thioctic acid has been researched along with Depression in 8 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mirtazapine (MIRT) is a multi-target antidepressant used in treatment of severe depression with promising efficacy, but also with important side effects, mainly sedation and weight gain." | 8.12 | Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. ( Chaves Filho, AJM; Cunha, NL; De Oliveira, GMF; Gadelha Filho, CVJ; Jucá, PM; Macedo, DS; Oliveira, TQ; Soares, MVR; Vasconcelos, SMM; Viana, GA; Vieira, CFX, 2022) |
| "The effects of 3-oxypyridine and succinic acid derivatives (emoxipine, reamberin and mexidol) on affective disorders in rats with alloxan diabetes were studied." | 7.81 | [Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes]. ( Faizullin, RM; Kalugina, AV; Miroshnichenko, IY; Pryakhina, KE; Rassokhina, LM; Volchegorskii, LA, 2015) |
| "Mirtazapine (MIRT) is a multi-target antidepressant used in treatment of severe depression with promising efficacy, but also with important side effects, mainly sedation and weight gain." | 4.12 | Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. ( Chaves Filho, AJM; Cunha, NL; De Oliveira, GMF; Gadelha Filho, CVJ; Jucá, PM; Macedo, DS; Oliveira, TQ; Soares, MVR; Vasconcelos, SMM; Viana, GA; Vieira, CFX, 2022) |
| "The effects of 3-oxypyridine and succinic acid derivatives (emoxipine, reamberin and mexidol) on affective disorders in rats with alloxan diabetes were studied." | 3.81 | [Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes]. ( Faizullin, RM; Kalugina, AV; Miroshnichenko, IY; Pryakhina, KE; Rassokhina, LM; Volchegorskii, LA, 2015) |
| "This study was designed to investigate the possible antidepressant effects of the antioxidant alpha-lipoic acid (ALA) as a stand-alone treatment or in association with desvenlafaxine (DVS) in the chronic corticosterone (CORT)-induced depression model." | 3.79 | Augmentation therapy with alpha-lipoic acid and desvenlafaxine: a future target for treatment of depression? ( Araújo, PV; da Silva, JC; de Oliveira, SL; de Sousa, CN; Macêdo, DS; Sampaio, LR; Silva, MC; Sousa, FC; Vasconcelos, SM; Ximenes, NC, 2013) |
| "Insulin resistance has been associated with people diagnosed with depression." | 1.31 | Alpha lipoic acid: a novel treatment for depression. ( Salazar, MR, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Oliveira, TQ | 1 |
| Chaves Filho, AJM | 1 |
| Jucá, PM | 1 |
| Soares, MVR | 1 |
| Cunha, NL | 1 |
| Vieira, CFX | 1 |
| Gadelha Filho, CVJ | 1 |
| Viana, GA | 1 |
| De Oliveira, GMF | 1 |
| Macedo, DS | 2 |
| Vasconcelos, SMM | 2 |
| de Sousa, CNS | 1 |
| Meneses, LN | 2 |
| Vasconcelos, GS | 2 |
| da Silva Medeiros, I | 1 |
| Silva, MCC | 1 |
| Mouaffak, F | 1 |
| Kebir, O | 1 |
| da Silva Leite, CMG | 1 |
| Patrocinio, MCA | 1 |
| Macedo, D | 2 |
| Silva, MC | 2 |
| de Sousa, CN | 2 |
| Sampaio, LR | 1 |
| Ximenes, NC | 1 |
| Araújo, PV | 1 |
| da Silva, JC | 2 |
| de Oliveira, SL | 1 |
| Sousa, FC | 1 |
| Vasconcelos, SM | 2 |
| Volchegorskii, LA | 1 |
| Miroshnichenko, IY | 1 |
| Rassokhina, LM | 2 |
| Faizullin, RM | 1 |
| Pryakhina, KE | 1 |
| Kalugina, AV | 1 |
| de Lucena, DF | 1 |
| Volchegorskiĭ, IA | 1 |
| Alekseev, MN | 1 |
| Volchegorskaia, MI | 1 |
| Kim, E | 1 |
| Park, DW | 1 |
| Choi, SH | 1 |
| Kim, JJ | 1 |
| Cho, HS | 1 |
| Salazar, MR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Alpha-lipoic Acid Adjunctive Therapy in Schizophrenia: A Randomized, Double-blind, Placebo-controlled Trial[NCT03788759] | Phase 2/Phase 3 | 48 participants (Actual) | Interventional | 2019-09-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for thioctic acid and Depression
| Article | Year |
|---|---|
[Effect of alpha-lipoic acid and mexidol on neuro- and the affective status in patients at early stages of diabetic foot syndrome].
Topics: Antioxidants; Depression; Diabetic Foot; Drug Therapy, Combination; Female; Follow-Up Studies; Human | 2008 |
A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia.
Topics: Adult; Antioxidants; Antipsychotic Agents; Appetite; Blood Glucose; Body Mass Index; Brief Psychiatr | 2008 |
6 other studies available for thioctic acid and Depression
| Article | Year |
|---|---|
Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Cognitive Dysfunction; Corticosteron | 2022 |
Neuroprotective evidence of alpha-lipoic acid and desvenlafaxine on memory deficit in a neuroendocrine model of depression.
Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Behavior, Animal; Brain; Corticosterone; Depre | 2018 |
Augmentation therapy with alpha-lipoic acid and desvenlafaxine: a future target for treatment of depression?
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Corticosterone; Cyclohexanols; Depre | 2013 |
[Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes].
Topics: Animals; Anti-Anxiety Agents; Anxiety; Depression; Diabetes Mellitus, Experimental; Humans; Hypergly | 2015 |
Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine: Emphasis on the neurotrophic hypothesis of depression.
Topics: Animals; Antidepressive Agents; Antioxidants; Brain-Derived Neurotrophic Factor; Corticosterone; Dep | 2015 |
Alpha lipoic acid: a novel treatment for depression.
Topics: Antidepressive Agents; Depression; Humans; Insulin; Insulin Resistance; Serotonin; Thioctic Acid | 2000 |