thioctic acid has been researched along with Central Nervous System Disease in 3 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Data suggests that ALA has a short half-life and bioavailability (about 30%) triggered by its hepatic degradation, reduced solubility as well as instability in the stomach." | 2.61 | Insights on the Use of α-Lipoic Acid for Therapeutic Purposes. ( Akram, M; Antika, G; Berkay Yılmaz, Y; Boyunegmez Tumer, T; Capanoglu, E; Cho, WC; Fawzi Mahomoodally, M; Lobine, D; Martins, N; Riaz, M; Salehi, B; Sharifi-Rad, J; Sharopov, F, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Salehi, B | 1 |
| Berkay Yılmaz, Y | 1 |
| Antika, G | 1 |
| Boyunegmez Tumer, T | 1 |
| Fawzi Mahomoodally, M | 1 |
| Lobine, D | 1 |
| Akram, M | 1 |
| Riaz, M | 1 |
| Capanoglu, E | 1 |
| Sharopov, F | 1 |
| Martins, N | 1 |
| Cho, WC | 1 |
| Sharifi-Rad, J | 1 |
| Seifar, F | 1 |
| Khalili, M | 1 |
| Khaledyan, H | 1 |
| Amiri Moghadam, S | 1 |
| Izadi, A | 1 |
| Azimi, A | 1 |
| Shakouri, SK | 1 |
| Salinthone, S | 1 |
| Yadav, V | 1 |
| Bourdette, DN | 1 |
| Carr, DW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for thioctic acid and Central Nervous System Disease
| Article | Year |
|---|---|
Insights on the Use of α-Lipoic Acid for Therapeutic Purposes.
Topics: Animals; Antioxidants; Biological Availability; Central Nervous System Diseases; Diabetic Neuropathi | 2019 |
α-Lipoic acid, functional fatty acid, as a novel therapeutic alternative for central nervous system diseases: A review.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Central Nervous System Diseases; Che | 2019 |
Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS.
Topics: Alzheimer Disease; Animals; Antioxidants; Central Nervous System Diseases; Diabetic Neuropathies; Hu | 2008 |