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thioctic acid and Colorectal Cancer

thioctic acid has been researched along with Colorectal Cancer in 7 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Research Excerpts

ExcerptRelevanceReference
" In the present study, we analyzed the cytotoxicity of LA on colorectal cancer (CRC) cells differing in their p53 status and investigated a putative synergistic effect with the anticancer drug 5-fluorouracil (5-FU)."7.81Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil. ( Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Seiwert, N, 2015)
"Incubation of HCT116 colorectal cancer cells with LA altered their glutathione pool and caused a decline in MGMT activity."5.42Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction. ( Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Kraus, A; Nagel, G; Seiwert, N, 2015)
" In the present study, we analyzed the cytotoxicity of LA on colorectal cancer (CRC) cells differing in their p53 status and investigated a putative synergistic effect with the anticancer drug 5-fluorouracil (5-FU)."3.81Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil. ( Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Seiwert, N, 2015)
"Incubation of HCT116 colorectal cancer cells with LA altered their glutathione pool and caused a decline in MGMT activity."1.42Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction. ( Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Kraus, A; Nagel, G; Seiwert, N, 2015)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's6 (85.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Emami, F1
Banstola, A1
Vatanara, A1
Lee, S1
Kim, JO1
Jeong, JH1
Yook, S1
Neitzel, C1
Seiwert, N3
Göder, A3
Diehl, E1
Weber, C1
Nagel, G2
Stroh, S1
Rasenberger, B1
Christmann, M1
Fahrer, J3
Hiratsuka, T1
Inomata, M1
Kono, Y1
Yokoyama, S1
Shiraishi, N1
Kitano, S1
Dörsam, B2
Kaina, B2
Kraus, A1
Al-Mulla, F1
Bitar, MS1
Feng, J1
Park, S1
Yeung, KC1
Gedlicka, C1
Scheithauer, W1
Schüll, B1
Kornek, GV1

Other Studies

7 other studies available for thioctic acid and Colorectal Cancer

ArticleYear
Doxorubicin and Anti-PD-L1 Antibody Conjugated Gold Nanoparticles for Colorectal Cancer Photochemotherapy.
    Molecular pharmaceutics, 2019, 03-04, Volume: 16, Issue:3

    Topics: Animals; Antibodies; Apoptosis; B7-H1 Antigen; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Surviv

2019
Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation.
    Cells, 2019, 07-30, Volume: 8, Issue:8

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Do

2019
DHL‑TauZnNa, a newly synthesized α-lipoic acid derivative, induces autophagy in human colorectal cancer cells.
    Oncology reports, 2013, Volume: 29, Issue:6

    Topics: Animals; Antineoplastic Agents; Autophagy; Cell Cycle; Cell Survival; Colorectal Neoplasms; Coordina

2013
Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil.
    Archives of toxicology, 2015, Volume: 89, Issue:10

    Topics: Antimetabolites, Antineoplastic; Caco-2 Cells; Caspases; Cell Death; Cell Survival; Colorectal Neopl

2015
Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.
    Carcinogenesis, 2015, Volume: 36, Issue:8

    Topics: Animals; Antineoplastic Agents, Alkylating; Autophagy; Colorectal Neoplasms; Cysteine; Dacarbazine;

2015
A new model for raf kinase inhibitory protein induced chemotherapeutic resistance.
    PloS one, 2012, Volume: 7, Issue:1

    Topics: Acetylcysteine; Active Transport, Cell Nucleus; Antioxidants; Apoptosis; Blotting, Western; Cisplati

2012
Effective treatment of oxaliplatin-induced cumulative polyneuropathy with alpha-lipoic acid.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Aug-01, Volume: 20, Issue:15

    Topics: Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Humans; Male; Middle Aged; Nervous System

2002