thioctic acid has been researched along with Chronic Illness in 26 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " It was found that 14-day course of dihydroquercetin (50 mg/kg) and lipoic acid (50 mg/kg) administered intragastrically prevented the increase in hind limb volume and reduced the severity of edema of rat muscle tissue in chronic venous insufficiency." | 3.77 | Antioxidant composition causes antiexsudorific effect in the model of chronic venous insufficiency. ( Aliev, OI; Ermolaeva, LA; Fomina, TI; Ivanov, IS; Plotnikov, MB; Sidekhmenova, AV; Tyukavkin, NA, 2011) |
| "A woman affected by chronic progressive external ophthalmoplegia and muscle mitochondrial DNA deletion was studied by phosphorus magnetic resonance spectroscopy (31P-MRS) prior to and after 1 and 7 months of treatment with oral lipoic acid." | 3.69 | Lipoic (thioctic) acid increases brain energy availability and skeletal muscle performance as shown by in vivo 31P-MRS in a patient with mitochondrial cytopathy. ( Barbiroli, B; Iotti, S; Klopstock, T; Lodi, R; Medori, R; Reichmann, H; Seibel, P; Tritschler, HJ; Zaniol, P, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (57.69) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 5 (19.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giammusso, B | 1 |
| Di Mauro, R | 1 |
| Bernardini, R | 1 |
| Yorek, MS | 1 |
| Obrosov, A | 1 |
| Shevalye, H | 1 |
| Coppey, LJ | 1 |
| Kardon, RH | 1 |
| Yorek, MA | 1 |
| Cui, J | 1 |
| Le, G | 1 |
| Yang, R | 1 |
| Shi, Y | 1 |
| Ziegler, D | 1 |
| Brenner, SR | 1 |
| Ivanov, IS | 1 |
| Sidekhmenova, AV | 1 |
| Aliev, OI | 1 |
| Fomina, TI | 1 |
| Ermolaeva, LA | 1 |
| Tyukavkin, NA | 1 |
| Plotnikov, MB | 1 |
| Nasole, E | 1 |
| Nicoletti, C | 1 |
| Yang, ZJ | 1 |
| Girelli, A | 1 |
| Rubini, A | 1 |
| Giuffreda, F | 1 |
| Di Tano, A | 1 |
| Camporesi, E | 1 |
| Bosco, G | 1 |
| CHIANCA, L | 1 |
| CICOIRA, E | 1 |
| Smith, AR | 1 |
| Shenvi, SV | 1 |
| Widlansky, M | 1 |
| Suh, JH | 1 |
| Hagen, TM | 1 |
| Petcu, M | 1 |
| Ongali, B | 1 |
| El Midaoui, A | 1 |
| de Champlain, J | 1 |
| Couture, R | 1 |
| Bansal, V | 1 |
| Kalita, J | 1 |
| Misra, UK | 1 |
| László, B | 1 |
| Méhesfalvy, E | 1 |
| Grigor'ian, VA | 1 |
| Klantsa, NA | 1 |
| Prishliak, VD | 1 |
| Klantsa, PN | 1 |
| Huslarová, A | 1 |
| Fric, P | 1 |
| Barbiroli, B | 1 |
| Medori, R | 1 |
| Tritschler, HJ | 1 |
| Klopstock, T | 1 |
| Seibel, P | 1 |
| Reichmann, H | 1 |
| Iotti, S | 1 |
| Lodi, R | 1 |
| Zaniol, P | 1 |
| Romanov, VS | 2 |
| Möller, E | 3 |
| Schmitt, R | 1 |
| Pincus, JH | 1 |
| Brinkmann, W | 2 |
| Weber, O | 1 |
| Wildhirt, E | 2 |
| Loginov, AS | 1 |
| Isakova, ZS | 1 |
| Bakumenko, MS | 1 |
| Iutanova, II | 1 |
| Dabski, H | 1 |
| Brzeski, Z | 1 |
| Sauer, H | 1 |
| Böninger, C | 1 |
| Loginow, AS | 1 |
| Klein, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blinded, Placebo-controlled Trial of Idebenone in the Prevention of Episodic Migraine[NCT04151472] | Phase 3 | 180 participants (Anticipated) | Interventional | 2021-12-08 | Recruiting | ||
| Effects of Enriched Oxygen Mixtures and Exercise on Oxidative Stress and Stem Cells Proliferation in Athletes.[NCT04366427] | Phase 2 | 42 participants (Actual) | Interventional | 2020-09-15 | Completed | ||
| Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups[NCT00328601] | Phase 3 | 170 participants | Interventional | 2005-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for thioctic acid and Chronic Illness
| Article | Year |
|---|---|
Painful diabetic neuropathy: advantage of novel drugs over old drugs?
Topics: Amitriptyline; Analgesics; Antioxidants; Antipruritics; Capsaicin; Chronic Disease; Diabetic Neuropa | 2009 |
Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress.
Topics: Animals; Antioxidants; Chelation Therapy; Chronic Disease; Coenzymes; Diabetic Neuropathies; Free Ra | 2004 |
Diabetic neuropathy.
Topics: Aldehyde Reductase; Antioxidants; Autonomic Nervous System Diseases; Chronic Disease; Diabetic Neuro | 2006 |
4 trials available for thioctic acid and Chronic Illness
| Article | Year |
|---|---|
The efficacy of an association of palmitoylethanolamide and alpha-lipoic acid in patients with chronic prostatitis/chronic pelvic pain syndrome: A randomized clinical trial.
Topics: Adult; Amides; Chronic Disease; Chronic Pain; Ethanolamines; Humans; Male; Middle Aged; Palmitic Aci | 2017 |
Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing.
Topics: Aged; Aged, 80 and over; Antioxidants; Chronic Disease; Combined Modality Therapy; Diabetic Foot; Do | 2014 |
[A contribution to the treatment of chronic liver diseases (author's transl)].
Topics: Administration, Oral; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Chronic Disease; Cl | 1976 |
[Is the rebound effect in liver diseases following glucocorticoid therapy avoidable by using alpha-lipoic acid?].
Topics: Chronic Disease; Drug Interactions; Humans; Liver Diseases; Paramethasone; Substance Withdrawal Synd | 1971 |
19 other studies available for thioctic acid and Chronic Illness
| Article | Year |
|---|---|
Early vs. late intervention of high fat/low dose streptozotocin treated C57Bl/6J mice with enalapril, α-lipoic acid, menhaden oil or their combination: Effect on diabetic neuropathy related endpoints.
Topics: Acute Disease; Animals; Chronic Disease; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dru | 2017 |
Lipoic acid attenuates high fat diet-induced chronic oxidative stress and immunosuppression in mice jejunum: a microarray analysis.
Topics: Animals; Antioxidants; Chronic Disease; Dietary Fats; Gene Expression; Gene Expression Profiling; Im | 2009 |
Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs.
Topics: Brain Diseases, Metabolic; Chronic Disease; Disease Progression; DNA, Mitochondrial; Genetic Predisp | 2010 |
Antioxidant composition causes antiexsudorific effect in the model of chronic venous insufficiency.
Topics: Animals; Antioxidants; Chronic Disease; Edema; Hindlimb; Male; Muscle, Skeletal; Quercetin; Rats; Ra | 2011 |
[Thioctic acid in therapy of chronic pulmonary heart disease].
Topics: Chronic Disease; Humans; Pulmonary Heart Disease; Thioctic Acid; Vitamin K; Vitamins | 1958 |
Effects of alpha-lipoic acid on kinin B1 and B2 receptor binding sites in the spinal cord of chronically angiotensin-treated rats.
Topics: Angiotensin II; Animals; Binding Sites; Blood Glucose; Blood Pressure; Body Weight; Chronic Disease; | 2005 |
[Lipoic acid therapy in chronic active hepatitis].
Topics: Chronic Disease; Female; Hepatitis; Humans; Liver; Male; Middle Aged; Thioctic Acid | 1980 |
[Effect of prodectin and lipoic acid on the lipid metabolism indicators in chronic ischemic heart disease].
Topics: Adult; Aged; Carbamates; Cholesterol; Chronic Disease; Coronary Disease; Female; Humans; Hyperlipopr | 1981 |
[Contribution to the treatment of chronic liver diseases with Thioctacid].
Topics: Adult; Aged; Chronic Disease; Female; Humans; Liver Diseases; Male; Middle Aged; Thioctic Acid | 1982 |
Lipoic (thioctic) acid increases brain energy availability and skeletal muscle performance as shown by in vivo 31P-MRS in a patient with mitochondrial cytopathy.
Topics: Adenosine Diphosphate; Adult; Brain Chemistry; Chronic Disease; Energy Metabolism; Exercise; Female; | 1995 |
[Dosage of lipoic acid preparations in chronic diseases of the liver].
Topics: Chronic Disease; Humans; Liver Diseases; Thioctic Acid | 1977 |
Subacute necrotizing encephalomyelopathy (Leigh's disease): a consideration of clinical features and etiology.
Topics: Age Factors; Brain Stem; Carbon Dioxide; Chronic Disease; Encephalomalacia; Humans; Infant; Infant, | 1972 |
[Treatment of chronic liver diseases with thioctic acid].
Topics: Adult; Alcoholism; Chronic Disease; Female; Hepatitis; Humans; Injections, Intravenous; Liver Cirrho | 1967 |
[Treatment of chronic liver disease with lipoic acid].
Topics: Adolescent; Adult; Aged; Chronic Disease; Female; Humans; Liver Diseases; Male; Middle Aged; Thiocti | 1967 |
[Therapeutic progress in chronic liver diseases].
Topics: Choline; Chronic Disease; Folic Acid; Hepatitis; Humans; Liver Cirrhosis; Orotic Acid; Thioctic Acid | 1968 |
[Treatment of chronic diseases of the liver parenchyma with thioctic acid].
Topics: Adult; Aged; Chronic Disease; Female; Humans; Liver Diseases; Male; Middle Aged; Thioctic Acid | 1970 |
[What is reliable in the therapy of diabetes mellitus?].
Topics: Carbutamide; Chlorpropamide; Chronic Disease; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nep | 1970 |
[Therapy of chronic liver diseases with prednisolone and alpha-lipoic acid].
Topics: Amides; Bilirubin; Blood Proteins; Cholesterol; Chronic Disease; Depression, Chemical; Esophageal Di | 1970 |
[Use of lipoic acid and its amide in chronic liver diseases].
Topics: Amides; Chronic Disease; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Thioctic Acid | 1971 |