thioctic acid has been researched along with Cataract in 13 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model." | 7.81 | Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( Ayar, A; Çolak, R; Kan, E; Kiliçkan, E, 2015) |
| "To evaluate whether alpha-lipoic acid (LA) inhibits lens opacity of naphthalene-induced cataract by altering post-translational modifications (PTMs) and protecting the chaperone activity of alpha-crystallins." | 7.76 | alpha-Lipoic acid alters post-translational modifications and protects the chaperone activity of lens alpha-crystallin in naphthalene-induced cataract. ( Chen, Y; Fang, Y; Jang, Y; Wei, L; Wu, X; Yan, G; Yi, L; Zhou, X, 2010) |
| "This study revealed a marked stereospecificity in the prevention of buthionine sulfoximine-induced cataract, and in the protection of lens antioxidants, in newborn rats by alpha-lipoate, R- and racemic alpha-lipoate decreased cataract formation from 100% (buthionine sulfoximine only) to 55% (buthionine sulfoximine + R-alpha-lipoic acid) and 40% (buthionine sulfoximine + rac-alpha-lipoic acid) (p<0." | 7.69 | Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats. ( Maitra, I; Packer, L; Serbinova, E; Tritschler, HJ, 1996) |
| "The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model." | 3.81 | Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( Ayar, A; Çolak, R; Kan, E; Kiliçkan, E, 2015) |
| "To evaluate whether alpha-lipoic acid (LA) inhibits lens opacity of naphthalene-induced cataract by altering post-translational modifications (PTMs) and protecting the chaperone activity of alpha-crystallins." | 3.76 | alpha-Lipoic acid alters post-translational modifications and protects the chaperone activity of lens alpha-crystallin in naphthalene-induced cataract. ( Chen, Y; Fang, Y; Jang, Y; Wei, L; Wu, X; Yan, G; Yi, L; Zhou, X, 2010) |
| "This study revealed a marked stereospecificity in the prevention of buthionine sulfoximine-induced cataract, and in the protection of lens antioxidants, in newborn rats by alpha-lipoate, R- and racemic alpha-lipoate decreased cataract formation from 100% (buthionine sulfoximine only) to 55% (buthionine sulfoximine + R-alpha-lipoic acid) and 40% (buthionine sulfoximine + rac-alpha-lipoic acid) (p<0." | 3.69 | Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats. ( Maitra, I; Packer, L; Serbinova, E; Tritschler, HJ, 1996) |
| "Diabetic cataracts are caused by an elevation of polyols within the lens of the eye catalyzed by the enzyme aldose reductase." | 2.41 | Natural therapies for ocular disorders, part two: cataracts and glaucoma. ( Head, KA, 2001) |
| "Cataract was assessed using cross line grey scale measurement." | 1.39 | Alpha lipoic acid protects lens from H(2)O(2)-induced cataract by inhibiting apoptosis of lens epithelial cells and inducing activation of anti-oxidative enzymes. ( Jia, SB; Li, Y; Liu, YZ; Shi, JM, 2013) |
| "Formation of lens opacities in vitro was correlated with lactate dehydrogenase (LDH) leakage into the incubation medium." | 1.29 | Modelling cortical cataractogenesis 17: in vitro effect of a-lipoic acid on glucose-induced lens membrane damage, a model of diabetic cataractogenesis. ( Handelman, GJ; Kilic, F; Packer, L; Serbinova, E; Trevithick, JR, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Liu, YZ | 1 |
| Shi, JM | 1 |
| Jia, SB | 1 |
| Kan, E | 1 |
| Kiliçkan, E | 1 |
| Ayar, A | 1 |
| Çolak, R | 1 |
| Chen, Y | 1 |
| Yi, L | 1 |
| Yan, G | 1 |
| Fang, Y | 1 |
| Jang, Y | 1 |
| Wu, X | 1 |
| Zhou, X | 1 |
| Wei, L | 1 |
| Sun, L | 1 |
| Zhang, JS | 1 |
| Maitra, I | 2 |
| Serbinova, E | 3 |
| Trischler, H | 1 |
| Packer, L | 6 |
| Tritschler, HJ | 1 |
| Kilic, F | 2 |
| Handelman, GJ | 2 |
| Trevithick, JR | 3 |
| Bantseev, V | 1 |
| Bhardwaj, R | 1 |
| Rathbun, W | 1 |
| Nagasawa, H | 1 |
| Traber, K | 1 |
| Tsang, K | 1 |
| Head, KA | 1 |
| Kraemer, K | 1 |
| Rimbach, G | 1 |
| Bilska, A | 1 |
| Włodek, L | 1 |
4 reviews available for thioctic acid and Cataract
| Article | Year |
|---|---|
Antioxidant properties of lipoic acid and its therapeutic effects in prevention of diabetes complications and cataracts.
Topics: Animals; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Cataract; Diabetes Mellitus, Experim | 1994 |
Natural therapies for ocular disorders, part two: cataracts and glaucoma.
Topics: Cataract; Diabetes Complications; Diabetes Mellitus; Female; Glaucoma; Glucose; Glutathione; Humans; | 2001 |
Molecular aspects of lipoic acid in the prevention of diabetes complications.
Topics: Antioxidants; Biological Availability; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetic | 2001 |
[Biologic properties of lipoic acid].
Topics: Acquired Immunodeficiency Syndrome; Aging; Animals; Antioxidants; Cataract; Decarboxylation; Diabeti | 2002 |
9 other studies available for thioctic acid and Cataract
| Article | Year |
|---|---|
Alpha lipoic acid protects lens from H(2)O(2)-induced cataract by inhibiting apoptosis of lens epithelial cells and inducing activation of anti-oxidative enzymes.
Topics: Animals; Antioxidants; Apoptosis; Cataract; Epithelial Cells; Glutathione; Hydrogen Peroxide; L-Lact | 2013 |
Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice.
Topics: Animals; Antioxidants; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Pr | 2015 |
alpha-Lipoic acid alters post-translational modifications and protects the chaperone activity of lens alpha-crystallin in naphthalene-induced cataract.
Topics: Acetylation; alpha-Crystallins; Animals; Antioxidants; Cataract; Chromatography, High Pressure Liqui | 2010 |
[Effects of DL-alpha-lipoic acid on the experimentally induced diabetic cataract in rats].
Topics: Animals; Antioxidants; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Disease Models, Ani | 2004 |
Alpha-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats.
Topics: Animals; Buthionine Sulfoximine; Cataract; Female; Free Radicals; Glutamate-Cysteine Ligase; Glutath | 1995 |
Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats.
Topics: Animals; Animals, Newborn; Ascorbic Acid; Buthionine Sulfoximine; Cataract; Female; Glutathione; Glu | 1996 |
Modelling cortical cataractogenesis 17: in vitro effect of a-lipoic acid on glucose-induced lens membrane damage, a model of diabetic cataractogenesis.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glucose; In Vitr | 1995 |
Antioxidants and cataract: (cataract induction in space environment and application to terrestrial aging cataract).
Topics: Animals; Antioxidants; Ascorbic Acid; Carbolines; Cataract; Cysteine; Dose-Response Relationship, Ra | 1997 |
Modelling cortical cataractogenesis XX. In vitro effect of alpha-lipoic acid on glutathione concentrations in lens in model diabetic cataractogenesis.
Topics: Animals; Cataract; Culture Techniques; Diabetes Complications; Diabetes Mellitus; Disease Models, An | 1998 |