thioctic acid has been researched along with Cognitive Dysfunction in 7 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Cognitive Dysfunction: Diminished or impaired mental and/or intellectual function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mirtazapine (MIRT) is a multi-target antidepressant used in treatment of severe depression with promising efficacy, but also with important side effects, mainly sedation and weight gain." | 8.12 | Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. ( Chaves Filho, AJM; Cunha, NL; De Oliveira, GMF; Gadelha Filho, CVJ; Jucá, PM; Macedo, DS; Oliveira, TQ; Soares, MVR; Vasconcelos, SMM; Viana, GA; Vieira, CFX, 2022) |
| "Mirtazapine (MIRT) is a multi-target antidepressant used in treatment of severe depression with promising efficacy, but also with important side effects, mainly sedation and weight gain." | 4.12 | Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. ( Chaves Filho, AJM; Cunha, NL; De Oliveira, GMF; Gadelha Filho, CVJ; Jucá, PM; Macedo, DS; Oliveira, TQ; Soares, MVR; Vasconcelos, SMM; Viana, GA; Vieira, CFX, 2022) |
| "Given the aging population, the treatment of vascular dementia (VaD) is becoming increasingly important." | 1.51 | Effects of α-lipoic acid on chronic cerebrovascular hypoperfusion in an animal model of vascular dementia. ( Han, CY; Lee, HS; Lee, S; Park, JH; Young Park, H, 2019) |
| "Sepsis is a complication of an infection which imbalance the normal regulation of several organ systems, including the central nervous system (CNS)." | 1.46 | Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis. ( Barichello, T; Bellettini-Santos, T; Budni, J; da Rosa, N; Dal-Pizzol, F; Danielski, LG; Della Giustina, A; Fileti, ME; Florentino, D; Fortunato, JJ; Garbossa, L; Goldim, MP; Martins Laurentino, AO; Mathias, K; Mina, F; Oliveira Junior, AN; Petronilho, F; Zarbato, GF, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 4 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Oliveira, TQ | 1 |
| Chaves Filho, AJM | 1 |
| Jucá, PM | 1 |
| Soares, MVR | 1 |
| Cunha, NL | 1 |
| Vieira, CFX | 1 |
| Gadelha Filho, CVJ | 1 |
| Viana, GA | 1 |
| De Oliveira, GMF | 1 |
| Macedo, DS | 1 |
| Vasconcelos, SMM | 1 |
| Lal, R | 1 |
| Dharavath, RN | 1 |
| Chopra, K | 1 |
| El-Kafoury, BMA | 1 |
| Abdel-Hady, EA | 1 |
| El Bakly, W | 1 |
| Elayat, WM | 1 |
| Hamam, GG | 1 |
| Abd El Rahman, SMM | 1 |
| Lasheen, NN | 1 |
| Giustina, AD | 1 |
| de Souza Goldim, MP | 1 |
| Danielski, LG | 2 |
| Garbossa, L | 2 |
| Junior, ANO | 1 |
| Cidreira, T | 1 |
| Denicol, T | 1 |
| Bonfante, S | 1 |
| da Rosa, N | 2 |
| Fortunato, JJ | 2 |
| Palandi, J | 1 |
| de Oliveira, BH | 1 |
| Martins, DF | 1 |
| Bobinski, F | 1 |
| Garcez, M | 1 |
| Bellettini-Santos, T | 2 |
| Budni, J | 2 |
| Colpo, G | 1 |
| Scaini, G | 1 |
| Giridharan, VV | 1 |
| Barichello, T | 2 |
| Petronilho, F | 2 |
| Della Giustina, A | 1 |
| Goldim, MP | 1 |
| Florentino, D | 1 |
| Mathias, K | 1 |
| Oliveira Junior, AN | 1 |
| Fileti, ME | 1 |
| Zarbato, GF | 1 |
| Martins Laurentino, AO | 1 |
| Mina, F | 1 |
| Dal-Pizzol, F | 1 |
| Park, JH | 1 |
| Young Park, H | 1 |
| Lee, HS | 1 |
| Han, CY | 1 |
| Lee, S | 1 |
| Cave, AE | 1 |
| Chang, DH | 1 |
| Münch, GW | 1 |
| Steiner, GZ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for thioctic acid and Cognitive Dysfunction
| Article | Year |
|---|---|
Efficacy of Cognition Support Formula® on cognitive function in older adults with subjective cognitive impairment: a protocol for a 26-week, randomised, double-blind, placebo-controlled trial.
Topics: Bacopa; Cognition; Cognitive Dysfunction; Dietary Supplements; Double-Blind Method; Electroencephalo | 2019 |
6 other studies available for thioctic acid and Cognitive Dysfunction
| Article | Year |
|---|---|
Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Cognitive Dysfunction; Corticosteron | 2022 |
Alpha-Lipoic Acid Ameliorates Doxorubicin-Induced Cognitive Impairments by Modulating Neuroinflammation and Oxidative Stress via NRF-2/HO-1 Signaling Pathway in the Rat Hippocampus.
Topics: Acetylcholinesterase; Animals; Antioxidants; Cognitive Dysfunction; Doxorubicin; Hippocampus; Neuroi | 2023 |
Lipoic acid inhibits cognitive impairment induced by multiple cell phones in young male rats: role of Sirt1 and Atg7 pathway.
Topics: Animals; Autophagy-Related Protein 7; Cell Phone; Child; Cognitive Dysfunction; Electromagnetic Fiel | 2023 |
Lipoic Acid and Fish Oil Combination Potentiates Neuroinflammation and Oxidative Stress Regulation and Prevents Cognitive Decline of Rats After Sepsis.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Catalase; Cells, Cultured; Cognitive Dysfunction; | 2020 |
Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis.
Topics: Acute Disease; Animals; Antioxidants; Brain; Cognitive Dysfunction; Coinfection; Inflammation; Infla | 2017 |
Effects of α-lipoic acid on chronic cerebrovascular hypoperfusion in an animal model of vascular dementia.
Topics: Animals; Carotid Stenosis; Cognitive Dysfunction; Dementia, Vascular; Disease Models, Animal; Drug A | 2019 |