thioctic acid has been researched along with Cerebral Ischemia in 23 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Experimental and clinical suppositions of the use of a-lipoic acid as one of the most studied antioxidant in the treatment of brain ischemia as well as the results of own studies on the preparation berlition which contains a-lipoic acid used in the neuroprotective therapy of chronic brain ischemia for correction of free-radical processes are discussed." | 5.13 | [The free-radical processes and antioxidant therapy in brain ischemia]. ( Aseĭchev, AV; Azizova, OA; Baranova, OA; Bekman, EM; Fedin, AI; Mironova, OP; Solov'eva, EIu, 2008) |
| "The effect of original domestic derivatives of 3-oxypiridine and succinic acid (emoxipine, reamberin and mexidol) on the resistance to acute brain ischemia was studied in an experimental mouse models." | 3.80 | [The effect of 3-oxypyridine and succinic acid derivatives on the resistance to acute cerebral ischemia]. ( Faĭzullin, RM; Kalugina, AV; Malkin, MP; Miroshnichenko, II; Priakhina, KE; Rassokhina, LM; Volchegorskiĭ, IA, 2014) |
| "We studied the effect of deproteinized hemoderivative of calf blood, thioctic acid and vinpocetine with piracetam on the endothelial function in patients with chronic cerebral ischemia stage III." | 3.79 | [Pharmacotherapy of endothelial dysfunction in patients with atherosclerotic brain ischemia]. ( Abdrakhmanova, EK; Fedin, AI; Mironova, OP; Parfenov, AS; Starykh, EP; Starykh, EV, 2013) |
| "alpha-Lipoic acid (thioctic acid) was tested for its neuroprotective activity in a Mongolian gerbil model of forebrain ischemia/reperfusion." | 3.69 | The free radical scavenger, alpha-lipoic acid, protects against cerebral ischemia-reperfusion injury in gerbils. ( Cao, X; Phillis, JW, 1995) |
| " Both α-lipoic acid and etanercept markedly reduced cerebral infarct, blood-brain barrier disruption, and neurological motor deficits with the former drug being more effective with the dosage used." | 1.43 | Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke. ( Chang, CP; Chio, CC; Huang, CC; Lin, MT; Lin, NK; Tsai, KJ; Wu, MH, 2016) |
| "We used the models of focal cerebral ischemia in mice and rats." | 1.29 | Neuroprotective effects of alpha-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia. ( Krieglstein, J; Wolz, P, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 14 (60.87) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, X | 1 |
| Chen, W | 1 |
| Li, J | 1 |
| Shen, C | 1 |
| Zhou, P | 1 |
| Che, X | 1 |
| Li, X | 1 |
| Xie, R | 1 |
| Zhang, J | 3 |
| Xiao, F | 1 |
| Zhang, L | 1 |
| Wang, X | 2 |
| Lai, X | 1 |
| Shen, Y | 1 |
| Zhang, M | 1 |
| Zhou, B | 1 |
| Lang, H | 1 |
| Yu, P | 1 |
| Hua, F | 1 |
| Fedin, AI | 3 |
| Starykh, EP | 1 |
| Parfenov, AS | 1 |
| Mironova, OP | 3 |
| Abdrakhmanova, EK | 1 |
| Starykh, EV | 1 |
| Connell, BJ | 5 |
| Saleh, MC | 3 |
| Kucukkaya, I | 2 |
| Abd-El-Aziz, AS | 2 |
| Khan, BV | 3 |
| Saleh, TM | 5 |
| Rajagopal, D | 2 |
| Fu, B | 1 |
| Zhang, X | 1 |
| Zhang, C | 1 |
| Li, Y | 1 |
| Zhang, Y | 2 |
| He, T | 1 |
| Li, P | 1 |
| Zhu, X | 1 |
| Zhao, Y | 1 |
| Deng, H | 1 |
| Zuo, X | 1 |
| Liu, X | 1 |
| Liu, L | 1 |
| Xu, Q | 1 |
| Wu, Z | 1 |
| Ji, A | 1 |
| Volchegorskiĭ, IA | 1 |
| Miroshnichenko, II | 1 |
| Rassokhina, LM | 1 |
| Faĭzullin, RM | 1 |
| Priakhina, KE | 1 |
| Malkin, MP | 1 |
| Kalugina, AV | 1 |
| Wu, MH | 1 |
| Huang, CC | 1 |
| Chio, CC | 1 |
| Tsai, KJ | 1 |
| Chang, CP | 1 |
| Lin, NK | 1 |
| Lin, MT | 1 |
| Solov'eva, EIu | 2 |
| Baranova, OA | 2 |
| Bekman, EM | 1 |
| Aseĭchev, AV | 1 |
| Azizova, OA | 1 |
| Saleh, M | 1 |
| Röhnert, P | 1 |
| Schröder, UH | 1 |
| Ziabreva, I | 1 |
| Täger, M | 1 |
| Reymann, KG | 1 |
| Striggow, F | 1 |
| Chekanov, AV | 1 |
| Karneev, AN | 1 |
| Miachin, IV | 1 |
| Panasenko, OM | 1 |
| do Vale, OC | 1 |
| Fonteles, DS | 1 |
| Cabral, FR | 1 |
| Fonteles, MC | 1 |
| Iksanova, GR | 1 |
| Saĭfullina, EI | 1 |
| Kolchina, EM | 1 |
| Novikova, LB | 1 |
| Cao, X | 1 |
| Phillis, JW | 1 |
| Panigrahi, M | 1 |
| Sadguna, Y | 1 |
| Shivakumar, BR | 1 |
| Kolluri, SV | 1 |
| Roy, S | 2 |
| Packer, L | 2 |
| Ravindranath, V | 1 |
| Wolz, P | 1 |
| Krieglstein, J | 2 |
| Gohil, K | 1 |
| Sen, CK | 1 |
| Piotrowski, P | 1 |
| Wierzbicka, K | 1 |
| Smiałek, M | 1 |
| Prehn, JH | 1 |
| Karkoutly, C | 1 |
| Nuglisch, J | 1 |
| Peruche, B | 1 |
1 trial available for thioctic acid and Cerebral Ischemia
| Article | Year |
|---|---|
[The free-radical processes and antioxidant therapy in brain ischemia].
Topics: Aged; Antioxidants; Brain Ischemia; Drug Administration Schedule; Female; Free Radicals; Humans; Mal | 2008 |
22 other studies available for thioctic acid and Cerebral Ischemia
| Article | Year |
|---|---|
The protective effect of alpha-lipoic acid against brain ischemia and reperfusion injury via mTOR signaling pathway in rats.
Topics: Animals; Brain Ischemia; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injur | 2018 |
Alpha-Lipoic Acid Preconditioning and Ischaemic Postconditioning Synergistically Protect Rats from Cerebral Injury Induced by Ischemia and Reperfusion Partly via Inhibition TLR4/MyD88/ NF-κB Signaling Pathway.
Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Ischemia; Ischemic Postconditioning; Male; Myeloid D | 2018 |
[Pharmacotherapy of endothelial dysfunction in patients with atherosclerotic brain ischemia].
Topics: Aged; Aged, 80 and over; Antioxidants; Brain Ischemia; Calcium Channel Blockers; Endothelium, Vascul | 2013 |
UPEI-300, a conjugate of lipoic acid and edaravone, mediates neuroprotection in ischemia/reperfusion.
Topics: Animals; Antipyrine; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Drug Combinations; Male; Neocort | 2014 |
Co-administration of resveratrol and lipoic acid, or their synthetic combination, enhances neuroprotection in a rat model of ischemia/reperfusion.
Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Humans; Male; Rats; Rats, Sprague-Daw | 2014 |
Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression and protects mouse brain against focal ischemia.
Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; M | 2014 |
Α‑lipoic acid protects against cerebral ischemia/reperfusion-induced injury in rats.
Topics: Animals; Antioxidants; Apoptosis; Brain Edema; Brain Ischemia; Brain-Derived Neurotrophic Factor; Ca | 2015 |
[The effect of 3-oxypyridine and succinic acid derivatives on the resistance to acute cerebral ischemia].
Topics: Acute Disease; Animals; Brain Ischemia; Disease Models, Animal; Female; Male; Meglumine; Mice; Picol | 2014 |
Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Dose-Response Relationship, Drug; Down-Regulation; Dru | 2016 |
UPEI-400, a conjugate of lipoic acid and scopoletin, mediates neuroprotection in a rat model of ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Male; Neuroprotective Agents; Rats; Rats, Sprague-D | 2017 |
Lipoic acid protects against reperfusion injury in the early stages of cerebral ischemia.
Topics: Animals; Antioxidants; Baroreflex; Blotting, Western; Brain Ischemia; Cerebral Infarction; Cerebrova | 2011 |
Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion.
Topics: Animals; Brain Ischemia; Cell Death; Disease Models, Animal; Ethidium; Fluoresceins; Gerbillinae; Gl | 2012 |
Co-administration of apocynin with lipoic acid enhances neuroprotection in a rat model of ischemia/reperfusion.
Topics: Acetophenones; Animals; Brain; Brain Ischemia; Drug Combinations; Humans; Male; Neuroprotective Agen | 2012 |
[A search for new markers of oxidative stress in brain ischemia for the optimization of treatment approaches].
Topics: Aged; Antioxidants; Biomarkers; Brain Ischemia; Female; Humans; Lipid Peroxidation; Male; Middle Age | 2011 |
A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Dr | 2003 |
[Assessment of berlition effectiveness in ischemic stroke with CT perfusion imaging of the brain].
Topics: Adult; Brain; Brain Ischemia; Cerebrovascular Circulation; Female; Humans; Male; Middle Aged; Thioct | 2008 |
The free radical scavenger, alpha-lipoic acid, protects against cerebral ischemia-reperfusion injury in gerbils.
Topics: Animals; Brain Ischemia; Free Radical Scavengers; Gerbillinae; Locomotion; Reperfusion Injury; Thioc | 1995 |
alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats.
Topics: Animals; Antioxidants; Brain Chemistry; Brain Ischemia; Glutathione; Injections, Intravenous; Male; | 1996 |
Neuroprotective effects of alpha-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Hemodynamics; Male; Mice; Rats; Rats, Sprague-D | 1996 |
Antioxidant regulation of gene expression: analysis of differentially expressed mRNAs.
Topics: Animals; Antioxidants; Brain Ischemia; Cerebellum; Cloning, Molecular; DNA, Complementary; Flavonoid | 1999 |
Neuronal death in the rat hippocampus in experimental diabetes and cerebral ischaemia treated with antioxidants.
Topics: Animals; Antioxidants; Apoptosis; Blood Glucose; Brain Ischemia; Caspase 3; Caspases; Cell Count; Co | 2001 |
Dihydrolipoate reduces neuronal injury after cerebral ischemia.
Topics: Animals; Blood Glucose; Blood Pressure; Body Temperature; Brain; Brain Ischemia; Glutamates; Glutami | 1992 |