Page last updated: 2024-10-19

thioctic acid and Choline Deficiency

thioctic acid has been researched along with Choline Deficiency in 4 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Choline Deficiency: A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)

Research Excerpts

ExcerptRelevanceReference
"Non-alcoholic steatohepatitis (NASH) is a liver disease that causes fat accumulation, inflammation and fibrosis."1.38Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice. ( Kim, HS; Kim, JG; Kim, MK; Lee, IK; Lee, KU; Min, AK; Park, KG; Seo, HY, 2012)
"Carnitine treatment increased the mRNA expression of carnitine palmitoyltransferase 1A and peroxisome proliferator-activated receptor-γ, and carnitine-lipoic acid further augmented the mRNA expression."1.37Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction. ( Cho, WK; Choi, HS; Hahm, JS; Jang, KS; Jeon, HJ; Jun, DW; Jun, JH; Kim, HJ; Kwon, HJ; Lee, HL; Lee, KN; Lee, MH; Lee, OY; Yoon, BC, 2011)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Veskovic, M1
Mladenovic, D1
Jorgacevic, B1
Stevanovic, I1
de Luka, S1
Radosavljevic, T1
Jun, DW1
Cho, WK1
Jun, JH1
Kwon, HJ1
Jang, KS1
Kim, HJ1
Jeon, HJ1
Lee, KN1
Lee, HL1
Lee, OY1
Yoon, BC1
Choi, HS1
Hahm, JS1
Lee, MH1
Min, AK1
Kim, MK1
Kim, HS1
Seo, HY1
Lee, KU1
Kim, JG1
Park, KG1
Lee, IK1
Perra, A1
Pibiri, M1
Sulas, P1
Simbula, G1
Ledda-Columbano, GM1
Columbano, A1

Other Studies

4 other studies available for thioctic acid and Choline Deficiency

ArticleYear
Alpha-lipoic acid affects the oxidative stress in various brain structures in mice with methionine and choline deficiency.
    Experimental biology and medicine (Maywood, N.J.), 2015, Volume: 240, Issue:4

    Topics: Animals; Brain; Catalase; Cerebral Cortex; Choline Deficiency; Corpus Striatum; Disease Models, Anim

2015
Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction.
    Liver international : official journal of the International Association for the Study of the Liver, 2011, Volume: 31, Issue:9

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Carnitine; Carnitine O-Palmitoyltransferase; Choline Def

2011
Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice.
    Life sciences, 2012, Jan-30, Volume: 90, Issue:5-6

    Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline; Choline Deficiency; Cyto

2012
Alpha-lipoic acid promotes the growth of rat hepatic pre-neoplastic lesions in the choline-deficient model.
    Carcinogenesis, 2008, Volume: 29, Issue:1

    Topics: Animals; Antioxidants; Cell Death; Choline Deficiency; Lipid Peroxidation; Liver Neoplasms; Precance

2008
chemdatabank.com