thioctic acid has been researched along with Cognition Disorders in 17 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the putative neurotherapeutic effects of the mitochondrial cofactors, L-carnitine, acetyl-L-carnitine, and alpha-lipoic acid; and to provide a rationale for investigating their efficacy in the treatment of neurocognitive deficits associated with mood disorders." | 8.84 | Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders? ( Chow, CS; Kennedy, SH; Konarski, JZ; McIntyre, RS; Soczynska, JK; Woldeyohannes, HO, 2008) |
| "To evaluate the putative neurotherapeutic effects of the mitochondrial cofactors, L-carnitine, acetyl-L-carnitine, and alpha-lipoic acid; and to provide a rationale for investigating their efficacy in the treatment of neurocognitive deficits associated with mood disorders." | 4.84 | Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders? ( Chow, CS; Kennedy, SH; Konarski, JZ; McIntyre, RS; Soczynska, JK; Woldeyohannes, HO, 2008) |
| "Thioctic acid treatment did not improve cognitive function." | 2.69 | A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment. Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders. ( , 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Basile, GA | 1 |
| Iannuzzo, F | 1 |
| Xerra, F | 1 |
| Genovese, G | 1 |
| Pandolfo, G | 1 |
| Cedro, C | 1 |
| Muscatello, MRA | 1 |
| Bruno, A | 1 |
| Ahuja, S | 1 |
| Uniyal, A | 1 |
| Akhtar, A | 1 |
| Sah, SP | 1 |
| Shinto, L | 1 |
| Quinn, J | 1 |
| Montine, T | 1 |
| Dodge, HH | 1 |
| Woodward, W | 1 |
| Baldauf-Wagner, S | 1 |
| Waichunas, D | 1 |
| Bumgarner, L | 1 |
| Bourdette, D | 1 |
| Silbert, L | 1 |
| Kaye, J | 1 |
| Mehrotra, A | 1 |
| Kanwal, A | 1 |
| Banerjee, SK | 1 |
| Sandhir, R | 1 |
| Snigdha, S | 1 |
| de Rivera, C | 1 |
| Milgram, NW | 1 |
| Cotman, CW | 1 |
| Zhang, S | 1 |
| Li, H | 1 |
| Zhang, L | 1 |
| Li, J | 1 |
| Wang, R | 1 |
| Wang, M | 1 |
| Suchy, J | 1 |
| Chan, A | 1 |
| Shea, TB | 1 |
| Volchegorskiĭ, IA | 1 |
| Rassokhina, LM | 1 |
| Koliadich, MI | 1 |
| Alekseev, MI | 1 |
| Sharma, M | 1 |
| Gupta, YK | 1 |
| Manda, K | 1 |
| Ueno, M | 1 |
| Moritake, T | 1 |
| Anzai, K | 1 |
| Liu, J | 1 |
| Hager, K | 1 |
| Kenklies, M | 1 |
| McAfoose, J | 1 |
| Engel, J | 1 |
| Münch, G | 1 |
| Soczynska, JK | 1 |
| Kennedy, SH | 1 |
| Chow, CS | 1 |
| Woldeyohannes, HO | 1 |
| Konarski, JZ | 1 |
| McIntyre, RS | 1 |
| Di Rocco, A | 1 |
| Roesler, R | 1 |
| Quevedo, J | 1 |
| Walz, R | 1 |
| Bianchin, M | 1 |
| Chukanova, EI | 1 |
| Sokolova, NA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Alpha Lipoic Acid on Non-alcoholic Fatty Liver Diseases: A Randomized Placebo-controlled Clinical Trial[NCT04475276] | Phase 4 | 120 participants (Anticipated) | Interventional | 2021-02-23 | Recruiting | ||
| Fish Oil and Alpha Lipoic Acid in Mild Alzheimer's Disease[NCT00090402] | Phase 1/Phase 2 | 39 participants (Actual) | Interventional | 2004-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Activities of Daily Living/Instrumental Activities of Daily Living (ADL/IADL) measures an individual's ability to carry out tasks that are important for daily living and capture functional changes. Scores for each question range from 0 (no assistance needed) to 2 (full assistance needed), and were assessed by informant interview. The combination of scores for ADL (ranging from 0-18) and IADL (0-14) is the outcome (0-32), with higher scores indicating lesser ability to carry out daily living tasks. (NCT00090402)
Timeframe: baseline, 12 months
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 4.2 |
| Fish Oil | 0.7 |
| Fish Oil and Lipoic Acid | 0.9 |
The MMSE is a measure of global cognitive function, and scores range from 0-30, with a lower score indicates greater cognitive impairment. (NCT00090402)
Timeframe: baseline, 12 months
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | -4.64 |
| Fish Oil | -4.27 |
| Fish Oil Plus Lipoic Acid | -1.00 |
F2-isoprostane is a biomarker was used as an effective indicator for detecting a decrease in systemic oxidative damage (oxidative damage in lipids). Urine F2-Isoprostanes were used to avoid ex vivo lipid peroxidation that can occur with plasma samples. (NCT00090402)
Timeframe: baseline, 12 months
| Intervention | nanogram per miligram (Mean) |
|---|---|
| Placebo | 0.40 |
| Fish Oil | -2.02 |
| Fish Oil Plus Lipoic Acid | 0.45 |
2 reviews available for thioctic acid and Cognition Disorders
| Article | Year |
|---|---|
The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview.
Topics: Aging; Animals; Cognition Disorders; Humans; Mitochondria; Thioctic Acid | 2008 |
Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders?
Topics: Acetylcarnitine; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carnitine; Cl | 2008 |
7 trials available for thioctic acid and Cognition Disorders
| Article | Year |
|---|---|
A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cognit | 2014 |
[Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients].
Topics: Antioxidants; Attention; Cognition; Cognition Disorders; Diabetes Complications; Diabetes Mellitus; | 2011 |
Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis.
Topics: Aged; Alzheimer Disease; Antioxidants; Cholinesterase Inhibitors; Cognition Disorders; Disease Progr | 2007 |
A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment. Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antioxidants; Cognition Disorders; Double-Blind Method; F | 1998 |
A randomized, double-blind, placebo-controlled trial of deprenyl and thiotic acid in HIV-associated cognitive impairment.
Topics: Antioxidants; Cognition Disorders; Double-Blind Method; Humans; Monoamine Oxidase Inhibitors; Selegi | 1999 |
A randomized, double-blind, placebo-controlled trial of deprenyl and thiotic acid in HIV-associated cognitive impairment.
Topics: Antioxidants; Cognition Disorders; Double-Blind Method; Humans; Monoamine Oxidase Inhibitors; Selegi | 1999 |
[Efficiency of thioctacid in dyscirculatory encephalopathy].
Topics: Aged; Brain; Cerebrovascular Circulation; Cognition Disorders; Diabetes Complications; Female; Human | 2001 |
8 other studies available for thioctic acid and Cognition Disorders
| Article | Year |
|---|---|
Cognitive and Mood Effect of Alpha-Lipoic Acid Supplementation in a Nonclinical Elder Sample: An Open-Label Pilot Study.
Topics: Alzheimer Disease; Cognition; Cognition Disorders; Dietary Supplements; Humans; Pilot Projects; Thio | 2023 |
Alpha lipoic acid and metformin alleviates experimentally induced insulin resistance and cognitive deficit by modulation of TLR2 signalling.
Topics: Animals; Anti-Inflammatory Agents; Cognition Disorders; Disease Models, Animal; Insulin; Insulin Res | 2019 |
Mitochondrial modulators in experimental Huntington's disease: reversal of mitochondrial dysfunctions and cognitive deficits.
Topics: Acetylcarnitine; Animals; Cognition Disorders; Drug Therapy, Combination; Female; Huntington Disease | 2015 |
Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine.
Topics: Acetylcarnitine; Aging; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Coenzymes | 2016 |
Effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits in the hippocampus of streptozotocin-induced type 1 diabetes mellitus rats.
Topics: Animals; Cognition Disorders; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Evalu | 2017 |
Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance.
Topics: Acetylcarnitine; Alzheimer Disease; Animals; Antioxidants; Apolipoproteins E; Cognition Disorders; D | 2009 |
Effect of alpha lipoic acid on intracerebroventricular streptozotocin model of cognitive impairment in rats.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Avoidance Learning; Behavior, Animal; Brain; Bra | 2003 |
Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: protective effect of alpha-lipoic acid.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cerebellum; Cognition Disorders; Exploratory Behavi | 2007 |