thioctic acid has been researched along with Cerebral Infarction, Middle Cerebral Artery in 6 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, using a rat model of permanent middle cerebral artery occlusion (MCAO), we demonstrated that administration of LA 30 min prior to stroke, reduces infarct volume in a dose dependent manner." | 1.37 | Cellular mechanisms by which lipoic acid confers protection during the early stages of cerebral ischemia: a possible role for calcium. ( Connell, BJ; Khan, BV; Richard, MJ; Saleh, TM, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, C | 2 |
| Maharjan, S | 1 |
| Wang, Q | 2 |
| Sun, Y | 2 |
| Han, X | 2 |
| Wang, S | 2 |
| Mao, Z | 2 |
| Xin, Y | 2 |
| Zhang, B | 2 |
| Fu, B | 1 |
| Zhang, J | 1 |
| Zhang, X | 1 |
| Zhang, C | 1 |
| Li, Y | 1 |
| Zhang, Y | 2 |
| He, T | 1 |
| Li, P | 1 |
| Zhu, X | 1 |
| Zhao, Y | 1 |
| Wang, X | 1 |
| Choi, KH | 1 |
| Park, MS | 1 |
| Kim, HS | 2 |
| Kim, KT | 1 |
| Kim, JT | 1 |
| Kim, BC | 1 |
| Kim, MK | 1 |
| Park, JT | 1 |
| Cho, KH | 1 |
| Richard, MJ | 1 |
| Connell, BJ | 2 |
| Khan, BV | 2 |
| Saleh, TM | 2 |
| Saleh, MC | 1 |
| Rajagopal, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Lipoic Acid Use on Stroke Outcome After Reperfusion Therapy in Patients With Diabetes[NCT04041167] | Phase 3 | 120 participants (Anticipated) | Interventional | 2018-08-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for thioctic acid and Cerebral Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
α-Lipoic Acid Promotes Neurological Recovery After Ischemic Stroke by Activating the Nrf2/HO-1 Pathway to Attenuate Oxidative Damage.
Topics: Animals; Brain; Brain Edema; Cell Hypoxia; Cell Survival; Cells, Cultured; Disease Models, Animal; G | 2017 |
The Role of Alpha-Lipoic Acid in the Pathomechanism of Acute Ischemic Stroke.
Topics: Animals; Behavior, Animal; Brain Edema; Cell Line; Cyclooxygenase 2; Disease Models, Animal; Infarct | 2018 |
Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression and protects mouse brain against focal ischemia.
Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; M | 2014 |
Alpha-lipoic acid treatment is neurorestorative and promotes functional recovery after stroke in rats.
Topics: Animals; Biomarkers; Brain; Brain Infarction; Bromodeoxyuridine; Cell Proliferation; Doublecortin Pr | 2015 |
Cellular mechanisms by which lipoic acid confers protection during the early stages of cerebral ischemia: a possible role for calcium.
Topics: Animals; Antioxidants; Calcium; Excitatory Postsynaptic Potentials; Infarction, Middle Cerebral Arte | 2011 |
UPEI-100, a conjugate of lipoic acid and apocynin, mediates neuroprotection in a rat model of ischemia/reperfusion.
Topics: Acetophenones; Animals; Biomarkers; Disease Models, Animal; Glutathione Disulfide; Infarction, Middl | 2012 |