thioctic acid has been researched along with Colitis in 6 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin or/and α-LA attenuated the severity of the DSS-induced colitis through improving the reductions in body weights, the DAI, the colonic oxidative stress markers, TNF-α, and NF-κB levels, and the morphological mucosal damage scores." | 7.88 | New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats. ( Elaidy, SM; Essawy, SS; Hassan, MS; Samman, FS, 2018) |
| " In this study, we investigated the anti-inflammatory effects of AL-1 in C57BL/6 mice with trinitrobenzenesulfonic acid (TNBS)-induced colitis." | 7.83 | Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-кB and PPAR-γ signaling pathways. ( Jing, M; Shan, L; Sun, Y; Wang, Y; Xu, L; Yan, H; Yang, Y; Yu, P; Zhang, G; Zhang, Z, 2016) |
| "Metformin or/and α-LA attenuated the severity of the DSS-induced colitis through improving the reductions in body weights, the DAI, the colonic oxidative stress markers, TNF-α, and NF-κB levels, and the morphological mucosal damage scores." | 3.88 | New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats. ( Elaidy, SM; Essawy, SS; Hassan, MS; Samman, FS, 2018) |
| " We examined the inhibitory effects of a selective phosphodiesterase-3 inhibitor, cilostazol (CZ), and two antioxidants, enzymatically modified isoquercitrin (EMIQ) and α-lipoic acid (ALA), against dextran sulphate sodium (DSS)-induced colitis." | 3.85 | Anti-inflammatory effects of the selective phosphodiesterase 3 inhibitor, cilostazol, and antioxidants, enzymatically-modified isoquercitrin and α-lipoic acid, reduce dextran sulphate sodium-induced colorectal mucosal injury in mice. ( Abe, H; Hayashi, SM; Kangawa, Y; Kihara, T; Miyashita, T; Nakamura, M; Seto, Y; Shibutani, M; Yoshida, T, 2017) |
| " In this study, we investigated the anti-inflammatory effects of AL-1 in C57BL/6 mice with trinitrobenzenesulfonic acid (TNBS)-induced colitis." | 3.83 | Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-кB and PPAR-γ signaling pathways. ( Jing, M; Shan, L; Sun, Y; Wang, Y; Xu, L; Yan, H; Yang, Y; Yu, P; Zhang, G; Zhang, Z, 2016) |
| " This study aimed to evaluate the potential beneficial effect of ALA on trinitrobenzenesulfonic acid (TNBS)-induced gut ileitis and colitis in rats." | 3.74 | Alpha-lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats. ( Alican, I; Ercan, F; Jahovic, N; Kolgazi, M; Yüksel, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Z | 1 |
| Iida, N | 1 |
| Seishima, J | 1 |
| Okafuji, H | 1 |
| Yutani, M | 1 |
| Fujinaga, Y | 1 |
| Hashimoto, Y | 1 |
| Tomita, H | 1 |
| Mizukoshi, E | 1 |
| Kaneko, S | 1 |
| Samman, FS | 1 |
| Elaidy, SM | 1 |
| Essawy, SS | 1 |
| Hassan, MS | 1 |
| Yang, Y | 1 |
| Yan, H | 1 |
| Jing, M | 1 |
| Zhang, Z | 1 |
| Zhang, G | 1 |
| Sun, Y | 1 |
| Shan, L | 1 |
| Yu, P | 1 |
| Wang, Y | 1 |
| Xu, L | 1 |
| Özbeyli, D | 1 |
| Berberoglu, AC | 1 |
| Özen, A | 1 |
| Erkan, O | 1 |
| Başar, Y | 1 |
| Şen, T | 1 |
| Akakın, D | 1 |
| Yüksel, M | 2 |
| Kasımay Çakır, Ö | 1 |
| Kangawa, Y | 1 |
| Yoshida, T | 1 |
| Abe, H | 1 |
| Seto, Y | 1 |
| Miyashita, T | 1 |
| Nakamura, M | 1 |
| Kihara, T | 1 |
| Hayashi, SM | 1 |
| Shibutani, M | 1 |
| Kolgazi, M | 1 |
| Jahovic, N | 1 |
| Ercan, F | 1 |
| Alican, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of Metformin as Adjuvant Therapy in Patients With Ulcerative Colitis[NCT04750135] | Phase 2 | 40 participants (Anticipated) | Interventional | 2021-02-07 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for thioctic acid and Colitis
| Article | Year |
|---|---|
Patient-derived Enterococcus faecium with inflammatory genotypes promote colitis.
Topics: Animals; Antioxidants; Colitis; Colitis, Ulcerative; Dysbiosis; Enterococcus faecium; Genotype; Huma | 2022 |
New insights on the modulatory roles of metformin or alpha-lipoic acid versus their combination in dextran sulfate sodium-induced chronic colitis in rats.
Topics: Animals; Antioxidants; Body Weight; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Male; M | 2018 |
Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-кB and PPAR-γ signaling pathways.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Diterpenes; Inflammation Mediators; Mi | 2016 |
Protective effect of alpha-lipoic acid, aerobic or resistance exercise from colitis in second hand smoke exposed young rats.
Topics: Animals; Colitis; Male; Physical Conditioning, Animal; Protective Agents; Random Allocation; Rats; R | 2017 |
Anti-inflammatory effects of the selective phosphodiesterase 3 inhibitor, cilostazol, and antioxidants, enzymatically-modified isoquercitrin and α-lipoic acid, reduce dextran sulphate sodium-induced colorectal mucosal injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cilostazol; Colitis; Dextran Sulfate; Disease Model | 2017 |
Alpha-lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Colon; Disease Models, Animal; Gastrointes | 2007 |