; Hermann, R; Niebch, G; Nowak, H; Ruus, P; Wildgrube, HJ, 1998) |
| "Diabetic polyneuropathy is a serious complication in patients with diabetes mellitus." | 2.69 | Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy. ( Amini, P; Frommeyer, R; Haak, E; Haak, T; Kusterer, K; Tritschler, HJ; Usadel, KH, 2000) |
| "Fulminant type 1 diabetes mellitus (FT1DM) has received clinical attention for its low incidence and poor prognosis." | 1.56 | Fulminant type 1 diabetes mellitus in pregnancy. ( Li, CY; Li, Y; Liu, YR; Mu, T; Wang, YJ; Yi, ZM; You, ZY; Zhang, YW; Zhao, CZ, 2020) |
| "Mitochondria play a role in type 1 diabetes (T1D) particularly in the treatment and prevention of disorder consequences." | 1.48 | Antibodies to post-translationally modified mitochondrial peptide PDC-E2(167-184) in type 1 diabetes. ( Crulli, M; Gallo, A; Lapolla, A; Nuti, F; Papini, AM; Peroni, E; Piarulli, F; Real-Fernandez, F; Rentier, C; Rossi, G; Rovero, P; Traldi, P, 2018) |
| " Dosage of the drug was 600 mg daily." | 1.39 | [Efficacy of thiolepta in diabetic polyneuropathy: results of the study ETIKA]. ( Fokina, AS; Golovacheva, VA; Kochetov, AG; Strokov, IA, 2013) |
| "In alloxan-treated mice (a model of type 1 diabetes), drugs were administered orally once daily for 6 days post-alloxan treatment." | 1.35 | Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment. ( Jiang, J; Larrick, JW; Wang, Y; Yu, P; Zeng, X; Zhang, Z, 2009) |
| "We included 43 patients with type 1 diabetes in this cross-sectional study." | 1.30 | Insufficient glycemic control increases nuclear factor-kappa B binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes. ( Bierhaus, A; Hofmann, MA; Joswig, M; Kanitz, M; Klevesath, MS; Lee, V; Morcos, M; Nawroth, PP; Schiekofer, S; Tritschler, H; Wahl, P; Ziegler, R, 1998) |
| "Patients with diabetic nephropathy showed higher NF-kappaB binding activity in Electrophoretic Mobility Shift Assays and stronger immunohistological staining for activated NF-kappaBp65 than patients without renal complications." | 1.30 | Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB. ( Abdel Khalek, AK; Amiral, J; Bierhaus, A; Borcea, V; Henkels, M; Hofmann, MA; Isermann, B; Joswig, M; Kanitz, M; Morcos, M; Nawroth, PP; Ritz, E; Schiekofer, S; Treusch, A; Tritschler, H; Wahl, P; Weiss, T; Ziegler, R, 1999) |
| "As thioctic acid (TA) has favourable effects on glucose metabolism, the influence of this drug at two different doses (0." | 1.29 | The influence of thioctic acid on metabolism and function of the diabetic heart. ( Bretzel, RG; Federlin, K; Lehmann, E; Lehmann, U; Strödter, D; Tritschler, HJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (21.21) | 18.2507 |
| 2000's | 12 (36.36) | 29.6817 |
| 2010's | 11 (33.33) | 24.3611 |
| 2020's | 3 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, SH | 1 |
| Kuo, SL | 1 |
| Chen, SJ | 1 |
| Lin, JR | 1 |
| Chen, YW | 1 |
| Hong, ZJ | 1 |
| Sytwu, HK | 1 |
| Lin, GJ | 1 |
| Orellana-Donoso, M | 1 |
| López-Chaparro, M | 1 |
| Barahona-Vásquez, M | 1 |
| Santana-Machuca, A | 1 |
| Bruna-Mejias, A | 1 |
| Nova-Baeza, P | 1 |
| Valenzuela-Fuenzalida, JJ | 1 |
| Li, CY | 1 |
| Li, Y | 1 |
| You, ZY | 1 |
| Liu, YR | 1 |
| Wang, YJ | 1 |
| Mu, T | 1 |
| Zhao, CZ | 1 |
| Yi, ZM | 1 |
| Zhang, YW | 1 |
| Jurisic-Erzen, D | 1 |
| Starcevic-Klasan, G | 1 |
| Ivanac, D | 1 |
| Peharec, S | 1 |
| Girotto, D | 1 |
| Jerkovic, R | 1 |
| Nuti, F | 1 |
| Gallo, A | 1 |
| Real-Fernandez, F | 1 |
| Crulli, M | 1 |
| Rentier, C | 1 |
| Piarulli, F | 1 |
| Peroni, E | 1 |
| Rossi, G | 1 |
| Traldi, P | 1 |
| Rovero, P | 1 |
| Lapolla, A | 1 |
| Papini, AM | 1 |
| Strokov, IA | 2 |
| Fokina, AS | 1 |
| Golovacheva, VA | 1 |
| Kochetov, AG | 1 |
| Hegazy, SK | 1 |
| Tolba, OA | 1 |
| Mostafa, TM | 1 |
| Eid, MA | 1 |
| El-Afify, DR | 1 |
| Gębka, A | 1 |
| Serkies-Minuth, E | 1 |
| Raczyńska, D | 1 |
| Scaramuzza, A | 1 |
| Giani, E | 1 |
| Redaelli, F | 1 |
| Ungheri, S | 1 |
| Macedoni, M | 1 |
| Giudici, V | 1 |
| Bosetti, A | 1 |
| Ferrari, M | 1 |
| Zuccotti, GV | 1 |
| Verma, H | 1 |
| Garg, R | 1 |
| Zhang, S | 1 |
| Li, H | 1 |
| Zhang, L | 1 |
| Li, J | 1 |
| Wang, R | 1 |
| Wang, M | 1 |
| Du, X | 1 |
| Edelstein, D | 1 |
| Brownlee, M | 1 |
| Bureković, A | 1 |
| Terzić, M | 1 |
| Alajbegović, S | 1 |
| Vukojević, Z | 1 |
| Hadzić, N | 1 |
| Zhang, Z | 1 |
| Jiang, J | 1 |
| Yu, P | 1 |
| Zeng, X | 1 |
| Larrick, JW | 1 |
| Wang, Y | 1 |
| Navarese, EP | 2 |
| Mollo, R | 2 |
| Buffon, A | 1 |
| Haritoglou, C | 1 |
| Gerss, J | 1 |
| Hammes, HP | 1 |
| Kampik, A | 1 |
| Ulbig, MW | 1 |
| Zaccardi, F | 1 |
| Scalone, G | 1 |
| Scavone, G | 1 |
| Rizzo, P | 1 |
| Manto, A | 1 |
| Pitocco, D | 1 |
| Lanza, GA | 1 |
| Ghirlanda, G | 1 |
| Crea, F | 1 |
| Maritim, AC | 1 |
| Sanders, RA | 1 |
| Watkins, JB | 1 |
| Tankova, T | 1 |
| Koev, D | 1 |
| Dakovska, L | 1 |
| Song, KH | 1 |
| Lee, WJ | 1 |
| Koh, JM | 1 |
| Kim, HS | 1 |
| Youn, JY | 1 |
| Park, HS | 1 |
| Koh, EH | 1 |
| Kim, MS | 1 |
| Youn, JH | 1 |
| Lee, KU | 1 |
| Park, JY | 1 |
| Hermann, R | 1 |
| Wildgrube, HJ | 1 |
| Ruus, P | 1 |
| Niebch, G | 1 |
| Nowak, H | 1 |
| Gleiter, CH | 1 |
| Bregovskiĭ, VB | 1 |
| Posokhina, OV | 1 |
| Karpova, IA | 1 |
| Huang, EA | 1 |
| Gitelman, SE | 1 |
| Faust, A | 1 |
| Burkart, V | 1 |
| Ulrich, H | 1 |
| Weischer, CH | 1 |
| Kolb, H | 1 |
| Kähler, W | 1 |
| Kuklinski, B | 1 |
| Rühlmann, C | 1 |
| Plötz, C | 1 |
| Strödter, D | 1 |
| Lehmann, E | 1 |
| Lehmann, U | 1 |
| Tritschler, HJ | 3 |
| Bretzel, RG | 1 |
| Federlin, K | 1 |
| Hofmann, MA | 2 |
| Schiekofer, S | 3 |
| Kanitz, M | 2 |
| Klevesath, MS | 1 |
| Joswig, M | 2 |
| Lee, V | 1 |
| Morcos, M | 3 |
| Tritschler, H | 3 |
| Ziegler, R | 3 |
| Wahl, P | 3 |
| Bierhaus, A | 2 |
| Nawroth, PP | 3 |
| Isermann, B | 2 |
| Henkels, M | 2 |
| Treusch, A | 1 |
| Weiss, T | 1 |
| Borcea, V | 2 |
| Abdel Khalek, AK | 1 |
| Amiral, J | 2 |
| Ritz, E | 1 |
| Reljanovic, M | 1 |
| Reichel, G | 1 |
| Rett, K | 1 |
| Lobisch, M | 1 |
| Schuette, K | 1 |
| Möller, W | 1 |
| Mehnert, H | 1 |
| Tabatabaie, T | 1 |
| Graham, KL | 1 |
| Vasquez, AM | 1 |
| Floyd, RA | 1 |
| Kotake, Y | 1 |
| Haak, E | 1 |
| Usadel, KH | 1 |
| Kusterer, K | 1 |
| Amini, P | 1 |
| Frommeyer, R | 1 |
| Haak, T | 1 |
| Manukhina, EB | 1 |
| Bakhtina, LY | 1 |
| Malyshev, IY | 1 |
| Zoloev, GK | 1 |
| Kazikhanova, SI | 1 |
| Ametov, AS | 1 |
| Gehrke, S | 1 |
| Ehret, T | 1 |
| Hofmann, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of the Glucosamine Pathway and Reactive Oxygen Species in the Pathogenesis of Diabetic Complications[NCT00703989] | 21 participants (Actual) | Interventional | 2005-02-28 | Completed | |||
| Dose Finding and Tolerability Study of Alpha-lipoic Acid in Patients at Risk for Paclitaxel Induced Peripheral Neuropathy[NCT01313117] | Phase 1/Phase 2 | 9 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| The Effect of Alpha Lipoic Acid on the Incidence and Severity of Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients[NCT05023863] | Phase 2/Phase 3 | 70 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups[NCT00328601] | Phase 3 | 170 participants | Interventional | 2005-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01313117)
Timeframe: 4 months
| Intervention | participants (Number) |
|---|---|
| Alpha Lipoic Acid | 9 |
Based on acceptable adverse event (AE) profile and continual reassessment method dose escalation. (NCT01313117)
Timeframe: 4 months
| Intervention | mg (Number) |
|---|---|
| Alpha Lipoic Acid | 500 |
(NCT01313117)
Timeframe: 4 months
| Intervention | participants (Number) |
|---|---|
| Alpha Lipoic Acid | 7 |
1 review available for thioctic acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis.
Topics: Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Neuralgia; Thioctic Acid | 2023 |
15 trials available for thioctic acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Alpha-lipoic acid improves subclinical left ventricular dysfunction in asymptomatic patients with type 1 diabetes.
Topics: Adolescent; Antioxidants; Child; Diabetes Mellitus, Type 1; Diabetic Cardiomyopathies; Female; Human | 2013 |
Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes.
Topics: Adult; Aged; Antioxidants; Case-Control Studies; Contrast Sensitivity; Diabetes Mellitus, Type 1; Di | 2014 |
Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial.
Topics: Adolescent; Adolescent Nutritional Physiological Phenomena; Antioxidants; Cohort Studies; Combined M | 2015 |
Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Cytochrome P-450 Enzyme System; Diabe | 2008 |
Effect of alpha lipoic acid on cardiac autonomic dysfunction and platelet reactivity in type 1 diabetes: rationale and design of the AUTOnomic function and platelet REACTivity trial (AUTO-REACT protocol).
Topics: Antioxidants; Autonomic Nervous System; Blood Platelets; Diabetes Mellitus, Type 1; Humans; Thioctic | 2011 |
Alpha-lipoic acid for the prevention of diabetic macular edema.
Topics: Administration, Oral; Adult; Aged; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes | 2011 |
Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients.
Topics: Adult; Antioxidants; Blood Platelets; C-Reactive Protein; Diabetes Mellitus, Type 1; Dinoprost; Fema | 2012 |
Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study).
Topics: Adult; Antioxidants; Autonomic Nervous System Diseases; Blood Pressure; Diabetes Mellitus, Type 1; D | 2004 |
Gastric emptying in patients with insulin dependent diabetes mellitus and bioavailability of thioctic acid-enantiomers.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Diabetes | 1998 |
The effect of oral alpha-lipoic acid on oxidative stress in adolescents with type 1 diabetes mellitus.
Topics: Administration, Oral; Adolescent; Age of Onset; Body Mass Index; Body Weight; Child; Delayed-Action | 2008 |
[Diabetes mellitus--a free radical-associated disease. Results of adjuvant antioxidant supplementation].
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropat | 1993 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy.
Topics: Antioxidants; Blood Flow Velocity; Capillaries; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2000 |
The function of endogenous protective systems in patients with insulin-dependent diabetes mellitus and polyneuropathy: effect of antioxidant therapy.
Topics: Adolescent; Adult; Antioxidants; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Female; Heat-Shoc | 2000 |
Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study.
Topics: Albuminuria; Antioxidants; Biomarkers; Blood Pressure; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 2001 |
17 other studies available for thioctic acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Alpha-Lipoic Acid Inhibits Spontaneous Diabetes and Autoimmune Recurrence in Non-Obese Diabetic Mice by Enhancing Differentiation of Regulatory T Cells and Showed Potential for Use in Cell Therapies for the Treatment of Type 1 Diabetes.
Topics: Animals; Antioxidants; Autoimmunity; Cell Differentiation; Diabetes Mellitus, Experimental; Diabetes | 2022 |
Fulminant type 1 diabetes mellitus in pregnancy.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glycated Hemoglobin; Humans; Incidence; Inf | 2020 |
The effects of alpha-lipoic acid on diabetic myopathy.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Male; Muscle Fibe | 2018 |
Antibodies to post-translationally modified mitochondrial peptide PDC-E2(167-184) in type 1 diabetes.
Topics: Adult; Antibodies; Diabetes Mellitus, Type 1; Female; Glycosylation; Humans; Male; Mitochondrial Pro | 2018 |
[Efficacy of thiolepta in diabetic polyneuropathy: results of the study ETIKA].
Topics: Antioxidants; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropat | 2013 |
Comment on "Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial".
Topics: Adolescent Nutritional Physiological Phenomena; Antioxidants; Diabetes Mellitus, Type 1; Diabetic An | 2015 |
Effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits in the hippocampus of streptozotocin-induced type 1 diabetes mellitus rats.
Topics: Animals; Cognition Disorders; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Evalu | 2017 |
The role of alpha-lipoic acid in diabetic polyneuropathy treatment.
Topics: Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Hu | 2008 |
Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment.
Topics: Alloxan; Animals; Blood Glucose; Cytoprotection; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2009 |
Effects of alpha-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Diabete | 2003 |
alpha-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats.
Topics: Animals; Antioxidants; Body Weight; Diabetes Mellitus, Type 1; Disease Susceptibility; Male; Obesity | 2005 |
[Predictors of alpha-lipoic acid treatment efficacy in diabetic polyneuropathy of the lower limbs].
Topics: Adult; Antioxidants; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Electrophysiology; Female; Hu | 2005 |
Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice.
Topics: Animals; Antioxidants; Cyclophosphamide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; | 1994 |
The influence of thioctic acid on metabolism and function of the diabetic heart.
Topics: Adenosine Triphosphate; Animals; Cardiac Output; Cardiomyopathies; Diabetes Mellitus, Experimental; | 1995 |
Insufficient glycemic control increases nuclear factor-kappa B binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes.
Topics: Adult; Antioxidants; Biomarkers; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 1; | 1998 |
Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB.
Topics: Adult; Albuminuria; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nep | 1999 |
Inhibition of the cytokine-mediated inducible nitric oxide synthase expression in rat insulinoma cells by phenyl N-tert-butylnitrone.
Topics: Acetylcysteine; Animals; Blotting, Northern; Cell Survival; Cyclic N-Oxides; Cytokines; Diabetes Mel | 2000 |