thioctic acid has been researched along with Colorectal Cancer in 7 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, we analyzed the cytotoxicity of LA on colorectal cancer (CRC) cells differing in their p53 status and investigated a putative synergistic effect with the anticancer drug 5-fluorouracil (5-FU)." | 7.81 | Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil. ( Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Seiwert, N, 2015) |
| "Incubation of HCT116 colorectal cancer cells with LA altered their glutathione pool and caused a decline in MGMT activity." | 5.42 | Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction. ( Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Kraus, A; Nagel, G; Seiwert, N, 2015) |
| " In the present study, we analyzed the cytotoxicity of LA on colorectal cancer (CRC) cells differing in their p53 status and investigated a putative synergistic effect with the anticancer drug 5-fluorouracil (5-FU)." | 3.81 | Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil. ( Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Seiwert, N, 2015) |
| "Incubation of HCT116 colorectal cancer cells with LA altered their glutathione pool and caused a decline in MGMT activity." | 1.42 | Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction. ( Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Kraus, A; Nagel, G; Seiwert, N, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Emami, F | 1 |
| Banstola, A | 1 |
| Vatanara, A | 1 |
| Lee, S | 1 |
| Kim, JO | 1 |
| Jeong, JH | 1 |
| Yook, S | 1 |
| Neitzel, C | 1 |
| Seiwert, N | 3 |
| Göder, A | 3 |
| Diehl, E | 1 |
| Weber, C | 1 |
| Nagel, G | 2 |
| Stroh, S | 1 |
| Rasenberger, B | 1 |
| Christmann, M | 1 |
| Fahrer, J | 3 |
| Hiratsuka, T | 1 |
| Inomata, M | 1 |
| Kono, Y | 1 |
| Yokoyama, S | 1 |
| Shiraishi, N | 1 |
| Kitano, S | 1 |
| Dörsam, B | 2 |
| Kaina, B | 2 |
| Kraus, A | 1 |
| Al-Mulla, F | 1 |
| Bitar, MS | 1 |
| Feng, J | 1 |
| Park, S | 1 |
| Yeung, KC | 1 |
| Gedlicka, C | 1 |
| Scheithauer, W | 1 |
| Schüll, B | 1 |
| Kornek, GV | 1 |
7 other studies available for thioctic acid and Colorectal Cancer
| Article | Year |
|---|---|
Doxorubicin and Anti-PD-L1 Antibody Conjugated Gold Nanoparticles for Colorectal Cancer Photochemotherapy.
Topics: Animals; Antibodies; Apoptosis; B7-H1 Antigen; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Surviv | 2019 |
Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Do | 2019 |
DHL‑TauZnNa, a newly synthesized α-lipoic acid derivative, induces autophagy in human colorectal cancer cells.
Topics: Animals; Antineoplastic Agents; Autophagy; Cell Cycle; Cell Survival; Colorectal Neoplasms; Coordina | 2013 |
Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil.
Topics: Antimetabolites, Antineoplastic; Caco-2 Cells; Caspases; Cell Death; Cell Survival; Colorectal Neopl | 2015 |
Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.
Topics: Animals; Antineoplastic Agents, Alkylating; Autophagy; Colorectal Neoplasms; Cysteine; Dacarbazine; | 2015 |
A new model for raf kinase inhibitory protein induced chemotherapeutic resistance.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Antioxidants; Apoptosis; Blotting, Western; Cisplati | 2012 |
Effective treatment of oxaliplatin-induced cumulative polyneuropathy with alpha-lipoic acid.
Topics: Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Humans; Male; Middle Aged; Nervous System | 2002 |