thioctic acid has been researched along with Complications of Diabetes Mellitus in 30 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Excerpt | Relevance | Reference |
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"The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model." | 7.81 | Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( Ayar, A; Çolak, R; Kan, E; Kiliçkan, E, 2015) |
"The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model." | 3.81 | Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( Ayar, A; Çolak, R; Kan, E; Kiliçkan, E, 2015) |
" However, a randomized, double-blind, placebo-controlled, multicenter trial showed that thioctic acid at an oral dosage of 800 mg/day for 4 months significantly improved cardiac autonomic neuropathy in type 2 diabetic patients." | 2.42 | The role of antioxidant micronutrients in the prevention of diabetic complications. ( Bonnefont-Rousselot, D, 2004) |
"Diabetic cataracts are caused by an elevation of polyols within the lens of the eye catalyzed by the enzyme aldose reductase." | 2.41 | Natural therapies for ocular disorders, part two: cataracts and glaucoma. ( Head, KA, 2001) |
"The incidence of NIDDM is highest in economically developed nations, particularly the U." | 2.41 | Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes. ( McDonald, RB; Ruhe, RC, 2001) |
"The etiology of diabetic complications is strongly associated with increased oxidative stress." | 1.39 | Ischemia-reperfusion injury of the isolated diabetic rat heart: effect of the antioxidant stobadine. ( Broskova, Z; Knezl, V; Kyselova, Z, 2013) |
"ALA plays an important role in treatment of erectile dysfunction by decreasing iNOS and increasing other isoforms of NOS." | 1.33 | The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats. ( Citci, S; Demirci, C; Hurdag, C; Ozkara, H; Uyaner, I, 2005) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (6.67) | 18.7374 |
1990's | 1 (3.33) | 18.2507 |
2000's | 12 (40.00) | 29.6817 |
2010's | 11 (36.67) | 24.3611 |
2020's | 4 (13.33) | 2.80 |
Authors | Studies |
---|---|
Cai, J | 1 |
Chen, J | 1 |
Zeng, Q | 1 |
Liu, J | 1 |
Zhang, Y | 1 |
Cheng, H | 1 |
Yao, S | 1 |
Chen, Q | 1 |
Cure, E | 1 |
Cumhur Cure, M | 1 |
Jeffrey, S | 1 |
Samraj, PI | 1 |
Raj, BS | 1 |
Behl, T | 1 |
Gupta, A | 1 |
Sehgal, A | 1 |
Sharma, S | 1 |
Singh, S | 1 |
Sharma, N | 1 |
Diaconu, CC | 1 |
Rahdar, A | 1 |
Hafeez, A | 1 |
Bhatia, S | 1 |
Al-Harrasi, A | 1 |
Bungau, S | 1 |
Hu, J | 1 |
Qin, X | 1 |
Song, ZY | 1 |
Yang, PP | 1 |
Feng, Y | 1 |
Sun, Q | 1 |
Xu, GY | 1 |
Zhang, HH | 1 |
Cicek, M | 1 |
Yıldırır, A | 1 |
Okyay, K | 1 |
Yazici, AC | 1 |
Aydinalp, A | 1 |
Kanyilmaz, S | 1 |
Muderrisoglu, H | 1 |
Broskova, Z | 1 |
Kyselova, Z | 1 |
Knezl, V | 1 |
Papanas, N | 1 |
Ziegler, D | 1 |
Kan, E | 1 |
Kiliçkan, E | 1 |
Ayar, A | 1 |
Çolak, R | 1 |
Alvarez-Rivera, F | 1 |
Fernández-Villanueva, D | 1 |
Concheiro, A | 1 |
Alvarez-Lorenzo, C | 1 |
Stirban, A | 1 |
Gianturco, V | 1 |
Bellomo, A | 1 |
D'Ottavio, E | 1 |
Formosa, V | 1 |
Iori, A | 1 |
Mancinella, M | 1 |
Troisi, G | 1 |
Marigliano, V | 1 |
Chandrasekharan, B | 1 |
Anitha, M | 1 |
Blatt, R | 1 |
Shahnavaz, N | 1 |
Kooby, D | 1 |
Staley, C | 1 |
Mwangi, S | 1 |
Jones, DP | 1 |
Sitaraman, SV | 1 |
Srinivasan, S | 1 |
Kashyap, P | 1 |
Farrugia, G | 1 |
Golbidi, S | 1 |
Ebadi, SA | 1 |
Laher, I | 1 |
Volchegorskiĭ, IA | 1 |
Rassokhina, LM | 1 |
Koliadich, MI | 1 |
Alekseev, MI | 1 |
BOCK, E | 1 |
SCHNEEWEISS, J | 1 |
Bonnefont-Rousselot, D | 1 |
Thirunavukkarasu, V | 1 |
Nandhini, AT | 1 |
Anuradha, CV | 1 |
Hurdag, C | 1 |
Ozkara, H | 1 |
Citci, S | 1 |
Uyaner, I | 1 |
Demirci, C | 1 |
Wernicke, JF | 1 |
Wang, F | 1 |
Pritchett, YL | 1 |
Smith, TR | 1 |
Raskin, J | 1 |
D'Souza, DN | 1 |
Iyengar, S | 1 |
Chappell, AS | 1 |
Jiang, YJ | 1 |
Gong, DX | 1 |
Liu, HB | 1 |
Yang, CM | 1 |
Sun, ZX | 1 |
Kong, CZ | 1 |
Barbeau, A | 1 |
Kilic, F | 1 |
Handelman, GJ | 1 |
Traber, K | 1 |
Tsang, K | 1 |
Packer, L | 2 |
Trevithick, JR | 1 |
Head, KA | 1 |
Ruhe, RC | 1 |
McDonald, RB | 1 |
Kraemer, K | 1 |
Rimbach, G | 1 |
Chukanova, EI | 1 |
Sokolova, NA | 1 |
Skoromets, AA | 1 |
Barantsevich, ER | 1 |
Petrova, NN | 1 |
Mel'nikova, EV | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
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Treatment With Alpha-lipoic Acid Over 16 Weeks in Type 2 Diabetic Patients With Symptomatic Polyneuropathy Who Responded to Initial 4-week High-dose Loading[NCT02439879] | Phase 4 | 45 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
Double Blind, Placebo Controlled, Cross Over Study to Investigate the Effectiveness and Safety of Eluxadoline in the Treatment of Diabetic Diarrhea[NCT04313088] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2022-07-01 | Withdrawn (stopped due to This study did not enroll any subjects) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Total symptoms score is a summation of presence, severity, and duration of the four main positive neuropathic sensory symptoms: lancinating/stabbing pain, burning pain, paresthesia, and asleep numbness (NCT02439879)
Timeframe: 20 weeks
Intervention | units on a scale (Mean) |
---|---|
Alpha Lipoic Acid Treatment | 2.5 |
Alpha Lipoic Acid Withdrawal | 3.1 |
10 reviews available for thioctic acid and Complications of Diabetes Mellitus
Article | Year |
---|---|
The Role of Alpha-lipoic Acid Supplementation in the Prevention of Diabetes Complications: A Comprehensive Review of Clinical Trials.
Topics: Antioxidants; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Dietary Supplements; | 2021 |
A spotlight on underlying the mechanism of AMPK in diabetes complications.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Diabetes Complications; Diabetes Mellitus, Type 2 | 2021 |
Efficacy of α-lipoic acid in diabetic neuropathy.
Topics: Antioxidants; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropat | 2014 |
Drugs for the treatment of diabetes complications. Zycose: a new player in the field?
Topics: 4-Aminobenzoic Acid; Animals; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus, T | 2008 |
Antioxidants in the treatment of diabetes.
Topics: Antioxidants; Ascorbic Acid; Carnitine; Clinical Trials as Topic; Diabetes Complications; Diabetes M | 2011 |
The role of antioxidant micronutrients in the prevention of diabetic complications.
Topics: Antioxidants; Ascorbic Acid; Diabetes Complications; Diet; Flavonoids; Humans; Metals; Micronutrient | 2004 |
Friedreich's ataxia 1980. An overview of the physiopathology.
Topics: Cardiomyopathy, Hypertrophic; Cell Membrane; Chemical Phenomena; Chemistry; Diabetes Complications; | 1980 |
Natural therapies for ocular disorders, part two: cataracts and glaucoma.
Topics: Cataract; Diabetes Complications; Diabetes Mellitus; Female; Glaucoma; Glucose; Glutathione; Humans; | 2001 |
Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes.
Topics: Antioxidants; Blood Glucose; Cardiovascular Diseases; Developed Countries; Diabetes Complications; D | 2001 |
Molecular aspects of lipoic acid in the prevention of diabetes complications.
Topics: Antioxidants; Biological Availability; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetic | 2001 |
7 trials available for thioctic acid and Complications of Diabetes Mellitus
Article | Year |
---|---|
Use of alpha-lipoic acid in prevention of contrast-induced nephropathy in diabetic patients.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Contrast Media; Coronary Angiography; Diabetes Complic | 2013 |
[Correction of endothelial dysfunction in patients with essential hypertension and type 2 diabetes].
Topics: Adult; Blood Glucose; Carotid Arteries; Carotid Intima-Media Thickness; Diabetes Complications; Diab | 2014 |
Impact of therapy with alpha-lipoic acid (ALA) on the oxidative stress in the controlled NIDDM: a possible preventive way against the organ dysfunction?
Topics: Administration, Oral; Antioxidants; C-Reactive Protein; Cholesterol, HDL; Cholesterol, LDL; Diabetes | 2009 |
[Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients].
Topics: Antioxidants; Attention; Cognition; Cognition Disorders; Diabetes Complications; Diabetes Mellitus; | 2011 |
An open-label 52-week clinical extension comparing duloxetine with routine care in patients with diabetic peripheral neuropathic pain.
Topics: Acetaminophen; Amitriptyline; Analgesics; Carbamazepine; Diabetes Complications; Diabetic Neuropathi | 2007 |
[Efficiency of thioctacid in dyscirculatory encephalopathy].
Topics: Aged; Brain; Cerebrovascular Circulation; Cognition Disorders; Diabetes Complications; Female; Human | 2001 |
[Complex evaluation of treatment efficacy in diabetic encephalopathy].
Topics: Adult; Brain Diseases, Metabolic; Diabetes Complications; Diabetes Mellitus; Female; Humans; Male; M | 2002 |
13 other studies available for thioctic acid and Complications of Diabetes Mellitus
Article | Year |
---|---|
Assessment of the efficacy of α-lipoic acid in treatment of diabetes mellitus patients with erectile dysfunction: A protocol for systematic review and meta-analysis.
Topics: Diabetes Complications; Erectile Dysfunction; Humans; Male; Meta-Analysis as Topic; Randomized Contr | 2020 |
Alpha-lipoic acid may protect patients with diabetes against COVID-19 infection.
Topics: ADAM17 Protein; Angiotensin-Converting Enzyme 2; Antioxidants; Betacoronavirus; Coronavirus Infectio | 2020 |
Alpha-lipoic Acid suppresses P2X receptor activities and visceral hypersensitivity to colorectal distention in diabetic rats.
Topics: Animals; Colon; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Fem | 2017 |
Ischemia-reperfusion injury of the isolated diabetic rat heart: effect of the antioxidant stobadine.
Topics: Animals; Antioxidants; Carbolines; Diabetes Complications; Male; Myocardial Reperfusion Injury; Rats | 2013 |
Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice.
Topics: Animals; Antioxidants; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Pr | 2015 |
α-Lipoic Acid in Soluplus(®) Polymeric Nanomicelles for Ocular Treatment of Diabetes-Associated Corneal Diseases.
Topics: Administration, Ophthalmic; Animals; Antioxidants; Cattle; Chorioallantoic Membrane; Cornea; Corneal | 2016 |
Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress.
Topics: Aged; Animals; Antioxidants; Apoptosis; Biopsy; Case-Control Studies; Cell Line; Colon; Diabetes Com | 2011 |
Oxidative stress: key player in gastrointestinal complications of diabetes.
Topics: Animals; Antioxidants; Apoptosis; Cell Line; Colon; Diabetes Complications; Disease Models, Animal; | 2011 |
[A contribution to the therapy of neuropathia diabetica].
Topics: Central Nervous System Depressants; Diabetes Complications; Nervous System; Thioctic Acid | 1959 |
Lipoic acid prevents collagen abnormalities in tail tendon of high-fructose-fed rats.
Topics: Animals; Collagen; Diabetes Complications; Dietary Carbohydrates; Fructose; Male; Models, Animal; Ra | 2005 |
The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Diabetes Complications; Diabetes Mellitus, Experimental; Erectile Dysfunction | 2005 |
Ability of alpha-lipoic acid to reverse the diabetic cystopathy in a rat model.
Topics: Animals; Antioxidants; Catalase; Diabetes Complications; Diabetes Mellitus, Experimental; Male; Malo | 2008 |
Modelling cortical cataractogenesis XX. In vitro effect of alpha-lipoic acid on glutathione concentrations in lens in model diabetic cataractogenesis.
Topics: Animals; Cataract; Culture Techniques; Diabetes Complications; Diabetes Mellitus; Disease Models, An | 1998 |