Compounds > thioctic acid
Page last updated: 2024-10-19

thioctic acid and Chronic Progressive Multiple Sclerosis

thioctic acid has been researched along with Chronic Progressive Multiple Sclerosis in 4 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Research Excerpts

ExcerptRelevanceReference
"Gait and balance impairment is common in secondary progressive multiple sclerosis (SPMS)."2.87Effects of lipoic acid on walking performance, gait, and balance in secondary progressive multiple sclerosis. ( Bourdette, DN; Fling, BW; Horak, FB; Loy, BD; Spain, RI, 2018)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (75.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Cameron, M1
Taylor, C1
Lapidus, J1
Ramsey, K1
Koop, D1
Spain, R2
Fiedler, SE1
Yadav, V2
Kerns, AR1
Tsang, C1
Markwardt, S1
Kim, E1
Bourdette, D2
Salinthone, S1
Loy, BD1
Fling, BW1
Horak, FB1
Bourdette, DN1
Spain, RI1
Shinto, L1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Defining the Anti-inflammatory Role of Lipoic Acid in Multiple Sclerosis[NCT00997438]Phase 169 participants (Actual)Interventional2010-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

cAMP Levels

(NCT00997438)
Timeframe: 2 hours

Interventionpmol cAMP/mg protein (Median)
MS - Secondary Progressive75.9
MS - Relapsing Remmitting75.8
Healthy Controls96.6

cAMP Levels

(NCT00997438)
Timeframe: 4 hours

Interventionpmol cAMP/mg protein (Median)
MS - Secondary Progressive72.6
MS - Relapsing Remmitting79.1
Healthy Controls103.5

Lipoic Acid Levels

Plasma concentration of LA (NCT00997438)
Timeframe: 1 hour

Interventionng/mL (Mean)
MS - Secondary Progressive1376.14
MS - Relapsing Remmitting1609.07
Healthy Controls1428.05

Lipoic Acid Levels

Plasma concentration of LA (NCT00997438)
Timeframe: 2 hours

Interventionng/mL (Mean)
MS - Secondary Progressive1125.71
MS - Relapsing Remmitting1167.33
Healthy Controls1348

Lipoic Acid Levels

Plasma concentration of LA (NCT00997438)
Timeframe: 24 hour

Interventionng/mL (Mean)
MS - Secondary Progressive0.78
MS - Relapsing Remmitting0.87
Healthy Controls0.78

Lipoic Acid Levels

Plasma concentration of LA (NCT00997438)
Timeframe: 3 hours

Interventionng/mL (Mean)
MS - Secondary Progressive667.86
MS - Relapsing Remmitting638.4
Healthy Controls793.89

Lipoic Acid Levels

Plasma concentration of LA (NCT00997438)
Timeframe: 4 hours

Interventionng/mL (Mean)
MS - Secondary Progressive268.6
MS - Relapsing Remmitting252.75
Healthy Controls394.1

Lipoic Acid Levels

Plasma concentration of LA (NCT00997438)
Timeframe: 48 hour

Interventionng/mL (Mean)
MS - Secondary Progressive0.55
MS - Relapsing Remmitting0.7
Healthy Controls0.57

RANTES Levels

(NCT00997438)
Timeframe: 24 hour

Interventionpg/mL (Mean)
MS - Secondary Progressive47184.9
MS - Relapsing Remitting36281.4
Healthy Controls76751.7

RANTES Levels

(NCT00997438)
Timeframe: 48 hour

Interventionpg/mL (Mean)
MS - Secondary Progressive44905.8
MS - Relapsing Remmitting42593.8
Healthy Controls60578.5

Trials

3 trials available for thioctic acid and Chronic Progressive Multiple Sclerosis

ArticleYear
Gastrointestinal Tolerability and Absorption of R- Versus R,S-Lipoic Acid in Progressive Multiple Sclerosis: A Randomized Crossover Trial.
    Journal of clinical pharmacology, 2020, Volume: 60, Issue:8

    Topics: Administration, Oral; Aged; Area Under Curve; Biological Availability; Cross-Over Studies; Double-Bl

2020
Lipoic Acid Stimulates cAMP Production in Healthy Control and Secondary Progressive MS Subjects.
    Molecular neurobiology, 2018, Volume: 55, Issue:7

    Topics: Administration, Oral; Adult; Aged; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Femal

2018
Effects of lipoic acid on walking performance, gait, and balance in secondary progressive multiple sclerosis.
    Complementary therapies in medicine, 2018, Volume: 41

    Topics: Exercise Test; Female; Gait; Humans; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Pos

2018

Other Studies

1 other study available for thioctic acid and Chronic Progressive Multiple Sclerosis

ArticleYear
Complementary and alternative medicine for the treatment of multiple sclerosis.
    Expert review of clinical immunology, 2010, Volume: 6, Issue:3

    Topics: Adult; Antioxidants; Clinical Trials as Topic; Complementary Therapies; Diet, Fat-Restricted; Dietar

2010