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thioctic acid and Complications of Diabetes Mellitus

thioctic acid has been researched along with Complications of Diabetes Mellitus in 30 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Research Excerpts

ExcerptRelevanceReference
"The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model."7.81Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( Ayar, A; Çolak, R; Kan, E; Kiliçkan, E, 2015)
"The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model."3.81Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( Ayar, A; Çolak, R; Kan, E; Kiliçkan, E, 2015)
" However, a randomized, double-blind, placebo-controlled, multicenter trial showed that thioctic acid at an oral dosage of 800 mg/day for 4 months significantly improved cardiac autonomic neuropathy in type 2 diabetic patients."2.42The role of antioxidant micronutrients in the prevention of diabetic complications. ( Bonnefont-Rousselot, D, 2004)
"Diabetic cataracts are caused by an elevation of polyols within the lens of the eye catalyzed by the enzyme aldose reductase."2.41Natural therapies for ocular disorders, part two: cataracts and glaucoma. ( Head, KA, 2001)
"The incidence of NIDDM is highest in economically developed nations, particularly the U."2.41Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes. ( McDonald, RB; Ruhe, RC, 2001)
"The etiology of diabetic complications is strongly associated with increased oxidative stress."1.39Ischemia-reperfusion injury of the isolated diabetic rat heart: effect of the antioxidant stobadine. ( Broskova, Z; Knezl, V; Kyselova, Z, 2013)
"ALA plays an important role in treatment of erectile dysfunction by decreasing iNOS and increasing other isoforms of NOS."1.33The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats. ( Citci, S; Demirci, C; Hurdag, C; Ozkara, H; Uyaner, I, 2005)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19902 (6.67)18.7374
1990's1 (3.33)18.2507
2000's12 (40.00)29.6817
2010's11 (36.67)24.3611
2020's4 (13.33)2.80

Authors

AuthorsStudies
Cai, J1
Chen, J1
Zeng, Q1
Liu, J1
Zhang, Y1
Cheng, H1
Yao, S1
Chen, Q1
Cure, E1
Cumhur Cure, M1
Jeffrey, S1
Samraj, PI1
Raj, BS1
Behl, T1
Gupta, A1
Sehgal, A1
Sharma, S1
Singh, S1
Sharma, N1
Diaconu, CC1
Rahdar, A1
Hafeez, A1
Bhatia, S1
Al-Harrasi, A1
Bungau, S1
Hu, J1
Qin, X1
Song, ZY1
Yang, PP1
Feng, Y1
Sun, Q1
Xu, GY1
Zhang, HH1
Cicek, M1
Yıldırır, A1
Okyay, K1
Yazici, AC1
Aydinalp, A1
Kanyilmaz, S1
Muderrisoglu, H1
Broskova, Z1
Kyselova, Z1
Knezl, V1
Papanas, N1
Ziegler, D1
Kan, E1
Kiliçkan, E1
Ayar, A1
Çolak, R1
Alvarez-Rivera, F1
Fernández-Villanueva, D1
Concheiro, A1
Alvarez-Lorenzo, C1
Stirban, A1
Gianturco, V1
Bellomo, A1
D'Ottavio, E1
Formosa, V1
Iori, A1
Mancinella, M1
Troisi, G1
Marigliano, V1
Chandrasekharan, B1
Anitha, M1
Blatt, R1
Shahnavaz, N1
Kooby, D1
Staley, C1
Mwangi, S1
Jones, DP1
Sitaraman, SV1
Srinivasan, S1
Kashyap, P1
Farrugia, G1
Golbidi, S1
Ebadi, SA1
Laher, I1
Volchegorskiĭ, IA1
Rassokhina, LM1
Koliadich, MI1
Alekseev, MI1
BOCK, E1
SCHNEEWEISS, J1
Bonnefont-Rousselot, D1
Thirunavukkarasu, V1
Nandhini, AT1
Anuradha, CV1
Hurdag, C1
Ozkara, H1
Citci, S1
Uyaner, I1
Demirci, C1
Wernicke, JF1
Wang, F1
Pritchett, YL1
Smith, TR1
Raskin, J1
D'Souza, DN1
Iyengar, S1
Chappell, AS1
Jiang, YJ1
Gong, DX1
Liu, HB1
Yang, CM1
Sun, ZX1
Kong, CZ1
Barbeau, A1
Kilic, F1
Handelman, GJ1
Traber, K1
Tsang, K1
Packer, L2
Trevithick, JR1
Head, KA1
Ruhe, RC1
McDonald, RB1
Kraemer, K1
Rimbach, G1
Chukanova, EI1
Sokolova, NA1
Skoromets, AA1
Barantsevich, ER1
Petrova, NN1
Mel'nikova, EV1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Treatment With Alpha-lipoic Acid Over 16 Weeks in Type 2 Diabetic Patients With Symptomatic Polyneuropathy Who Responded to Initial 4-week High-dose Loading[NCT02439879]Phase 445 participants (Actual)Interventional2009-12-31Completed
Double Blind, Placebo Controlled, Cross Over Study to Investigate the Effectiveness and Safety of Eluxadoline in the Treatment of Diabetic Diarrhea[NCT04313088]Phase 2/Phase 30 participants (Actual)Interventional2022-07-01Withdrawn (stopped due to This study did not enroll any subjects)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Total Symptoms Score

Total symptoms score is a summation of presence, severity, and duration of the four main positive neuropathic sensory symptoms: lancinating/stabbing pain, burning pain, paresthesia, and asleep numbness (NCT02439879)
Timeframe: 20 weeks

Interventionunits on a scale (Mean)
Alpha Lipoic Acid Treatment2.5
Alpha Lipoic Acid Withdrawal3.1

Reviews

10 reviews available for thioctic acid and Complications of Diabetes Mellitus

ArticleYear
The Role of Alpha-lipoic Acid Supplementation in the Prevention of Diabetes Complications: A Comprehensive Review of Clinical Trials.
    Current diabetes reviews, 2021, Volume: 17, Issue:9

    Topics: Antioxidants; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Dietary Supplements;

2021
A spotlight on underlying the mechanism of AMPK in diabetes complications.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2021, Volume: 70, Issue:9

    Topics: AMP-Activated Protein Kinases; Animals; Berberine; Diabetes Complications; Diabetes Mellitus, Type 2

2021
Efficacy of α-lipoic acid in diabetic neuropathy.
    Expert opinion on pharmacotherapy, 2014, Volume: 15, Issue:18

    Topics: Antioxidants; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropat

2014
Drugs for the treatment of diabetes complications. Zycose: a new player in the field?
    Drugs of today (Barcelona, Spain : 1998), 2008, Volume: 44, Issue:10

    Topics: 4-Aminobenzoic Acid; Animals; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus, T

2008
Antioxidants in the treatment of diabetes.
    Current diabetes reviews, 2011, Volume: 7, Issue:2

    Topics: Antioxidants; Ascorbic Acid; Carnitine; Clinical Trials as Topic; Diabetes Complications; Diabetes M

2011
The role of antioxidant micronutrients in the prevention of diabetic complications.
    Treatments in endocrinology, 2004, Volume: 3, Issue:1

    Topics: Antioxidants; Ascorbic Acid; Diabetes Complications; Diet; Flavonoids; Humans; Metals; Micronutrient

2004
Friedreich's ataxia 1980. An overview of the physiopathology.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1980, Volume: 7, Issue:4

    Topics: Cardiomyopathy, Hypertrophic; Cell Membrane; Chemical Phenomena; Chemistry; Diabetes Complications;

1980
Natural therapies for ocular disorders, part two: cataracts and glaucoma.
    Alternative medicine review : a journal of clinical therapeutic, 2001, Volume: 6, Issue:2

    Topics: Cataract; Diabetes Complications; Diabetes Mellitus; Female; Glaucoma; Glucose; Glutathione; Humans;

2001
Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes.
    Journal of the American College of Nutrition, 2001, Volume: 20, Issue:5 Suppl

    Topics: Antioxidants; Blood Glucose; Cardiovascular Diseases; Developed Countries; Diabetes Complications; D

2001
Molecular aspects of lipoic acid in the prevention of diabetes complications.
    Nutrition (Burbank, Los Angeles County, Calif.), 2001, Volume: 17, Issue:10

    Topics: Antioxidants; Biological Availability; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetic

2001

Trials

7 trials available for thioctic acid and Complications of Diabetes Mellitus

ArticleYear
Use of alpha-lipoic acid in prevention of contrast-induced nephropathy in diabetic patients.
    Renal failure, 2013, Volume: 35, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Contrast Media; Coronary Angiography; Diabetes Complic

2013
[Correction of endothelial dysfunction in patients with essential hypertension and type 2 diabetes].
    Georgian medical news, 2014, Issue:229

    Topics: Adult; Blood Glucose; Carotid Arteries; Carotid Intima-Media Thickness; Diabetes Complications; Diab

2014
Impact of therapy with alpha-lipoic acid (ALA) on the oxidative stress in the controlled NIDDM: a possible preventive way against the organ dysfunction?
    Archives of gerontology and geriatrics, 2009, Volume: 49 Suppl 1

    Topics: Administration, Oral; Antioxidants; C-Reactive Protein; Cholesterol, HDL; Cholesterol, LDL; Diabetes

2009
[Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients].
    Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:11

    Topics: Antioxidants; Attention; Cognition; Cognition Disorders; Diabetes Complications; Diabetes Mellitus;

2011
An open-label 52-week clinical extension comparing duloxetine with routine care in patients with diabetic peripheral neuropathic pain.
    Pain medicine (Malden, Mass.), 2007, Volume: 8, Issue:6

    Topics: Acetaminophen; Amitriptyline; Analgesics; Carbamazepine; Diabetes Complications; Diabetic Neuropathi

2007
[Efficiency of thioctacid in dyscirculatory encephalopathy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2001, Volume: 101, Issue:11

    Topics: Aged; Brain; Cerebrovascular Circulation; Cognition Disorders; Diabetes Complications; Female; Human

2001
[Complex evaluation of treatment efficacy in diabetic encephalopathy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2002, Volume: 102, Issue:3

    Topics: Adult; Brain Diseases, Metabolic; Diabetes Complications; Diabetes Mellitus; Female; Humans; Male; M

2002

Other Studies

13 other studies available for thioctic acid and Complications of Diabetes Mellitus

ArticleYear
Assessment of the efficacy of α-lipoic acid in treatment of diabetes mellitus patients with erectile dysfunction: A protocol for systematic review and meta-analysis.
    Medicine, 2020, Sep-04, Volume: 99, Issue:36

    Topics: Diabetes Complications; Erectile Dysfunction; Humans; Male; Meta-Analysis as Topic; Randomized Contr

2020
Alpha-lipoic acid may protect patients with diabetes against COVID-19 infection.
    Medical hypotheses, 2020, Volume: 143

    Topics: ADAM17 Protein; Angiotensin-Converting Enzyme 2; Antioxidants; Betacoronavirus; Coronavirus Infectio

2020
Alpha-lipoic Acid suppresses P2X receptor activities and visceral hypersensitivity to colorectal distention in diabetic rats.
    Scientific reports, 2017, 06-28, Volume: 7, Issue:1

    Topics: Animals; Colon; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Fem

2017
Ischemia-reperfusion injury of the isolated diabetic rat heart: effect of the antioxidant stobadine.
    General physiology and biophysics, 2013, Volume: 32, Issue:2

    Topics: Animals; Antioxidants; Carbolines; Diabetes Complications; Male; Myocardial Reperfusion Injury; Rats

2013
Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice.
    International ophthalmology, 2015, Volume: 35, Issue:1

    Topics: Animals; Antioxidants; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Pr

2015
α-Lipoic Acid in Soluplus(®) Polymeric Nanomicelles for Ocular Treatment of Diabetes-Associated Corneal Diseases.
    Journal of pharmaceutical sciences, 2016, Volume: 105, Issue:9

    Topics: Administration, Ophthalmic; Animals; Antioxidants; Cattle; Chorioallantoic Membrane; Cornea; Corneal

2016
Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress.
    Neurogastroenterology and motility, 2011, Volume: 23, Issue:2

    Topics: Aged; Animals; Antioxidants; Apoptosis; Biopsy; Case-Control Studies; Cell Line; Colon; Diabetes Com

2011
Oxidative stress: key player in gastrointestinal complications of diabetes.
    Neurogastroenterology and motility, 2011, Volume: 23, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Cell Line; Colon; Diabetes Complications; Disease Models, Animal;

2011
[A contribution to the therapy of neuropathia diabetica].
    Munchener medizinische Wochenschrift (1950), 1959, Oct-23, Volume: 101

    Topics: Central Nervous System Depressants; Diabetes Complications; Nervous System; Thioctic Acid

1959
Lipoic acid prevents collagen abnormalities in tail tendon of high-fructose-fed rats.
    Diabetes, obesity & metabolism, 2005, Volume: 7, Issue:3

    Topics: Animals; Collagen; Diabetes Complications; Dietary Carbohydrates; Fructose; Male; Models, Animal; Ra

2005
The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats.
    International journal of tissue reactions, 2005, Volume: 27, Issue:3

    Topics: Animals; Antioxidants; Diabetes Complications; Diabetes Mellitus, Experimental; Erectile Dysfunction

2005
Ability of alpha-lipoic acid to reverse the diabetic cystopathy in a rat model.
    Acta pharmacologica Sinica, 2008, Volume: 29, Issue:6

    Topics: Animals; Antioxidants; Catalase; Diabetes Complications; Diabetes Mellitus, Experimental; Male; Malo

2008
Modelling cortical cataractogenesis XX. In vitro effect of alpha-lipoic acid on glutathione concentrations in lens in model diabetic cataractogenesis.
    Biochemistry and molecular biology international, 1998, Volume: 46, Issue:3

    Topics: Animals; Cataract; Culture Techniques; Diabetes Complications; Diabetes Mellitus; Disease Models, An

1998