thioctic acid has been researched along with Degenerative Diseases, Central Nervous System in 16 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the putative neurotherapeutic effects of the mitochondrial cofactors, L-carnitine, acetyl-L-carnitine, and alpha-lipoic acid; and to provide a rationale for investigating their efficacy in the treatment of neurocognitive deficits associated with mood disorders." | 8.84 | Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders? ( Chow, CS; Kennedy, SH; Konarski, JZ; McIntyre, RS; Soczynska, JK; Woldeyohannes, HO, 2008) |
| "To evaluate the putative neurotherapeutic effects of the mitochondrial cofactors, L-carnitine, acetyl-L-carnitine, and alpha-lipoic acid; and to provide a rationale for investigating their efficacy in the treatment of neurocognitive deficits associated with mood disorders." | 4.84 | Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders? ( Chow, CS; Kennedy, SH; Konarski, JZ; McIntyre, RS; Soczynska, JK; Woldeyohannes, HO, 2008) |
| "The incidence of neurodegenerative diseases has increased greatly worldwide due to the rise in life expectancy." | 2.72 | Natural Molecules and Neuroprotection: Kynurenic Acid, Pantethine and α-Lipoic Acid. ( Cseh, EK; Tóth, F; Vécsei, L, 2021) |
| "Carvedilol is an adrenergic receptor antagonist." | 1.91 | Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination. ( Ahmed, KA; Ibrahim Fouad, G, 2023) |
| "Scopolamine- induced memory loss is used to study new drug discovery in Alzheimer's disease (AD) pathogenesis." | 1.62 | Alpha lipoic acid ameliorates scopolamine induced memory deficit and neurodegeneration in the cerebello-hippocampal cortex. ( Adewumi, AE; Memudu, AE, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 8 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khan, H | 1 |
| Singh, TG | 1 |
| Dahiya, RS | 1 |
| Abdel-Daim, MM | 1 |
| Zhang, J | 1 |
| Zhao, Y | 1 |
| Zhang, Y | 1 |
| Gao, Y | 1 |
| Li, S | 1 |
| Chang, C | 1 |
| Gao, X | 1 |
| Zhao, J | 1 |
| Yang, G | 1 |
| Ibrahim Fouad, G | 1 |
| Ahmed, KA | 1 |
| Talaverón-Rey, M | 1 |
| Álvarez-Córdoba, M | 1 |
| Villalón-García, I | 1 |
| Povea-Cabello, S | 1 |
| Suárez-Rivero, JM | 1 |
| Gómez-Fernández, D | 1 |
| Romero-González, A | 1 |
| Suárez-Carrillo, A | 1 |
| Munuera-Cabeza, M | 1 |
| Cilleros-Holgado, P | 1 |
| Reche-López, D | 1 |
| Piñero-Pérez, R | 1 |
| Sánchez-Alcázar, JA | 1 |
| Zheng, Q | 1 |
| Ma, P | 1 |
| Yang, P | 1 |
| Zhai, S | 1 |
| He, M | 1 |
| Zhang, X | 1 |
| Tu, Q | 1 |
| Jiao, L | 1 |
| Ye, L | 1 |
| Feng, Z | 1 |
| Zhang, C | 1 |
| Pagano, G | 1 |
| Pallardó, FV | 1 |
| Lyakhovich, A | 1 |
| Tiano, L | 1 |
| Fittipaldi, MR | 1 |
| Toscanesi, M | 1 |
| Trifuoggi, M | 1 |
| Tóth, F | 1 |
| Cseh, EK | 1 |
| Vécsei, L | 1 |
| Memudu, AE | 1 |
| Adewumi, AE | 1 |
| Landgraf, BJ | 1 |
| McCarthy, EL | 1 |
| Booker, SJ | 1 |
| Ghibu, S | 1 |
| Richard, C | 1 |
| Delemasure, S | 1 |
| Vergely, C | 1 |
| Mogosan, C | 1 |
| Muresan, A | 1 |
| Lee, BS | 1 |
| Yuan, X | 1 |
| Xu, Q | 1 |
| McLafferty, FS | 1 |
| Petersen, BA | 1 |
| Collette, JC | 1 |
| Black, KL | 1 |
| Yu, JS | 1 |
| Bastianetto, S | 1 |
| Quirion, R | 1 |
| Cui, X | 1 |
| Zuo, P | 1 |
| Zhang, Q | 1 |
| Li, X | 1 |
| Hu, Y | 1 |
| Long, J | 1 |
| Packer, L | 1 |
| Liu, J | 1 |
| Soczynska, JK | 1 |
| Kennedy, SH | 1 |
| Chow, CS | 1 |
| Woldeyohannes, HO | 1 |
| Konarski, JZ | 1 |
| McIntyre, RS | 1 |
| Lynch, MA | 1 |
| Bilska, A | 1 |
| Włodek, L | 1 |
9 reviews available for thioctic acid and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
α-Lipoic Acid, an Organosulfur Biomolecule a Novel Therapeutic Agent for Neurodegenerative Disorders: An Mechanistic Perspective.
Topics: Animals; Antioxidants; Neurodegenerative Diseases; Neuroprotective Agents; Oxidation-Reduction; Thio | 2022 |
Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures.
Topics: Aging; Animals; Antioxidants; Cardiovascular Diseases; Carnitine; Cell Line; Diabetes Mellitus, Type | 2020 |
Natural Molecules and Neuroprotection: Kynurenic Acid, Pantethine and α-Lipoic Acid.
Topics: Animals; Antioxidants; Humans; Kynurenic Acid; Metabolic Networks and Pathways; Neurodegenerative Di | 2021 |
Radical S-Adenosylmethionine Enzymes in Human Health and Disease.
Topics: Carbon-Carbon Lyases; Diabetes Mellitus, Type 2; Gene Expression; Heart Defects, Congenital; Histone | 2016 |
[An endogenous dithiol with antioxidant properties: alpha-lipoic acid, potential uses in cardiovascular diseases].
Topics: 8,11,14-Eicosatrienoic Acid; Animal Experimentation; Animals; Antioxidants; Cardiovascular Diseases; | 2008 |
Natural antioxidants and neurodegenerative diseases.
Topics: Acetylcarnitine; Aging; Animals; Antioxidants; Brain; Food; Ginkgo biloba; Humans; Neurodegenerative | 2004 |
Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders?
Topics: Acetylcarnitine; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carnitine; Cl | 2008 |
Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue.
Topics: Aging; Animals; Antioxidants; Glutamic Acid; Humans; Long-Term Potentiation; Mitochondria; Nervous S | 2001 |
[Biologic properties of lipoic acid].
Topics: Acquired Immunodeficiency Syndrome; Aging; Animals; Antioxidants; Cataract; Decarboxylation; Diabeti | 2002 |
7 other studies available for thioctic acid and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Alpha lipoic acid treatment in late middle age improves cognitive function: Proteomic analysis of the protective mechanisms in the hippocampus.
Topics: Alzheimer Disease; Animals; Cell Cycle Proteins; Chromatography, Liquid; Cognition; Cytoskeletal Pro | 2023 |
Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination.
Topics: Animals; Carvedilol; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Mice; Mice, Inbred C | 2023 |
Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels.
Topics: Dietary Supplements; Humans; Iron; Mitochondria; Neurodegenerative Diseases; Pantothenate Kinase-Ass | 2023 |
Alpha lipoic acid ameliorates motor deficits by inhibiting ferroptosis in Parkinson's disease.
Topics: Animals; Iron; Iron Chelating Agents; Neurodegenerative Diseases; NF-E2-Related Factor 2; Parkinson | 2023 |
Alpha lipoic acid ameliorates scopolamine induced memory deficit and neurodegeneration in the cerebello-hippocampal cortex.
Topics: Animals; Astrocytes; Body Weight; Brain; Cerebellum; Hippocampus; Male; Memory Disorders; Neurodegen | 2021 |
Preparation and characterization of antioxidant nanospheres from multiple alpha-lipoic acid-containing compounds.
Topics: Antioxidants; Biocompatible Materials; Chemistry; Drug Design; Models, Chemical; Nanospheres; Nanote | 2009 |
Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Dementia; Disease Models, Animal; Galactose; | 2006 |