thioctic acid has been researched along with Colorectal Cancer in 7 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Excerpt | Relevance | Reference |
---|---|---|
" In the present study, we analyzed the cytotoxicity of LA on colorectal cancer (CRC) cells differing in their p53 status and investigated a putative synergistic effect with the anticancer drug 5-fluorouracil (5-FU)." | 7.81 | Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil. ( Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Seiwert, N, 2015) |
"Incubation of HCT116 colorectal cancer cells with LA altered their glutathione pool and caused a decline in MGMT activity." | 5.42 | Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction. ( Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Kraus, A; Nagel, G; Seiwert, N, 2015) |
" In the present study, we analyzed the cytotoxicity of LA on colorectal cancer (CRC) cells differing in their p53 status and investigated a putative synergistic effect with the anticancer drug 5-fluorouracil (5-FU)." | 3.81 | Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil. ( Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Seiwert, N, 2015) |
"Incubation of HCT116 colorectal cancer cells with LA altered their glutathione pool and caused a decline in MGMT activity." | 1.42 | Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction. ( Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Kraus, A; Nagel, G; Seiwert, N, 2015) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (14.29) | 29.6817 |
2010's | 6 (85.71) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Emami, F | 1 |
Banstola, A | 1 |
Vatanara, A | 1 |
Lee, S | 1 |
Kim, JO | 1 |
Jeong, JH | 1 |
Yook, S | 1 |
Neitzel, C | 1 |
Seiwert, N | 3 |
Göder, A | 3 |
Diehl, E | 1 |
Weber, C | 1 |
Nagel, G | 2 |
Stroh, S | 1 |
Rasenberger, B | 1 |
Christmann, M | 1 |
Fahrer, J | 3 |
Hiratsuka, T | 1 |
Inomata, M | 1 |
Kono, Y | 1 |
Yokoyama, S | 1 |
Shiraishi, N | 1 |
Kitano, S | 1 |
Dörsam, B | 2 |
Kaina, B | 2 |
Kraus, A | 1 |
Al-Mulla, F | 1 |
Bitar, MS | 1 |
Feng, J | 1 |
Park, S | 1 |
Yeung, KC | 1 |
Gedlicka, C | 1 |
Scheithauer, W | 1 |
Schüll, B | 1 |
Kornek, GV | 1 |
7 other studies available for thioctic acid and Colorectal Cancer
Article | Year |
---|---|
Doxorubicin and Anti-PD-L1 Antibody Conjugated Gold Nanoparticles for Colorectal Cancer Photochemotherapy.
Topics: Animals; Antibodies; Apoptosis; B7-H1 Antigen; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Surviv | 2019 |
Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Do | 2019 |
DHL‑TauZnNa, a newly synthesized α-lipoic acid derivative, induces autophagy in human colorectal cancer cells.
Topics: Animals; Antineoplastic Agents; Autophagy; Cell Cycle; Cell Survival; Colorectal Neoplasms; Coordina | 2013 |
Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil.
Topics: Antimetabolites, Antineoplastic; Caco-2 Cells; Caspases; Cell Death; Cell Survival; Colorectal Neopl | 2015 |
Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.
Topics: Animals; Antineoplastic Agents, Alkylating; Autophagy; Colorectal Neoplasms; Cysteine; Dacarbazine; | 2015 |
A new model for raf kinase inhibitory protein induced chemotherapeutic resistance.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Antioxidants; Apoptosis; Blotting, Western; Cisplati | 2012 |
Effective treatment of oxaliplatin-induced cumulative polyneuropathy with alpha-lipoic acid.
Topics: Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Humans; Male; Middle Aged; Nervous System | 2002 |