thioctic acid has been researched along with Complications of Diabetes Mellitus in 30 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model." | 7.81 | Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( Ayar, A; Çolak, R; Kan, E; Kiliçkan, E, 2015) |
| "The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model." | 3.81 | Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( Ayar, A; Çolak, R; Kan, E; Kiliçkan, E, 2015) |
| " However, a randomized, double-blind, placebo-controlled, multicenter trial showed that thioctic acid at an oral dosage of 800 mg/day for 4 months significantly improved cardiac autonomic neuropathy in type 2 diabetic patients." | 2.42 | The role of antioxidant micronutrients in the prevention of diabetic complications. ( Bonnefont-Rousselot, D, 2004) |
| "Diabetic cataracts are caused by an elevation of polyols within the lens of the eye catalyzed by the enzyme aldose reductase." | 2.41 | Natural therapies for ocular disorders, part two: cataracts and glaucoma. ( Head, KA, 2001) |
| "The incidence of NIDDM is highest in economically developed nations, particularly the U." | 2.41 | Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes. ( McDonald, RB; Ruhe, RC, 2001) |
| "The etiology of diabetic complications is strongly associated with increased oxidative stress." | 1.39 | Ischemia-reperfusion injury of the isolated diabetic rat heart: effect of the antioxidant stobadine. ( Broskova, Z; Knezl, V; Kyselova, Z, 2013) |
| "ALA plays an important role in treatment of erectile dysfunction by decreasing iNOS and increasing other isoforms of NOS." | 1.33 | The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats. ( Citci, S; Demirci, C; Hurdag, C; Ozkara, H; Uyaner, I, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.67) | 18.7374 |
| 1990's | 1 (3.33) | 18.2507 |
| 2000's | 12 (40.00) | 29.6817 |
| 2010's | 11 (36.67) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, J | 1 |
| Chen, J | 1 |
| Zeng, Q | 1 |
| Liu, J | 1 |
| Zhang, Y | 1 |
| Cheng, H | 1 |
| Yao, S | 1 |
| Chen, Q | 1 |
| Cure, E | 1 |
| Cumhur Cure, M | 1 |
| Jeffrey, S | 1 |
| Samraj, PI | 1 |
| Raj, BS | 1 |
| Behl, T | 1 |
| Gupta, A | 1 |
| Sehgal, A | 1 |
| Sharma, S | 1 |
| Singh, S | 1 |
| Sharma, N | 1 |
| Diaconu, CC | 1 |
| Rahdar, A | 1 |
| Hafeez, A | 1 |
| Bhatia, S | 1 |
| Al-Harrasi, A | 1 |
| Bungau, S | 1 |
| Hu, J | 1 |
| Qin, X | 1 |
| Song, ZY | 1 |
| Yang, PP | 1 |
| Feng, Y | 1 |
| Sun, Q | 1 |
| Xu, GY | 1 |
| Zhang, HH | 1 |
| Cicek, M | 1 |
| Yıldırır, A | 1 |
| Okyay, K | 1 |
| Yazici, AC | 1 |
| Aydinalp, A | 1 |
| Kanyilmaz, S | 1 |
| Muderrisoglu, H | 1 |
| Broskova, Z | 1 |
| Kyselova, Z | 1 |
| Knezl, V | 1 |
| Papanas, N | 1 |
| Ziegler, D | 1 |
| Kan, E | 1 |
| Kiliçkan, E | 1 |
| Ayar, A | 1 |
| Çolak, R | 1 |
| Alvarez-Rivera, F | 1 |
| Fernández-Villanueva, D | 1 |
| Concheiro, A | 1 |
| Alvarez-Lorenzo, C | 1 |
| Stirban, A | 1 |
| Gianturco, V | 1 |
| Bellomo, A | 1 |
| D'Ottavio, E | 1 |
| Formosa, V | 1 |
| Iori, A | 1 |
| Mancinella, M | 1 |
| Troisi, G | 1 |
| Marigliano, V | 1 |
| Chandrasekharan, B | 1 |
| Anitha, M | 1 |
| Blatt, R | 1 |
| Shahnavaz, N | 1 |
| Kooby, D | 1 |
| Staley, C | 1 |
| Mwangi, S | 1 |
| Jones, DP | 1 |
| Sitaraman, SV | 1 |
| Srinivasan, S | 1 |
| Kashyap, P | 1 |
| Farrugia, G | 1 |
| Golbidi, S | 1 |
| Ebadi, SA | 1 |
| Laher, I | 1 |
| Volchegorskiĭ, IA | 1 |
| Rassokhina, LM | 1 |
| Koliadich, MI | 1 |
| Alekseev, MI | 1 |
| BOCK, E | 1 |
| SCHNEEWEISS, J | 1 |
| Bonnefont-Rousselot, D | 1 |
| Thirunavukkarasu, V | 1 |
| Nandhini, AT | 1 |
| Anuradha, CV | 1 |
| Hurdag, C | 1 |
| Ozkara, H | 1 |
| Citci, S | 1 |
| Uyaner, I | 1 |
| Demirci, C | 1 |
| Wernicke, JF | 1 |
| Wang, F | 1 |
| Pritchett, YL | 1 |
| Smith, TR | 1 |
| Raskin, J | 1 |
| D'Souza, DN | 1 |
| Iyengar, S | 1 |
| Chappell, AS | 1 |
| Jiang, YJ | 1 |
| Gong, DX | 1 |
| Liu, HB | 1 |
| Yang, CM | 1 |
| Sun, ZX | 1 |
| Kong, CZ | 1 |
| Barbeau, A | 1 |
| Kilic, F | 1 |
| Handelman, GJ | 1 |
| Traber, K | 1 |
| Tsang, K | 1 |
| Packer, L | 2 |
| Trevithick, JR | 1 |
| Head, KA | 1 |
| Ruhe, RC | 1 |
| McDonald, RB | 1 |
| Kraemer, K | 1 |
| Rimbach, G | 1 |
| Chukanova, EI | 1 |
| Sokolova, NA | 1 |
| Skoromets, AA | 1 |
| Barantsevich, ER | 1 |
| Petrova, NN | 1 |
| Mel'nikova, EV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment With Alpha-lipoic Acid Over 16 Weeks in Type 2 Diabetic Patients With Symptomatic Polyneuropathy Who Responded to Initial 4-week High-dose Loading[NCT02439879] | Phase 4 | 45 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| Double Blind, Placebo Controlled, Cross Over Study to Investigate the Effectiveness and Safety of Eluxadoline in the Treatment of Diabetic Diarrhea[NCT04313088] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2022-07-01 | Withdrawn (stopped due to This study did not enroll any subjects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total symptoms score is a summation of presence, severity, and duration of the four main positive neuropathic sensory symptoms: lancinating/stabbing pain, burning pain, paresthesia, and asleep numbness (NCT02439879)
Timeframe: 20 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Alpha Lipoic Acid Treatment | 2.5 |
| Alpha Lipoic Acid Withdrawal | 3.1 |
10 reviews available for thioctic acid and Complications of Diabetes Mellitus
| Article | Year |
|---|---|
The Role of Alpha-lipoic Acid Supplementation in the Prevention of Diabetes Complications: A Comprehensive Review of Clinical Trials.
Topics: Antioxidants; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Dietary Supplements; | 2021 |
A spotlight on underlying the mechanism of AMPK in diabetes complications.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Diabetes Complications; Diabetes Mellitus, Type 2 | 2021 |
Efficacy of α-lipoic acid in diabetic neuropathy.
Topics: Antioxidants; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropat | 2014 |
Drugs for the treatment of diabetes complications. Zycose: a new player in the field?
Topics: 4-Aminobenzoic Acid; Animals; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus, T | 2008 |
Antioxidants in the treatment of diabetes.
Topics: Antioxidants; Ascorbic Acid; Carnitine; Clinical Trials as Topic; Diabetes Complications; Diabetes M | 2011 |
The role of antioxidant micronutrients in the prevention of diabetic complications.
Topics: Antioxidants; Ascorbic Acid; Diabetes Complications; Diet; Flavonoids; Humans; Metals; Micronutrient | 2004 |
Friedreich's ataxia 1980. An overview of the physiopathology.
Topics: Cardiomyopathy, Hypertrophic; Cell Membrane; Chemical Phenomena; Chemistry; Diabetes Complications; | 1980 |
Natural therapies for ocular disorders, part two: cataracts and glaucoma.
Topics: Cataract; Diabetes Complications; Diabetes Mellitus; Female; Glaucoma; Glucose; Glutathione; Humans; | 2001 |
Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes.
Topics: Antioxidants; Blood Glucose; Cardiovascular Diseases; Developed Countries; Diabetes Complications; D | 2001 |
Molecular aspects of lipoic acid in the prevention of diabetes complications.
Topics: Antioxidants; Biological Availability; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetic | 2001 |
7 trials available for thioctic acid and Complications of Diabetes Mellitus
| Article | Year |
|---|---|
Use of alpha-lipoic acid in prevention of contrast-induced nephropathy in diabetic patients.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Contrast Media; Coronary Angiography; Diabetes Complic | 2013 |
[Correction of endothelial dysfunction in patients with essential hypertension and type 2 diabetes].
Topics: Adult; Blood Glucose; Carotid Arteries; Carotid Intima-Media Thickness; Diabetes Complications; Diab | 2014 |
Impact of therapy with alpha-lipoic acid (ALA) on the oxidative stress in the controlled NIDDM: a possible preventive way against the organ dysfunction?
Topics: Administration, Oral; Antioxidants; C-Reactive Protein; Cholesterol, HDL; Cholesterol, LDL; Diabetes | 2009 |
[Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients].
Topics: Antioxidants; Attention; Cognition; Cognition Disorders; Diabetes Complications; Diabetes Mellitus; | 2011 |
An open-label 52-week clinical extension comparing duloxetine with routine care in patients with diabetic peripheral neuropathic pain.
Topics: Acetaminophen; Amitriptyline; Analgesics; Carbamazepine; Diabetes Complications; Diabetic Neuropathi | 2007 |
[Efficiency of thioctacid in dyscirculatory encephalopathy].
Topics: Aged; Brain; Cerebrovascular Circulation; Cognition Disorders; Diabetes Complications; Female; Human | 2001 |
[Complex evaluation of treatment efficacy in diabetic encephalopathy].
Topics: Adult; Brain Diseases, Metabolic; Diabetes Complications; Diabetes Mellitus; Female; Humans; Male; M | 2002 |
13 other studies available for thioctic acid and Complications of Diabetes Mellitus
| Article | Year |
|---|---|
Assessment of the efficacy of α-lipoic acid in treatment of diabetes mellitus patients with erectile dysfunction: A protocol for systematic review and meta-analysis.
Topics: Diabetes Complications; Erectile Dysfunction; Humans; Male; Meta-Analysis as Topic; Randomized Contr | 2020 |
Alpha-lipoic acid may protect patients with diabetes against COVID-19 infection.
Topics: ADAM17 Protein; Angiotensin-Converting Enzyme 2; Antioxidants; Betacoronavirus; Coronavirus Infectio | 2020 |
Alpha-lipoic Acid suppresses P2X receptor activities and visceral hypersensitivity to colorectal distention in diabetic rats.
Topics: Animals; Colon; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Fem | 2017 |
Ischemia-reperfusion injury of the isolated diabetic rat heart: effect of the antioxidant stobadine.
Topics: Animals; Antioxidants; Carbolines; Diabetes Complications; Male; Myocardial Reperfusion Injury; Rats | 2013 |
Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice.
Topics: Animals; Antioxidants; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Pr | 2015 |
α-Lipoic Acid in Soluplus(®) Polymeric Nanomicelles for Ocular Treatment of Diabetes-Associated Corneal Diseases.
Topics: Administration, Ophthalmic; Animals; Antioxidants; Cattle; Chorioallantoic Membrane; Cornea; Corneal | 2016 |
Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress.
Topics: Aged; Animals; Antioxidants; Apoptosis; Biopsy; Case-Control Studies; Cell Line; Colon; Diabetes Com | 2011 |
Oxidative stress: key player in gastrointestinal complications of diabetes.
Topics: Animals; Antioxidants; Apoptosis; Cell Line; Colon; Diabetes Complications; Disease Models, Animal; | 2011 |
[A contribution to the therapy of neuropathia diabetica].
Topics: Central Nervous System Depressants; Diabetes Complications; Nervous System; Thioctic Acid | 1959 |
Lipoic acid prevents collagen abnormalities in tail tendon of high-fructose-fed rats.
Topics: Animals; Collagen; Diabetes Complications; Dietary Carbohydrates; Fructose; Male; Models, Animal; Ra | 2005 |
The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Diabetes Complications; Diabetes Mellitus, Experimental; Erectile Dysfunction | 2005 |
Ability of alpha-lipoic acid to reverse the diabetic cystopathy in a rat model.
Topics: Animals; Antioxidants; Catalase; Diabetes Complications; Diabetes Mellitus, Experimental; Male; Malo | 2008 |
Modelling cortical cataractogenesis XX. In vitro effect of alpha-lipoic acid on glutathione concentrations in lens in model diabetic cataractogenesis.
Topics: Animals; Cataract; Culture Techniques; Diabetes Complications; Diabetes Mellitus; Disease Models, An | 1998 |