Page last updated: 2024-10-19

thioctic acid and Chronic Kidney Failure

thioctic acid has been researched along with Chronic Kidney Failure in 13 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Research Excerpts

ExcerptRelevanceReference
"Combination of oral mixed tocopherols and ALA treatment for 2 months does not influence biomarkers of oxidative stress and inflammation in patients with stage 3 to 4 CKD."5.15Effects of combination tocopherols and alpha lipoic acid therapy on oxidative stress and inflammatory biomarkers in chronic kidney disease. ( Himmelfarb, J; Ikizler, TA; Kane, J; Le, P; McMonagle, E; Ramos, LF; Shintani, A; Wu, P, 2011)
"Vitamin D deficiency is a common health complication in patients with chronic kidney disease and can be treated with an abundance of classical and advanced pharmaceutics."2.77A cost effective complement to managing the vitamin D deficient and anemic dialysis patient in the bundled world. ( Bea, L; Larkin, J; Sharma, A, 2012)
"In an open-label, parallel-group study involving 16 patients (8 with severely reduced renal function, 8 with end-stage renal disease needing hemodialysis), the effect of renal function on the pharmacokinetics, metabolism, and safety and of alpha-lipoic acid (thioctic acid) was evaluated by comparing the pharmacokinetic parameters with those of a reference group of 8 healthy subjects."2.71Pharmacokinetics of alpha-lipoic acid in subjects with severe kidney damage and end-stage renal disease. ( Achenbach, H; Hermann, R; Preiss, C; Preiss, R; Ruus, P; Teichert, J; Tuemmers, T, 2005)
"Thioctic acid treatment was discontinued 2 days after admission."1.37Thioctic acid-induced acute cholestatic hepatitis. ( Castiglioni, T; Ridruejo, E; Silva, MO, 2011)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's2 (15.38)29.6817
2010's10 (76.92)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kohlová, M1
Amorim, CG1
Araújo, A1
Santos-Silva, A1
Solich, P1
Montenegro, MCBSM1
Safa, J2
Ardalan, MR1
Rezazadehsaatlou, M1
Mesgari, M1
Mahdavi, R2
Jadid, MP1
Iciek, M2
Marcykiewicz, B1
Bilska-Wilkosz, A1
Sokołowska-Jeżewicz, M1
Kłapcińska, J1
Ergür, BU1
Çilaker Mıcılı, S1
Yılmaz, O1
Akokay, P1
Ramos, LF1
Kane, J1
McMonagle, E1
Le, P1
Wu, P1
Shintani, A1
Ikizler, TA1
Himmelfarb, J1
Sokołowska, M1
Niedzielska, E1
Bilska, A1
Lorenc-Koci, E1
Włodek, L1
Ridruejo, E1
Castiglioni, T1
Silva, MO1
Khabbazi, T1
Pour-Abdollahi, P1
Yu, X1
Liu, H1
Zou, J1
Zhu, J1
Xu, X1
Ding, X1
Larkin, J1
Bea, L1
Sharma, A1
Teichert, J1
Tuemmers, T1
Achenbach, H1
Preiss, C1
Hermann, R1
Ruus, P1
Preiss, R1
Chang, JW1
Lee, EK1
Kim, TH1
Min, WK1
Chun, S1
Lee, KU1
Kim, SB1
Park, JS1
Reddi, AS1
Baskin, S1
Wassel, E1
DeAngelis, B1
Baker, H1

Reviews

1 review available for thioctic acid and Chronic Kidney Failure

ArticleYear
The biocompatibility and bioactivity of hemodialysis membranes: their impact in end-stage renal disease.
    Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2019, Volume: 22, Issue:1

    Topics: Antioxidants; Biocompatible Materials; Cellulose; Humans; Inflammation; Kidney Failure, Chronic; Mem

2019

Trials

6 trials available for thioctic acid and Chronic Kidney Failure

ArticleYear
Effects of alpha lipoic acid supplementation on serum levels of IL-8 and TNF-α in patient with ESRD undergoing hemodialysis.
    International urology and nephrology, 2014, Volume: 46, Issue:8

    Topics: Adult; Aged; Antioxidants; Diabetic Nephropathies; Dietary Supplements; Double-Blind Method; Female;

2014
Effects of combination tocopherols and alpha lipoic acid therapy on oxidative stress and inflammatory biomarkers in chronic kidney disease.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2011, Volume: 21, Issue:3

    Topics: Administration, Oral; Aged; Antioxidants; Biomarkers; C-Reactive Protein; Double-Blind Method; Drug

2011
Effects of alpha-lipoic acid supplementation on inflammation, oxidative stress, and serum lipid profile levels in patients with end-stage renal disease on hemodialysis.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2012, Volume: 22, Issue:2

    Topics: Adult; Aged; Antioxidants; C-Reactive Protein; Cholesterol; Dietary Supplements; Double-Blind Method

2012
A cost effective complement to managing the vitamin D deficient and anemic dialysis patient in the bundled world.
    Nephrology news & issues, 2012, Volume: 26, Issue:8

    Topics: Anemia; Antioxidants; C-Reactive Protein; Cholecalciferol; Cost-Benefit Analysis; Dietary Supplement

2012
Pharmacokinetics of alpha-lipoic acid in subjects with severe kidney damage and end-stage renal disease.
    Journal of clinical pharmacology, 2005, Volume: 45, Issue:3

    Topics: Adult; Aged; Antioxidants; Female; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Renal

2005
Effects of alpha-lipoic acid on the plasma levels of asymmetric dimethylarginine in diabetic end-stage renal disease patients on hemodialysis: a pilot study.
    American journal of nephrology, 2007, Volume: 27, Issue:1

    Topics: Adult; Antioxidants; Arginine; Biomarkers; C-Reactive Protein; Cholesterol; Chromatography, High Pre

2007

Other Studies

6 other studies available for thioctic acid and Chronic Kidney Failure

ArticleYear
The effect of lipoate on anaerobic cysteine metabolism in erythrocytes of patients treated with peritoneal dialysis.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:2

    Topics: Adult; Aged; Cysteine; Dietary Supplements; Erythrocytes; Female; Humans; Kidney Failure, Chronic; M

2014
The effects of α-lipoic acid on aortic injury and hypertension in the rat remnant kidney (5/6 nephrectomy) model.
    Anatolian journal of cardiology, 2015, Volume: 15, Issue:6

    Topics: Administration, Oral; Animals; Antioxidants; Aorta, Abdominal; Blood Pressure; Dietary Supplements;

2015
The effect of the uremic toxin cyanate (CNO⁻) on anaerobic cysteine metabolism and oxidative processes in the rat liver: a protective effect of lipoate.
    Toxicology mechanisms and methods, 2011, Volume: 21, Issue:6

    Topics: Animals; Antioxidants; Cyanates; Cysteine; Hydrogen Sulfide; Kidney Failure, Chronic; Lipid Peroxida

2011
Thioctic acid-induced acute cholestatic hepatitis.
    The Annals of pharmacotherapy, 2011, Volume: 45, Issue:7-8

    Topics: Antioxidants; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Diabetes Mellitus,

2011
Oxidative stress in 5/6 nephrectomized rat model: effect of alpha-lipoic acid.
    Renal failure, 2012, Volume: 34, Issue:7

    Topics: Animals; Antioxidants; Disease Models, Animal; Kidney; Kidney Failure, Chronic; Kidney Function Test

2012
Plasma alpha-lipoic acid and total glutathione levels in patients on maintenance hemodialysis.
    Nephron, 1999, Volume: 82, Issue:4

    Topics: Female; Glutathione; Humans; Kidney Failure, Chronic; Male; Renal Dialysis; Thioctic Acid

1999